Autor: Wójcik, Elżbieta - Katalog OPAC zbiorów

Tytuł:: Telomery - duża rola małych sekwencji
Telomeres - a significant role of small sequences
Autorzy:: Gągała, Urszula
Andraszek, Katarzyna
Wójcik, Ewa
Smalec, Elżbieta
Powiązania:: https://bibliotekanauki.pl/articles/1197489.pdf
Data publikacji:: 2008
Wydawca:: Polskie Towarzystwo Przyrodników im. Kopernika
Opis:: Telomeres are distal structures of eukaryotic chromosomes, which are responsible for their stability and functioning. They assure complete replication of terminal fragments of chromosomes, prevent degradation and fusion of chromosomes. Telomeres of most chordates are comprised of tandem repeats of the basic unit 5'-(TTAGGG)n-3'. The number of repeats of the basic telomeric sequence differs between the chromosomes of one and the same cell. However, in remains within the strictly determined range for a given species, for man it ranges from 2 to 30 th pairs of nucleotides. Younger cells have got longer telomeres whereas the telomeres of older cells are shorter. Cytogenetic studies on telomeric regions of chromosomes have gained significance since the moment of the discovery that this chromosomal fragment actively participates in the process of cancer development, cell ageing and apoptosis. Telomeres consist of non-coding DNA sequences. They contain no genes and they code no proteins but their role in medicine, genetics and evolutionary studies is becoming more and more significant.
Źródło:: Kosmos; 2008, 57, 3-4; 331-341
0023-4249
Pojawia się w:: Kosmos
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Łamliwe miejsca chromosomu
Chromosome fragile sites
Autorzy:: Wójcik, Ewa
Smalec, Elżbieta
Góral, Karolina
Powiązania:: https://bibliotekanauki.pl/articles/1196856.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Przyrodników im. Kopernika
Opis:: Fragile sites on chromosomes are the sites which exhibit tendency towards breaks and gaps under specific conditions of in vitro cultured cells, and after induction with chemical agents. They are categorised as either rare and common. Fragile sites are evolutionary conserved. They are observed in all organisms and play a significant role as far as an occurrence of gene and chromosome disorders in animals and humans is concerned, thus constituting instable regions of the genome. The instabilities may initiate inappropriate expression of genes determining various characteristics. They may give rise to developmental disorders, high mortality at an early stage of life, poorer animal liveability and reproduction as well as tumour expansions. Fragile sites constitute a subject of cytogenetic studies in diagnosing genetic disorders. They can also serve as a selection tool in an assessment of health, and identification of individuals with genetic disorders.
Źródło:: Kosmos; 2009, 58, 1-2; 135-142
0023-4249
Pojawia się w:: Kosmos
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Wymiana chromatyd siostrzanych w chromosomach
Sister chromatid exchange in chromosomes
Autorzy:: Wójcik, Ewa
Smalec, Elżbieta
Powiązania:: https://bibliotekanauki.pl/articles/1195929.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Przyrodników im. Kopernika
Opis:: Sister chromatid exchange (SCE) is a reciprocal exchange of homologous chromatids of the same chromosome. SCEs result from replicating DNA from a damaged matrix and can occur only when changes in DNA have not been removed before the cell enters phase S of the cell cycle when condensed sister chromatids "pair" and exchanges take place between identical DNA sequences situated close to each other. Sister chromatid exchanges are often used in biomonitoring of potentially carcinogenic substance genotoxicity. Due to their sensitivity they enable determining the degree of DNA damage or deficiencies in its repair. The SCE test answers the question of how much chromosomes are sensitive to the damaging factor and how strong the genotoxic impact of the factor is. The SCE is a reliable technique which makes it possible to select from a populations the individuals which are genetically most prone to illnesses and to remove them from further reproduction and breeding.
