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Wyświetlanie 1-15 z 26
Tytuł:
Czym jest życie? Czyli jeśli spotkamy nieznaną formę istnienia w kosmosie, to kiedy nazwiemy ją żywą istotą
Autorzy:
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/2028036.pdf
Data publikacji:
2022
Wydawca:
Instytut Metropolitalny
Tematy:
życie
definicje życia
organizmy żywe
życie w kosmosie
life
definitions of life
living organisms
life in the space
Opis:
Mimo iż biologia jest nauką zajmującą się żywymi organizmami, to nie istnieje jedna, akceptowana przez wszystkich, definicja życia. Wszystkie zaproponowane dotychczas definicje życia proponują kryteria, które nie są spełniane przez niektóre formy istnienia, co do których nie mamy wątpliwości, że powinny być zaliczone do organizmów żywych. Jak zatem można odpo- wiedzieć na pytanie – kiedy potencjalną, nieznaną nam wcześniej, spotkaną w kosmosie formę istnienia nazwiemy organizmem żywym, a kiedy nie? Te dylematy są dyskutowane w tym artykule, a rozważania te doprowadziły do wniosku, że zaklasyfikowanie danej formy istnienia do organizmów żywych nie ma większego znaczenia, jeśli tylko poznamy i zrozumiemy jej budowę i mechanizmy funkcjonowania.
Despite biology is a scientific discipline focused on living organisms, there is no single, accepted by all biologists, definition of live. All such definitions proposed to date suggest criteria which are not fulfilled by some creatures which undoubtedly should be classified as living organisms. Therefore, how to answer the question: when a potential, previously unknown, form of existence met in the space should be called living organism, and when not? These dilemmas as discussed in this article, and my disputes led to the conclusion that classification of a given form of existence to living organisms is not essential if we recognize and understand its structure and mechanisms of functioning.
Źródło:
Ad Astra. Program badań nad astropolityką i prawem kosmicznym; 2022, 3; 23-27
2720-4456
Pojawia się w:
Ad Astra. Program badań nad astropolityką i prawem kosmicznym
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
O istocie i granicach życia, ziemskiego i nie tylko.
Autorzy:
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1997556.pdf
Data publikacji:
2021
Wydawca:
Instytut Metropolitalny
Opis:
Wywiad z prof. zw. dr hab. Grzegorzem Węgrzynem. Rozmawiał dr Jakub H. Szlachetko
Źródło:
Ad Astra. Program badań nad astropolityką i prawem kosmicznym; 2021, 2; 1-4
2720-4456
Pojawia się w:
Ad Astra. Program badań nad astropolityką i prawem kosmicznym
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differential effects of various soy isoflavone dietary supplements (nutraceuticals) on bacterial growth and human fibroblast viability
Autorzy:
Pierzynowska, Karolina
Rzeszótko, Agata
Blendowska, Aleksandra
Wieczerzak, Ewa
Rodziewicz-Motowidło, Sylwia
Piotrowska, Ewa
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1038411.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
genistein
soy isoflavone extracts
anti-menopausal dietary supplements
bacterial growth
viability of human cells
Opis:
Flavonoids, polyphenolic compounds present in many food products, affect growth of different bacterial species when tested as purified or synthetic substances. They can also influence gene expression in human cells, like fibroblasts. Here, we asked if soy isoflavone extracts, commonly used in many products sold as anti-menopausal dietary supplements, influence bacterial growth similarly to a synthetic isoflavone, genistein. Four commercially available products were tested in amounts corresponding to genistein concentrations causing inhibition of growth of Vibrio harveyi (a model bacterium sensitive to this isoflavone) and Escherichia coli (a model bacterium resistant to genistein). Differential effects of various extracts on V. harveyi and E. coli growth, from stimulation, to no changes, to inhibition, were observed. Moreover, contrary to genistein, the tested extracts caused a decrease (to different extent) in viability of human dermal fibroblasts. These results indicate that effects of various soy isoflavone extracts on bacterial growth and viability of human cells are different, despite similar declared composition of the commercially available products.
