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Wyszukujesz frazę "Shafiee, A. R." wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Biological evaluation of [18F]-nifedipine as a novel PET tracer for L-type calcium channel imaging
Autorzy:
Sadeghpour, H.
Jalilian, A. R.
Akhlaghi, M.
Shafiee, A.
Mirzaii, M.
Miri, R.
Saddadi, F.
Powiązania:
https://bibliotekanauki.pl/articles/147732.pdf
Data publikacji:
2008
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
dihydropyridines
flourine-18
PET
biodistribution
Opis:
Due to interesting role of dihydropyridines in cardiovascular diseases and drug resistance studies and lack of a fluorine-18 labeled imaging agent for L-type calcium channel studies, this study was designed. [18F]Dimethyl 2-(fluoromethyl)-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 2 was prepared in no-carrier-added (n.c.a.) form from a starting brominated compound in one step at 80°C in Kryptofix2.2.2/[18F]. Compound 2 was administered to normal rats via their tail veins for preliminary biodistribution studies and the ID/g% of the labeled compound was determined up to 3 h post injections. Coincidence images were obtained in rats 5 to 120 min. Radiofluorination on bromo precursor gave a fluorinated compound in 95% radiochemical purity and a 8% yield shown by RTLC and HPLC. Biodistribution studies showed that the tracer is accumulated in the heart in the first few minutes, followed by metabolism resulting in very soluble 18F-containing metabolites eliminated through the urinary tract. In coincidence images, the target organ was shown to be the heart. Lung had high accumulation possibly due to the presence of Ca2+ channels and/or hydrolyzing enzymes showing a significant myocardial uptake at 120 min. The data demonstrates a significant agreement with the reported L-type calcium channels throughout the animal body. To our knowledge, this is the first example of 18F-DHPs in the literature.
Źródło:
Nukleonika; 2008, 53, 4; 151-154
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of technology factor in companies’ business strategy with the use of sense and respond method
Autorzy:
Tilabi, Sara
Tasmin, Rosmaini
Takala, Josu
Muazu, M. H.
Nor Aziati, A. H.
Shafiee, A. R.
Kaprawi, Noraini
Che Rusuli, M. S.
Powiązania:
https://bibliotekanauki.pl/articles/407062.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
technology
knowledge
sense
respond
sustainable competitive advantage
Opis:
The focus of this paper is to propose a method for prioritizing knowledge and technology factor in companies’ business strategy. The data has been gathered and analyzed from Malaysian-owned company of medium size type industry, employing around 250 employees and listed in the Malaysian Bourse Stock of Exchange, since 2000. Sense and respond model is used to determine competitive priorities of the firms. Then knowledge and technology part of sense and respond questionnaire is used to calculate the variability coefficient i.e. the uncertainty caused by technology and knowledge factor. The results show that the company is not leading in term of technology (spear head technology share is around 33%). Therefore, the enhancement of technology and knowledge to SCA values is not significantly seen in this study. The usage of the core technologies is around 41% and it might seem relatively enough. In terms of basic technology, while its share is the lowest (around 25%), it has the highest source of uncertainties among technology types. In this case, the proposed model helped to have a clear and precise improvement plan towards prioritizing technology and knowledge focus.
Źródło:
Management and Production Engineering Review; 2019, 10, 3; 81--89
2080-8208
2082-1344
Pojawia się w:
Management and Production Engineering Review
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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