Autor: Seweryn, Sylwia. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Godzina obywatela
Autorzy:: Seweryn, Sylwia.
Powiązania:: Wojsko i Wychowanie 2003, nr 6, s. 52-56
Data publikacji:: 2003
Tematy:: Transformacja systemu społeczno-gospodarczego Europa Środkowo-Wschodnia od 1989 r.
Dostawca treści:: Bibliografia CBW

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Skocz do pozycji: 2.

Tytuł:: Komórka ds. planowania polityki i wczesnego ostrzegania
Autorzy:: Seweryn, Sylwia.
Powiązania:: Wojsko i Wychowanie 2003, nr 5, s. 125-129
Data publikacji:: 2003
Tematy:: Unia Europejska polityka wojskowa
Unia Europejska. Komitet Wojskowy.
Unia Europejska współpraca wojskowa
Wojska szybkiego reagowania organizacja Unia Europejska
Dostawca treści:: Bibliografia CBW

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Skocz do pozycji: 3.

Tytuł:: Polityka bezpieczeństwa i doktryny obronne wschodnich sąsiadów Polski. Cz. 1
Współwytwórcy:: Stańczyk, Jerzy. Redakcja
Kamiński, Krzysztof. Tłumaczenie
Seweryn, Sylwia. Tłumaczenie
Data publikacji:: 2001
Wydawca:: Warszawa : ISP PAN
Tematy:: Doktryny obronne Europa Środkowo-Wschodnia
Bezpieczeństwo międzynarodowe polityka Europa Środkowo-Wschodnia
Dostawca treści:: Bibliografia CBW

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Skocz do pozycji: 4.

Tytuł:: Kinetic and thermodynamic characterization of the interactions between the components of human plasma kinin-forming system and isolated and purified cell wall proteins of Candida albicans
Autorzy:: Seweryn, Karolina
Karkowska-Kuleta, Justyna
Wolak, Natalia
Bochenska, Oliwia
Kedracka-Krok, Sylwia
Kozik, Andrzej
Rapala-Kozik, Maria
Powiązania:: https://bibliotekanauki.pl/articles/1038926.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Candida albicans cell wall
candidiasis
contact system
surface plasmon resonance
Opis:: Cell wall proteins of Candida albicans, besides their best known role in the adhesion of this fungal pathogen to host's tissues, also bind some soluble proteins, present in body fluids and involved in maintaining the biochemical homeostasis of the human organism. In particular, three plasma factors - high-molecular-mass kininogen (HK), factor XII (FXII) and prekallikrein (PPK) - have been shown to adhere to candidal cells. These proteins are involved in the surface-contact-catalyzed production of bradykinin-related peptides (kinins) that contribute to inflammatory states associated with microbial infections. We recently identified several proteins, associated with the candidal cell walls, and probably involved in the binding of HK. In our present study, a list of potential FXII- and PPK-binding proteins was proposed, using an affinity selection (on agarose-coupled FXII or PPK) from a whole mixture of β-1,3-glucanase-extrated cell wall-associated proteins and the mass-spectrometry protein identification. Five of these fungal proteins, including agglutinin-like sequence protein 3 (Als3), triosephosphate isomerase 1 (Tpi1), enolase 1 (Eno1), phosphoglycerate mutase 1 (Gpm1) and glucose-6-phosphate isomerase 1 (Gpi1), were purified and characterized in terms of affinities to the human contact factors, using the surface plasmon resonance measurements. Except Gpm1 that bound only PPK, and Als3 that exhibited an affinity to HK and FXII, the other isolated proteins interacted with all three contact factors. The determined dissociation constants for the identified protein complexes were of 10-7 M order, and the association rate constants were in a range of 104-105 M-1s-1. The identified fungal pathogen-host protein interactions are potential targets for novel anticandidal therapeutic approaches.
Źródło:: Acta Biochimica Polonica; 2015, 62, 4; 825-835
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Characterization of the interactions between human high-molecular-mass kininogen and cell wall proteins of pathogenic yeasts Candida tropicalis
Autorzy:: Karkowska-Kuleta, Justyna
Zajac, Dorota
Bras, Grazyna
Bochenska, Oliwia
Seweryn, Karolina
Kedracka-Krok, Sylwia
Jankowska, Urszula
Rapala-Kozik, Maria
Kozik, Andrzej
Powiązania:: https://bibliotekanauki.pl/articles/1038758.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: contact system
kinins
inflammation
candidiasis
cell wall proteins
adhesion
Opis:: Candida tropicalis is one of the most frequent causes of serious disseminated candidiasis in human patients infected by non-albicans Candida species, but still relatively little is known about its virulence mechanisms. In our current study, the interactions between the cell surface of this species and a multifunctional human protein - high-molecular-mass kininogen (HK), an important component of the plasma contact system involved in the development of the inflammatory state - were characterized at the molecular level. The quick release of biologically active kinins from candidal cell wall-adsorbed HK was presented and the HK-binding ability was assigned to several cell wall-associated proteins. The predicted hyphally regulated cell wall protein (Hyr) and some housekeeping enzymes exposed at the cell surface (known as "moonlighting proteins") were found to be the major HK binders. Accordingly, after purification of selected proteins, the dissociation constants of the complexes of HK with Hyr, enolase, and phosphoglycerate mutase were determined using surface plasmon resonance measurements, yielding the values of 2.20 × 10-7 M, 1.42 × 10-7 M, and 5.81 × 10-7 M, respectively. Therefore, in this work, for the first time, the interactions between C. tropicalis cell wall proteins and HK were characterized in molecular terms. Our findings may be useful for designing more effective prevention and treatment approaches against infections caused by this dangerous fungal pathogen.
Źródło:: Acta Biochimica Polonica; 2016, 63, 3; 427-436
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki