Autor: Sielewiesiuk, Jan - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: A cycle of enzymatic reactions with some properties of neuronal circuits
Autorzy:: Sielewiesiuk, Jan
Powiązania:: https://bibliotekanauki.pl/articles/763374.pdf
Data publikacji:: 2014
Wydawca:: Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Opis:: A cycle of four methylation and four demethylation reactions with repression or allosteric inhibition of enzymes is considered. The corresponding dynamical system is characterised by two parameters: the sum of reagent concentrations (C) and the ratio of rate constants of forward and backward reactions (k). In a symmetrical case (k=1) the system has a unique equilibrium. At C>4 the equilibrium is unstable and the system has oscillatory solutions. At k essentially different from 1, the system becomes excitable or behaves as a bistable trigger.
Źródło:: Annales Universitatis Mariae Curie-Skłodowska, sectio AAA – Physica; 2014, 69
0137-6861
Pojawia się w:: Annales Universitatis Mariae Curie-Skłodowska, sectio AAA – Physica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Positive and negative feedback loops coupled by common transcription activator and repressor
Autorzy:: Sielewiesiuk, Jan
Łopaciuk, Agata
Powiązania:: https://bibliotekanauki.pl/articles/763393.pdf
Data publikacji:: 2014
Wydawca:: Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Opis:: Dynamical systems consisting of two interlocked loops with negative and positive feedback have been studied using the linear analysis of stability and numerical solutions. Conditions for saddle-node bifurcation were formulated in a general form. Conditions for Hopf bifurcations were found in a few symmetrical cases. Auto-oscillations, when they exist, are generated by the negative feedback repressive loop. This loop determines the frequency and amplitude of oscillations. The positive feedback loop of activation slightly modifies the oscillations. Oscillations are possible when the difference between Hilll’s coefficients of the repression and activation is sufficiently high. The highly cooperative activation loop with a fast turnover slows down or even makes the oscillations impossible. The system under consideration can constitute a component of epigenetic or enzymatic regulation network.
Źródło:: Annales Universitatis Mariae Curie-Skłodowska, sectio AAA – Physica; 2014, 69
0137-6861
Pojawia się w:: Annales Universitatis Mariae Curie-Skłodowska, sectio AAA – Physica
Dostawca treści:: Biblioteka Nauki

Artykuł

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