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Wyszukujesz frazę "Singh, Hardeep" wg kryterium: Autor


Wyświetlanie 1-5 z 5
Tytuł:
The Effect of Dual Hyperparameter Optimization on Software Vulnerability Prediction Models
Autorzy:
Bassi, Deepali
Singh, Hardeep
Powiązania:
https://bibliotekanauki.pl/articles/2203949.pdf
Data publikacji:
2023
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
software vulnerability
hyperparameter optimization
machine learning algorithm
data balancing techniques
data complexity measures
Opis:
Background: Prediction of software vulnerabilities is a major concern in the field of software security. Many researchers have worked to construct various software vulnerability prediction (SVP) models. The emerging machine learning domain aids in building effective SVP models. The employment of data balancing/resampling techniques and optimal hyperparameters can upgrade their performance. Previous research studies have shown the impact of hyperparameter optimization (HPO) on machine learning algorithms and data balancing techniques. Aim: The current study aims to analyze the impact of dual hyperparameter optimization on metrics-based SVP models. Method: This paper has proposed the methodology using the python framework Optuna that optimizes the hyperparameters for both machine learners and data balancing techniques. For the experimentation purpose, we have compared six combinations of five machine learners and five resampling techniques considering default parameters and optimized hyperparameters. Results: Additionally, the Wilcoxon signed-rank test with the Bonferroni correction method was implied, and observed that dual HPO performs better than HPO on learners and HPO on data balancers. Furthermore, the paper has assessed the impact of data complexity measures and concludes that HPO does not improve the performance of those datasets that exhibit high overlap. Conclusion: The experimental analysis unveils that dual HPO is 64% effective in enhancing the productivity of SVP models.
Źródło:
e-Informatica Software Engineering Journal; 2023, 17, 1; art. no. 230102
1897-7979
Pojawia się w:
e-Informatica Software Engineering Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effectiveness of novel iron regulators in the treatment of diabetic nephropathy
Autorzy:
Banerjee, Dekai
Kaur, Ginpreet
Chatterjee, Bappaditya
Joshi, Hemant
Ramniwas, Seema
Singh Tuli, Hardeep
Powiązania:
https://bibliotekanauki.pl/articles/29519511.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
acute kidney injury
chronic kidney disease
end-stage renal disease
iron chelators
renal iron handling
Opis:
Introduction and aim. The novel advancements of upcoming iron regulators used to treat diabetic nephropathy have implicated a common manifestation of combination chelation therapy used to eliminate end-stage renal disease associated with inflammation and iron imbalance that is altered by renal iron absorption. However, iron accumulation in the clustered kidneys that filter blood may cause problems that affect diabetic blood sugar regulation. Material and methods. A well-designed method was employed to discover relevant research publications on iron chelators and their potential to treat diabetic nephropathy. “Iron chelators”, “diabetic nephropathy”, “end-stage renal disease”, and “chelation therapy” were searched in Google Scholar, Web of Science, PubMed, and EMBASE. Analysis of literature. Although the specific etiology and development have not been fully explored, emerging evidence on iron pathophysiology helps comprehend the pathogenesis of acute kidney damage and chronic kidney disease, which crucially provides novel iron chelation therapy techniques. Ferroptosis and hepcidin marker proteins increase oxidative/nitrifying stress and kidney injury. Iron chelator medicines including deferoxamine, deferasirox, and deferiprone were tested as prophylactic strategies. Conclusion. This article covers both preclinical and clinical aspects of iron chelators to avoid diabetic nephropathy, including novel iron therapies that must be reviewed when selecting dosing regimens.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 639-647
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, characterization of isoxazole derivatives and evaluation of their antibacterial, antioxidant and anticancer activity
Autorzy:
Vashisht, Ketan
Sethi, Pooja
Bansal, Anshul
Singh, Tejveer
Kumar, Raman
Singh Tuli, Hardeep
Saini, Shallu
Powiązania:
https://bibliotekanauki.pl/articles/40570865.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
antibacterial
antioxidant activity and anticancer potential
isoxazole
pathogenic bacterial
Opis:
