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    Wyświetlanie 1-5 z 5
    Tytuł:
    Retinol binding protein-4 as a serum biomarker of intrahepatic lipid content in obese children - preliminary report
    Autorzy:
    Romanowska, Anna
    Lebensztejn, Dariusz
    Skiba, Elżbieta
    Tarasów, Eugeniusz
    Kaczmarski, Maciej
    Powiązania:
    https://bibliotekanauki.pl/articles/1039944.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    NAFLD
    RBP-4
    obesity
    children
    biomarker
    adipokines
    Opis:
    Objectives: Obesity, insulin resistance and dyslipidemia are the most significant risk factors of non-alcoholic fatty liver disease (NAFLD) but the role of adipokines in the pathogenesis of this disease is not clear. Assessment of retinol binding protein (RBP-4) seems to be promising because data from animal and human studies suggest its role in the patomechanism of insulin resistance. Therefore, the aim of the study was to evaluate the serum levels of RBP-4 in children with NAFLD. Methods: Fasting serum level of RBP-4 was determined in 42 obese children with suspected liver disease and 20 lean controls. The degree of liver steatosis was graded in ultrasound according to Saverymuttu. The intrahepatic lipid content was assessed noninvasively in a semiquantitative fashion using 1HMR spectroscopy (1.5-T scanner with PRESS sequence). Results: Fatty liver was confirmed in 30 children by ultrasonography (16 of them had also increased alanine transaminase (ALT) activity). Serum concentrations of RBP-4 were significantly higher in obese children with NAFLD compared to controls. Significant correlations were found between RBP-4 level and ultrasonographic grade of liver steatosis, intrahepatic lipid content (1HMRS) and triglycerides level, while the serum level of RBP-4 was not significantly higher in children with advanced liver steatosis (grade 2-3, n = 11) compared to patients with mild steatosis (grade 1, n = 19). The ability of RBP-4 to differentiate children with advanced liver steatosis from those with mild steatosis was not significant. Conclusion: RBP-4 can be considered as a convenient serum marker of intrahepatic lipid content in obese children.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 1; 35-38
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease
    Autorzy:
    Lebensztejn, Dariusz
    Wierzbicka, Aldona
    Socha, Piotr
    Pronicki, Maciej
    Skiba, Elżbieta
    Werpachowska, Irena
    Kaczmarski, Maciej
    Powiązania:
    https://bibliotekanauki.pl/articles/1039852.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    NAFLD
    laminin
    cytokeratin-18
    hyaluronic acid
    YKL-40
    children
    Opis:
    Objectives: There is a need to replace liver biopsy with non-invasive markers that predict the degree of liver fibrosis in fatty liver disease related to obesity. Therefore, we studied four potential serum markers of liver fibrosis and compared them with histopathological findings in liver biopsy in children with non-alcoholic fatty liver disease (NAFLD). Methods: We determined fasting serum level of hyaluronic acid (HA), laminin, YKL-40 and cytokeratin-18 M30 in 52 children (age range 4-19, mean 12 years, 80 % of them were overweight or obese) with biopsy-verified NAFLD. Viral hepatitis, autoimmune and metabolic liver diseases (Wilson's disease, alpha-1-antitrypsin deficiency, cystic fibrosis) were excluded. Fibrosis stage was assessed in a blinded fashion by one pathologist according to Kleiner. Receiver operating characteristics (ROC) analysis was used to calculate the power of the assays