Autor: Sobocińska, M. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Premises and potential for the application of semiotics in marketing research
Przesłanki i możliwości zastosowania semiotyki w marketingu
Autorzy:: Sobocinska, M.
Powiązania:: https://bibliotekanauki.pl/articles/38146.pdf
Data publikacji:: 2016
Wydawca:: Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
Źródło:: Acta Scientiarum Polonorum. Oeconomia; 2016, 15, 1
1644-0757
Pojawia się w:: Acta Scientiarum Polonorum. Oeconomia
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Charakterystyka endogennych inhibitorów enzymów rozkładających enkefaliny
Characteristic of the endogenous enkephalin degrading enzymes inhibitors
Autorzy:: Sobocińska, M.
Maćkiewicz, Z.
Powiązania:: https://bibliotekanauki.pl/articles/171530.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: inhibitory
inhibitory enzymów rozkładających enkefaliny
Els
endogenne inhibitory enzymów rozkładających enkefaliny
opiody
peptydy
ból
środki przeciwbólowe
inhibitors
endogenous enkephalin degrading enzymes inhibitors
opioid
peptides
pain
analgesicagents
Opis:: Management of acute and chronic pain has always been a key area of clinical research. Pain and stress stimulation may cause an increase in the level of endogenous opioids in the body. Endogenous enkephalins activate opioid receptors in the brain, leading to the analgesic effect. Enkephalinases inactivate endogenous opioids, abolishing their activity. Enkephalin degrading enzyme inhibitors (EIs) in turn inhibit these enzymes, preventing them from degrading endogenous enkephalins what leads to analgesia. The enkephalin degrading enzyme inhibitors seem to be promising analgesic agents [2]. Analgesic effect of EIs has been discovered recently and their therapeutic potential has not been effectively investigated yet. The main advantage of enkephalinase inhibitors is that they do not show adverse effects characteristic for opioids. EIs play an important role in modulating nociception, so they are potential agents for the treatment of acute and chronic pain. They often possess also additional antidiarrheal, antidepressant and anticancer properties [3]. The potential EIs targets appear to be aminopeptidase N (APN), dipeptidyl peptidase III (DPP III), angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) [4]. EIs may be broadly classified as endogenous and those that are obtained synthetically [4]. The purpose of this work is to present a review of endogenous enkephalinase inhibitors: sialorphin, opiorphin, and spinorphin. Sialorphin (Gln-His-Asn-Pro-Arg) is synthesized predominantly in the submandibular gland and prostate of adult rats in response to androgen steroids and is released locally and systemically in response to stress. Sialorphin protects endogenous enkephalins released after nociceptive stimuli by inhibiting NEP in vivo. Sialorphin prevents spinal and renal NEP from breaking down substance P and Met-enkephalin in vitro. Sialorphin suppressed pain sensation for both chemical- -induced inflammation and acute physical pain [8, 9, 12]. Opiorphin (Gln-Arg-Phe-Ser-Arg) is an endogenous chemical compound first isolated from human saliva. Opiorphin is a natural analgesic. Opiorphin protects enkephalins from degradation by human neutral endopeptidase and aminopeptidase N. Opiorphin is closely related to the rat sialorphin peptide [12, 13, 19]. Spinorphin (Leu-Val-Val-Tyr-Pro-Trp-Thr) has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin - degrading enzymes. Spinorphin is an antagonist of the P2X3 receptor and a weak partial agonist/antagonist of the FP1 receptor [24, 25, 26].
Źródło:: Wiadomości Chemiczne; 2014, 68, 3-4; 317-327
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Potencjalne zastosowanie enkefalin w diagnostyce i terapii różnych chorób
Potential application enkephalns in diagnostics and treatment of various diseases
Autorzy:: Sobocińska, M.
Kamysz, E.
Powiązania:: https://bibliotekanauki.pl/articles/172068.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: endogenne peptydy opioidowe
enkefaliny
Leu-enkefalina
Met-enkefalina
endogenous opioid peptides
enkephalins
Met-enkephalin
Leu-enkephalin
Opis:: For the past few years enkephalins have been a center of appreciation and interest. Enkephalins were discovered in 1975 by Hughes, Kosterlitz and coworkers [1]. They can be described as short sequences of amino acids that are naturally produced in the central nervous system (CNS) in various glands throughout the body, such as the pituitary and adrenal glands [7, 9]. There were revealed two forms of enkephalins, one containing leucine, and the other containing methionine. Enkephalins are produced by the cleavage of a precursor protein called proenkephalin. From proenkephalin originate Met- and Leu-enkephalin, Met-enkephalin-Arg⁶-Gly⁷- -Leu⁸, Met-enkephalin-Arg⁶-Phe⁷ [1–3]. Enkephalins are involved in phenomena associated with modulated pain perception [13], regulation of memory and emotional conditions [21] and regulation of immunological system [29]. They also have an impact on the cardiovascular system [17], motility of the digestive system and metabolism of carbohydrates [8]. This article is a review of the current knowledge about enkephalins and their usage in the diagnostics and treatment of a variety of diseases: diseases/disorders of the central nervous system [21, 22], Parkinson’s disease [27], disease of the immune system [29], chronic pain [12], tumor diseases/cancer [33], heart and cardiovascular diseases [19] and inflammatory bowel disease [23].
