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    Wyświetlanie 1-5 z 5
    Tytuł:
    A renal abscess in the isthmus of horseshoe kidney
    Autorzy:
    Balawender, Krzysztof
    Orkisz, Stanisław
    Biela, Przemysław
    Sęk-Mastej, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/454881.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    horseshoe kidney
    renal fusion
    urinary tract infection
    renal abscess
    Opis:
    Horseshoe kidney (HSK) is the renal fusion anomaly caused by disturbances in embryonic development when the kidneys are fused together in the lower or upper pole forming an isthmus. The most common disorders in urinary tract related to horseshoe kidney are ureteral pelvic junction obstruction, urinary tract infection and urolithiasis. In our study, we present a rare case of an abscess in the isthmus of horseshoe kidney after extracorporeal shockwave lithotripsy on the right kidney was performed. The patient has had recurrent urolithiasis and underwent 4 treatments on the left kidney in the past without complications.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 3; 279-281
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The outcomes in children with Hirschsprung’s disease treated with transanal endorectal pull-through method
    Autorzy:
    Szymczak, Artur
    Ogorzałek, Anna
    Leksa, Natalia
    Sęk-Mastej, Anna
    Orkisz, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/2054538.pdf
    Data publikacji:
    2022-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    aganglionosis
    constipation
    encopresis
    soiling
    Opis:
    Introduction and aim. The evaluation of functional results, complications and problems of children with Hirschsprung’s disease treated with one-stage surgery (TEPT) or two-stage surgery (colostomy, TEPT) in Paediatric Surgery Clinic in Rzeszów. Material and methods. Medical documentation of 41 children treated due to Hirschsprung’s disease in years 2006-2018 in Rzeszów were retrospectively analysed. The results of the questionnaires conducted among the parents of operated children were surveyed. Results. The average time of the radical surgery was 189 minutes. The mean length of the resected intestine in the classic form was 19 centimeters, in long-segment 35 centimeters. In the post-operative period, 15 patients had a blood transfusion. The mean time of the children’s stay calculated from the date of surgery until the discharge equaled 13.4 days. Early post-operative complications: enterocolitis occurred in 6 patients (1 death in a septic shock mechanism), total dehiscence of anastomosis in 1 patient, abscess of perirectal space in 1 patient, anastomotic retraction in 1 patient and in 3 patients inaccurate intra-operative evaluation of the section (intra), buttock dermatitis appeared in all patients. Late post-operative complications (a control trial of 38 patients): Soiling was confirmed in 9 patients, periodic constipation in one. The abnormal consistency of stool was signaled in 3 children. Two children were repetitively hospitalized due to enterocolitis. The frequency of defecation almost in all patients was reduced after a three, four-month period since the operation from 10-15 per day to the age norm. In one child, where the retraction of the anastomosis was diagnosed, the soiling and heightened frequency of defecation throughout the day persists. All of the parents of the older children view the outcome of the surgery as positive and the life quality of their children does not differ from their peers. Conclusion. TEPT is a method which can be performed in newborns, infants, babies as well as in case of a long-segment aganglionosis. Barium enema is not reliable in evaluation of the length of the aganglionic section in the long-segment type of Hirschsprung’s disease. The treatment of choice in the early post-operative enterocolitis should be colostomy. Worse functional results were observed in children after two-stage treatment – especially, in cases where the colostomy was created due to the intestinal re-distention.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2022, 2; 194-201
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical aspects of protein glycation
    Autorzy:
    Galiniak, Sabina
    Krawczyk-Marć, Izabela
    Sęk-Mastej, Anna
    Leksa, Natalia
    Biesiadecki, Marek
    Orkisz, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/454911.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    AGEs
    glycation
    advanced glycation end products
    multiple sclerosis
    Opis:
    Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple sclerosis. Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge about the role of glycation in multiple sclerosis. Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature. Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 3; 263-267
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of alcohol on neuroglia in the developing brain and in adults
    Autorzy:
    Krawczyk-Marć, Izabela
    Galiniak, Sabina
    Sęk-Mastej, Anna
    Marć, Mateusz
    Orkisz, Stanisław
    Wawrzyniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/454917.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    brain
    alcohol
    neuroglia
    Opis:
    Introduction. During puberty, the young body undergoes transformation not only within the reproductive and hormonal systems, but also significant changes in the central nervous system (CNS). Matured neural connections improve the integration of distant brain regions, the plasticity of neurons increases, and thus specialization of the brain occurs in the performance of specific tasks. During these transformations, both neurons and the accompanying neuroglia are sensitive to all toxic factors, among which ethanol occupies a special place. It causes an increase in the activity of glial cells, which by directing pro-inflammatory cytokines directly contribute to the death of apoptotic neurons. A long-lasting and irreversible impairment of brain function, especially in the hippocampus occurs as a result of alcohol abuse during the period of development. Aim. This paper presents an overview of current knowledge about the effects of alcohol on neuroglia in the developing brain and in adults. Materials and methods. The literature review of the following databases has been conducted: EBSCO, PubMed, Science Direct, Springer Link. Conclusions. The results of alcohol research have shown that it affects the neurotransmission and fluidity of cell membranes, changing the activity of neurons. By binding to GABA receptor (GABA) and N-methyl-D-aspartate receptors (NMDA receptor for glutamate), ethanol suppresses brain function. In addition to increased sensitivity and susceptibility to the addictive effects of ethanol, the neurogeneration activity is intensified followed by the induction and release of pro-inflammatory cytokines, which in the first stage disrupt the cortical function hindering logical thinking and disrupting the limbic system, directly affecting the memory and learning processes. Next, the cerebellum is attacked, which results in the impairment of balance and motor coordination, and consequently acts on the brain stem, directly affecting the respiratory and circulatory control centers.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 335-340
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development
    Autorzy:
    Sęk-Mastej, Anna
    Galiniak, Sabina
    Krawczyk-Marć, Izabela
    Balawender, Krzysztof
    Szymczak, Artur
    Kaniewski, Maciej
    Leksa, Natalia
    Biesiadecki, Marek
    Orkisz, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/454733.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    pregnancy
    foetus
    congenital defect
    teratogen
    Opis:
    Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 85-91
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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