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Wyświetlanie 1-10 z 10
Tytuł:
Innowacyjne firmy w Polsce - stan obecny i perspektywy w świetle nowego planu rozwojowego
Innovative Companies in Poland - the Current State and Future Prospects in Light of the New Development Plan
Autorzy:
Sęk, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1828252.pdf
Data publikacji:
2017
Wydawca:
Politechnika Gdańska
Tematy:
innovation
innovative company
research and development
innowacyjność
innowacyjna firma
badania i rozwój
Opis:
Currently many countries tend to foster innovative character of their economies. For Poland there has been formulated a new plan, whose one of the main elements is the development of entrepreneurship and innovation. A Strategy for Responsible Growth (Strategia na rzecz Odpowiedzialnego Rozwoju) in part dedicated to innovation introduces systemic changes designed to facilitate cooperation between representatives of science and business, as well as provides many new regulations enhancing creation and functioning of innovative companies. The conducted study applies, on the one hand, to the conditions for innovative activity that have determined the Polish scientific and economic sphere to date and, on the other, it discusses the prospects in this area. For this purpose there have been analysed experts and entrepreneurs’ opinions on the present solutions, as well as on the planned ones and their potential influence on the development of innovative companies. The gathered data have shown that the current level of innovation among Polish companies seems to be insufficient to give them significant competitive advantage. Although entrepreneurs have an interest in innovative activity, they often lack impetus to start it since business and legal barriers are impossible to overcome. Changes improving the whole process of commercialisation of scientific research are generally welcome by both entrepreneurs and experts but their opinions on the particular systemic changes proposed by the government are not entirely consistent. Nevertheless, entrepreneurs and analysts agree as to the need of introducing the proposed changes ambitious though they may seem.
Aktualnie wiele krajów podąża w kierunku wspierania innowacyjności narodowej gospodarki. Dla Polski opracowano nowy plan, którego jednym z głównych filarów jest rozwój przedsiębiorczości i innowacyjności. Strategia na rzecz Odpowiedzialnego Rozwoju w części dotyczącej innowacyjności zakłada wprowadzenie zmian systemowych mających ułatwić współpracę przedstawicielom nauki i biznesu oraz zapowiada szereg nowych uregulowań usprawniających powstawanie i funkcjonowanie innowacyjnych przedsiębiorstw. Przeprowadzone badanie dotyczy oceny uwarunkowań dla innowacyjności, które dotychczas obowiązywały w polskiej przestrzeni naukowo-gospodarczej oraz perspektyw w tym obszarze. W tym celu przeanalizowane zostały opinie analityków i przedsiębiorców na temat obecnych rozwiązań oraz tych dopiero wprowadzanych lub planowanych i ich potencjalnego wpływu na rozwój innowacyjnych firm. Pozyskane dane wskazują, że aktualny poziom innowacyjności polskich firm wydaje się być niewystarczający do osiągania przez nie znaczących przewag konkurencyjnych. Mimo że przedsiębiorcy wykazują znaczne zainteresowanie innowacyjną działalnością, często brakuje im impulsu do jej rozpoczęcia, a bariera biznesowo-prawna bywa nie do przejścia. Zmiany prowadzące do usprawnienia całego procesu komercjalizacji badań są zasadniczo pożądane zarówno przez środowisko przedsiębiorców, jak i ekspertów, ale oceny aktualnie proponowanych przez państwo rozwiązań systemowych nie są jednolite. Niemniej jednak, wśród przedsiębiorców i analityków panuje przekonanie, że wprowadzane zmiany, choć zakrojone z rozmachem, powinny być realizowane.