Źródło:
Acta Biochimica Polonica; 2018, 65, 2; 325-332
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of conditions and determination of practical tips for mtDNA level estimation in various human cells
Autorzy:
Jędrak, Paulina
Sowa, Natalia
Barańska, Sylwia
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1038562.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mtDNA level
leukocytes
fibroblasts
qPCR methodology
Huntington disease
Opis:
Determination of mtDNA copy number in the cell is crucial to understand many cellular processes. Recently, the number of studies with the use of mitochondrial DNA (mtDNA) content as the determinant of mitochondrial abnormalities increased greatly and is still growing, therefore, optimization of technical conditions for this analysis is crucial. Despite using similar laboratory protocols, some results cannot be compared between research centers, thus causing discrepancies in the assessment of mtDNA content. The aim of this work was to test which conditions of biological sample collection and storage affect estimation of mtDNA level relative to the nuclear DNA (nDNA) in the blood samples and dermal fibroblasts. We found that the time and temperature of sample storage, as well as the type of the blood sample (whole blood or leukocytes) influence the estimate of mtDNA/nDNA ratio in the blood. In the case of dermal fibroblasts collected from healthy control and Huntington disease patients, our data indicate that the passage number of cells is essential to obtain reliable results.
Źródło:
Acta Biochimica Polonica; 2017, 64, 4; 699-704
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes is genes coding for laccases 1 and 2 may contribute to deformation and reduction of wings in apollo butterfly (Parnassius apollo, Lepidoptera: Papilionidae) from the isolated population in Pieniny National Park (Poland)
Autorzy:
Łukasiewicz, Kinga
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1038862.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
apollo butterfly
deformed wings
reduced wings
genes of laccases
Opis:
An isolated population of apollo butterfly (Parnassius apollo, Lepidoptera: Papilionidae) occurs in Pieniny National Park (Poland). Deformations and reductions of wings in a relatively large number of individuals from this population is found, yet the reasons for these defects are unknown. During studies devoted to identify cause(s) of this phenomenon, we found that specific regions of genes coding of enzymes laccases 1 and 2 could not be amplified from DNA samples isolated from large fractions of malformed insects while expected PCR products were detected in almost all (with one exception) normal butterflies. Laccases (p-diphenol:dioxygen oxidoreductases) are oxidases containing several copper atoms. They catalyse single-electron oxidations of phenolic or other compounds with concomitant reduction of oxygen to water. In insects, their enzymatic activities were found previously in epidermis, midgut, Malpighian tubules, salivary glands, and reproductive tissues. Therefore, we suggest that defects in genes coding for laccases might contribute to deformation and reduction of wings in apollo butterflies, though it seems obvious that deficiency in these enzymes could not be the sole cause of these developmental improperties in P. apollo from Pieniny National Park.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 177-180
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Autonomia Górnego Śląska a społeczeństwo obywatelskie
Silesian Autonomy Versus Citizens Society
Autorzy:
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/589923.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Ekonomiczny w Katowicach
Tematy:
Autonomia lokalna
Społeczeństwo obywatelskie
Civic society
Local autonomy
Opis:
One of the basic features of citizens of each society is their interest of the problems of the community and the sense of responsibility for its future. At the core of such society there must exist the sense of community, not only as regards its needs, but also its values and culture; this sense must be based on the feeling of identity and responsibility for its fate. These premises seem to refer to the conception of Silesian autonomy. This conceptions, which became a fact in the 20th century, may become a formula according to which the social and economic development of the region can be identified. It should also help to ease the social problems connected with the economic crisis
Źródło:
Studia Ekonomiczne; 2014, 179; 105-114,
2083-8611
Pojawia się w:
Studia Ekonomiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pracownicy przyjezdni (zakordonowi) na górnośląskim rynku pracy. Lata 1850-1939
The Employees Who Arrived to Work in Upper Silesia from Abroad in the Years 1850-1939
Autorzy:
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/592419.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Ekonomiczny w Katowicach
Tematy:
Pracownicy tymczasowi
Przemysł
Rynek pracy
Industry
Labour market
Temporary workers
Opis:
In the period of open work markets in the European Union, and frequent migrations caused by search for employment it seems important to pay attention to experience gained due to the arrival of workers to the Upper Silesian work market as well as its results in the economic and social sphere. No state activity is able to defend the country from their consequences if so called "migration capacity" of the local community has expired. This "migratin capacity" of the local community defines the possibilities of the acceptance of assimilation of the newcomers without any social tensions as well as negative results in the eonomic and social sphere.
