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Wyszukujesz frazę "Tang, Li." wg kryterium: Autor


Tytuł:
Research on speed control of high speed trains based on hybrid modeling
Autorzy:
Hou, Tao
Tang, Li.
Niu, Hong-xia
Zhao, Tingyang
Powiązania:
https://bibliotekanauki.pl/articles/27311802.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
high-speed train
hybrid modeling
speed control
error compensation
pociąg ekspresowy
modelowanie hybrydowe
kontrola prędkości
kompensacja błędów
Opis:
With the continuous improvement of train speed, the automatic driving of trains instead of driver driving has become the development direction of rail transit in order to realize traffic automation. The application of single modeling methods for speed control in the automatic operation of high-speed trains lacks exploration of the combination of train operation data information and physical model, resulting in low system modeling accuracy, which impacts the effectiveness of speed control and the operation of high-speed trains. To further increase the dynamic modeling accuracy of high-speed train operation and the high-speed train's speed control effect, a high-speed train speed control method based on hybrid modeling of mechanism and data drive is put forward. Firstly, a model of the high-speed train's mechanism was created by analyzing the train's dynamics. Secondly, the improved kernel-principal component regression algorithm was used to create a data-driven model using the actual operation data of the CRH3 (China Railway High-speed 3) high-speed train from Huashan North Railway Station to Xi'an North Railway Station of "Zhengxi High-speed Railway," completing the mechanism model compensation and the error correction of the speed of the actual operation process of the high-speed train, and realizing the hybrid modeling of mechanism and data-driven. Finally, the prediction Fuzzy PID control algorithm was developed based on the natural line and train characteristics to complete the train speed control simulation under the hybrid model and the mechanism model, respectively. In addition, analysis and comparison analysis were conducted. The results indicate that, compared to the high-speed train speed control based on the mechanism model, the high-speed train speed control based on hybrid modeling is more accurate, with an average speed control error reduced by 69.42%. This can effectively reduce the speed control error, improve the speed control effect and operation efficiency, and demonstrate the efficacy of the hybrid modeling and algorithm. The research results can provide a new ideal of multi-model fusion modeling for the dynamic modeling of high-speed train operation, further improve control objectives such as safety, comfort, and efficiency of high-speed train operation, and provide a reference for automatic driving and intelligent driving of high-speed trains.
Źródło:
Archives of Transport; 2023, 66, 2; 77--82
0866-9546
2300-8830
Pojawia się w:
Archives of Transport
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis
Autorzy:
Chen, Wei-Ping
Yu, Chong
Hu, Peng-Fei
Bao, Jia-Peng
Tang, Jing-Li
Wu, Li-Dong
Powiązania:
https://bibliotekanauki.pl/articles/1039645.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
matrix metalloproteinases
stigmasterol
osteoarthritis
Opis:
Stigmasterol has been shown exihbit anti-osteoarthritic properties in vitro studies. However, the in vivo effects of stigmasterol on cartilage are still unclear. This study investigated the anti-osteoarthritic properties of stigmasterol on cartilage degradation in a rabbit model of osteoarthritis (OA). Twenty rabbits underwent bilateral anterior cruciate ligament transection (ACLT) to induce OA. Five rabbits were used as normal control. Two weeks after operation, the rabbits were randomly divided into two groups. Each group of 10 rabbits received intra-articular injection with 0.3 ml of stigmasterol in left knees and vehicle in right knees, once weekly. Group 1 was killed 6 weeks after ACLT and 2 were sacrificed 9 weeks after ACLT. The knee joints were assessed by gross morphology, histology and gene expression analysis. We found that expression of genes encoding matrix metalloproteinases (MMPs) was significantly higher while tissue inhibitors of metalloproteinase (TIMP)-1 was significantly lower in the both joints of the two OA groups compared to normal contrals. Stigmasterol reduced the cartilage degradation as assessed by histological analysis and markedly suppressed MMPs expression both in group 1 and group 2. Our results suggest that stigmasterol may be considered as a possible therapeutical agent in the treatment of OA.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 537-541
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anonymous traffic classification based on three-dimensional Markov image and deep learning
Autorzy:
Tang, Xin
Li, Huanzhou
Zhang, Jian
Tang, Zhangguo
Wang, Han
Cai, Cheng
Powiązania:
https://bibliotekanauki.pl/articles/27311448.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
anonymous network
traffic classification
three-dimensional Markov image
output self-attention
deep learning
sieć anonimowa
klasyfikacja ruchu
trójwymiarowy obraz Markowa
samouwaga wyjściowa