Źródło:
Przedsiębiorstwo we współczesnej gospodarce - teoria i praktyka; 2017, 4, 23; 109-129
2084-6495
Pojawia się w:
Przedsiębiorstwo we współczesnej gospodarce - teoria i praktyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Projekt konstrukcji przekrycia pływalni miejskiej
Design of the shell roof structure of the swimming pool
Autorzy:
Sęk, Anna Małgorzata
Prusiel, Jolanta Anna
Powiązania:
https://bibliotekanauki.pl/articles/162085.pdf
Data publikacji:
2020
Wydawca:
Polski Związek Inżynierów i Techników Budownictwa
Tematy:
basen
pływalnia publiczna
przekrycie dachowe
przekrycie cienkościenne
powłoka walcowa
obliczenia statyczne
analiza statyczno-wytrzymałościowa
metoda numeryczna
metoda analityczna
swimming pool
public swimming pool
roof cover
thin-walled covering
cylindrical shell
static calculations
static-strength analysis
numerical method
analitycal method
Opis:
Opracowano koncepcję architektoniczną obiektu pływalni miejskiej z dwoma wariantami konstrukcji przekrycia w postaci powłoki walcowej. Przeprowadzono analizę porównawczą sił wewnętrznych w powłoce uzyskanych metodą numeryczną i analityczną. Zwymiarowano żelbetową konstrukcję przekrycia powłokowego zgodnie z obowiązującymi eurokodami.
The architectural and construction concept of the swimming pool with two types of cylindrical shell roof was designed. A comparative analysis of internal forces using a numerical and analytical method has been carried out. The reinforced structure of cylindrical shell roof has been designed according to required eurocodes.
Źródło:
Przegląd Budowlany; 2020, 91, 5; 43-48
0033-2038
Pojawia się w:
Przegląd Budowlany
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A renal abscess in the isthmus of horseshoe kidney
Autorzy:
Balawender, Krzysztof
Orkisz, Stanisław
Biela, Przemysław
Sęk-Mastej, Anna
Powiązania:
https://bibliotekanauki.pl/articles/454881.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
horseshoe kidney
renal fusion
urinary tract infection
renal abscess
Opis:
Horseshoe kidney (HSK) is the renal fusion anomaly caused by disturbances in embryonic development when the kidneys are fused together in the lower or upper pole forming an isthmus. The most common disorders in urinary tract related to horseshoe kidney are ureteral pelvic junction obstruction, urinary tract infection and urolithiasis. In our study, we present a rare case of an abscess in the isthmus of horseshoe kidney after extracorporeal shockwave lithotripsy on the right kidney was performed. The patient has had recurrent urolithiasis and underwent 4 treatments on the left kidney in the past without complications.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 3; 279-281
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The outcomes in children with Hirschsprung’s disease treated with transanal endorectal pull-through method
Autorzy:
Szymczak, Artur
Ogorzałek, Anna
Leksa, Natalia
Sęk-Mastej, Anna
Orkisz, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/2054538.pdf
Data publikacji:
2022-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
aganglionosis
constipation
encopresis
soiling
Opis:
Introduction and aim. The evaluation of functional results, complications and problems of children with Hirschsprung’s disease treated with one-stage surgery (TEPT) or two-stage surgery (colostomy, TEPT) in Paediatric Surgery Clinic in Rzeszów. Material and methods. Medical documentation of 41 children treated due to Hirschsprung’s disease in years 2006-2018 in Rzeszów were retrospectively analysed. The results of the questionnaires conducted among the parents of operated children were surveyed. Results. The average time of the radical surgery was 189 minutes. The mean length of the resected intestine in the classic form was 19 centimeters, in long-segment 35 centimeters. In the post-operative period, 15 patients had a blood transfusion. The mean time of the children’s stay calculated from the date of surgery until the discharge equaled 13.4 days. Early post-operative complications: enterocolitis occurred in 6 patients (1 death in a septic shock mechanism), total dehiscence of anastomosis in 1 patient, abscess of perirectal space in 1 patient, anastomotic retraction in 1 patient and in 3 patients inaccurate intra-operative evaluation of the section (intra), buttock dermatitis appeared in all patients. Late post-operative complications (a control trial of 38 patients): Soiling was confirmed in 9 patients, periodic constipation in one. The abnormal consistency of stool was signaled in 3 children. Two children were repetitively hospitalized due to enterocolitis. The frequency of defecation almost in all patients was reduced after a three, four-month period since the operation from 10-15 per day to the age norm. In one child, where the retraction of the anastomosis was diagnosed, the soiling and heightened frequency of defecation throughout the day persists. All of the parents of the older children view the outcome of the surgery as positive and the life quality of their children does not differ from their peers. Conclusion. TEPT is a method which can be performed in newborns, infants, babies as well as in case of a long-segment aganglionosis. Barium enema is not reliable in evaluation of the length of the aganglionic section in the long-segment type of Hirschsprung’s disease. The treatment of choice in the early post-operative enterocolitis should be colostomy. Worse functional results were observed in children after two-stage treatment – especially, in cases where the colostomy was created due to the intestinal re-distention.
