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    Wyświetlanie 1-6 z 6
    Tytuł:
    Lack of Association Between the 135G/C Rad51 Gene Polymorphism and the Risk of Colorectal Cancer Among Polish Population
    Autorzy:
    Mucha, Bartosz
    Przybyłowska-Sygut, Karolina
    Dziki, Łukasz
    Dziki, Adam
    Sygut, Andrzej
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1396683.pdf
    Data publikacji:
    2012-07-01
    Wydawca:
    Index Copernicus International
    Tematy:
    polymorphism
    135G/C RAD51 gene
    colorectal cancer
    Opis:
    One of the major causes of carcinogenesis is loss of genome stability. RAD51 in process of homologous recombination (HR) played crucial role in maintenance integrity of genome through initiate of DNA double strand breaks repair. Presence of single nucleotide polymorphism (SNP) in RAD51 gene could change the capacity of DNA repair and altered the response to damaging agents. Research on potential impact of genetic variability on development and progression CRC may contribute to setting new genetic markers or/and determined individual susceptibility to CRC.The aim of the study. This study was designed to evaluate the effect of 135 G/C (rs1801320) RAD51 polymorphism located in the 5' untraslated region on the risk and progression of CRC.Material and methods. The subjects consisted of histologically confirmed colorectal cancer (n = 200) and controls (n = 200) with lack of previous history of cancer. The distribution of genotypes was determined by restriction fragment length polymorphism PCR (RFLP - PCR). Statistical analysis was based on multivariate regression model.Results and conclusion. Our study reveal no significance association of 135 G/C RAD51 polymorphism with occurrence and progression of colorectal cancer.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 7; 358-362
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Genetic Variations of the CTNNA1 And The CTNNB1 Genes in Sporadic Colorectal Cancer in Polish Population
    Autorzy:
    Sygut, Andrzej
    Przybyłowska, Karolina
    Ferenc, Tomasz
    Dziki, Łukasz
    Spychalski, Michał
    Mik, Michał
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1396892.pdf
    Data publikacji:
    2012-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    sporadic colorectal cancer
    muations
    catenin gene
    adhesion molecules
    Opis:
    Experimental as well as clinical observations have demonstrated that the E-cadherin/catenin complex is a powerful inhibitor of invasion. Abrogation of this pathway is implicated in the carcinogenesis of several malignancies, especially colorectal cancer. The aim of the study was to determine the CTNNA1 and the CTNNB1 mutations and its relationship to clinical and pathological features of sporadic colorectal cancer (CRC) in Polish patients. Material and methods. Paired tumor and normal tissue samples from 110 sporadic CRC patients undergoing resective surgery were prospectively studied for the alpha catenin (CTNNA1) gene and beta catenin (CTNNB1)gene mutations by PCR/single strand conformation polymorphism (SSCP). Results. The CTNNA1 gene alteration in exon 7 were detected in 4 samples and in exon 3 of CTNNB1 gene were found in 3 samples. There was a trend at the limit of statistical significance associating younger age at diagnosis (<50) with CTNNA1 and the CTNNB1 mutations. The mutation of CTNNB1 seemed to occur more frequently in the proximal colon than distal. The CRC patients with CTNNA1 mutation had a significantly increased lymph node metastasis. On the other hand, there was no correlation between mutations and the other clinical variables (e.g. sex, grade and depth of invasion). Conclusion. Although we found a low frequency of mutations in the CTNNA1 and the CTNNB1 genes, but the analysis the relationship with clinical and pathological features of CRC patients may indicated an association of these mutations with the risk and progression of CRC.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 11; 560-564
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association of Polymorphism of Lys589glu Exo1 Gene with the Risk of Colorectal Cancer in the Polish Population
    Autorzy:
    Kabziński, Jacek
    Przybylowska, Karolina
    Mik, Michał
    Sygut, Andrzej
    Dziki, Łukasz
    Dziki, Adam
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1395790.pdf
    Data publikacji:
    2014-08-01
    Wydawca:
