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Wyszukujesz frazę "Thompson, M." wg kryterium: Autor

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    Wyświetlanie 1-9 z 9
    Tytuł:
    Searching for the proper foundation, or Mortimer Adler versus John Locke
    Autorzy:
    Thompson, Ewa M.
    Powiązania:
    https://bibliotekanauki.pl/articles/571864.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Warszawski. Wydział Neofilologii
    Tematy:
    nominalism
    John Locke
    tabula rasa
    Mortimer Adler
    Opis:
    The paper addresses a crucial problem of the philosophical grounds of knowledge, particularly in the context of humanistic research and education. It unfolds an argument against modern nominalism inherited from John Locke and other thinkers of the Enlightenment and defends the epistemological stance of realism as represented by Aristotle and Thomas Aquinas and more recently by Mortimer Adler and Alasdair MacIntyre.
    Źródło:
    Acta Philologica; 2016, 49; 45-52
    0065-1524
    Pojawia się w:
    Acta Philologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of susceptibility loci for juvenile idiopathic arthritis in the extended MHC region using high resolution SNP and HLA allele typing
    Autorzy:
    Biesiada, J.
    Sudman, M.
    Wagner, M.
    Rupert, A.
    Hollenbach, J.
    Haas, J. P.
    Meller, J.
    Thompson, S. D.
    Powiązania:
    https://bibliotekanauki.pl/articles/1935824.pdf
    Data publikacji:
    2014
    Wydawca:
    Politechnika Gdańska
    Tematy:
    HLA
    MHC region
    autoimmunology
    Juvenile Idiopathic Arthritis
    HLA independent association
    SNP genotyping
    HLA alleles
    Opis:
    Juvenile idiopathic arthritis ( JIA ) spans several pediatric arthropathies that involve autoimmune responses. Primary genetic risk factors for JIA have been mapped to Major Histocompatibility Complex ( MHC ) class I and class II genes. Recent genome-wide association studies using SNP arrays have shown that the nonHLA genetic component of JIA involves multiple low-risk loci, reinforcing the notion that JIA is a complex genetic trait with a strong HLA component. In this work, with the goal of detailed mapping and analysis of lin kage disequilibrium ( LD ) patterns and associations with JIA in the extended MHC (x MHC ) region, we combined SNP data from Affymetrix SNP Array 6.0 and Immunochip ( IC ) platforms with high resolution typing of 8 classical HLA genes. A cohort of about 800 affected individuals and about 500 ethnically matched controls from the Cincinnati region, as well as secondary validation cohorts of affected individuals and matched controls from Germany were used to perform the analysis, and to assess reproducibility of the results across different platforms and p opulations. Accurate high resolution maps of linkage with classical HLA genes and association with individual HLA alleles were generated. High concordance of results obtained using Affymetrix SNP Array 6.0 and IC was observed, with an additional resolution and improved mapping of associat ions provided by the latter in some regions. Several new peaks of statistically signific ant and reproducible association with JIA outside the regions of strong LD with classical HLA genes were observed, including one peak in the class III region, and one in the telomeric end of x MHC . Conditional analysis provided further evidence that these associations appear to be independent of classical HLA genes studied here. The results and observed association patterns are further discussed in the context of other recent studies on autoimmune diseases, including the role of HLA DRB 1 in adult Rheumatoid Arthritis.
    Źródło:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2014, 18, 4; 305--320
    1428-6394
    Pojawia się w:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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