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Wyświetlanie 1-15 z 20
Tytuł:
Changes in ATP level and iron-induced ultra-weak photon emission in bull spermatozoa, caused by membrane peroxidation during thermal stress
Autorzy:
Gumińska, Maria
Kędryna, Teresa
Laszczka, Andrzej
Godlewski, Marek
Sławiński, Janusz
Szczęśniak-Fabiańczyk, Barbara
Kwiecińska, Teresa
Rajfur, Zenon
Wierzuchowska, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/1044974.pdf
Data publikacji:
1997
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1997, 44, 1; 131-138
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Powrót żołnierza niepodległości : płk Kukliński w Polsce.
Autorzy:
Niemiec, Barbara.
Kłosiński, Jerzy.
Szcześniak, Maria.
Kuźma, Małgorzata.
Powiązania:
Tygodnik Solidarność 1998, nr 19, s. 4-5
Data publikacji:
1998
Tematy:
Kukliński, Ryszard Jerzy (1930-2004)
Opis:
Fot.; Zawiera: Miejsce w historii / Barbara Niemiec. [w Hucie im. Sendzimira] / Jerzy Kłosiński. W hołdzie bohaterom / Maria Szcześniak. Po honory i jacht / Małgorzata Kuźma.
Dostawca treści:
Bibliografia CBW
Artykuł
Tytuł:
Investigation of fenofibrate dissolution rate incorporated on solid dispersions into chitosan
Autorzy:
Grimling, Bożena
Szcześniak, Maria
Meler, Jan
Pluta, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1035351.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
dissolution
fenofibrate
molecular weight of the chitosan
solid state
Opis:
The aim of the study was to investigate the effect of chitosan on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in physical mixtures at the drug to polymer ratio of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 13 to 70 times) in fenofibrate solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of fenofibrate in the presence of chitosan at the weight ratio 1:9 increased with the increment of the molecular weight of the chitosan. The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 149-156
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adsorption studies of ketoconazole with chitosan
Autorzy:
Meler, Jan
Szcześniak, Maria
Pluta, Janusz
Grimling, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1035196.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
absorption
chitosan
ketokonazol
Opis:
Combinations of polymers and biopolymers of biologically active compounds in the last period have been the subject of intensive research. The active substance linked to a polymer often has a modified function and sometimes no action. On the other hand, the use of unsuitable polymers may result in a type of mismatch of drug-polymer. The aim of the study was to examine whether the active substance ketoconazole causes incompatibility with dietary supplements containing chitosan. Antifungal drug adsorption phenomenon was investigated by the static method in the concentration range of the single dose using a pharmaceutical model of the gastrointestinal tract. The test results show that the antifungal agent is adsorbed onto the chitosan in the pH ranges used, and the binding ability of the chitosan depends on the variety, or indirectly from the reaction environment. It was observed that the average sorption, depending on the variety of chitosan, was located in the limit from 94% to 100%. The increase of the size of the adsorption of anti-inflammatory drugs on the polymer with increasing pH from 7.6 to 8.0 can be explained by the swelling properties of chitosan, which grow with increasing pH of the environment in the direction of alkaline pH. Thus, the specific surface area and polymer sorption capacity is increased. Based on the above considerations, it can be concluded that, between the test drug and the polymer, there is antagonistic interaction involving the adsorption of the drug of this group on a polymer which is chitosan.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 111-117
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of chitosan in the formulation of methyl cellulose-based hydrogels
Autorzy:
Szcześniak, Maria
Grimling, Bożena
Meler, Jan
Pluta, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1035190.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
methylcellulose
pharmaceutical availability
rheological parameters
Opis:
The aim of this work was to study the properties of methylcellulose hydrogels with supplements containing chitosan and 1% hydrocortisone. Depending on the composition of the substrate, gels are characterised by a variety of pharmaceutical availabilities. Increasing the concentration of chitosan has an influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 139-144
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterisation and dissolution properties of ketoprofen in binary solid dispersion with chitosan
Autorzy:
Grimling, Bożena
Górniak, Agata
Meler, Jan
Szcześniak, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1035185.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
different molecular weights of chitosan
dissolution
ketoprofen
solid dispersion prepared solvent evaporation
Opis:
BCS class II includes drugs with low solubility and high permeability. Ketoprofen is an example of this class of drugs. The aim of the study was to investigate the effect of chitosan with average molecular weights in various formulations on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in solid dispersions using a method of the solvent evaporations at the drug to polymer ratios of 1:9. 3:7, and 5:5. The highest dissolution of fenofibrate, amounting to 98.8%, was observed after 60 minutes from solid dispersions with a drug-polymer weight ratio 1:9 in the presence of chitosan B and was 32-times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. DSC and IR investigations showed that ketoprofen remained in its crystalline state in solid dispersion. There was no change in the chemical structure of the drug after the incorporation of the drug onto the polymer. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 23-31
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vitro studies of adsorption of erythromycin on chitosans from dietary supplements
Autorzy:
Meler, Jan
Grimling, Bożena
Szcześniak, Maria
Biernat, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/1035189.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Erythromycin
adsorption
chitosan
Opis:
In clinical practice, in the treatment of obesity, a plurality of natural high-molecular compounds are used, the activity of which supports weight loss. During the use of dietary supplements containing chitosan, illness sometimes develops and other therapeutic agents are applied as antibiotics The aim of our study was to determine the binding capacity of the antibiotic erythromycin depending on variable physicochemical factors, in the model of the gastrointestinal tract, by chitosans found in slimming dietary supplements Erythromycin adsorption phenomenon was studied by static and dynamic pharmaceutical model (according to the modified method of the Polish Pharmacopoeia) simulating in vitro conditions. The amount of bound drug was used to calculate the average percentage of the adsorbed dose. The results obtained show that erythromycin is adsorbed by chitosans at various pH ranges, and the binding capacity of the environment depends on the pH, viscosity and concentration of the antibiotic, as well as the chitosan and type and additional substances present in the gastrointestinal tract. The average level of the adsorption of erythromycin in the chitosan-nutrients system depends on the pH of the medium. The highest amount of adsorption was noted above pH 7 (chitosan precipitated polymer forming the emulsion-gel system).