Źródło:: Kosmos; 2010, 59, 3-4; 513-526
0023-4249
Pojawia się w:: Kosmos
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Rola eksemestanu w leczeniu raka piersi
Exemestan in breast cancer treatment
Autorzy:: Wójcik, Elżbieta
Powiązania:: https://bibliotekanauki.pl/articles/1067895.pdf
Data publikacji:: 2012
Wydawca:: Medical Education
Tematy:: eksemestan
hormonoterapia
inhibitory aromatazy
rak piersi
Opis:: Hormonotherapy is one of the most important therapeutic options in the breast cancer treatment, either locally advanced or metastatic. Tamoxifen has been standard of care for many years, however new clinical trials results indicates aromatase inhibitors as a valuable alternative for postmenopausal patients. Exemestane is a steroid aromatase inhibitor with effectiveness proven in clinical trials discussed in this article.
Leczenie hormonalne jest jedną z podstawowych opcji terapeutycznych w leczeniu raka piersi, zarówno miejscowo zaawansowanego, jak i przerzutowego. Standardem od wielu lat pozostaje tamoksyfen, jednak wyniki nowych badań klinicznych wskazują na inhibitory aromatazy jako na wartościową alternatywę w terapii pacjentek po menopauzie. Eksemestan jest steroidowym inhibitorem aromatazy, którego skuteczność została udowodniona na podstawie wyników badań omówionych w poniższym artykule.
Źródło:: OncoReview; 2012, 2, 4; 264-268
2450-6125
Pojawia się w:: OncoReview
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Sustained virologic response and IL28B single-nucleotide polymorphisms in patients with chronic hepatitis C treated with pegylated interferon alfa and ribavirin
Autorzy:: Jabłonowska, Elżbieta
Piekarska, Anna
Koślińska-Berkan, Ewa
Omulecka, Aleksandra
Szymańska, Bożena
Wójcik, Kamila
Powiązania:: https://bibliotekanauki.pl/articles/1039705.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: ribavirin
interferon
HCV
IL28B
HIV
sustained virologic response
Opis:: Introduction. Hepatitis C virus (HCV) infection is a global health problem which can lead to liver cirrhosis or hepatocellular carcinoma in one-fifth of chronically infected patients. Materials and methods. The study group consisted of 123 patients: 90 with HCV mono- and 33 with HIV/HCV co-infection, who were treated with pegylated interferon alfa (Peg-IFN-α) and ribavirin. We analyzed selected pretreatment factors: age, sex, HIV/HCV co-infection, grade of inflammation, necrotic changes and fibrosis in histological analysis of liver bioptates, HCV viral load, HCV genotypes, and single nucleotide polymorphisms (SNPs) of IL28B and tried to find out which of them influence sustained virological response (SVR). The IL28B SNP C/T (rs12979860) was analyzed using Custom® SNP Genotyping Assays (Applied Biosystems). Results. Multivariate analysis demonstrated that after adjusting for the other variables three predictors independently influence SVR, namely genotype 3 of HCV, presence of the CC genotype and age >40 years (OR respectively 15.14, 3.62, and 0.36). HCV mono-infected patients were infected with HCV genotype 3 or 4 less frequently (p=0.0001) compared to HIV/HCV co-infected individuals. In patients with HIV/HCV co-infection the CC variant occurred more frequently whereas CT was found less frequently (p=0.001, p=0.0146, respectively). In patients with HIV/HCV co-infection, 3 and 4 genotype of HCV occurred more frequently compared to patients with HCV mono-infection (p=0.0001). Conclusions. These data suggest that age, HCV genotype and IL28B polymorphism are useful for prediction of the response to treatment with Peg-IFN-α and ribavirin. The more frequent occurrence of HCV genotypes 3 or 4 in patients with HIV/HCV co-infection could be associated with the route of transmission.
