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    Wyświetlanie 1-4 z 4
    Tytuł:
    Evaluation of clinical usefulness of serum neopterin determination in children with bacterial infections
    Autorzy:
    Plata-Nazar, Katarzyna
    Luczak, Grażyna
    Liberek, Anna
    Dudzinska-Gehrmann, Julita
    Sznurkowska, Katarzyna
    Landowski, Piotr
    Kaminska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1039150.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    neopterin
    children
    urinary tract infections
    Opis:
    Neopterin (NPT) (6-D-erythro-trihydroxypropyl pteridin) is one of the indicators of the immune system activity. Elevated neopterin concentration occurs in diseases mostly involving stimulation of cellular immunity. The determination of neopterin concentration, usually in blood serum and urine but also in many other bodily fluids, has already been applied in many areas of medicine, such as transfusiology, transplantology, oncology, infectious diseases and autoimmunological diseases. Objective. The aim of this work is to evaluate clinical usefulness of serum neopterin determination in children with urinary tract infections of confirmed bacterial etiology. Material. The study involved 56 children with bacterial urinary tract infections - patients of the Clinic of Paediatrics, Paediatric Gastroenterology, Hepatology & Paediatric Nutrition of Medical University of Gdańsk in the years 2012-2013. The control group included 105 healthy children. Results. The values of NPT concentration in blood serum obtained in the group of children with urinary tract infections did not significantly differ from the values obtained in the control group. Conclusions. The determination of neopterin concentration in children with bacterial urinary tract infections is not a clinically useful parameter.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 133-137
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Peripheral regulatory T cells and anti-inflammatory cytokines in children with juvenile idiopathic arthritis
    Autorzy:
    Sznurkowska, Katarzyna
    Boćkowska, Małgorzata
    Zieliński, Maciej
    Plata-Nazar, Katarzyna
    Trzonkowski, Piotr
    Liberek, Anna
    Kamińska, Barbara
    Szlagatys-Sidorkiewicz, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1038532.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Tregs
    IL-10
    TGF-β1
    juvenile idiopathic arthritis
    Opis:
    Background: Juvenile idiopathic arthritis (JIA) is a chronic, heterogenous inflammatory disease of unclear pathogenesis. JIA is hypothesized to be linked to a defective immune regulation. Anti-inflammatory cytokines belong to the best known regulatory factors. T-regulatory cells are a crucial cellular component of immune tolerance. One of their functions is synthesis of interleukin 10 (IL-10) and transforming growth factor beta1 (TGF-β1). The aim of this study was to determine the proportion of T-regulatory cells (CD4+CD25highFOXP3+) in peripheral blood, and serum levels of TGF-β1 and IL-10 in patients with JIA. Methods: The study included 25 patients with newly diagnosed JIA: oligoarthritis (n=17) and polyarthritis (n=8). The control group was comprised of 17 healthy children. CD4+CD25highFOXP3+ T cells in peripheral blood were quantified by means of three-color flow cytometry. Serum concentrations of TGF-β1 and IL-10 were estimated with ELISA. Results: The proportion of peripheral CD4+CD25highFOXP3+ cells in patients with JIA was significantly higher than in the controls (p=0.04). The two groups did not differ significantly in terms of their TGF-β1 and IL-10 concentrations. Conclusions: At the time of diagnosis, children with JIA presented with an elevated proportion of T-regulatory cells (CD4+CD25highFOXP3+) in peripheral blood. Anti-inflammatory cytokines, IL-10 and TGF-β1, are not upregulated in the serum of patients with JIA, and therefore should not be considered as biomarkers of this condition.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 119-123
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Graves disease, celiac disease and liver function abnormalities in a patient - clinical manifestation and diagnostic difficulties
    Autorzy:
    Góra-Gębka, Magdalena
    Woźniak, Małgorzata
    Cielecka-Kuszyk, Joanna
    Korpal-Szczyrska, Maria
    Sznurkowska, Katarzyna
    Zagierski, Maciej
    Jankowska, Irena
    Plata-Nazar, Katarzyna
    Kamińska, Barbara
    Liberek, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039288.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    autoimmune disease
    Graves' disease
    celiac disease
    liver abnormalities
    children
    Opis:
    Autoimmune diseases due to probable common pathogenesis tend to coexist in some patients. Complex clinical presentation with diverse timing of particular symptoms and sophisticated treatment with numerous side effects, may cause diagnostic difficulties, especially in children. The paper presents diagnostic difficulties and pitfalls in a child with Graves' disease, celiac disease and liver function abnormalities.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 2; 281-284
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association between uridin diphosphate glucuronosylotransferase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia
    Autorzy:
    Mazur-Kominek, Katarzyna
    Romanowski, Tomasz
    Bielawski, Krzysztof
    Kiełbratowska, Bogumiła
    Preis, Krzysztof
    Domżalska-Popadiuk, Iwona
    Słomińska-Frączek, Magdalena
    Sznurkowska, Katarzyna
    Renke, Joanna
    Plata-Nazar, Katarzyna
    Śledzińska, Karolina
    Sikorska-Wiśniewska, Grażyna
    Góra-Gębka, Magdalena
    Liberek, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038662.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    UGT1A1 gene
    polymorphism
    hyperbilirubinemia
    neonates
    Opis:
    Objective: To assess the prevalence of UGT1A1*28 and UGT1A1*60 polymorphisms of UGT1A1 gene and their association with hyperbilirubinemia. Study design: The study was performed at a single centre - at the Department of Obstetrics of the Medical University of Gdansk in Poland. DNA was isolated from Guthrie cards of 171 infants. Only full term newborns (gestational age 38-42 weeks) were included in the study. Fluorescent molecular probes were used for UGT1A1 promoter variation analysis. The presence of UGT1A1*28 polymorphism was detected with a dual-probe system, and UGT1A1*60 with a SimpleProbe™. Result: Homozygous UGT1A1*28 and UGT1A1*60 genotypes were detected in 14.6% and 20.5% of the newborns, respectively. Homozygous (G/G) genotypes of UGT1A1*60 polymorphism were found in all of the UGT1A1*28 (i.e. (TA)7/(TA)7) homozygotes. More than 80% (55/66) of the children with "wild" type UGT1A1*28 genotype (where no polymorphism was detected) (i.e. (TA)6/(TA)6) carried the "wild" (T/T) genotype of UGT1A1*60 as well. The UGT1A1*28 polymorphism was detected more often among neonates with elevated bilirubin. Hyperbilirubinemia was diagnosed more frequently in boys. Conclusion: Polymorphisms of the UGT1A1 gene frequently co-exist in neonates. The presence of UGT1A1*28 polymorphism and male gender seem to predispose to neonatal hyperbilirubinemia.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 2; 351-356
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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