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 119-123
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przedstawienia Komunii św. Onufrego w zachodnioruskim malarstwie ikonowym
The representations of St. Onuphrius’ communion in west Russian icon painting
Autorzy:
Szcześniak, Maria
Powiązania:
https://bibliotekanauki.pl/articles/595456.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Opolski. Redakcja Wydawnictw Wydziału Teologicznego
Opis:
The representations of St. Onuphrius’ communion in west Russian icon painting became popular in 17th and 18th century. This subject has its source in life of the saint. The comparison with the other representations of communion in art shows that the representations drew on both: Latin and Greek tradition of painting. St. Onuphrius communion is an excellent example of combination of western and eastern culture – their iconography, spirituality and trends. Borderland is a place where many different influences and inspirations merge and coexist. The representation of St. Onuphrius’ communion is one of the best proofs of this interaction.
Źródło:
Studia Teologiczno-Historyczne Śląska Opolskiego; 2014, 34; 321-332
0137-3420
Pojawia się w:
Studia Teologiczno-Historyczne Śląska Opolskiego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Technology of preparation and evaluation of ketoprofen-chitosan solid dispersion
Autorzy:
Grimling, Bożena
Szcześniak, Maria
Meler, Jan
Pluta, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1035182.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
dissolution
ketoprofen
molecular weight of the chitosan
solid state
Opis:
The aim of the study was to investigate the effect of chitosan on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in physical mixtures at the drug to polymer ratios of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; the mean amount of dissolved ketoprofen and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multifold increase (33 times) in ketoprofen solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of ketoprofen in the presence of chitosan at the weight ratio 1:9 increased with the decrease of the molecular weight of the chitosan. The results obtained may help to develop new technologies for ketoprofen preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 15-22
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of chitosan on the rheological properties of hydrogels based on sodium carboxymethylcellulose
Autorzy:
Szcześniak, Maria
Grimling, Bożena
Pluta, Janusz
Meler, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1034876.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
pharmaceutical availability
rheological parameters
sodium carboxymethylcellulose
Opis:
The aim of the study was to evaluate the effect of changing the concentrations of chitosan on the rheological properties of the obtained formulation. Hydrogels were prepared with 1% hydrocortisone containing 4% sodium carboxymethylcellulose with the addition of chitosan, propylene glycol-1,2 or polyethylene glycol 400 and glycerol or paraffin. The concentration of chitosan and excipients affects the rheological properties of gels and the pharmaceutical availability of hydrocortisone. Increasing the concentration of chitosan have influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 254-259
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The study of physicochemical properties of solid dispersions of ibuprofen in the presence of chitosan
Autorzy:
Grimling, Bożena
Meler, Jan
Szcześniak, Maria
Pluta, Janusz
Górniak, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1034797.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
dissolution
ibuprofen
solid dispersion
Opis:
The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 64-72
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physicochemical characterization and dissolution studies of solid dispersions of clotrimazole with chitosan
Autorzy:
Grimling, Bożena
Jasińska, Justyna
Meler, Jan
Szcześniak, Maria
Pluta, Janusz M.
Górniak, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1034642.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
FTIR
XRPD
chitosan
clotrimazole
solid dispersion
Opis:
The aim of the present study was to increase the solubility of clotrimazole. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Clotrimazole was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of clotrimazole and chitosan (1:9, 3:7, 5:5, 7:3, 9:1). Formulations were tested dissolution rate of the drug. The highest dissolution of clotrimazole, amounting to 47.95%, was observed after 60 minutes from solid dispersion prepared by grinding method and 42.84% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 37-fold. XRPD analysis indicates the presence of the clotrimazole in crystalline form in the solid dispersion obtained by kneading method.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 63-72
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of substrate composition on the physicochemical properties of hydrogels with chitosan
Autorzy:
Szcześniak, Maria
Grimling, Bożena
Meler, Jan
Pluta, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1034687.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Carbopl 934P
PVP
chitosane
hydrogels
pharmaceutical availability
rheological parameters
Opis:
The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene glycol-1,2 or polyethyleneglycol 400 and glycerol. Addition of polymers had positive influence on the dispersion of hydrogels. The studied gels have thixotropic properties, their viscosity increases with the increase of the concentration of polymers. Increase of the content of polyvinylpyrrolidone K 90 and Carbopol 934 P increases the consistence, gels are more firm and cohesive. Gels with 5 % chitosane, 15% polyvinylpyrrolidone K 90 and Carbopol 934 P in the presence of additives have prolonged half release period of hydrocortisone.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 187-191
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
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