uczenie głębokie
Opis:
Illegal elements use the characteristics of an anonymous network hidden service mechanism to build a dark network and conduct various illegal activities, which brings a serious challenge to network security. The existing anonymous traffic classification methods suffer from cumbersome feature selection and difficult feature information extraction, resulting in low accuracy of classification. To solve this problem, a classification method based on three-dimensional Markov images and output self-attention convolutional neural network is proposed. This method first divides and cleans anonymous traffic data packets according to sessions, then converts the cleaned traffic data into three-dimensional Markov images according to the transition probability matrix of bytes, and finally inputs the images to the output self-attention convolution neural network to train the model and perform classification. The experimental results show that the classification accuracy and F1-score of the proposed method for Tor, I2P, Freenet, and ZeroNet can exceed 98.5%, and the average classification accuracy and F1-score for 8 kinds of user behaviors of each type of anonymous traffic can reach 93.7%. The proposed method significantly improves the classification effect of anonymous traffic compared with the existing methods.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2023, 71, 4; art. no. e145676
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on Dynamic Recrystallization Models of 21-4N Heat Resistant Steel
Autorzy:
Li, Yiming
Huang, Xiaomin
Ji, Hongchao
Li, Yaogang
Wang, Baoyu
Tang, Xuefeng
Powiązania:
https://bibliotekanauki.pl/articles/2049422.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
21-4N
hot deformation
dynamic recrystallization
critical strain
volume fraction
Opis:
The high-temperature deformation process and dynamic recrystallization (DRX) process of 21-4N were investigated under the conditions of the deformation temperature range of 1273~1453K, the strain rate range of 0.01~10s-1 and the deformation degree of 60% (the total deformation is 0.916) by using Gleeble-1500D thermal simulated test machine. The curves of stress-strain (σ – ε) were obtained, and the curves of work hardening rate (θ) and strain (ε) were obtained by taking derivative of σ – ε. The DRX critical strains under different conditions were determined by the curves of work hardening rate (θ – ε), and the DRX critical strain model was established. The peak strains of 21-4N were obtained by the curves of σ – ε, the relationship between peak stress (σp) and critical strain (εc) was determined, and the peak strain model was established. The DRX volume fraction models of 21-4N were established by using Avrami equation. The DRX grain size of 21-4N was calculated by Image Pro Plus 6.0, and its DRX grain size models were established.
Źródło:
Archives of Metallurgy and Materials; 2021, 66, 1; 145-152
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The mediating effect of psychological flexibility on fatigue and depressive symptoms among nursing staff
Autorzy:
Yao, Yongcheng
Tang, Jie
Meng, Hongling
Li, Yuping
Du, Haixia
Li, Zhenzhen
Powiązania:
https://bibliotekanauki.pl/articles/21375407.pdf
Data publikacji:
2023-11-13
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
fatigue
depressive symptoms
nurses
bootstrap
psychological flexibility
mediating effect
Opis:
Objectives To explore the relationship between depressive symptoms, fatigue and psychological flexibility, as well as their interactions on depression in Chinese nurses. Material and Methods Using convenience sampling, a cross-sectional survey of 796 nurses in municipal hospitals of Zhengzhou, Henan Province, China, was conducted. The questionnaires of Work-related Acceptance and Action Questionnaire, Center for Epidemiological Studies Depression Scale and Fatigue Assessment Instrument were used. Hierarchical regression and bootstrap methods were used to examine the mediating effect of psychological flexibility between fatigue and depression. Results More than 51.8% of the nurses were at risk of depression and 62.3% were at risk of fatigue. There was a significantly positive and moderate correlation between depression and fatigue severity, situation specificity, and consequences (r = 0.43, r = 0.24 and r = 0.31, respectively, p < 0.01). Depression was negatively correlated with psychological flexibility (r = –0.28, p < 0.01). Psychological flexibility had a negative impact on depression with the explained variance increased by 4.2% (β = –0.211, p < 0.001). The bootstrap method showed that the mediating effect of psychological flexibility accounting for 8.5% and 12.3% on fatigue and depressive symptoms, respectively. Conclusions Psychological flexibility plays a partial mediating role between the fatigue severity, consequences of fatigue and depressive symptoms of nurses. Hospital managers should improve medical staff work acceptance to alleviate their depressive symptoms.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2023, 36, 4; 563-574
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dynamic stability of a stepped drillstring conveying drilling fluid
Autorzy:
Zhao, G.-H.
Tang, S.
Liang, Z.