Źródło:: Wiadomości Chemiczne; 2017, 71, 1-2; 33-44
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Analiza zagrożeń fizycznych występujących w żywności na podstawie raportów Systemu Wczesnego Ostrzegania o Niebezpiecznych Produktach Żywnościowych i Środkach Żywienia Zwierząt z lat 2008 – 2012
Analysis of the physical hazards of food based on The Rapid Alert System for Food and Feed reports from the years 2008 – 2012
Autorzy:: Ciecierska, M.
Sobocińska, M.
Powiązania:: https://bibliotekanauki.pl/articles/228225.pdf
Data publikacji:: 2013
Wydawca:: Wyższa Szkoła Menedżerska w Warszawie
Tematy:: zagrożenia fizyczne
bezpieczeństwo żywności
raporty RASFF
physical hazards
food safety
RASFF reports
Opis:: Celem artykułu jest przedstawienie wyników z analizy raportów RASFF z lat 2008 – 2012 w aspekcie zagrożeń fizycznych występujących w żywności. Zanieczyszczenia fizyczne stanowiły ok. 4% wszystkich zgłoszeń dotyczących niebezpiecznej żywności. Zanieczyszczenia fizyczne najczęściej odnotowywano w grupie owoców i warzyw, grupie orzechów, produktów orzechowych i nasion oraz grupie zbóż i produktów piekarskich. Najwięcej powiadomień dotyczyło obecności owadów, szkła oraz metali w produktach spożywczych.
The aim of this article is the presentation of results from analysis of RASFF reports from the years 2008 – 2012 in terms of physical hazards in food. Physical contaminants constitute about 4% of all notifications of hazardous foodstuffs. Physical hazards were stated the most frequently in the group of fruits and vegetables, nuts, nut products and seeds as well as cereals and bakery products. Majority of notifications was related to the presence of insects, glass and metals
Źródło:: Postępy Techniki Przetwórstwa Spożywczego; 2013, 2; 109-112
0867-793X
2719-3691
Pojawia się w:: Postępy Techniki Przetwórstwa Spożywczego
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Postepy w opracowywaniu szczepionek przeciwko robakom pasozytniczym
Progress in the development of vaccines against helminths
Autorzy:: Kozak, M
Kolodziej-Sobocinska, M.
Powiązania:: https://bibliotekanauki.pl/articles/836521.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: przywry
choroby pasozytnicze
helminty
szczepionki przeciwpasozytnicze
nicienie
pasozyty
helmintozy
tasiemce
Źródło:: Annals of Parasitology; 2009, 55, 2; 147-156
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Postępy w opracowywaniu szczepionek przeciwko robakom pasożytniczym
Progress in the development of vaccines against helminths
Autorzy:: Kozak, M.
Kołodziej-Sobocińska, M.
Powiązania:: https://bibliotekanauki.pl/articles/2143534.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: przywry
choroby pasozytnicze
helminty
szczepionki przeciwpasozytnicze
nicienie
pasozyty
helmintozy
tasiemce
Opis:: Helminth infections are an important health problem for both humans and animals worldwide. The most sought for prophylactic strategy is vaccination due to the increasing incidence of anthelminthic resistance with little progress towards the discovery of novel drugs. However, the development of efficient anti-parasitic vaccines was proven to be a far greater challenge than in the case of bacteria or viruses. This is partly a result of the complex immunological interactions occurring during helminth infections, which are not yet fully understood, especially regarding the immune mechanisms conveying protection. Another problem is progressing from the research phase of vaccine development to commercial production and marketing. The advances made so far in developing efficient vaccines against helminth vary among the different classes, with a wide spectrum of both native and recombinant vaccine candidates. This review aims at presenting the current status and most important achievements in the field of helminth vaccine development, as well as the main obstacles and difficulties standing in the way of progress and practical applications.
