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    Wyświetlanie 1-4 z 4
    Tytuł:
    Current clinical management of malignant melanoma – diagnosis process and innovative therapies
    Autorzy:
    Kwiatkowski, Stanisław
    Przystupski, Dawid
    Kotowski, Krzysztof
    Kolasińska, Karolina
    Saczko, Jolanta
    Kulbacka, Julita
    Powiązania:
    https://bibliotekanauki.pl/articles/1177464.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    AJCC
    Melanoma malignum
    dabrafenib
    electrochemotherapy
    ipilimumab
    melanoma
    melanoma staging
    pembrolizumab
    photodynamic therapy
    vemurafenib
    Opis:
    Malignant melanoma is a highly invasive cancer which derives from neuroectodermic melanocytic cells. It is characterized by the highest frequency of cases in both sexes and all age groups. High metastatic potential of melanoma and its multidrug resistance might be a significant problem in the treatment. Permanent and complete remissions are rare, while the 5-year survival rate remains relatively low. In the last years there has been a breakthrough in the systemic therapy of malignant melanoma. Modern drugs have revolutionized previous therapeutic management of melanoma. As part of therapeutic programs, new medicines are available: dabrafenib, ipilimumab, pembrolizumab, trametinib and vemurafenib. The following paper presents current clinical management standards for melanoma diagnoses, based on the widely accepted scientific data and expert experience - with emphasis on modern methods of treatment of this cancer.
    Źródło:
    World Scientific News; 2018, 102; 30-46
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The favourable effect of catechin in electrochemotherapy in human pancreatic cancer cells
    Autorzy:
    Michel, Olga
    Przystupski, Dawid
    Saczko, Jolanta
    Szewczyk, Anna
    Niedzielska, Natalia
    Rossowska, Joanna
    Kulbacka, Julita
    Powiązania:
    https://bibliotekanauki.pl/articles/1038385.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    electroporation
    cisplatin
    catechin
    pancreatic cancer
    in vitro
    Opis:
    Until recently, green tea polyphenols were considered strong antioxidants. However, the latest reports have revealed that bioflavonoids can play a multiple role in anticancer therapy, including the inhibition of cell proliferation and generation of the oxidative stress in a dose-dependent manner. The presented research was designed to examine the potential of the green tea (±)-catechin as a reinforcement of the electrochemotherapy (ECT) with cisplatin in pancreatic cancer in vitro. The study was performed on two cell lines of the pancreatic ductal adenocarcinoma (PDA) - parental EPP85-181P and multidrug-resistant EPP85-181RNOV. Prior to the ECT protocol the cells were preincubated with high or low concentration of catechin for 2 or 24 hours, respectively. We assessed the influence of preincubation on the cisplatin toxicity with and without electroporation (EP), the electrosensitivity of PDA cell lines and the uptake of the daunorubicin and propidium iodide. Additionally, we evaluated the antioxidative properties of catechin by the measurement of the ROS-related fluorescence and the immunoreactivity of the oxidative stress-related enzymes superoxide dismutase (SOD2) and glutathione S-transferase (GST). We found that co-treatment with catechin can firmly enhance the efficacy of electroporation with cisplatin in vitro. More favorable effect was obtained for 2-hour incubation, which indicates the involvement of the transcriptional-independent mechanisms of catechin action. The effect may be partially explained by the increased oxidative stress level, which was higher in multidrug-resistant cells. However, further studies on cisplatin-catechin interplay and the thorough examination of the catechin-cell membrane interaction need to be performed.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 2; 173-184
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Uptake of photofrin II, a photosensitizer used in photodynamic therapy, by tumour cells in vitro
    Autorzy:
    Chwiłkowska, Agnieszka
    Saczko, Jolanta
    Modrzycka, Teresa
    Marcinkowska, Anna
    Malarska, Anna
    Bielewicz, Julita
    Patalas, Dorota
    Banaś, Teresa
    Powiązania:
    https://bibliotekanauki.pl/articles/1043629.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    photofrin II
    photodynamic therapy
    fluorescence spectra
    Opis:
    Photosensitizing dyes are used in fluorescence diagnostics and photodynamic therapy (PDT). These usually hematoporphyrin derivatives (HpD) accumulate preferentially within neoplastic tissues. HpD is a mixture of ether and ester linked porphyrins. Its partially purified form is known under the commercial name of photofrin II (PII). PII emission spectra were studied in a hydrophilic (PBS) and a lipophilic (PC liposomes) environment. Red shift was observed in their emission maxima from 615 nm in buffer solution to 635 nm in lipid. Identical red shift was obtained when the intracellular fluorescence of two cancer cell lines, MCF 7 and Jurkat, incubated with PII was investigated. Thus, intramembrane localization of PII may be suggested. As determined from the total fluorescence intensity, the uptake of PII was only slightly higher for Jurkat than for MCF 7 cells. Nevertheless the kinetics of the uptake was found to be different for both cell lines.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 2; 509-513
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Contemporary management and novel therapies in ovarian cancer – literature review
    Autorzy:
    Kotowski, Krzysztof
    Przystupski, Dawid
    Kwiatkowski, Stanisław
    Kolasińska, Karolina
    Bartosik, Weronika
    Górska, Agata
    Saczko, Jolanta
    Baczyńska, Dagmara
    Kulbacka, Julita
    Powiązania:
    https://bibliotekanauki.pl/articles/1162168.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Anti-VEGF monoclonal IgG1 antibody
    Interval Cytoreductive Surgery
    Interval Debuking Surgery
    bevacizumab
    electrochemotherapy
    hormone therapy
    immunotherapy
    ovarian cancer
    photodynamic therapy
    Opis:
    Ovarian cancer is characterized by an extremely poor prognosis in women with an advanced stage of this carcinoma. In United States every year 20,000 women are diagnosed with ovarian cancer. It is the fifth most frequent cause of death from cancer in females and the most common cause of death for 15 years after diagnosis in women with stage III-IV tumors. Among ovarian neoplasms the most frequent are surface epithelial-stromal tumors. Moreover, non-epithelial ovarian tumors are distinguished. This group matters 10% of patients with diagnosed ovarian tumors. Due to a huge variety of ovarian tumors, the following work focuses mainly on the current clinical treatment of the epithelial ovarian cancer. The following paper summarizes current clinical treatment of epithelial ovarian cancer, including surgical procedure, chemo- and immunotherapy including modern therapeutic approaches.
    Źródło:
    World Scientific News; 2018, 111; 51-63
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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