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Wyświetlanie 1-4 z 4
Tytuł:
Uptake of photofrin II, a photosensitizer used in photodynamic therapy, by tumour cells in vitro
Autorzy:
Chwiłkowska, Agnieszka
Saczko, Jolanta
Modrzycka, Teresa
Marcinkowska, Anna
Malarska, Anna
Bielewicz, Julita
Patalas, Dorota
Banaś, Teresa
Powiązania:
https://bibliotekanauki.pl/articles/1043629.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
photofrin II
photodynamic therapy
fluorescence spectra
Opis:
Photosensitizing dyes are used in fluorescence diagnostics and photodynamic therapy (PDT). These usually hematoporphyrin derivatives (HpD) accumulate preferentially within neoplastic tissues. HpD is a mixture of ether and ester linked porphyrins. Its partially purified form is known under the commercial name of photofrin II (PII). PII emission spectra were studied in a hydrophilic (PBS) and a lipophilic (PC liposomes) environment. Red shift was observed in their emission maxima from 615 nm in buffer solution to 635 nm in lipid. Identical red shift was obtained when the intracellular fluorescence of two cancer cell lines, MCF 7 and Jurkat, incubated with PII was investigated. Thus, intramembrane localization of PII may be suggested. As determined from the total fluorescence intensity, the uptake of PII was only slightly higher for Jurkat than for MCF 7 cells. Nevertheless the kinetics of the uptake was found to be different for both cell lines.
Źródło:
Acta Biochimica Polonica; 2003, 50, 2; 509-513
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contemporary management and novel therapies in ovarian cancer – literature review
Autorzy:
Kotowski, Krzysztof
Przystupski, Dawid
Kwiatkowski, Stanisław
Kolasińska, Karolina
Bartosik, Weronika
Górska, Agata
Saczko, Jolanta
Baczyńska, Dagmara
Kulbacka, Julita
Powiązania:
https://bibliotekanauki.pl/articles/1162168.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Anti-VEGF monoclonal IgG1 antibody
Interval Cytoreductive Surgery
Interval Debuking Surgery
bevacizumab
electrochemotherapy
hormone therapy
immunotherapy
ovarian cancer
photodynamic therapy
Opis:
Ovarian cancer is characterized by an extremely poor prognosis in women with an advanced stage of this carcinoma. In United States every year 20,000 women are diagnosed with ovarian cancer. It is the fifth most frequent cause of death from cancer in females and the most common cause of death for 15 years after diagnosis in women with stage III-IV tumors. Among ovarian neoplasms the most frequent are surface epithelial-stromal tumors. Moreover, non-epithelial ovarian tumors are distinguished. This group matters 10% of patients with diagnosed ovarian tumors. Due to a huge variety of ovarian tumors, the following work focuses mainly on the current clinical treatment of the epithelial ovarian cancer. The following paper summarizes current clinical treatment of epithelial ovarian cancer, including surgical procedure, chemo- and immunotherapy including modern therapeutic approaches.
Źródło:
World Scientific News; 2018, 111; 51-63
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current clinical management of malignant melanoma – diagnosis process and innovative therapies
Autorzy:
Kwiatkowski, Stanisław
Przystupski, Dawid
Kotowski, Krzysztof
Kolasińska, Karolina
Saczko, Jolanta
Kulbacka, Julita
Powiązania:
https://bibliotekanauki.pl/articles/1177464.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
AJCC
Melanoma malignum
dabrafenib
electrochemotherapy
ipilimumab
melanoma
melanoma staging
pembrolizumab
photodynamic therapy
vemurafenib
Opis:
Malignant melanoma is a highly invasive cancer which derives from neuroectodermic melanocytic cells. It is characterized by the highest frequency of cases in both sexes and all age groups. High metastatic potential of melanoma and its multidrug resistance might be a significant problem in the treatment. Permanent and complete remissions are rare, while the 5-year survival rate remains relatively low. In the last years there has been a breakthrough in the systemic therapy of malignant melanoma. Modern drugs have revolutionized previous therapeutic management of melanoma. As part of therapeutic programs, new medicines are available: dabrafenib, ipilimumab, pembrolizumab, trametinib and vemurafenib. The following paper presents current clinical management standards for melanoma diagnoses, based on the widely accepted scientific data and expert experience - with emphasis on modern methods of treatment of this cancer.
Źródło:
World Scientific News; 2018, 102; 30-46
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The favourable effect of catechin in electrochemotherapy in human pancreatic cancer cells
Autorzy:
Michel, Olga
Przystupski, Dawid
Saczko, Jolanta
Szewczyk, Anna
Niedzielska, Natalia
Rossowska, Joanna
Kulbacka, Julita
Powiązania:
https://bibliotekanauki.pl/articles/1038385.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
electroporation
cisplatin
catechin
pancreatic cancer
in vitro
Opis:
Until recently, green tea polyphenols were considered strong antioxidants. However, the latest reports have revealed that bioflavonoids can play a multiple role in anticancer therapy, including the inhibition of cell proliferation and generation of the oxidative stress in a dose-dependent manner. The presented research was designed to examine the potential of the green tea (±)-catechin as a reinforcement of the electrochemotherapy (ECT) with cisplatin in pancreatic cancer in vitro. The study was performed on two cell lines of the pancreatic ductal adenocarcinoma (PDA) - parental EPP85-181P and multidrug-resistant EPP85-181RNOV. Prior to the ECT protocol the cells were preincubated with high or low concentration of catechin for 2 or 24 hours, respectively. We assessed the influence of preincubation on the cisplatin toxicity with and without electroporation (EP), the electrosensitivity of PDA cell lines and the uptake of the daunorubicin and propidium iodide. Additionally, we evaluated the antioxidative properties of catechin by the measurement of the ROS-related fluorescence and the immunoreactivity of the oxidative stress-related enzymes superoxide dismutase (SOD2) and glutathione S-transferase (GST). We found that co-treatment with catechin can firmly enhance the efficacy of electroporation with cisplatin in vitro. More favorable effect was obtained for 2-hour incubation, which indicates the involvement of the transcriptional-independent mechanisms of catechin action. The effect may be partially explained by the increased oxidative stress level, which was higher in multidrug-resistant cells. However, further studies on cisplatin-catechin interplay and the thorough examination of the catechin-cell membrane interaction need to be performed.
Źródło:
Acta Biochimica Polonica; 2018, 65, 2; 173-184
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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