Źródło:
Studia Ekonomiczne; 2014, 196; 222-232
2083-8611
Pojawia się w:
Studia Ekonomiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Parametryzacja edukacji drogą donikąd
The Use of Parameters in Education: a Road to Nowhere
Autorzy:
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/589897.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Ekonomiczny w Katowicach
Tematy:
Edukacja
System edukacji
Education
Educational system
Opis:
Education stops being an autotelic value, growing from natural cognitive needs, from natural cognitive needs, from a desire to understand oneself, as well as the surrounding word better; instead, it becomes a certificate giving definite rights. In search of specific requirements we lose the ability at things; we lose the ability of e.g. independent thinking, intellectual openness. The process of introducing parameters to education also leads to various consequences contradictory to the idea of increasing its quality; this is connected with the general conviction about the low intellectual level of people starting university education, and in consequence, receiving university diplomas.
Źródło:
Studia Ekonomiczne; 2013, 131; 116-124
2083-8611
Pojawia się w:
Studia Ekonomiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wskaźniki dotyczące rynku pracy wśród osób deklarujących narodowość śląską
Indicators Concerning the Work Market Among People Declaring Silesian Nationality
Autorzy:
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/591050.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Ekonomiczny w Katowicach
Tematy:
Mniejszości narodowe
Rynek pracy
Ethnic minority
Labour market
Opis:
Due to the questions concerning the Silesian autonomy it seems important to estimate whether and to what extend Silesians constitute a national minority. National minorities differ in terms of culture, language, religion, as well as in the sphere of economy. Analyses of the records of the year 2002 allow to confirm the existence of such differences of the people declaring Silesian nationality. It can be seen on the job market, not only in comparison with the inhabitants of other parts of Poland, but also in the Silesian and the Opole voyevodship.
Źródło:
Studia Ekonomiczne; 2013, 161; 173-183
2083-8611
Pojawia się w:
Studia Ekonomiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical parameters of inflammatory bowel disease in children do not correlate with four common polymorphisms of the transforming growth factor β1 gene
Autorzy:
Liberek, Anna
Jakóbkiewicz-Banecka, Joanna
Kloska, Anna
Świderska, Joanna
Kmieć, Zbigniew
Łuczak, Grażyna
Wierzbicki, Piotr
Liberek, Tomasz
Marek, Krzysztof
Plata-Nazar, Katarzyna
Sikorska-Wiśniewska, Grażyna
Kamińska, Barbara
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1039871.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pediatric patients
gene polymorphism
Transforming growth factor β1
inflammatory bowel disease
Opis:
Transforming growth factor β1 (TGF-β1) is a cytokine affecting cell proliferation and development, which also has an immunomodulatory activity. Correlations between polymorphisms of the TGF-β1 gene and clinical parameters of inflammatory bowel disease (IBD) were reported previously in adults. Here, we tested whether such correlations occur in pediatric patients suffering from IBD. One hundred and four pediatric IBD patients were involved in this study. Among them, 36 were diagnosed with Crohn's Disease (CD) and 68 were diagnosed with ulcerative colitis (UC). The control group consisted of 103 children, in which IBD was excluded. TGF-β1 levels were determined in plasma and intestinal mucosa samples. The presence of the TGF β1 protein and the amount of TGF β1 mRNA were estimated in intestinal mucosa by immunohistochemistry and reverse transcription Real-Time PCR, respectively. Four common polymorphisms of the TGF-β1 gene were investigated: -800G/A, -509C/T, 869T/C and 915G/C. No significant correlation between TGF-β1 genotypes and (i) TGF-β1 levels in plasma and tissue samples, (ii) TGF-β1 gene expression efficiency in intestinal mucosa, (iii) IBD clinical parameters and (iv) inflammatory activity could be detected in children suffering from IBD. We conclude that, contrary to previous suggestions, the four common polymorphisms of the TGF-β1 gene do not influence the susceptibility to or clinical parameters of IBD in the tested population of children.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 641-644
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity
Autorzy:
Plata, Konrad
Rosato, Adriana
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1040468.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Staphylococcus aureus
virulence
pathogenicity genes
toxins
methicillin resistance
Opis:
Although it is estimated that 20-30% of the general human population are carriers of Staphylococcus aureus, this bacterium is one of the most important etiological agents responsible for healthcare-associated infections. The appearance of methicillin resistant S. aureus (MRSA) strains has created serious therapeutical problems. Detailed understanding of the mechanisms of S. aureus infections seems necessary to develop new effective therapies against this pathogen. In this article, we present an overview of the biochemical and genetic mechanisms of pathogenicity of S. aureus strains. Virulence factors, organization of the genome and regulation of expression of genes involved in virulence, and mechanisms leading to methicilin resistance are presented and briefly discussed.