to detect liver fibrosis (AccuROC, Canada). Results: Liver fibrosis was diagnosed in 19 children (37 %). The levels of HA and CK18M30 were significantly higher in children with fibrosis compared to children without fibrosis (p=0.04 and 0.05 respectively). The ability of serum HA (cut-off 19.1 ng/ml, Se=84 %, Sp=55 %, PPV=52 %, NPV=86 %) and CK18M30 (cut-off 210 u/l, Se=79 %, Sp=60 %, PPV=56 %, NPV=82 %) to differentiate children with fibrosis from those without fibrosis was significant (AUC=0.672 and 0.666, respectively). The combination of both markers was superior (AUC=0.73, p=0.002). Laminin and YKL-40 levels did not allow a useful prediction. Conclusions: Cytokeratin-18 and hyaluronic acid are suitable serum markers predicting liver fibrosis in children with NAFLD. Studying these markers may identify patients at risk of disease progression.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 4; 563-566
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cechy temperamentu i charakteru a skłonność do kształtowania pracy
    Character and temperament traits and tendency to job crafting
    Autorzy:
    Kasprzak, Elżbieta
    Skiba, Kamilla
    Powiązania:
    https://bibliotekanauki.pl/articles/560878.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Kazimierza Wielkiego w Bydgoszczy
    Tematy:
    kształtowanie pracy
    praca
    pracownik
    osobowość
    charakter
    temperament
    job crafting
    work
    employee
    personality
    character
    Opis:
    Celem artykułu jest wykazanie, czy dyspozycje pracownika w postaci cechy charakteru i temperamentu R. Cloningera mogą sprzyjać skłonności do kształtowania pracy. Kształtowanie pracy1 jest zachowaniem polegającym na dokonywaniu zmian w zadaniach oraz relacjach w ramach wykonywanej przez siebie pracy. Badanie przeprowadzono wśród 162 pracowników z wykorzystaniem Kwestionariusza Temperamentu i Charakteru TCI-R (56) oraz Kwestionariusza Kształtowania Pracy – KKPracy. Zaprezentowane wyniki potwierdzają, iż poziom kształtowania pracy jest zależny (R2=0,36) od unikania szkody (β=-0,39), uzależnienia od nagrody (β=0,32), samokierowania (β=-0,28), autotranscendencji (β=0,24) oraz skłonności do współpracy (β=0,15). Kształtowanie zadań jest objaśniane przez 24% zmiennych unikanie szkody (β=-0,42) oraz wytrwałość (β=0,16). Kształtowanie myślenia o pracy jest wyjaśniane w 22% przez autotranscendencję (β=0,39) i skłonność do współpracy (β=0,19), natomiast skłonność do kształtowania relacji interpersonalnych jest objaśniana w 22% przez uzależnienie od nagrody (β=0,40) oraz skłonność do współpracy (β=0,17).
    The aim of this article is to show if the disposition of the employee in the form of his/her personality traits and temperament according to R. Cloninger, may further form proclivities while doing the work. Job crafting is a behaviour which consists in making changes to many tasks or relationships while doing someone’s work. The study was performed among 162 employees with the use of The Temperament and Character Inventory TCI-R (56) and The Job Crafting Questionnaire. The presented results confirm that the level of job crafting (R2=0,36) depends on: harm avoidance (β=-0,39), reward dependence (β=0,32), self-directedness (β=-0,28), self-transcendence (β=0,24) and cooperativeness (β=0,15). Tasks crafting is explicated by 24% variables – harm avoidance (β=-0,42) and persistence (β=0,16). Cognitive crafting is clarified in 22% by self-transcendence (β=0,39) and cooperativeness (β=0,19). However, relational crafting is explained in 22% by reward dependence (β=0,40) and cooperativeness (β=0,17).
