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    Wyświetlanie 1-4 z 4
    Tytuł:
    Isolation, characterization and evaluation of anti-proliferative properties of andrographolide isolated from Andrographis paniculata on cultured HaCaT cells
    Autorzy:
    Jindal, S.
    Awasthi, R.
    Singare, D.
    Kulkarni, G.T.
    Powiązania:
    https://bibliotekanauki.pl/articles/2049322.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    Andrographis paniculata
    andrographolide
    psoriasis
    inflammatory skin disease
    proliferation
    keratinocyte
    epidermis
    andrografolid
    brodziuszka wiechowata
    łuszczyca
    keratynocyty naskórka
    działanie antyproliferacyjne
    Opis:
    Introduction: Psoriasis is an inflammatory skin disease characterized by hyper-proliferation, abnormal epidermal keratinocytes and inflammatory infiltration. It affects approximately 4% of the population globally. Herbal extracts have better results with less toxic effects than the synthetic drugs in the treatment of psoriasis. Objective: Present study was aimed to access the anti-psoriatic effect of andrographolide extracted from Andrographis paniculate (A. paniculata). Method: We extracted, characterized, and screened the extracted andrographolide for anti-proliferative characteristics using cultured cell model of human HaCaT keratinocyte. Results: Andrographolide at 31.25 µg/mL (90 µM) demonstrated significant inhibitory effect on human HaCaT keratinocytes proliferation in cell culture. To our best knowledge, we reported the anti-proliferative potency of andrographolide extracted from A. paniculata for the first time. Conclusion: The results suggest that the andrographolide extracted from A. paniculata plant may have potential to be used in the management of psoriasis.
    Źródło:
    Herba Polonica; 2021, 67, 1; 35-45
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparative study on cytotoxicity activity of N-α-acylarginine ethyl ester
    Autorzy:
    Mhatre, J.D.
    Singare, P.U.
    Powiązania:
    https://bibliotekanauki.pl/articles/412185.pdf
    Data publikacji:
    2013
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    cytotoxicity
    arginine
    IC50
    microbicidal
    monolaurin
    Opis:
    Amino-acid derived compounds, for example N-α-lauroylarginine ethyl ester (LAE), N-α-myristoylarginine ethyl ester (MAE) and a 1:1 mixture of N-α-myristoylarginine ethyl ester with monolaurin (MAE + MLN) are examined for their cytotoxicity towards L929-Mouse connective tissue to explore their use as microbicidal agent, in comparison to sodium dodecylsulfate (SDS) as an anionic control detergent. MTT (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Cytotoxicity assay method was used to determine IC50 value. Cytotoxicity of MAE is found to be more toxic as compared to LAE, having IC50 value 0.052 mg/ml against 0.68 mg/ml of LAE. But MAE when mixed with monolaurin (1:1), showed less toxicity with IC50 0.89 mg/ml. These results suggest that a combination of MAE and Monolaurin can be a potential candidate for studying its microbicidal properties.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2013, 8, 1; 1-7
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Heavy metals in sediment ecosystem of Bhavans College Lake of Andheri, Mumbai
    Autorzy:
    Singare, P. U.
    Talpade, M. S.
    Dagli, D. V.
    Bhawe, V. G.
    Powiązania:
    https://bibliotekanauki.pl/articles/412407.pdf
    Data publikacji:
    2013
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    lake sediments
    heavy metal toxicity
    Central Pollution Control Board (CPCB)
    World Health Organisation (WHO)
    AAS technique
    Opis:
    The present study was initiated to understand the accumulation of toxic heavy metals in sediments of Bhavan's College Lake of Andheri, Mumbai. The study was performed for a period of one year starting from June 2011 to May 2012 to quantify the toxic heavy metals like Cu, Pb, Cr, Ni, Fe, Hg, As and Cd by atomic absorption spectroscopy technique coupled with cold vapour technique (for Hg analysis) and hydride generation technique(for As analysis). It was observed that the yearly average concentrations of these heavy metals in lake sediments were 0.53, 0.25, 0.42, 0.43, 4.6, 0.14, 0.12 and 0.11 ppm respectively which were above the WHO limits for aquatic life and CPCB limits for inland surface water. These heavy metals accumulated in lake sediments may enter the water thereby creating threat to aquatic life. They may enter the food chain through biomagnifications and may create adverse effect on human health. It is expected that in addition to the water analysis which is practiced for years, sediment analysis performed in the present investigation will help in evaluating quality of the total ecosystem of the lake. It will also provide environmentally significant information about natural and anthropogenic influence on the water body.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2013, 8, 2; 105-112
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Heavy Metal Content in Water of Bhavans College Lake of Andheri, Mumbai
    Autorzy:
    Singare, P. U.
    Talpade, M. S.
    Dagli, D. V.
    Bhawe, V. G.
    Powiązania:
    https://bibliotekanauki.pl/articles/412414.pdf
    Data publikacji:
    2013
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Toxic Heavy Metals
    lake water
    AAS
    Cold Vapour Technique
    hydride generation
    health hazards
    water pollution
    Bhavan's College
    Andheri
    Mumbai
    Opis:
    The present research work deals with the quantification of toxic heavy metals in the water samples collected from Lake of the Bhavan's College campus of Andheri, Mumbai. The results of the present investigation indicates that yearly average concentration of toxic heavy metals like Pb, Zn, Cr, Fe and Hg was 0.16, 5.56, 2.09, 5.19 and 0.02 ppm respectively which were very much above their permissible limits set for inland surface water, while the yearly average concentration of Ni was found to be 2.76 ppm which was close to the maximum limit of 3.0 ppm. The results of the present investigation points out the need to implement common objectives, compatible policies and programs for improvement in treatment facilities for the treatment of discharged sewage and laboratory effluents.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2013, 8, 2; 94-104
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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