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    Tytuł:
    αB-crystallin as a promising target in pathological conditions - a review
    Autorzy:
    Maksymiuk, M.
    Sabiborowicz, A.
    Tuzimek, A.
    Deptała, A.
    Czerw, A.
    Badowska-Kozakiewicz, A.M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2086060.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    αB-crystallin
    small heat-shock proteins
    breast cancer
    renal cell carcinoma
    Opis:
    Introduction and objective. αB-crystallin belongs to the ubiquitous family of small heat-shock proteins. It was discovered as a physiological protein of the eye lens, maintaining its liquid-like property. Furthermore, αB-crystallin was proved to playa bipolar role in both physiological and pathophysiological conditions. This review discusses current knowledge about the biology and genetics of αB-crystallin, and summarizes recent advances in understanding its role in ophthalmic and neurological disorders, as well as breast cancer, renal cancer and other malignancies. State of knowledge. α-crystallins are established as important elements of the protein quality control network, and consequently their defects are related to multiple human diseases. New studies highlight αB-crystallin’s involvement in proliferative diabetic retinopathy angiogenesis and point out its therapeutic potential in age-related macular degeneration. αB-crystallin is thought to be associated with the disease-causing protein aggregates, leading to its connection with such neurological disturbances as anaplastic astrocytoma, Parkinson disease, aging deficits in the peripheral nervous system and multiple sclerosis. In breast cancer, it was proven to be a marker of aggressive behaviur and cerebral metastases. Strong expression of αB-crystallin promoted growth and migration of clear cell renal cell carcinoma cells and was correlated with lower overall survival rate. Considering other malignancies, its various roles were established in colorectal and gastric cancers, head and neck squamous cell carcinomas and osteosarcomas. Conclusions. Further studies concerning αB-crystallin seem to be enormously promising, as they might improve our understanding of common human pathologies as well as contemporary diagnostics and treatment.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 3; 326-334
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ wybranych warunków atmosferycznych na czas retencji gazów gaśniczych
    Effects of Temperature, Pressure and Humidity on Retention Time Extinguishing Gases
    Autorzy:
    Kubica, P.
    Wnęk, W.
    Tuzimek, Z.
    Domżał, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/136661.pdf
    Data publikacji:
    2013
    Wydawca:
    Szkoła Główna Służby Pożarniczej
    Tematy:
    SUG gazowe
    czas retencji
    gazy gaśnicze
    retention time
    extingushing gases
    Opis:
    Skuteczność gaszenia gazami gaśniczymi za pomocą stałych urządzeń gaśniczych (SUG) zależy od czasu utrzymywania stężenia, tzw. czasu retencji. Odpowiednio długi czas retencji umożliwia wychłodzenie źródła pożaru oraz interwencję ekip ratowniczych. Na długość czasu retencji ma wpływ przede wszystkim szczelność pomieszczenia oraz różnica gęstości mieszaniny gaśniczej i otaczającego powietrza. Gęstość gazów uzależniona jest od warunków klimatycznych, w szczególności: ciśnienia, temperatury i zawartości pary wodnej. Na podstawie analizy przeprowadzonej w oparciu o wybrany model stosowany do wyznaczania czasu retencji, wykazano że pomijanie wpływu tych wielkości może wiązać się z istotnym błędem przy wyznaczaniu czasu retencji gazów o gęstościach bliskich gęstości powietrza.