Źródło:
Acta Biochimica Polonica; 2009, 56, 4; 597-612
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Improved HPLC method for total plasma homocysteine detection and quantification
Autorzy:
Sawuła, Wojciech
Banecka-Majkutewicz, Zyta
Kadziński, Leszek
Jakóbkiewicz-Banecka, Joanna
Węgrzyn, Grzegorz
Nyka, Walenty
Banecki, Bogdan
Powiązania:
https://bibliotekanauki.pl/articles/1040824.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
homocysteine measurement
stroke risk factors
HPLC
validation
Opis:
Recent clinical research has pointed at hyperhomocysteinemia as an independent risk factor in a number of cardiovascular and neurological diseases. We have improved a chromatographic method of total plasma homocysteine measurements in order to obtain higher sensitivity, reliability and reproducibility. The method demonstrates excellent linearity (R = 0.999), range (< 2-100 µM), precision (instrumental RSD 0.06 and method RSD 1.17), accuracy (recovery of 99.92 and RSD 1.27), reproducibility, quantification limit and ruggedness (e.g. pH from 2.0 to 2.5). Because even a small increase in homocysteine level can be a significant risk factor of cardiovascular diseases, such a precise method is required. The constructed method allows the measurement of plasma pyridoxal phosphate, PLP, the co-enzyme form of vitamin B6, on the same column and similar reagents. The developed method has been successfully applied to measure both total plasma and serum homocysteine in a group of acute stroke patients.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 119-126
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Elektryczne biochipy
Electrical biochips
Autorzy:
Łoś, Marcin
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1198610.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Rapid detection and quantification of microorganisms, particularly their nucleic acids and proteins, appears to be crucial in clinical practice, veterinary medicine, agriculture, basic research as well as in biotechnological factories. Although various techniques were described and are currently used, development of more rapid, more sensitive and quantitative methods seems to be still important. Here we describe a method for rapid detection of nucleic acids, proteins and small molecules, based on electrical biochip technology. This method is quick and sensitive. It can be thus expected that electrical bio-chips will soon be commonly used in biotechnology and medicine.
Źródło:
Kosmos; 2005, 54, 2-3; 175-182
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone
Autorzy:
Piosik, Jacek
Gwizdek-Wiśniewska, Anna
Ulanowska, Katarzyna
Ochociński, Jakub
Czyż, Agata
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1041344.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Vibrio harveyi mutagenicity assay
mitoxantrone
doxorubicin
daunomycin
xanthines
Opis:
Previously performed experiments showed that methylxanthines, especially caffeine, may protect cells against cytostatic or cytotoxic effects of several aromatic compounds. One of the proposed mechanisms of this protection is based on stacking interactions between π electron systems of polycyclic aromatic molecules. In this work, we demonstrate that caffeine and other methylxanthines - pentoxifylline and theophylline - significantly decrease mutagenicity of the anticancer aromatic drugs daunomycin, doxorubicin and mitoxantrone. The spectrophotometric titration of these aromatic compounds by methylxanthines indicated formation of mixed aggregates. The concentrations of free active forms of the drugs decreased when the concentrations of methylxanthines increased in the mixture. Therefore, likely methylxanthines may play a role of scavengers of the free active forms of daunomycin, doxorubicin and mitoxantrone.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 923-926
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 26

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