Źródło:: Acta Biochimica Polonica; 2012, 59, 3; 333-337
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Stenoza zespolenia po częściowej resekcji żołądka jako nietypowa przyczyna choroby refluksowej przełyku – opis przypadku
Autorzy:: Dec, Małgorzata
Bartoszek, Elżbieta
Baraniak, Jerzy
Przybylska-Kuć, Sylwia
Mosiewicz, Jerzy
Rękas-Wójcik, Agata
Piekarczyk, Małgorzata
Powiązania:: https://bibliotekanauki.pl/articles/552328.pdf
Data publikacji:: 2013
Wydawca:: Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:: resekcja żołądka
stenoza
refluks żołądkowo-przełykowy.
Źródło:: Family Medicine & Primary Care Review; 2013, 3; 493-495
1734-3402
Pojawia się w:: Family Medicine & Primary Care Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Directions for land management in rural areas
Autorzy:: Dudzińska, Małgorzata
Jasińska, Elżbieta
Leń, Przemysław
Preweda, Edward
Sajnóg, Natalia
Sobolewska-Mikulska, Katarzyna
Steinsholt, Håvard
Walacik, Marek
Wójcik, Justyna
Kocur-Bera, Katarzyna
Powiązania:: https://bibliotekanauki.pl/books/1409927.zip
https://bibliotekanauki.pl/books/1409927.pdf
https://bibliotekanauki.pl/books/1409927.mobi
https://bibliotekanauki.pl/books/1409927.epub
Data publikacji:: 2014
Wydawca:: Croatian Information Technology Society. GIS Forum
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Expression of RUNX2 and its signaling partners TCF7, FGFR1/2 in cleidocranial dysplasia
Autorzy:: Pawłowska, Elżbieta
Wójcik, Katarzyna
Synowiec, Ewelina
Szczepańska, Joanna
Błasiak, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1039147.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: RUNX2
Wnt signaling
TCF7
fibroblast growth factor signaling
FGFR1
FGFR2
Opis:: RUNX2 is a member of the PEBP2/CBF transcription factors family controlling the expression of genes whose products are essential for bone formation. Mutations in the RUNX2 gene may be associated with cleidocranial dysplasia (CCD), a rare skeletal disease characterized by stature aberrations, delayed closure of the cranial sutures, hypoplastic or aplastic clavicles, and multiple dental abnormalities. As RUNX2 is involved in many signaling pathways, we hypothesize that CCD may be associated with their changes. We determined the expression of RUNX2 and its signaling partners TCF7, involved in canonical Wnt signaling, and fibroblast growth factor receptors, FGFR1 and FGFR2 in periodontum of CCD patients and control individuals. We did not observe any differences between the level of RUNX2, TCF7 and FGFR1/2 mRNA, determined by real-time PCR, in CDD patients and controls. Therefore, RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis.
Źródło:: Acta Biochimica Polonica; 2015, 62, 1; 123-126
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Hepatic expression of miR-122 and antioxidant genes in patients with chronic hepatitis B
Autorzy:: Wójcik, Kamila
Piekarska, Anna
Szymańska, Bożena
Jabłonowska, Elżbieta
Powiązania:: https://bibliotekanauki.pl/articles/1038774.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: hepatitis B
antioxidant genes
miR-122
Opis:: Introduction: The pathogenesis of chronic hepatitis B depends on both, the immune response and oxidative stress. Aim of the study: To assess the hepatic expression of miR-122 and the antioxidant genes: HMOX-1, NQO1 and GFER1, in liver biopsy specimens obtained from patients with chronic hepatitis B, with regard to selected clinical and histological parameters, using RT-PCR. Results: The study group comprised 34 HBV-infected patients. Statistically significant associations were found between lower hepatic expression of HMOX-1 and greater severity of liver inflammation (p=0.04). However, significantly higher expression of NQO1 was observed in patients with advanced liver fibrosis (p=0.035). Hepatic expression of miR-122 in HBV patients was not associated with viral load or liver injury. Conclusion: The hepatic expression of HMOX-1and NQO1 may be associated with liver injuries in chronic hepatitis B. However, hepatic expression of miR-122 does not seem to correspond to progression of the liver disease.
Źródło:: Acta Biochimica Polonica; 2016, 63, 3; 527-531
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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