Źródło:
European Journal of Clinical and Experimental Medicine; 2022, 2; 194-201
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical aspects of protein glycation
Autorzy:
Galiniak, Sabina
Krawczyk-Marć, Izabela
Sęk-Mastej, Anna
Leksa, Natalia
Biesiadecki, Marek
Orkisz, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/454911.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
AGEs
glycation
advanced glycation end products
multiple sclerosis
Opis:
Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple sclerosis. Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge about the role of glycation in multiple sclerosis. Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature. Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 3; 263-267
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of alcohol on neuroglia in the developing brain and in adults
Autorzy:
Krawczyk-Marć, Izabela
Galiniak, Sabina
Sęk-Mastej, Anna
Marć, Mateusz
Orkisz, Stanisław
Wawrzyniak, Agata
Powiązania:
https://bibliotekanauki.pl/articles/454917.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
brain
alcohol
neuroglia
Opis:
Introduction. During puberty, the young body undergoes transformation not only within the reproductive and hormonal systems, but also significant changes in the central nervous system (CNS). Matured neural connections improve the integration of distant brain regions, the plasticity of neurons increases, and thus specialization of the brain occurs in the performance of specific tasks. During these transformations, both neurons and the accompanying neuroglia are sensitive to all toxic factors, among which ethanol occupies a special place. It causes an increase in the activity of glial cells, which by directing pro-inflammatory cytokines directly contribute to the death of apoptotic neurons. A long-lasting and irreversible impairment of brain function, especially in the hippocampus occurs as a result of alcohol abuse during the period of development. Aim. This paper presents an overview of current knowledge about the effects of alcohol on neuroglia in the developing brain and in adults. Materials and methods. The literature review of the following databases has been conducted: EBSCO, PubMed, Science Direct, Springer Link. Conclusions. The results of alcohol research have shown that it affects the neurotransmission and fluidity of cell membranes, changing the activity of neurons. By binding to GABA receptor (GABA) and N-methyl-D-aspartate receptors (NMDA receptor for glutamate), ethanol suppresses brain function. In addition to increased sensitivity and susceptibility to the addictive effects of ethanol, the neurogeneration activity is intensified followed by the induction and release of pro-inflammatory cytokines, which in the first stage disrupt the cortical function hindering logical thinking and disrupting the limbic system, directly affecting the memory and learning processes. Next, the cerebellum is attacked, which results in the impairment of balance and motor coordination, and consequently acts on the brain stem, directly affecting the respiratory and circulatory control centers.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 335-340
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development
Autorzy:
Sęk-Mastej, Anna
Galiniak, Sabina
Krawczyk-Marć, Izabela
Balawender, Krzysztof
Szymczak, Artur
Kaniewski, Maciej
Leksa, Natalia
Biesiadecki, Marek
Orkisz, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/454733.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
pregnancy
foetus
congenital defect
teratogen
Opis:
Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 2; 85-91
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of molecular markers as IL-12, IL-22 and IFN-γ in correlation with a clinical course in patients with psoriasis
Autorzy:
Kutwin, Magdalena
Migdalska-Sęk, Monika
Brzeziańska-Lasota, Ewa
Zelga, Piotr
Woźniacka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/2116535.pdf
Data publikacji:
2020-09-17
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
psoriasis
