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Wyświetlanie 1-6 z 6
Tytuł:
Rola wolnych rodników w regulacji procesów fizjologicznych
Role of free radicals in physiological processes
Autorzy:
Gdula- Argasińska, Joanna
Tyszka- Czochara, Małgorzata
Paśko, Paweł
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033782.pdf
Data publikacji:
2012
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
hormeza
reaktywne formy azotu RFN
reaktywne formy tlenu RFT
regulacja procesów fizjologicznych
równowaga redox
wolne rodniki
Opis:
Free radicals containing one or more unpaired electrons have considerable reactivity. Those radicals derived from oxygen represent the most important class of such species. Free radicals generated in organism are reactive oxygen species (ROS) and reactive nitrogen species (RNS) well recognised for playing a dual role as both deleterious and beneficial species. The cumulative production of ROS/RNS is termed oxidative stress and were discovered in pathomechanism of many of diseases. It was observed that in medium concentration ROS and RNS are play a role in inflammation, apoptosis and as secondary messengers in intracellular signalling cascades.
Źródło:
Medicina Internacia Revuo; 2012, 25, 99; 41-46
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification of lipid derivatives in Hep G2 cells
Autorzy:
Gdula-Argasińska, Joanna
Garbacik, Aneta
Tyszka-Czochara, Małgorzata
Woźniakiewicz, Michał
Paśko, Paweł
Czepiel, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1039495.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
human hepatocellular carcinoma cells HepG2
eicosapentaenoic acid
benzo(a)pyrene
isoprostanes
prostaglandins
UHPLC/MS-TOF method validation
Opis:
Metabolism of polyunsaturated fatty acids results in biosynthesis of mediators with different physiological effects. These metabolites include prostaglandins, prostacyclins, isoprostanes and others that are important signalling molecules and regulate a variety of physiological and pathophysiological processes including inflammation. Prostaglandins and isoprostanes are produced by either non-enzymatic lipid peroxidation or by enzyme-induced peroxidation (cyclooxygenases and lipoxygenases). They are used as biomarkers of oxidative stress. The aim of our study was to assess the effect of eicosapentaenoic acid (EPA) supplementation with added benzo(a)pyrene (BaP) on HepG2 cells by using a UHPLC/MS-TOF method. This rapid and simple method was developed for the identification, separation and quantification of 8-iPGF3α, PGF3α, 8-isoPGF2α and 5-iPF2α in cultured cells. The UHPLC/MS-TOF method was validated. The calculated limit of detection was in the range of 0.16-0.50 ng/mL, precision (% RSD): 1.2-2.1% and recoveries better than 88%. This method empowered qualitative and quantitative analysis of the selected individual prostaglandins derived from arachidonic acid and eicosapentaenoic acid from cell extracts.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 811-815
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
Autorzy:
Grzywacz, Agata
Gdula-Argasińska, Joanna
Muszyńska, Bożena
Tyszka-Czochara, Małgorzata
Librowski, Tadeusz
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1038990.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metal responsive-transcription factor 1
cell signaling
inflammation
NF-κB
Opis:
Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 491-498
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zinc, the Trace Element Essential in Living Organisms
Autorzy:
SOLÉ PASCUAL, Anna
TYSZKA-CZOCHARA, Małgorzata
GDULA-ARGASIŃSKA, Joanna
LIBROWSKI, Tadeusz
GRZYWACZ, Agata
OPOKA, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033792.pdf
Data publikacji:
2012
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
biochemistry of zinc
zinc functions
Opis:
Zinc is a metallic element, of symbol Zn and atomic number 30, that is placed in the group 12 of the periodic table. As an essential trace element, zinc is required to support human biochemical processes. It is found in nearly 200 specific enzymes in the living organisms, and it also serves as structural cofactor for many cellular proteins. [1] Zinc may exert pleiotropic effects in organism; for that, deficits of cellular zinc content can have catastrophic consequences and are linked to major pathophysiology, such as diabetes, stroke and malformations of brain function [2]. The complexity and importance of zinc homeostasis is reflected by the large variety and number of zinc-related proteins found in almost every cell compartment; for example, this biometal is transported through ZnT (Zn2+ transporter) family and ZIP family, proteins that are completely dedicated to zinc transport [2]. It is also noticeable, that between three and ten percent of all protein products of genes in mammalian genomes bind zinc, which is essential for their folding, activity or conformational change [2].
Źródło:
Medicina Internacia Revuo; 2012, 25, 99; 55-59
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fructose Affects Fatty Acids Profile in Liver Cells in Vitro and In Vivo Models in Rats
Autorzy:
TYSZKA- CZOCHARA, Malgorzata
GDULA- ARGASIŃSKA, Joanna
PAŚKO, Paweł
LIBROWSKI, Tadeusz
GAWEŁ, Magdalena
OLBERT, Magdalena
LIPKOWSKA, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1033740.pdf
Data publikacji:
2014
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Diet
Fatty acids profile
Fructose
Hep G2 cell culture
Lipid metabolism
Opis:
It was reported that dietary fructose imposes a number of effects on lipid metabolism including hypertriglyceridemia. The daily intake of fructose in humans is mainly due to sucrose. It was reported that the consumption is still increasing, making a background for health implications. The mechanism of metabolic disorders is poorly understood, but a lot of studies indicate that the liver lipid homeostasis deregulation is essential for a fructose effect on metabolism. The aim of the study is to estimate if fructose affects the profile of fatty acids in in vitro and in vivo models. In this study in vitro and in vivo experiments were conducted to assess the effect of dietary fructose on the fatty acid profile in the cell culture or in the liver of rats. The results showed that in the fructose experimental groups, both in the cell and liver homogenates, the content of the saturated fatty acids were significantly higher than in control groups. According to the obtained data fructose in the medium and in the diet affects saturation of fatty acids in the cell cultures and in the livers of rats. The findings obtained in the experiments support the thesis that fructose influences the homeostasis of lipid metabolism in the liver and may give an opportunity to discuss the limitation of the content of this kind of sugar in food.
Źródło:
Medicina Internacia Revuo; 2014, 26, 102; 42- 46
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fatty Acids Profile in Phospholipids of The Erythrocyte Membranes in Swimming Rats
Autorzy:
GDULA-ARGASIŃSKA, Joanna
TYSZKA-CZOCHARA, Małgorzata
TELEGŁÓW, Aneta
DĄBROWSKI, Zbigniew
PAŚKO, Paweł
LIBROWSKI, Tadeusz
GAWEŁ, Magdalena
OLBERT, Magdalena
LIPKOWSKA, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1033756.pdf
Data publikacji:
2014
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
erythrocyte membranes
fatty acids
physical activity
rats
Opis:
Alterations in membrane lipid composition, particularly fatty acids content is known to result in functional and structural changes. Dietary lipids and physical activity or stress play an important role in this change. It was of interest to study the influence of swimming in different temperatures on the content of fatty acids in the phospholipids of the erythrocyte membranes of rats. Our research demonstrated a significant influence of swimming on the content of fatty acids in the phospholipids of the erythrocyte membranes of rats. These changes of fatty acids, particularly the decrease of arachidonic acid and significant increase of saturated fatty acids in the phospholipids of the erythrocyte membranes in swimming rats may be induced by oxygen radicals generated in different kinds of stress.
Źródło:
Medicina Internacia Revuo; 2014, 26, 102; 19-23
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-6 z 6

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