Li, J.
Powiązania:
https://bibliotekanauki.pl/articles/280899.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
drill string
stepped fluid-conveying pipe
complex frequency
stability
FEM
Opis:
Taking into account differences between a drill pipe (DP) and a drill collar (DC), the drillstring in a vertical well is modeled as a stepped pipe conveying a drilling fluid downwards to the bottom inside the string and then upwards to the ground from the annulus. An analytical model that describes lateral vibration of the drillstring and involves the drillstring gravity, weight on bit (WOB), hydrodynamic force and damping force of the drilling fluid is established. By analysis of complex frequencies, the influences of WOB, borehole diameter, DP length, velocity and density of the drilling fluid on the stability of the system are discussed.
Źródło:
Journal of Theoretical and Applied Mechanics; 2017, 55, 4; 1409-1422
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of recombinant expression of Bombyx mori bidensovirus ns1 using a modified vector
Autorzy:
Li, Guohui
Li, Mangmang
Wang, Peng
Hu, Zhaoyang
Yao, Qin
Tang, Qi
Chen, Keping
Powiązania:
https://bibliotekanauki.pl/articles/1039216.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
BmBDV
NS1
baculovirus expression vector
Sf9
egfp
Opis:
ns1 gene of Bombyx mori bidensovirus (BmBDV) consisted of 951 nucleotides encoding a deduced 316-amino aicd protein. In this study, the gene was cloned and fused in frame with a N-terminal 6×His tag under control of the polyhedrin promoter, which was transposed into the mini-attTn7 locus of a modified baculovirus vector. Transfection of Sf-9 cells with the resulting recombinant DNA was performed to prepare recombinant virus and the resultant supernatant of transfection with fluorescent signal was harvested. Western blot analysis revealed that NS1 protein was successfully expressed in Sf9 cells infected with the recombinant virus and was confirmed by LC-MS/MS analysis. Moreover, the expressed NS1 is a phosphorylated protein and the phosphorylation site is Thr-184. These results showed that the activity of BmBDV NS1 may be regulated by phosphorylation.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 787-794
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Time requirements in closed and open batch distillation arrangements for separation of a binary mixture
Autorzy:
Zhao, Shuo
Bai, Peng
Guo, Xianghai
Tang, Ke
Li, Guangzhong
Powiązania:
https://bibliotekanauki.pl/articles/778400.pdf
Data publikacji:
2014
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
time requirements
closed operation
multivessel column
binary mixture
Opis:
Batch time requirements are provided for the separation of binary zeotropic mixtures in two different multivessel columns (with and without vapor bypass), a non-cyclic two-vessel column and a regular batch column based on dynamic simulations. The first three columns are operated as closed (total reflux) systems and the regular batch column is operated as an open (partial reflux) system. We analyze the effects of feed composition, relative volatility and product specification on the time requirements. The multivessel arrangements perform better than the regular batch column, which requires from 4.00 to 34.67% more time to complete a given separation. The elimination of the vapor bypass in the multivessel column is impractical though it has a positive effect on the batch time requirements. Thus, the multivessel column, with the vapor stream bypassing the intermediate vessel, is proposed as the best candidate for a binary zeotropic mixture with low concentration of light component, low relative volatility and high product purity demand. Furthermore, an experimental multivessel column with vapor bypass is built and the corresponding experiments verify the simulations.
Źródło:
Polish Journal of Chemical Technology; 2014, 16, 4; 66-74
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Die Wall Lubrication on High Velocity Compaction Behavior and Sintering Properties of Fe-Based PM Alloy
Autorzy:
Liu, Zili
Li, Dong
Liu, Xiqin
Li, Haohao
Huang, Xin
Tang, Zhihao
Zou, Yuwen
Powiązania:
https://bibliotekanauki.pl/articles/352101.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
high velocity compaction
die wall lubrication
green density
impact force
cold welding
Opis:
Fe-based PM alloy powder of Fe-2.5Ni-0.5Mo-2Cu-0.4C was pressed by high velocity compaction combined with die wall lubrication, and the effect of die wall lubrication on high velocity compaction behavior and sintering properties of the Fe-based PM alloy were studied. The results indicate that the impact force, green density, sintered density of samples increase with the augment of the impact velocity and die wall lubrication. Compared with that without die wall lubrication, the green density and sintered density of the sample with die wall lubrication are about 0.07-0.12 g/cm3 and 0.08~0.11 g/cm3 higher at the same impact velocity, respectively, while the ejection force of the die wall lubricated sample is much smaller, and reduced about 26%~36%. The green compact with die wall lubrication has much fewer porosity than that without die wall lubrication, and more mechanical bonding and cold welding regions are observed. The sintered samples mainly consists of gray pearlite and white ferrite, and more pearlite is observed in the sintered sample with die wall lubrication.
