- Tytuł:
- Artificial extracellular matrices of collagen fibrils and lactoferrin as coatings to enhance osteoblast behavior
- Autorzy:
-
Vandorovcova, M.
Bacakova, L.
Dubruel, P.
Douglas, T. E. L. - Powiązania:
- https://bibliotekanauki.pl/articles/284321.pdf
- Data publikacji:
- 2012
- Wydawca:
- Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
- Tematy:
-
coating
collagen
osteoblasts
proliferation
extracellular matrix
lactoferrin - Opis:
- Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.
- Źródło:
-
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 132-134
1429-7248 - Pojawia się w:
- Engineering of Biomaterials
- Dostawca treści:
- Biblioteka Nauki
Artykuł