    Index Copernicus International
    Tematy:
    colorectal cancer
    polymorphisms
    EXO1
    DNA repair
    Opis:
    The incidence of colorectal cancer (CRC) is increasing from year to year. Despite intensive research CRC etiology remains unknown. Studies suggest that at the basis of the process of carcinogenesis can lie reduced efficiency of DNA repair mechanisms, often caused by polymorphisms in DNA repair genes. The aim of the study was to determine the relationship between gene polymorphism Lys589Glu of EXO1 gene and modulation of the risk of colorectal cancer in the Polish population. Determination of the molecular basis of carcinogenesis process and predicting increased risk will allow qualifying patients to increased risk group and including them in preventive program. Material and methods. The material used in study was blood collected from 130 patients diagnosed with colorectal cancer. The control group consisted of 135 healthy people. Genotyping was performed by TaqMan method. Results. The results obtained indicate that the genotype Lys/Glu is associated with an increased risk of colorectal cancer (OR 1.811, 95% Cl 1.031-3.181, p = 0.038). Conclusion. On the basis of these results, we conclude that Exo1 gene polymorphism Lys589Glu may be associated with an increased risk of colorectal cancer.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 8; 370-373
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The -2518 A/G MCP-1 polymorphism as a risk factor of inflammatory bowel disease
    Autorzy:
    Walczak, Anna
    Przybyłowska, Karolina
    Sygut, Andrzej
    Dziki, Łukasz
    Chojnacki, Cezary
    Chojnacki, Jan
    Dziki, Adam
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1394594.pdf
    Data publikacji:
    2012
    Wydawca:
    Index Copernicus International
    Tematy:
    single nucleotide polymorphism
    MCP-1 gene
    inflammatory bowel disease
    Opis:
    Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances. The aim of the study was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development. Material and methods. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn’s disease) as well as 210 healthy controls. Results. The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn’s disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively). Conclusions. Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 5; 238-241
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence
    Autorzy:
    Walczak, Anna
    Przybyłowska-Sygut, Karolina
    Sygut, Andrzej
    Cieślak, Adrianna
    Mik, Michał
    Dziki, Łukasz
    Dziki, Adam
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1393280.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    colorectal cancer
    MCP-1
    CCR-2
    single nucleotide polymorphisms
    Opis:
    The aim of the study: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Material and methods: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. Conclusion: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 5; 1-5
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Związek polimorfizmów genów MCP-1 i CCR2 z występowaniem raka jelita grubego
    Autorzy:
    Walczak, Anna
    Przybyłowska-Sygut, Karolina
    Sygut, Andrzej
    Cieślak, Adrianna
    Mik, Michał
    Dziki, Łukasz
    Dziki, Adam
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1393355.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    rak jelita grubego
    MCP-1
    CCR-2
    polimorfizmy pojedynczych nukleotydów
    Opis:
    Cel badania: Oceniono związek pomiędzy występowaniem wariantów dwóch polimorfizmów pojedynczego nukleotydu -2518 A/G MCP-1 oraz 190 G/A CCR2 z rakiem jelita grubego (RJG). Materiał i metody: Do badania włączono pacjentów z różnym stopniem zaawansowania RJG oraz osoby zdrowe. Genotypy oznaczono metodą reakcji łańcuchowej polimerazy – polimorfizmu długości fragmentów restrykcyjnych (RFLP-PCR). Wyniki: Zaobserwowano związek pomiędzy rakiem jelita grubego i genotypem GG polimorfizmu -2518 G/A MCP-1. Nie zaobserwowano natomiast istotnej statystycznie korelacji pomiędzy RJG a polimorfizmem 190 A/G CCR2. Wnioski: Wyniki tego badania potwierdzają hipotezę, że polimorfizm w promotorze genu MCP-1 może przyczyniać się do rozwoju raka jelita grubego.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 5; 1-5
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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