Źródło:: Wiadomości Parazytologiczne; 2009, 55, 2; 147-156
0043-5163
Pojawia się w:: Wiadomości Parazytologiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Creating Marketing Knowledge about the Consumer in the Context of the Development of Internet Tools
Autorzy:: Mazurek-Łopacińska, K.
Sobocińska, M.
Powiązania:: https://bibliotekanauki.pl/articles/118091.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Promocji Wiedzy
Tematy:: knowledge
marketing research
Internet
artificial intelligence
Opis:: The aim of the article is to present marketing knowledge about the consumer as an enterprise resource and the role of marketing research in expanding it in the context of progressive virtualization of social life and the development of Internet tools. The current article was written on the basis of an in-depth literature study and an analysis of the selected results of quantitative research conducted in 2013 on a sample of 152 enterprises.
Źródło:: Applied Computer Science; 2017, 13, 3; 90-101
1895-3735
Pojawia się w:: Applied Computer Science
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Detection of Trichinella spiralis antigens in urine of men and animals
Autorzy:: Machnicka, B
Prokopowicz, D.
Dziemian, E.
Kolodziej-Sobocinska, M.
Powiązania:: https://bibliotekanauki.pl/articles/839331.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: parasite
antigen
man
immunodiagnostic test
animal
urine
Trichinella spiralis
detection
antibody
Opis:: The practical inability to diagnose Trichinella spiralis antibodies in man before day 20 post infection (dpi) has stimulated interest in the development of immunodiagnostic test to detect circulating antigens. Our previous experience showed that soon after infection immune complexes as well as uncomplexed parasite antigens in sera of infected rats could be detected. To diagnose the presence of antigen in urine, double sandwich-capture ELISA was applied using a peroxidase-conjugated rabbit immunoglobulin to T. spiralis larval antigens. The plates were coated with metabolic (AES) or somatic (AS) larval antigens. Mice were infected with 500 T. spiralis larvae. The urine samples from experimentally infected mice taken from 1 to 41 dpi. and the urine samples from patients of the Clinical Hospital in Białystok taken from 3 to 120 dpi were examined. Before testing, the urine samples were heated for 6 min. at 100°C and centrifuged for 6 min. at 5000 g, supematants were used in ELISA. The presence of T. spiralis antigens in mice urine samples was detected between 6-26 days post infection (dpi) using double sandwich-capture ELISA. All samples taken later were negative as samples taken from uninfected mice. 3 from 9 human urine samples taken 3-10 dpi were positive, the remaining samples taken 3-10 and 10-30 dpi showed values near to "cut-off". In both mice and human urine samples the higher level of antigens was detected in ELISA when somatic larval antigen was used. The T. spiralis antigens were present in urine of infected men and mice in the first phase of infection.
Źródło:: Annals of Parasitology; 2001, 47, 2
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Detection of Trichinella spiralis antigens in urine of men and animals
Autorzy:: Machnicka, B.
Prokopowicz, D.
Dziemian, E.
Kołodziej-Sobocińska, M.
Powiązania:: https://bibliotekanauki.pl/articles/2147894.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: parasite
antigen
man
immunodiagnostic test
animal
urine
Trichinella spiralis
detection
antibody
Opis:: The practical inability to diagnose Trichinella spiralis antibodies in man before day 20 post infection (dpi) has stimulated interest in the development of immunodiagnostic test to detect circulating antigens. Our previous experience showed that soon after infection immune complexes as well as uncomplexed parasite antigens in sera of infected rats could be detected. To diagnose the presence of antigen in urine, double sandwich-capture ELISA was applied using a peroxidase-conjugated rabbit immunoglobulin to T. spiralis larval antigens. The plates were coated with metabolic (AES) or somatic (AS) larval antigens. Mice were infected with 500 T. spiralis larvae. The urine samples from experimentally infected mice taken from 1 to 41 dpi. and the urine samples from patients of the Clinical Hospital in Białystok taken from 3 to 120 dpi were examined. Before testing, the urine samples were heated for 6 min. at 100°C and centrifuged for 6 min. at 5000 g, supematants were used in ELISA. The presence of T. spiralis antigens in mice urine samples was detected between 6-26 days post infection (dpi) using double sandwich-capture ELISA. All samples taken later were negative as samples taken from uninfected mice. 3 from 9 human urine samples taken 3-10 dpi were positive, the remaining samples taken 3-10 and 10-30 dpi showed values near to "cut-off". In both mice and human urine samples the higher level of antigens was detected in ELISA when somatic larval antigen was used. The T. spiralis antigens were present in urine of infected men and mice in the first phase of infection.
