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    Tytuł:
    Zastosowanie cieczy jonowych jako modyfikatorów fazy ruchomej w chromatografii cieczowej
    Application of ionic liquids as mobile phase modifiers in liquid chromatorgaphy
    Autorzy:
    Kilanowska, Anna
    Zielak, Judyta
    Studzińska, Sylwia
    Powiązania:
    https://bibliotekanauki.pl/articles/172012.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    ciecze jonowe
    chromatografia cieczowa
    blokowanie wolnych silanoli
    chromatografia par jonowych
    oligonukleotydy antysensowne
    ionic liquids
    liquid chromatography
    free silanol suppressors
    ion pair chromatography
    antisense oligonucleotides
    Opis:
    Ionic liquids are molten salts composed of large, asymmetric, organic cations (e.g. imidazolium or piperidine) and inorganic anions such as e.g chloride or fluoroborate. These compounds are characterized by low melting point, below 1000C, however, they also have other interesting properties including high thermal stability, minor vapor pressure or negligible volatility. Moreover, by the appropriate selection of the cation and anion building the ionic liquid, it is possible to obtain the desired physicochemical properties of these salts. For this reason, ionic liquids are applied to the synthesis, catalysis, electrochemical methods, extraction methods, etc. Application of these compounds in separation techniques merits special attention, especially considering liquid chromatography. Ionic liquids are commonly used in this technique as free silanols suppressors, especially regarding the analysis of basic compounds. Moreover, the excess amount of ionic liquids ions may adsorb on the hydrophobic ligands present at the stationary phase surface, which also plays a significant role in the retention of analytes. Besides their application as silanols suppressors, these compounds were also used as ion pair reagents in the analysis of antisense oligonucleotides, which are short nucleic acid fragments with therapeutic potential due to the ability to bind with complementary sequences of ribonucleic acid. For this reason, antisense oligonucleotides are used in the treatment of several diseases. This article briefly presents structures, properties and the application of ionic liquids as mobile phase modifiers for the analysis of the wide range of different analytes using liquid chromatography. Moreover, a part of this paper was devoted to the analysis of antisense oligonucleotides with the use of the different chromatographic techniques, including the application of ionic liquids as mobile phase additives in ion pair chromatography.
    Źródło:
    Wiadomości Chemiczne; 2020, 74, 7-8; 507-525
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adsorbenty ze związanymi cieczami jonowymi i ich wykorzystanie w przygotowaniu próbek oligonukleotydów
    Adsorbents with bonded ionic liquids and their use in the preparation of oligonucleotides samples
    Autorzy:
    Nuckowski, Łukasz
    Zalesińska, Ewa
    Studzińska, Sylwia
    Powiązania:
    https://bibliotekanauki.pl/articles/172150.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    przygotowanie próbek
    oligonukleotydy
    ciecze jonowe
    adsorbenty
    sample preparation
    oligonucleotides
    ionic liquids
    adsorbents
    Opis:
    Oligonucleotides are short fragments of nucleic acids. They have a growing potential in medicine, especially as diagnostic and therapeutic agents. In most cases, these compounds are determined in the complex biological matrix. Thus, the sample preparation step is very important in their bioanalysis. Solid-phase extraction is a predominant technique in this field. However, presently used for this purpose adsorbents have disadvantages. They ensure low extraction effectiveness and procedures using them are labor-intensive or time-consuming. Ionic liquids, since their discovery, are objects of intensive interest of scientists. Their scientific attractiveness is connected with their unique properties. They are used in separation and sample preparation techniques, such as liquid-liquid extraction using water-immiscible ionic liquids. This approach was also used in the extraction of oligonucleotides. Adsorbents modified with ionic-liquids have growing potential in extraction techniques. Few types of materials are used, namely carbon, polymers, and silica. A common feature of these materials modified with ionic liquids is the ion exchange character. Nonetheless, carbon nanomaterials are coated or covalently modified with ionic liquids, and they are used mainly for nonpolar compounds. Polymer and silica-based adsorbents are used mainly for acidic compounds. Polymers are characterized by the highest stability of the presented materials. Due to their ion-exchange properties crosslinked poly(ionic liquids) were used also for extraction of unmodified and modified oligonucleotides. The optimized procedure applying the material with bonded zwitterion ionic liquid gives high recoveries. It is concurrent for presently used adsorbents, thus solves problems connected with their usage. Moreover, it can be used for biological samples without any pre-purification.
    Źródło:
    Wiadomości Chemiczne; 2020, 74, 7-8; 545-565
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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