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    Wyświetlanie 1-6 z 6
    Tytuł:
    Nucleoside phosphate analogues of biological interest, and their synthesis via aryl nucleoside H-phosphonates as intermediates.
    Autorzy:
    Cieślak, Jacek
    Sobkowski, Michał
    Jankowska, Jadwiga
    Wenska, Małgorzata
    Szymczak, Marzena
    Imiołczyk, Barbara
    Zagórowska, Izabela
    Shugar, David
    Stawiński, Jacek
    Kraszewski, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1044136.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    H-phosphono(di)thioates
    aryl nucleoside H-phosphonates
    nucleoside 2',3'-cyclic phosphate analogues
    H-phosphonamidates
    nucleophilic catalysis
    Opis:
    This review presents a brief account of the chemistry and mechanistic aspects of aryl H-phosphonates, and selected applications of this class of compounds as intermediates in the synthesis of a wide range of biologically important analogues of nucleoside phosphates, and oligonucleotides, in which the phosphate moieties are replaced by other structurally related groups. The aryl nucleoside H-phosphonates, compounds of controlled reactivity, have proven to be more versatile and superior to various mixed anhydrides as synthetic intermediates, particularly for preparation of nucleotide analogues bearing P-N or P-S bonds in various configurational arrangements at the phosphate moiety.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 2; 429-442
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties
    Autorzy:
    Framski, Grzegorz
    Wawrzyniak, Dariusz
    Jahnz-Wechmann, Zofia
    Szymanska-Michalak, Agnieszka
    Kraszewski, Adam
    Barciszewski, Jan
    Boryski, Jerzy
    Stawinski, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1038738.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ribonucleoside analogues
    anti-glioblastoma activity
    anticancer ribonucleotides
    Opis:
    Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 4; 765-771
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fringing field modelling in MEMS capacitive comb-drive accelerometers
    Autorzy:
    Maj, Cezary
    Nazdrowicz, Jacek
    Stawiński, Adam
    Powiązania:
    https://bibliotekanauki.pl/chapters/32083885.pdf
    Data publikacji:
    2021
    Wydawca:
    Politechnika Białostocka. Oficyna Wydawnicza Politechniki Białostockiej
    Tematy:
    Accelerometers
    MEMS devices
    fringing field
    Opis:
    Modelling is a crucial step in designing MEMS devices. It is needed to estimate the device performance without its fabrication. Initially, simple calculations are needed to verify the possibility of device production with a given performance and to know the basic parameters necessary to achieve the desired goals. Further, optimization is commonly performed in order to improve the design. Both steps require simulation methods that are very fast and precise enough to reduce time to market. In many cases, classical, precise FEM simulations are not necessary and simple analytical models are used. MEMS devices like accelerometers, commonly uses elements of simple shapes that can be easily described with simple analytical formulas. However, analytical modelling is getting more complicated in case of capacitive transduction. Typically, these devices operate in the range of linear response but nothing can be done to avoid the influence of non-uniform electric field. Due to fringing field, a capacitance is often underestimated when using classical parallel plate formula. Therefore, there is a need for proper fringing field modelling. In this chapter, analytical modelling of fringing field on an example of MEMS accelerometer is presented. Specific structure type known as comb-drive consists of many small capacitors that enhance the impact of fringing field. Accelerometers in all axes are analyzed. Moreover, Z-axis accelerometer induces different electric field distribution due to the use of thinned fingers. Thus, analytical formulas are derived for various conditions. Finally, the model is compared with Coventor MEMS+ and fabricated strictures are measured in order to validate analytical approach.
    Źródło:
    Methods and tools in CAD – selected issues; 15-27
    9788366391871
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modal analysis of vibratory microgyroscopes
    Autorzy:
    Nazdrowicz, Jacek
    Maj, Cezary
    Jankowski, Mariusz
    Szermer, Michał
    Stawiński, Adam
    Napieralski, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/chapters/32083882.pdf
    Data publikacji:
    2021
    Wydawca:
    Politechnika Białostocka. Oficyna Wydawnicza Politechniki Białostockiej
    Tematy:
    resonator
    accelerometer
    MEMS gyroscopes
    Opis:
    The aim of this paper is to bring up modal analysis of MEMS gyroscope operation with COMSOL and Matlab/SIMULINK software. Two different geometries are assumed and simulation results are presented. The other objective of the paper is to present modal analysis results by taking into consideration spring constants and variation in the damping coefficients as an effect of temperature variation.
    Źródło:
    Methods and tools in CAD – selected issues; 29-38
    9788366391871
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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