Źródło:
Archives of Metallurgy and Materials; 2020, 65, 2; 677-684
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Average capacity analysis of FSO system with Airy beam as carrier over exponentiated Weibull channels
Autorzy:
Li, Yi
Chu, Xingchun
Han, Zhongxiang
Tang, Hanling
Song, Xinkang
Powiązania:
https://bibliotekanauki.pl/articles/2202763.pdf
Data publikacji:
2023
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
Airy beam
free-space optical communication
channel capacity
exponentiated Weibull model
Opis:
Based on scintillation index of Airy beam and exponentiated Weibull channel model, analytical expressions of average channel capacity for free-space optical (FSO) communication links with Airy beam as signal carrier under weak atmospheric turbulence and on-off keying modulation scheme are derived. The average capacity at various propagation distances, transverse scale factors and exponential decay factors has been evaluated. And we compared the average capacity of FSO links with Airy beam and Gaussian beam as signal carrier. The results show that the average capacity of FSO links with Airy beam as carrier increases with the increase of mean signal-to-noise ratio and decreases uniformly with the increase of propagation distance. When the transverse scale factor of Airy beam is about 2 cm, a higher average capacity can be obtained. And the smaller the exponential decay factor of Airy beam, the larger the average capacity. Under the same source power or source width, the average capacity of FSO links with Airy beam as carrier is significantly higher than that of FSO links with Gaussian beam as carrier. The results of this research have some reference significance for the application of Airy beam in FSO communication system.
Źródło:
Optica Applicata; 2023, 53, 1; 35--48
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on combustion mode of methanol micro-reciprocating piston internal combustion engine
Autorzy:
Tang, Gang Zhi
Wang, Shuai Bin
Zhang, Li
Shang, Hui Chao
Powiązania:
https://bibliotekanauki.pl/articles/329276.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Polskie Towarzystwo Diagnostyki Technicznej PAN
Tematy:
micro-energy power systems
combustion diagnosis
combustion model
methanol
silnik spalinowy
diagnostyka spalania
model spalania
metanol
Opis:
Constrained by the micro-space structure, it is proposed to use platinum wire incandescent ignition combustion mode to achieve the operation of internal combustion engine. However, the combustion test of the platinum wire incandescent ignition in miniature piston internal combustion engine shows: the combustion mode of micro-space platinum wire incandescent ignition has a poor combustion characteristic, low heat release rate, long combustion duration, and low combustion pressure. Therefore, a homogenous charge compression ignition mode is proposed to realize the operation of miniature internal combustion engine. However, it is found that the compression combustion cannot be come true in the cold start-up state of the micro engine. And the compression combustion in the first cycle was realized by the way of increasing the temperature of the cylinder block and platinum wire appropriately. The results show that: The maximum heat release rate is obviously improved and the combustion duration shortened by 28.6ºCA, and pmi increased by 76%. So, a novel hybrid combustion mode of in-cylinder compression combustion supported by the platinum wire incandescent ignition is put forward, through the way of adjusting the temperature of platinum wire, and this combustion mode is regarded as the ideal combustion mode of micro reciprocating piston internal combustion engine.
Źródło:
Diagnostyka; 2020, 21, 1; 97-103
1641-6414
2449-5220
Pojawia się w:
Diagnostyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Strain measurement based on fixed wavelength transmission of tapered long-period fiber grating
Autorzy:
Tang, Yong
Zhang, Hao
Zhang, Li
Yu, Xin Feng
Bai, Yun Feng
Powiązania:
https://bibliotekanauki.pl/articles/2172862.pdf
Data publikacji:
2022
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
tapered fiber
long-period fiber
fiber grating
strain sensor
fixed dual-wavelength ratio
Opis:
This paper studies the relationship between transmission intensity and strain based on tapered long-period fiber grating at a fixed wavelength. In experiments, tapered long-period fiber grating was prepared by the electric melting method. Experimental results show that two resonance peaks appeared at 1482 and 1537 nm, respectively. Here is the elaboration of the relationship between the resonant wavelength and the strain, its wavelength-strain sensitivity is 20 pm/με, and the linearity was negative. Then our next study was about the relationship between transmission intensity and strain at a fixed wavelength. The results show that the transmission intensity at a fixed wavelength is related to the exponent with strain. The coupled-mode theory is applied to simulate the relationship between fixed wavelength and strain. The simulation results matched the experimental results. Two fixed wavelength transmission intensity ratio was used, and the ratio showed a linear relationship with the strain, and the slope is –0.018 dB/με. Therefore, within the 0.01% resolution of our detector, we could resolve a 0.16 με strain change. We can select the appropriate light source and detector to achieve higher measurement accuracy. Thus, there is a great potential in fiber grating strain sensors.