disease activity
proinflammatory cytokines
skin disease
immunology
molecular markers
Opis:
ObjectivesAs a chronic, recurrent, immunologically mediated systemic disease and a common cause of dermatological problems, psoriasis is often a subject of scientific research. Skin changes located on the hands can cause difficulties and limitations in the performance of professional activities, especially manual ones. The main role in pathogenesis is played by immunological factors – improper functioning of the components of the immune system, among others, T lymphocytes and cytokines like interleukin-12 (IL-12), interleukin-22 (IL-22) and interferon gamma (IFN-γ).Material and MethodsThe obtained tissue and blood were destined for RNA isolation. The RNA was then subjected to a reverse transcription reaction. The relative gene expression level was evaluated by the real-time polymerase chain reaction for IL-12B, IL-22 and IFN-γ genes, and presented as the relative quantification (RQ) value, relative to the reference gene GAPDH. In addition, a correlation analysis of the expression level of selected genes with the clinical course of the disease, as assessed by the Psoriasis Area and Severity Index (PASI), the Body Surface Area (BSA) and the Dermatology Life Quality Index (DLQI) scores was performed.ResultsStatistical analysis confirmed a significant increase in RQ values for IL-12B, IL-22 and IFN-γ in the group of psoriatic patients vs. the control group. A positive correlation was also found between BSA and PASI and RQ for the IL-12B gene.ConclusionsIncreased expression levels of IL-12B, IL-22 and IFN-γ genes in psoriatic skin confirm that selected cytokines play an important role in the initiation and sustenance of psoriasis.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2020, 33, 5; 635-647
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CTLA-4 polymorphisms (+49 A/G and -318 C/T) are important genetic determinants of AITD susceptibility and predisposition to high levels of thyroid autoantibodies in Polish children - preliminary study
Autorzy:
Pastuszak-Lewandoska, Dorota
Domańska, Daria
Rudzińska, Magdalena
Bossowski, Artur
Kucharska, Anna
Sewerynek, Ewa
Czarnecka, Karolina
Migdalska-Sęk, Monika
Czarnocka, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1039459.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Graves' disease
Hashimoto's thyroiditis
autoimmune thyroid disease
CTLA-4
single nucleotide polymorphism
TAb production
Opis:
Autoimmune thyroid diseases (AITDs), including Hashimoto' s thyroiditis (HT) and Graves' disease (GD), are related to environmental and genetic factors. We analyzed the association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene two polymorphisms (+49 A/G, -318 C/T) with HT and GD development in Polish children, and correlated both polymorphisms with the production of thyroid autoantibodies (TPOAb and TgAb). The study involved 49 AITD patients (age 10-19) with HT (n=25) or GD (n=24) and 69 healthy controls. SNP genotyping was performed using genomic DNA and TaqMan® probes. The obtained results indicated that CTLA-4 +49 GG genotype was significantly more frequent in both HT and GD patients, whereas the AA genotype was more common in controls. CTLA-4-318 CT genotype was significantly more frequent in AITD, and the CC genotype more often occurred in controls. Significantly higher median TPOAb and TgAb values were associated with G allele in HT, and with T allele in GD patients. Concluding, both studied polymorphisms seem to be important genetic determinants of the risk of HT and GD, and appear to be associated with a predisposition to high levels of TAbs and clinical AITD. The obtained results give more information on the distribution of the CTLA-4 polymorphism in Polish AITD children, and further support the proposal that the CTLA-4 gene plays an important role in a TAb production.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 641-646
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-10 z 10

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