Autor: Ushakova, S. E. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: A new model of public management in science financing in Russia
Nowy model zarządzania publicznego w finansowaniu nauki w Rosji
Autorzy:: Ushakova, S. E.
Gusev, A. B.
Vershinin, I. V.
Kornilov, A. M.
Powiązania:: https://bibliotekanauki.pl/articles/405173.pdf
Data publikacji:: 2016
Wydawca:: Politechnika Częstochowska
Tematy:: new public management
performance indicator
research organization
research effectiveness
publication activity
benchmarking principles
zarządzanie publiczne
wskaźnik wydajności
organizacja badawcza
efektywność badania
aktywność publikacji
zasady benchmarkingu
Opis:: The article describes current world trends in attempts to solve the problem of linking of remuneration for scientific work to its effectiveness; in particular the attempt to transfer the principles of the concept of New Public Management in the sphere of science funding is investigated. The article presents the analysis of results of the new public management model implementation in financing of Russian research organizations using the tools of econometric benchmarking. The analysis leads to the conclusion about the existence of the conceptual limitations of benchmarking and performance management applicability to the research and development sector.
W artykule przedstawiono aktualne trendy światowe w próbach rozwiązania problemu powiązania wynagrodzenia za pracę naukową z jej efektywnością; w szczególności badana jest próba przeniesienia zasad koncepcji nowego zarządzania publicznego w sferze finansowania nauki. Artykuł prezentuje analizę wyników wdrożenia nowego modelu zarządzania publicznego w finansowaniu rosyjskich organizacji badawczych z wykorzystaniem narzędzi ekonometrycznego benchmarkingu. Analiza prowadzi do konkluzji o istnieniu konceptualnych ograniczeń benchmarkingu i stosowaniu zarządzania wydajnością w sektorze badań i rozwoju.
Źródło:: Polish Journal of Management Studies; 2016, 13, 1; 206-216
2081-7452
Pojawia się w:: Polish Journal of Management Studies
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Novel potential of pancreatic-like enzymes of microbial origin in exocrine pancreatic insufficiency - study on a pig model
Autorzy:: Szwiec, K.
Goncharova, K.
Velverde-Piedra, J.L.
Ushakova, G.
Kovalenko, T.
Osadchenko, I.
Kardas, M.
Swieboda, P.
Podgurniak, P.
Winiarczyk, M.
Grochowska-Niedworok, E.
Lozinska, L.
Filip, R.
Pierzynowski, S.G.
Powiązania:: https://bibliotekanauki.pl/articles/3181.pdf
Data publikacji:: 2015
Wydawca:: Instytut Medycyny Wsi
Tematy:: pancreatic-like enzyme
microbial enzyme
exocrine pancreatic insufficiency
porcine model
pig
animal model
enzyme activity
Opis:: Introduction. The standard porcine-derived pancreatic enzyme replacement therapy (PERT) is a lifesaving treatment for patients with diseases causing exocrine pancreatic insufficiency (EPI). An attempt to replace PERT with microbial enzymes were undertaken. The aim was to highlight whether the mode of application, mixed with food or applied directly to the stomach, of pancreatic-like enzymes of microbial origin (PLEM) can affect their activity along the gastrointestinal tract. Materials and method. The activity of amylase, lipase and proteinase in the stomach, duodenum and ileum were tested in EPI pigs (n=6) after supplementation of PLEM, either orally – before and during feed consumption – or via the stomach – before and during feed consumption. Healthy pigs not treated with PLEM (n=3) served as controls. Activity of the enzymes measured in the chyme were obtained together with the digesta pH. Activity of the enzymatic residues in the stool samples was also checked. Results. The highest pancreatic enzyme activities were found in the duodenum of the healthy pigs (amylase 162,68 kU/ mL, lipase 507,34 kU/mL and protolitic (trypsin) activity 357,60 kU/mL). Nevertheless, the microbial enzymes remained also active along the entire length of the GIT – including stomach in EPI pigs, regardless of their route of administration. However, activity level was significantly lower. Discussion. Results indicate that the activity pattern of PLEM in the small intestine mimics the activity of the natural endogenous pancreatic enzymes in healthy pigs. The most physiological features of PLEM were observed when enzymes were offered orally. The magnitude of PLEM activity in the stomach of EPI pigs was essential and significantly higher than that measured in healthy pigs, thus being somewhat not physiological, and for health reasons of the patients should be further explored. Interestingly, specific trypsin-like activity was measured in all parts of the GIT after PLEM application. However, proteolytic activity of the experimental proteaze in in vitro studies did not exhibit trypsin-like activity.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2015, 09, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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