Źródło:
Optica Applicata; 2022, 52, 4; 511--519
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CdSe/ZnS Colloidal Quantum Dots with Alloyed Core/Shell Interfaces: A Photoluminescence Dynamics Study
Autorzy:
Dziatkowski, K.
Ratchford, D.
Hartsfield, T.
Li, X.
Gao, Y.
Tang, Z.
Powiązania:
https://bibliotekanauki.pl/articles/1492859.pdf
Data publikacji:
2011-11
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
78.67.Hc
78.47.jd
78.55.Et
Opis:
Time-resolved photon counting technique was employed to study dynamics of photoluminescence from the ensemble and single CdSe/ZnS quantum dots with the alloyed core/shell interfaces. The ensemble data revealed enhanced effect of disorder-induced trap states for increasing emission energy, as implied from the changes in the distribution of total decay rates. The emission trajectories collected for single quantum dots showed familiar, two-state blinking pattern. It suggests that in a large-band-offset CdSe/ZnS system, the introduced alloying of the core-to-shell region cannot smooth enough the confinement potential in order to suppress nonradiative Auger recombination and blinking.
Źródło:
Acta Physica Polonica A; 2011, 120, 5; 870-873
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Cryogenic Treatment on Wear Resistance and Microstructure of 42CrMo Steel
Autorzy:
Zhang, Haidong
Yan, Xianguo
Chen, Zhi
Zhao, Minna
Tang, Liang
Gao, Yuan
Li, Fan
Huang, Yao
Li, Junji
Powiązania:
https://bibliotekanauki.pl/articles/2048794.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
cryogenic treatment
orthogonal design method
hardness
coefficient of friction
wear resistance
microstructure
Opis:
In this work, thermo-mechanically treated 42CrMo steel was subjected to cryogenic treatment conducted by means of orthogonal design method, followed by low-temperature tempering to investigate the effect of different parameters of cryogenic treatment on wear resistance of 42CrMo steel and to optimize parameters of cryogenic treatment for improving wear resistance. The results of hardness test and wear test show that cryogenic treatment significantly improves wear resistance with marginal changes in coefficient of friction and hardness. Specifically, cryogenic temperature has the largest impact on wear resistance of 42CrMo steel, holding time has medium impact, and the parameter of treatment cycles has the least impact. The optimum parameters of cryogenic treatment are -196°C for 12 hours with one cycle for improving wear resistance. The results of scanning electron microscopy (SEM) and X-ray diffractometry (XRD) analysis indicate that marginal changes in hardness and coefficient of friction may be owing to little amount of transformation of retained austenite, and the significant influence of cryogenic treatment on improving wear resistance of 42CrMo steel can be mainly attributed to segregation of carbon atoms promoted by cryogenic treatment resulting in more precipitation of carbides in subsequent tempering.
Źródło:
Archives of Metallurgy and Materials; 2022, 67, 1; 127-135
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
HBx and SP1 upregulate DKK1 expression
Autorzy:
Peng, Hong
Li, Yongguo
Liu, Yunzhi
Zhang, Jingnan
Chen, Ke
Huang, Ailong
Tang, Hua
Powiązania:
https://bibliotekanauki.pl/articles/1038681.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
HCC
HBV
DKK1
SP1
Opis:
Numerous evidences suggested that the hepatitis B virus (HBV) was recognized as an important factor in the development of hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) recently was reported to be involved in the progress of HCC. HBV may regulate DKK1 expression in hematoma carcinogenesis. Here, we demonstrated that HBV could regulate DKK1 promoter activity which resulted in upregulation of its mRNA and protein expression in several HBV existing cell lines, and HBx played a prominent role in this process. Transcription factor binding site search result showed that there is a SP1 site in DKK1 promoter region. Luciferase assay showed that overexpression of SP1 could increase DKK1 promoter activity in a dose dependent manner. Accordingly, siRNA inhibition of SP1 expression reduced DKK1 promoter activity and decreased the expression of DKK1 protein.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 35-39
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł

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