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    Wyświetlanie 1-4 z 4
    Tytuł:
    Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development
    Autorzy:
    Sęk-Mastej, Anna
    Galiniak, Sabina
    Krawczyk-Marć, Izabela
    Balawender, Krzysztof
    Szymczak, Artur
    Kaniewski, Maciej
    Leksa, Natalia
    Biesiadecki, Marek
    Orkisz, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/454733.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    pregnancy
    foetus
    congenital defect
    teratogen
    Opis:
    Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 85-91
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rapidly progressing dementia as a manifestation of the Creutzfeldt-Jakob disease: an analysis of two cases
    Autorzy:
    Bartosz, Seweryn
    Leksa, Natalia
    Uberman-Kluz, Dominika
    Szymczak, Artur
    Biesiadecki, Marek
    Galiniak, Sabina
    Powiązania:
    https://bibliotekanauki.pl/articles/454939.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    14-3-3 protein
    brain biopsy
    cerebrospinal fluid
    Creutzfeldt-Jakob disease
    EEG
    prion
    Opis:
    Introduction. Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of the central nervous system which is caused by an infectious protein called prion. Multiple forms of CJD have been classified including sporadic (more than 90% cases), familial, iatrogenic and variant type of disease. CJD, especially in its early stages, is a highly challenging illness to diagnose. Aim. Article aims to present cases of Creutzfeldt-Jackob disease with early symptoms of rapidly progressing dementia at the initial stage of CJD. Description of the cases. This paper describes two cases of patients with suspected CJD with a history of rapidly progressive dementia admitted to the Department of Neurology, MSWiA Hospital in Rzeszów. Conclusion. Despite the fact that CJD is an incurable illness and there is no cure guaranteeing recovery, it is important to make the right diagnosis. Assay of 14-3-3 protein in cerebrospinal fluid is a sensitive and specific marker which is helpful in the diagnosis of CJD. The only relevant method of correctly confirming a diagnosis of this disease is by performing a brain biopsy.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 89-93
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of properties of Al-Cu soldered and resistance welded joints
    Porównanie własności złączy lutowanych i zgrzewanych Al-Cu
    Autorzy:
    Ambroziak, Andrzej
    Lange, Artur
    Białucki, Piotr
    Derlukiewicz, Wiesław
    Szymczak, Eryk
    Powiązania:
    https://bibliotekanauki.pl/articles/115151.pdf
    Data publikacji:
    2020
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    lutowanie twarde
    lutowanie miękkie
    zgrzewanie oporowe
    złącze Cu-Al
    właściwości
    soldering
    brazing
    resistance welding
    Cu-Al joint
    properties
    Opis:
    The paper presents the results of qualitative tests of Cu-Al joints made by soldering, brazing and resistance welding. Aluminum and copper tubes with a diameter of 6.9 mm, used, among others in refrigeration systems, were soldered with ZnAl2 and AlSi12 filler metal. In addition, similar connections were made by resistance welding. Macroscopic tests of soldered and welded joints were carried out and the hardness distribution on the cross-section of joints was determined. The analysis of research results allowed to state that resistance welding of Cu-Al joints can be a good alternative to the soldering process, especially in series production, due to the possibility of easy application of process mechanization.
    W pracy zamieszczono wyniki badań jakościowych złączy Cu-Al wykonanych metodami lutowania twardego i miękkiego oraz zgrzewania oporowego zwarciowego. Rurki aluminiowe i miedziane o średnicy 6,9 mm, stosowane m. in. w układach systemów chłodniczych lutowano spoiwem ZnAl2 oraz AlSi12. Ponadto wykonano podobne połączenia metodą zgrzewania oporowego. Przeprowadzono badania makroskopowe złączy lutowanych i zgrzewanych oraz określono rozkład twardości na przekroju złączy. Przeprowadzona analiza wyników badań pozwoliła na stwierdzenie, że zgrzewanie oporowe złączy Cu-Al może być dobrą alternatywą dla procesu lutowania zwłaszcza w produkcji seryjnej, z uwagi na możliwość łatwego zastosowania mechanizacji procesu.
    Źródło:
    Welding Technology Review; 2020, 92, 2; 25-32
    0033-2364
    2449-7959
    Pojawia się w:
    Welding Technology Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The outcomes in children with Hirschsprung’s disease treated with transanal endorectal pull-through method
    Autorzy:
    Szymczak, Artur
    Ogorzałek, Anna
    Leksa, Natalia
    Sęk-Mastej, Anna
    Orkisz, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/2054538.pdf
    Data publikacji:
    2022-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    aganglionosis
    constipation
    encopresis
    soiling
    Opis:
    Introduction and aim. The evaluation of functional results, complications and problems of children with Hirschsprung’s disease treated with one-stage surgery (TEPT) or two-stage surgery (colostomy, TEPT) in Paediatric Surgery Clinic in Rzeszów. Material and methods. Medical documentation of 41 children treated due to Hirschsprung’s disease in years 2006-2018 in Rzeszów were retrospectively analysed. The results of the questionnaires conducted among the parents of operated children were surveyed. Results. The average time of the radical surgery was 189 minutes. The mean length of the resected intestine in the classic form was 19 centimeters, in long-segment 35 centimeters. In the post-operative period, 15 patients had a blood transfusion. The mean time of the children’s stay calculated from the date of surgery until the discharge equaled 13.4 days. Early post-operative complications: enterocolitis occurred in 6 patients (1 death in a septic shock mechanism), total dehiscence of anastomosis in 1 patient, abscess of perirectal space in 1 patient, anastomotic retraction in 1 patient and in 3 patients inaccurate intra-operative evaluation of the section (intra), buttock dermatitis appeared in all patients. Late post-operative complications (a control trial of 38 patients): Soiling was confirmed in 9 patients, periodic constipation in one. The abnormal consistency of stool was signaled in 3 children. Two children were repetitively hospitalized due to enterocolitis. The frequency of defecation almost in all patients was reduced after a three, four-month period since the operation from 10-15 per day to the age norm. In one child, where the retraction of the anastomosis was diagnosed, the soiling and heightened frequency of defecation throughout the day persists. All of the parents of the older children view the outcome of the surgery as positive and the life quality of their children does not differ from their peers. Conclusion. TEPT is a method which can be performed in newborns, infants, babies as well as in case of a long-segment aganglionosis. Barium enema is not reliable in evaluation of the length of the aganglionic section in the long-segment type of Hirschsprung’s disease. The treatment of choice in the early post-operative enterocolitis should be colostomy. Worse functional results were observed in children after two-stage treatment – especially, in cases where the colostomy was created due to the intestinal re-distention.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2022, 2; 194-201
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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