Źródło:: Wiadomości Parazytologiczne; 2001, 47, 2; 217-225
0043-5163
Pojawia się w:: Wiadomości Parazytologiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Emerging sparganosis (Spirometra sp.) in wild boar (Sus scrofa): implications for veterinarians, hunters, and consumers
Autorzy:: Kolodziej-Sobocinska, M.
Miniuk, M.
Ruczynska, I.
Tokarska, M.
Powiązania:: https://bibliotekanauki.pl/articles/6375.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: parasite
zoonosis
sparganosis
Spirometra
larva
wild boar
Sus scrofa
veterinarian
hunter
consumer
Źródło:: Annals of Parasitology; 2016, 62, Suppl.
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Raccoon dog [Nyctereutes procyonoides] - the new host of Echinococcus multilocularis in Poland
Autorzy:: Machnicka-Rowinska, B
Rocki, B.
Dziemian, E.
Kolodziej-Sobocinska, M.
Powiązania:: https://bibliotekanauki.pl/articles/836320.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: Polska
racoon dog
Nyctereutes procyonoides
Echinococcus multilocularis
new host
Opis:: The alimentary canals of 9 species of domesticated or wild animals were examined for the presence of E. multilocularis. The tapeworm was found in 9 red foxes (Vulpes vulpes) out of 155 examined (5.8%) and in 2 raccoon dogs (Nyctereutes procyonoides) of 25 examined (8.0%). Our studies proved that in Poland the raccoon dog can also be infected with E. multilocularis.
Źródło:: Annals of Parasitology; 2002, 48, 1
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Raccoon dog [Nyctereutes procyonoides] - the new host of Echinococcus multilocularis in Poland
Autorzy:: Machnicka-Rowińska, B.
Rocki, B.
Dziemian, E.
Kolodziej-Sobocińska, M.
Powiązania:: https://bibliotekanauki.pl/articles/2147679.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: Polska
racoon dog
Nyctereutes procyonoides
Echinococcus multilocularis
new host
Opis:: The alimentary canals of 9 species of domesticated or wild animals were examined for the presence of E. multilocularis. The tapeworm was found in 9 red foxes (Vulpes vulpes) out of 155 examined (5.8%) and in 2 raccoon dogs (Nyctereutes procyonoides) of 25 examined (8.0%). Our studies proved that in Poland the raccoon dog can also be infected with E. multilocularis.
Źródło:: Wiadomości Parazytologiczne; 2002, 48, 1; 65-68
0043-5163
Pojawia się w:: Wiadomości Parazytologiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Separation of betalains by gradient high-speed counter-current chromatography
Autorzy:: Spórna-Kucab, A.
Udziela, D.
Sobocińska, M.
Szot, D.
Wybraniec, S.
Powiązania:: https://bibliotekanauki.pl/articles/115813.pdf
Data publikacji:: 2016
Wydawca:: Fundacja na Rzecz Młodych Naukowców
Tematy:: betanin
betalains
betacyanins
high-speed counter-current chromatography
Beta vulgaris L.
betanina
betalainy
betacyjaniny
HSCCC
Opis:: A study on separation of betalain mixture obtained from red beet juice (Beta vulgaris L.) by analytical high-speed counter-current chromatography (HSCCC) was performed. The extract was obtained by thermal treatment of acidified red beet juice for 30 min in 85 °C. The pigment mixture consisted of betanin/isobetanin as well as their decarboxy- and dehydro-derivatives. The HSCCC process was accomplished in the ‘tail to head’ mode with two polar solvent systems containing salt: BuOH-EtOH-NaClsolution-H2OH3PO4 (1300:700-1000:1300:700:2.5-5.5 (system I), 1300:200-400:1300:700:2.5-4.5 (system II); v/v/v/v/v). The retention of the stationary phase was 73% (system I) and 79% (system II). The mobile phase was pumped at 2 ml/min flow rate. HPLC-DAD-ESI-MS analyses were performed in reversed phase mode for the obtained HSCCC fractions and crude extract. The solvent systems enabled separation of betanin and decarboxy-betanins (system I and II) as well as neobetanin (system II). Additionally, some pure fractions of 17-decarboxy-betanin and 2,17-bidecarboxy-betanin were obtained in system II.
Źródło:: Challenges of Modern Technology; 2016, 7, 1; 23-28
2082-2863
2353-4419
Pojawia się w:: Challenges of Modern Technology
Dostawca treści:: Biblioteka Nauki