    Źródło:
    Szkoła - Zawód - Praca; 2019, 17; 143-165
    2082-6087
    Pojawia się w:
    Szkoła - Zawód - Praca
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    PCR-RFLP detection of point mutations A2143G and A2142G in 23S rRNA gene conferring resistance to clarithromycin in Helicobacter pylori strains
    Autorzy:
    Klesiewicz, Karolina
    Nowak, Paweł
    Karczewska, Elżbieta
    Skiba, Iwona
    Wojtas-Bonior, Izabela
    Sito, Edward
    Budak, Alicja
    Powiązania:
    https://bibliotekanauki.pl/articles/1039295.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Helicobacter pylori
    clarithromycin resistance
    PCR-RFLP
    point mutations
    Opis:
    Background. The occurrence of clarithromycin resistance among Helicobacter pylori strains is a major cause of the treatment failure. Resistance to this drug is conferred by point mutations in 23S rRNA gene and the most prevalent mutations are A2143G and A2142G. The aim of the study was to evaluate the occurrence of A2143G and A2142G mutations in a group of H. pylori strains resistant to clarithromycin. Materials and Methods. The study included 21 clarithromycin-resistant H. pylori strains collected between 2006 and 2009 in southern Poland. Resistance to clarithromycin was quantitatively tested with the E-test to determine the minimal inhibitory concentration (MIC value). The point mutations of H. pylori isolates were detected by PCR followed by RFLP analysis. Results. The MIC values for clarithromycin for the analyzed strains ranged from 1.5 mg/L to 64 mg/L. Nine H. pylori strains exhibited A2143G mutation and A2142G mutation was found in 9 isolates as well. The results of RFLP analysis of 3 clarithromycin-resistant strains were negative for both mutations. The average MIC values for A2143G and A2142G mutants were 6 and 30 mg/L, respectively. Conclusions. Frequencies of A2143G and A2142G mutations were the same in all isolates tested. Strains with A2143G mutation exhibited lower MIC values than A2142G mutants. Application of PCR-RFLP method for detection of clarithromycin resistance allows for better and more efficient management of H. pylori infections.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 2; 311-315
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    COMPARATIVE IN VITRO STUDIES OF FURAZIDIN AND NITROFURANTOIN ACTIVITIES AGAINST COMMON UROPATHOGENS INCLUDING MULTIDRUG-RESISTANT STRAINS OF E. COLI AND S. AUREUS
    Autorzy:
    Klesiewicz, Karolina
    Karczewska, Elżbieta
    Nowak, Paweł
    Mrowiec, Paulina M.
    Skiba-Kurek, Iwona
    Białecka, Joanna
    Majka, Zbigniew
    Berdzik-Kalarus, Sylwia
    Budak, Alicja
    Zajdel, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/895689.pdf
    Data publikacji:
    2018-06-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    ESBL-positive E. coli
    MRSA
    furazidin
    nitrofurantoin
    urinary tract infections
    Opis:
    Abstract: Urinary tract infections caused by wide range of pathogens including gram-negative and gram-positive bacteria as well as fungi are a severe public health problem. The predominant causative agent of both uncomplicated and complicated urinary tract infections is Escherichia coli. In an era of increasing bacterial resistance to antimicrobial agents and a high prevalence of multidrug-resistant (MDR) strains in community and hospital acquired infections, the re-evaluation of older generations of antimicrobial agents, such as nitrofuran derivatives, seems to be a reasonable approach. The aim of the study was to evaluate furazidin activity against common uropathogens in comparison to nitrofurantoin and other selected antimicrobial agents, routinely used in the treatment of urinary tract infections. Furazidin exhibited lower MICs than nitrofurantoin when tested against gram-negative and gram-positive bacteria including clinical MDR E. coli and methicillin-resistant Staphylococcus aureus. The MICs for furazidin ranged from 4 to 64 mg/L for Enterobacteriaceae strains, from 2 to 4 mg/L for gram-positive cocci, and 0.5 mg/L for anaerobic bacteria. The MICs for nitrofurantoin ranged from 16 to 64 mg/L for Enterobacteriaceae strains, from 8 to 64 mg/L for gram-positive cocci, and 4 mg/L for anaerobic bacteria. In addition, both nitrofurans displayed better activity against the tested bacterial strains than ciprofloxacin, fosfomycin, trimethoprim and co-trimoxazole. Nitrofuran derivatives displayed higher antimicrobial activity than other antimicrobial agents regardless of bacteria species or resistance mechanism.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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