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Wyszukujesz frazę "Sánchez, Elena" wg kryterium: Autor


Wyświetlanie 1-3 z 3
Tytuł:
Parameter identification and estimation for stage-structured population models
Autorzy:
Coll, Carmen
Sánchez, Elena
Powiązania:
https://bibliotekanauki.pl/articles/331082.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
system identification
parameter estimation
dynamic population
discrete time system
rank-one matrix
identyfikacja systemu
estymacja parametru
dynamika populacji
system czasu dyskretnego
Opis:
A stage-structured population model with unknown parameters is considered. Our purpose is to study the identifiability of the model and to develop a parameter estimation procedure. First, we analyze whether the parameter vector can or cannot uniquely be determined with the knowledge of the input-output behavior of the model. Second, we analyze how the information in the experimental data is translated into the parameters of the model. Furthermore, we propose a process to improve the recursive values of the parameters when successive observation data are considered. The structure of the state matrix leads to an analysis of the inverse of a sum of rank-one matrices.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2019, 29, 2; 327-336
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
La gènesi dels somatismes: accions humanes fossilitzades
The origin of somatisms: frozen human actions
Autorzy:
Sánchez-López, Elena
Powiązania:
https://bibliotekanauki.pl/articles/1877521.pdf
Data publikacji:
2021-10-14
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
somatic idioms
phraseologization
usage-based
corpus linguistics
inferences
Opis:
Somatic idioms – those including a part of the body – have been traditionally studied from a synchronic perspective, yielding different explanations for their semantic value. The main objective of this paper is to highlight the diachronic origin of idiomatic meaning, by illustrating the process of phraseologization from a historical, usage-based perspective. As the first step, we will reflect on the general nature of phraseological meaning, and then on the semantic particularities of somatic idioms. Secondly, we will carry out a corpus-based diachronic analysis of the Catalan idiom tapar-se el nas (to hold one’s nose) within the framework of the Invited Inference Theory of Semantic Change. The different stages of the process will be exemplified and discussed. As a result, a new notion of somatic idioms as frozen human actions will be presented.
Źródło:
Studia Romanica Posnaniensia; 2021, 48, 3; 133-147
0137-2475
2084-4158
Pojawia się w:
Studia Romanica Posnaniensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
„Iron Heart”: Reversible Cause of Dilated Cardiomyopathy Secondary to Cardiac Toxicity in Elderly Patient with Myelodysplastic Syndrome
Autorzy:
Martin-Garcia, Ana
Alonso Fernandez de Gatta, Marta
Diez-Campelo, María
Martín-García, Agustín C.
Barreiro Pérez, Manuel
Diaz-Pelaez, Elena
López Cadenas, Félix
Sanchez, Pedro L.
Powiązania:
https://bibliotekanauki.pl/articles/1035672.pdf
Data publikacji:
2019
Wydawca:
Medical Education
Tematy:
advanced prostate cancer
androgen depravation therapy
triptorelin
Opis:
Triptorelin as the luteinizing hormone releasing hormone (LHRH) analogue has its own place among other available forms of androgen-depravation therapy (ADT) of locally advanced and metastatic prostate cancer (PCa). Nowadays, in times of development of new therapies in castration-resistant PCa, ADT remains the back bone therapy, which may be supplemented with one of novel drugs. The results of basic research indicate, that apart from the main mechanism of action based on lowering a testosterone concentration to the castration level, triptorelin may have a direct inhibitory effect on tumor cells. Formulations of tryptorelin are available to administer as 1-month, 3-months and 6-months sustained-release forms that may be given intramuscularly or subcutaneously. Constant concentration of triptoreline is maintained by using special microspheres in drug production. Pharmacokinetic and pharmacodynamic properties of particular forms were extensively tested, which allows for safe usage and retain of predictable and high efficacy. Indicators of effective ADT are fast reduction and maintenance of the state of castration. This phenomenon translates into a decrease of the prostate-specific antigen and longer survival. Triptorelin successfully meets these objectives based on a number of phase I–III studies. There is a noticeable lack of comparative studies on effectiveness of particular ADT forms. This may stem from an assumption, that all LHRH analogues demonstrate similar effectiveness because of the class effect. However, some evidence highlight significant differences in efficacy among these drugs. Triptorelin compares especially favourably, particularly as a drug reducing the testosterone level to the lower recommended values (< 20 ng/dl). Side effect profile during the therapy with triptorelin is largely the result of inhibition of the hypothalamic- pituitary-testicular axis. Hormonal disturbances linked to hipoandrogenism cause changes in lipid metabolism and glucose tolerance, which may influence the cardiovascular risk. This article is a review of key reports regarding triptorelin and a summary of the role that triptorelin plays in contemporary ADT in advanced PCa.
Źródło:
OncoReview; 2019, 9, 4; 88-91
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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