Autor: Sulkowska, J. I. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Current approaches to disentagle the mystery of knotted protein folding
Autorzy:: Dabrowski-Tumanski, P.
Sklodowski, M.
Sulkowska, J. I.
Powiązania:: https://bibliotekanauki.pl/articles/1938626.pdf
Data publikacji:: 2016
Wydawca:: Politechnika Gdańska
Tematy:: knotted proteins
minimal contact map
YibK
Opis:: The folding of knotted proteins remains a mystery both for theoreticians and experimentalists. Despite the development of new models, the driving force for self-tying remains elusive and the principle of minimal frustration cannot be reproduced in silico. In this paper we review different models used to understand protein self-knotting and suggest, how to improve the structure based model to observe efficient folding. Our preliminary results show, that including information about some amino acids properties, or reducing the set of physical contacts may be beneficial for modeling of the knotted protein folding.
Źródło:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2016, 20, 4; 361-372
1428-6394
Pojawia się w:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Determining critical amino acid contacts for knotted protein folding
Autorzy:: Dąbrowski-Tumański, P.
Niewieczerzał, S.
Sułkowska, J. I.
Powiązania:: https://bibliotekanauki.pl/articles/1954247.pdf
Data publikacji:: 2022-02-01
Wydawca:: Politechnika Gdańska
Tematy:: knotted protein
slipknot
2efv folding
contact map
native
non-native
Opis:: Proteins with a non-trivial topological structure are currently well recognized, while a knotted protein chain represents a new motif in protein three dimensional folds. Recent comprehensive analysis of the Protein Data Base shows that knotted proteins represent 1.5% of known protein structures. Determination of a free energy landscape of knotted proteins, and its understanding provides a serious challenge for both experimentalists and theoreticians. Moreover the role of a knot for biological activity of protein still remains elusive. In this work we study the smallest knotted proteins ( PDB code 2efv) to understand/investigate their free energy landscape, by means of extensive molecular dynamics simulations. We explore the dependence of the thermodynamics, kinetics and protein folding pathways on the native-likes contact maps and on the length of the chain. We analyze two sets of native-like contacts , which differ by a number of long range interactions, and we consider the 2efv protein with two different lengths of its C-terminus end. We identify the subset of native contacts sufficient to explore the entire free energy landscape. Then, we analyze the influence of the remaining set of native contacts – we show that the set of additional contacts may enhance folding kinetics, and that it has an influence on folding pathways.
Źródło:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2014, 18, 3; 265--279
1428-6394
Pojawia się w:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Molecular dynamics and structural comparison approach to understanding the role of knots in proteins
Autorzy:: Perlinska, A. P.
Macnar, J. M.
Sulkowska, J. I.
Powiązania:: https://bibliotekanauki.pl/articles/1938625.pdf
Data publikacji:: 2016
Wydawca:: Politechnika Gdańska
Tematy:: knotted proteins
methyltransferases
TrmD
Trm5
TrmJ
Trm7
Opis:: The role of knots in proteins is still unclear. In this short review, we summarize the current knowledge about structural and dynamical differences between knotted and unknotted proteins. We show how the topological difference helps to distinguish the physical properties, characterize the biological activity or identify the biological function of knotted proteins. This knowledge can be used to correctly annotate protein family members and to identify new members.
Źródło:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2016, 20, 4; 373-381
1428-6394
Pojawia się w:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Coaching as a method for potentially reducing the risk of burnout in medical professionals
Autorzy:: Sułkowska, J.
Kuźmicz, I.
Malinowska-Lipień, I.
Lickiewicz, J.
Brzostek, T.
Makara-Studzińska, M.
Powiązania:: https://bibliotekanauki.pl/articles/1918569.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Medyczny w Białymstoku
Tematy:: coaching
burnout
medical professions
nurses
physicians
Opis:: In their daily work, medical professionals often encounter emotionally and mentally challenging situations, such as sudden health deterioration or death of their patients. The concern to ensure the highest possible level of healthcare and meet all the standards despite the limitations that come with working under the pressure of time, the interactions with other individuals, the physical burden and stress, as well as with the (sometimes limited) support from superiors and lack of satisfaction with salary may, as a result, translate into a higher risk of burnout. Research indicates a potential effectiveness of coaching with respect to medical personnel. However, there are no publications available concerning nurse-oriented coaching, which would be intended to reduce the risk of burnout in this professional group. The objective of this paper is to present coaching as a method that makes it possible to reduce the risk related to burnout in medical professionals.
Źródło:: Progress in Health Sciences; 2017, 7(2); 85-92
2083-1617
Pojawia się w:: Progress in Health Sciences
Dostawca treści:: Biblioteka Nauki