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    Wyświetlanie 1-4 z 4
    Tytuł:
    THE EEG EXAMINATION, TOGETHER WITH P300 POTENTIAL AS A METHOD FOR CAUSATIVE DIFFERENTIATION IN PATIENTS WITH A GENETIC AND ENVIRONMENTAL CONDITIONING TO ALCOHOL ADDICTION
    Autorzy:
    Chwedorowicz, Roman
    Raszewski, Grzegorz
    Studziński, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/2137788.pdf
    Data publikacji:
    2017-12-23
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    Alcoholism
    Evoked potentials P300
    Endophenotype
    Opis:
    The electrophysiological characteristics of alcoholics, such as the P300 amplitude of the Event-Related Potential (ERP), are related to high risk in their offspring, and are considered to be biological endophenotypes of a predisposition to develop alcohol use disorders. Contemporary knowledge justifies early diagnoses of the alcohol risk degree among adolescents, or even children, including their families, involving an examination of the P300 potential as an endophenotype, prior to achievement of an age of alcohol initiation. The results of such research approaches may be of importance not only cognitively, but also of prophylactically, in the early recognition of increased susceptibility to alcohol. The simplicity and non-invasiveness, and the exceptionally low costs of the methods described, should obtain for the present as well as in the future, a wider examination, one potentially even mass scope of in character and usefulness. The knowledge of such an endophenotype and genetically-related susceptibility, in the individual, family, and social dimension and transmission, and in the rearing of children and adolescents, could protect – not just individuals – but many from entering into the route of addiction, which is most frequently the effect of acting unaware and with negative life consequences, both generational and transgenerational for generations to come.
    Źródło:
    Acta Neuropsychologica; 2017, 15(4); 457-465
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The P300 event-related brain potential, relationship with functional, familial and chronic subtypes of alcohol dependence
    Autorzy:
    Chwedorowicz, Roman
    Skarżyński, Henryk
    Kapka-Skrzypczak, Lucyna
    Pucek, Weronika
    Studziński, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/972388.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    alcoholics
    endophenotypes
    evoked potentials
    National Institute on Alcohol Abuse and Alcoholism (U. S.)
    Opis:
    The results of contemporary studies confirm that the electrophysiological characteristics of alcoholics, such as low P300 amplitude of the Event-Related Potential (ERP), are related with high risk in their offspring, and are considered to be biological endophenotypes of predisposition to develop alcohol use disorders. The purpose of this study was to evaluate the differences in the theta (4–7 Hz) ERP occurring in the P300 response in the resting EEG of alcoholics in comparison to normal age- and gender-matched control subjects. The study included individuals of Polish ancestry with three generations (parents, siblings, spouses, marrying into the family, and children) from families with a positive diagnosis of alcohol dependence. Next, the group of alcoholics was subdivided into five distinct groups, according to the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The control group consisted of 25 unaffected individuals from families who were screened and assessed to be negative for a diagnosis of alcohol dependence. The theta band (4–7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in patients with alcohol addiction. The amplitude and latency of auditory P300 response was recorded in the frontal, central, occipital and temporal regions, in control and alcohol dependent individuals. The amplitude of auditory P300 response in the central areas of the brain was lower in alcoholics in all studied groups, compared to the control subjects, except for the young adult subtype. No statistical difference in the amplitude of P300 potential in the studied brain regions was observed between the young adult subtype, and the control group. Similar P300 amplitude values in the young adult subtype and in the controls, and different values in the remaining alcoholics in the study, allow the differentiation into two subtypes of young alcoholics, based on the P300 amplitude as the biological endophenotype, and provide the background related with causative environmental and genetic factors in alcohol addiction.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2016, 10, 2; 82-86
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage
    Autorzy:
    Chwedorowicz, Roman
    Raszewski, Grzegorz
    Kapka-Skrzypczak, Lucyna
    Sawicki, Krzysztof
    Studziński, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/991182.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    alcohol dependence
    event-related potentials
    resting theta eeg power
    sgip1 snps
    Opis:
    Objective. The electrophysiological characteristics may serve as valuable biomarkers for the genetic vulnerability underlying alcoholism. The purpose of this study was to evaluate the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and the theta ERP quantitative traits. Method. The theta band (4–7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in five regions: frontal, central, parietal, temporal and occipital in patients with alcohol addiction. In addition, we tested the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and ERP quantitative traits. Results. We found that the amplitude of the auditory P300 response differed considerably among groups of alcoholics in the frontal, central and temporal areas of the brain and it was lower in the studied brain regions in alcoholics in comparison to non-alcoholics. However, among subjects in the young adult group (GR-1) there was no statistical difference in amplitude of P300 response with control subjects in all studied brain regions in comparison with non-alcoholics. Moreover, we revealed that SNP rs10889635 had a significant effect on P300 amplitude in the central and temporal regions. The reduced P300 amplitude was in AA carriers in comparison to both carriers of GG and GA alleles. Conclusion. The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2016, 23, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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