    The effectiveness of fixed gaseous extinguishing system depends on retention time – period time after discharge in which concentration of agent is high enough. It is important that an effective extinguishant concentration not only be achieved, but is maintained for a sufficient period of time to allow effective emergency action. This equally important in all classes of fires since a persistent ignition source (e.g. an arc, heat source or deep-seated fire) can lead to resurgence of the initial event once the extinguishant has dissipated. The longer the gas remains after the discharge, the better the level of protection offered. It is essential to determine the likely period during which the extinguishing concentration will maintained within the protected enclosure. The retention time can be determined in two ways: 1) full discharge test and measurement of gas concentrations at the required height; 2) door fan test and calculations based on the model gas flow out. The first method is expensive and rarely applied. Using the second method requires choose an appropriate model. Each of the known models assume ideal mixing of gas during its discharge from the cylinder. The air-agent mixture is created. This mixture then flows out the lower leakages, and air influences the upper. Difference in density of the ambient air ρ0 and the mixture inside enclosure ρm drives the flow of gases. Currently the following models are used to determine the retention time: a) model with a sharp interface between the agent-air mixture and the inflowing air (fig. 1) – Assuming that gas species do not diffuse results in an infinitesimally thin interface between inflowing fresh air and the agent–air mix resulting after dis-charge – model used in the standard NFPA 2001:2012 [1]; b) with a wide interface between the agent-air mixture and the inflowing air (fig. 2) – the wide interface model assumes that inflowing fresh air mixes instantaneously with the agent–air mixture to form a linear decay of agent concentration from the leading edge o the interface, to the uppermost elevation in the protected enclosure. model used in the standard PN EN 15004-1:2008 [2]; c) model with continuous mixing (fig. 3) – The inflowing air dilutes the mixture evenly - model used in PN EN 15004-1:2008 and NFPA 2001:2012, provided that the occurrence of forced mixing of the gases in the protected enclosure, such as air conditioners. For the analysis carried out in the article is selected model with a wide interface used in European standard. Retention time in this model is determined by the equations (3,4). Retention time in PN-EN 15004 [2] is measured from the moment of achievement the throughout the enclosure design concentration to the moment when the extinguishant concentration at 10% or 50% or 90 % of the enclosure height is less then 85% of the design concentration. The retention time shall be not less than 10 min. The density of gases depends on temperature and pressure of according to the equation (6). Air contains another factor – humidity, according to the equation (5). The density of the mixture of air-agent is determined by the formula (7). The difference between the density of the air surrounding the protected enclosure ρ0 and density of air-agent mixture inside the room affects the length of the retention time ρm according to equation (3). Two cases were analyzed: c) protected room located inside the building and its walls bordering spaces with similar parameters of air, d) walls of protected room are walls of building; air parameters inside and outside significantly different. For these cases, the following extreme conditions: c) climatic conditions inside and outside the same temperature: 18-26 oC, actual pressure 868-1050 hPa, humidity 40-60 %. d) climatic conditions inside: temperature: 18-26 oC, actual pressure 868-1050 hPa, humidity 40-60 %; climatic condi-tions inside: temperature -35 do 35 oC, actual pressure 868-1050 hPa, humidity 0 – 100 % The results of calculations for the climatic conditions in which the density difference reaches the highest values are pre-sented in Tables 3 i 4. In order to determine the effect of climatic conditions on the length of the retention time of the calculations were performed according to the model with a wide interface. Assumed a room with a capacity of 70 m3, height 2,8 m. Assumed leakage area 377 cm2 (n = 0,2191; k1 = 0,0374). Retention times were calculated for each agent assuming normative conditions and the most adverse climatic conditions. The results are shown in Table 5. Extinguishing gases with a density similar to air density reached the longest retention times in the group of analyzed gases (fig. 4). Retention time, gas consisting of 92% N2 and 8% Ar was ca. 5 times longer than halocarbon and over 2-times then Nitrogen. Under adverse climatic conditions that may occur inside the building and are identical in a protected space, and outdoor the room, retention time is changing (fig. 5). Retention time of Novec 1230, FM200 and Argonit was slightly shortened 1-2% (fig. 6). In case of Nitrogen was slightly longer - about 1%. The most significant changes (shortening by about 45%) concerned a mixture of 92%N2-8%Ar, which has density similar to the density of air in normative conditions. Under adverse climatic conditions that may exist between the protected space and the outside of the building, the density difference ρm - ρ0 reaches higher values. Despite this, the retention times of gases with high densities (FM200, Novec 1230) were slightly reduced, about 3% (fig. 8). The extinguishing gas density was more similar to the density of air, the more significant was the reduction in retention time, reaching almost 80% in the case of a mixture 92%N2-8%Ar (fig. 8).
    Źródło:
    Zeszyty Naukowe SGSP / Szkoła Główna Służby Pożarniczej; 2013, 3, 47; 196-211
    0239-5223
    Pojawia się w:
    Zeszyty Naukowe SGSP / Szkoła Główna Służby Pożarniczej
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aktywność ruchowa osób w wieku 60-69 lat
    Physical activity of people aged 60-69 years
    Autorzy:
    Zawadzka, M.
    Tuzimek, M.
    Lewicka, M.
    Buczynski, A.
    Henrykowska, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/12252.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Szczeciński
    Źródło:
    Aktywność Ruchowa Ludzi w Różnym Wieku; 2018, 1[37]
    2299-744X
    Pojawia się w:
    Aktywność Ruchowa Ludzi w Różnym Wieku
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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