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    Wyświetlanie 1-4 z 4
    Tytuł:
    Predicting heart attack in a patient post-radiation therapy using plaque CCTA analysis and serum biomarker test. Case report
    Autorzy:
    Tariq, Hassan
    Amin, Shetal
    Singh, Millee
    Morales-Pabon, Cesar Alberto
    Cahill, Kristina Vanessa
    Harrison, Eric Edward
    Powiązania:
    https://bibliotekanauki.pl/articles/1065794.pdf
    Data publikacji:
    2014
    Wydawca:
    Medical Education
    Tematy:
    cardiac biomarkers
    chest irradiation
    coronary artery disease
    coronary computed tomography angiography
    myocardial infarction risk assessment
    plaque characterization
    Opis:
    Accelerated coronary artery disease (CAD) is a long term manifestation of chest irradiation that may progress to acute myocardial infarction (MI). We report the use of an algorithm-based biomarker test and coronary computed tomography angiography (CCTA) to identify accelerated CAD in a patient treated with chest irradiation and combination chemotherapy for non-Hodgkin’s lymphoma (NHL). Using a seven protein biomarker test with four incorporated clinical factors, we identified the patient had a 6 fold higher risk for future MI than expected for individuals at his age. Using CCTA, we characterized his plaques based on the following parameters: percent diameter stenosis (ranging from 30–70), percent area stenosis, percent necrotic core (NC), percent fibrotic core (FC), percent calcium core (CC), FC thickness, percent vessel wall to lumen, and NC to FC ratio. We identified a plaque in his left circumflex (LCX) with moderate percent diameter stenosis, high percent NC, low percent FC, absent FC thickness, high percent vessel wall to lumen ratio, and high NC to FC ratio as the most vulnerable to rupture and cause MI. The patient was educated about his risk of a future MI and started on maximum medical therapy. Nevertheless, he experienced a ST elevation MI (STEMI) in 185 days with occlusion at the vulnerable plaque site of his LCX. The recognition of a vulnerable plaque in a vulnerable patient may necessitate prophylactic stenting in vessels without severe obstruction. The serum biomarker test and CCTA plaque analysis may detect these patients in need of aggressive therapy.
    Źródło:
    OncoReview; 2014, 4, 2; A54-61
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An assessment of unstimulated salivary flow rate, IgA and clinical oral dryness among active and passive smokers
    Autorzy:
    Nigar, Seeme
    Hassan, Sobia
    Maqsood, Afsheen
    Ahmed, Naseer
    Al-Askar, Mansour
    Mokeem, Sameer A.
    Alqutub, Montaser N.
    Aldahian, Nada
    AlSagob, Eman I.
    AlMubarak, Abdulrahman A.
    Vohra, Fahim
    Abduljabbar, Tariq
    Powiązania:
    https://bibliotekanauki.pl/articles/2085673.pdf
    Data publikacji:
    2022-02-15
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    IgA
    xerostomia
    passive smokers
    active smokers
    salivary flow rate
    oral dryness
    Opis:
    ObjectivesThe aim of this study was to assess the impact of smoking on the whole salivary flow rate (SFR), IgA levels and clinical oral dryness (COD) among active and passive smokers.Material and MethodsThe participants were categorized as active smokers (N = 54) or passive smokers (N = 163). Saliva was collected in tubes and placed in ice storage at –70°C. Salivary IgA levels were assessed in duplication using the enzyme linked immunosorbent assay (ELISA) method. Following the saliva sample collection, the subjects were assessed for COD using the COD score, SFR and caries. Chi-square test, the t-test and ANOVA were employed to compare the clinical impact of the smoking status associated with specific variables (smoking status, number of cigarettes, active caries, gender, age, COD score, IgA level and SFR). A p-value of <0.05 was considered significant.ResultsTwo hundred and seventeen subjects with the mean age of 32.86±6.30 years, with 145 males (66.8%) and 72 females (33.2%), were included in the study. Among the active smokers, 88.8% were males compared to 11.2% females. The active smokers had the mean age of 32.52 years, a COD score of 1.43, an IgA level of 1.39 g/l, and a SFR of 0.37 ml/min. Among the passive smokers, 59.5% were males and 40.5% were females, with the mean age of 32.97 years, a COD score of 0.87 g/l, an IgA level of 1.47, and a SFR of 0.42 ml/min. Active caries showed a positive correlation with the number of cigarettes, with significance in the >35 years age group (p < 0.05).ConclusionsThe study demonstrated significant differences in SFR, IgA and COD scores among the active and passive smokers. The number of cigarettes had a negative impact on saliva production, IgA levels, the oral health status, and the progression of caries with respect to age and gender. Smoking potentially leads to xerostomia associated with active caries.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2022, 35, 1; 39-51
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sustained Release of Drug Facilitated Through Chemically Crosslinked Polyvinyl Alcohol-Gelatin (PVA-GE) Hydrogels. A sustainable biomedical approach
    Autorzy:
    Ali, Shaukat
    Ranjha, Nazar Muhammad
    Ahmad, Bashir
    Khan, Ayaz Ali
    Hassan, Fakhr Ul
    Aziz, Tariq
    Alharb, Metab
    Alshammari, Abdulrahman
    Alasmari, Abdullah F.
    Alharbi, Mousa Esa
    Powiązania:
    https://bibliotekanauki.pl/articles/27315648.pdf
    Data publikacji:
    2023
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    hydrogel
    gelatin
    drug release
    ciprofloxacin HCl
    polyvinyl alcohol
    Opis:
    The present study aimed to prepare hydrogel based on polyvinyl alcohol (PVA) and gelatin (Ge) and characterization of PVA/Ge hydrogel for their potential use as a sustained drug delivery system. Polyvinyl Alcohol (PVA) and-Gelatin (Ge) were cross-linked using glutaraldehyde (GA) as a crosslinking agent and hydrochloric acid (HCl) as a catalyst. Different feed polymer ratio and crosslinking agent concentration were used to prepare a series of PVA/Ge hydrogels. The obtained PVA/Ge hydrogels were investigated for dynamic and equilibrium swelling studies. The effect of polymers ratio, degree of crosslinking and pH of the medium on swelling of PVA/Ge hydrogels was investigated. Furthermore, the values of diffusion coeficient (D), volume fraction, polymer-solvent interaction parameter, molecular weight between crosslink and crosslink density were calculated. For swelling studies, 0.05M USP phosphate buffer solutions of different pH (1.2, 5.5, 6.5 and 7.5) were used. For the drug release study, ciprofloxacin HCl was loaded into selected samples as a model drug. The release of drug from these samples was performed for 12 hours in USP phosphate buffers of pH 1.2, 5.5 and 7.5. The release data from these samples were fitted into various kinetic models like zero order, first order, Higuchi and Peppas models to investigate the release mechanism. It was found that by varying the composition of PVA/Ge hydrogel and GA concentration, a significant difference was observed in drug release kinetics. FTIR spectroscopy and X-ray diffraction were used for the characterization of hydrogels. PVA/Ge hydrogel showed sustained release of the model drug at various pH values suggesting its potential use as a sustained drug delivery system.
    Źródło:
    Polish Journal of Chemical Technology; 2023, 25, 2; 56--65
    1509-8117
    1899-4741
    Pojawia się w:
    Polish Journal of Chemical Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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