Introduction and aim. The synthesis of heterocyclic compounds containing oxygen and nitrogen is profoundly intriguing due to their mechanistic implications in both research and development within organic chemistry and drug discovery. The primary aim of this study is to fabricate a range of pharmacologically active drugs containing the isoxazole moiety. Material and methods. The synthesis of new derivatives of isoxazole was achieved through a one-pot condensation reaction of 2-[(Substituted phenyl)hydrazono]malononitrile (1) and 3-[(Substituted phenyl)azo]-2,4-Pentanedione (2) with sodium acetate and hydroxylamine hydrochloride (1:1) in ethanol. All the compounds were screened for their in vitro antibacterial activity, in vitro antioxidant and anticancer activity. The synthesized compounds underwent characterization through FTIR, 1H NMR, and 13C NMR analyses, supported by mass spectral data and elemental analysis. Results. A set of novel isoxazole derivatives was synthesized with a favorable yield. Among compounds 1d, 1e, 2c, 2d, and 2e exhibited notable antioxidant activities. Compounds 1a, 1b, and 1c demonstrated significant anticancer potential against prostate cancer [PC3] cell lines compared to normal HEK cell lines, while 2a displayed the highest inhibitory zone against Escherichia coli. Conclusion. Novel compounds with multifaceted biological activities have been successfully designed, and a synthetic route to create isoxazole derivatives has been devised and verified.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 376-387
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibacterial, DNA photocleavage and molecular docking studies of newly prepared Schiff-based macrocyclic complexes
Autorzy:
Mishra, Purti
Sethi, Pooja
Kumar Ramasamy, Selva
Saini, Adesh K.
Singh Tuli, Hardeep
Mittal, Divya
Trehan, Aarti
Powiązania:
https://bibliotekanauki.pl/articles/40422849.pdf
Data publikacji:
2024-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
anti-bacterial
DFT
DNA photocleavage
molecular docking
template method
Opis:
Introduction and aim. At present, several microbial diseases are prominent and of concern worldwide. The intent of this study was to examine the antibacterial potential of newly synthesized tetradentate macrocyclic complexes against different bacterial strains. The macrocyclic scaffold has gained attention as a biologically active class of supramolecular chemistry due to its unique properties and ability to target various microorganisms. Thus, the goal of the present study was to develop a series of biologically active transition metal-based macrocycles. Material and methods. All macrocyclic compounds were synthesized by a template method and validated by molar conductivity, elemental studies, and spectral and magnetic studies. Antibacterial activities of all metal complexes were evaluated against Escherichia coli (MTCC 739) and Staphylococcus aureus (MTCC 731) bacterial strains by taking ampicillin as a standard reference drug. DNA photocleavage potential was explored using agarose gel electrophoresis. Results. Results revealed the formation of novel macrocyclic complexes via tetra nitrogen bond trapping of metals. Copper complexes have strong potential against S. aureus bacteria as copper and nickel both show good DNA photocleavage potential. Conclusion. The findings endorse the biomedical relevance of these macrocyclic scaffolds, suggesting avenues for further exploration in targeted drug delivery and potential clinical applications. The proposed octahedral geometry for the complexes enhances our understanding of their structural aspects. This research contributes substantively to the field, laying the foundation for future investigations in advanced antimicrobial design and application.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 154-163
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Design and Performance Analysis of Peltier & Piezoelectric Human Energy Harvesting Hybrid Model for WBAN Application
Autorzy:
Dhillon, Hardeep Singh
Chawla, Paras
Powiązania:
https://bibliotekanauki.pl/articles/227297.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
wireless
energy harvesting
body node
body node coordinator (BNC)
piezo-electric harvester
peltier
Opis:
Wireless body area network (WBAN) has evolved from Wireless personal area network (WPAN), a prominent area of research with vast applications in last decade. In WBAN, various wirelessly interconnected body node (BN) are implanted in or around the human body. Also due to advancement in technology a miniature low power device/BN is developed. The main challenge in WBAN body node is to maintain finite size of battery as well as to increase its capacity. Hence this issue can be resolved by using energy harvesting. Generally researchers have used piezoelectric, electromagnetic or solar harvester only. But, in this research energy harvesting using the hybrid optimization of Piezoelectric and Peltier sensors by controlling on-off timing of body nodes is introduced. A hybrid optimized algorithm is developed using MATLAB 2015b platform and extensive simulation is performed considering four different human gestures (relaxing, walking, running and fast running) which in turn improves overall Quality of Service (QoS) including average (packet loss, end to end delay, throughput) and overall detection efficiency.
Źródło:
International Journal of Electronics and Telecommunications; 2019, 65, 3; 435-440
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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