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    Wyświetlanie 1-4 z 4
    Tytuł:
    Low Power, High Dynamic Range Analogue Multiplexer for Multi-Channel Parallel Recording of Neuronal Signals Using Multi-Electrode Arrays
    Autorzy:
    Rydygier, P.
    Dąbrowski, W.
    Fiutowski, T.
    Wiącek, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/226679.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    analogue multiplexer
    low power amplifier
    multi-channel electronics
    multielectrode arrays
    neural signal
    Opis:
    In the paper we present the design and test resultsof an integrated circuit combining a sample & hold circuit andan analogue multiplexer. The circuit has been designed as abuilding block for a multi-channel Application Specific IntegratedCircuit (ASIC) for recording signals from alive neuronal tissueusing high-density micro-electrode arrays (MEAs). The designis optimised with respect to critical requirements for suchapplications, i.e. short sampling time, low power dissipation, goodl inearity and high dynamic range. Presented design comprisessample&hold circuits with class AB operational amplifier, novelshift register, which allows minimising cross-coupling of the clocksignal and control logic. The circuit has been designed in 0.35µm CMOS process and has been successfully implemented in aprototype multi-channel ASIC.
    Źródło:
    International Journal of Electronics and Telecommunications; 2010, 56, 4; 399-404
    2300-1933
    Pojawia się w:
    International Journal of Electronics and Telecommunications
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Studies of scintillator response to 60 MeV protons in a proton beam imaging system
    Autorzy:
    Rydygier, M.
    Mierzwińska, G.
    Czaderna, A.
    Swakoń, J.
    Waligórski, M. P. R.
    Powiązania:
    https://bibliotekanauki.pl/articles/146249.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    beam imaging
    CCD camera
    scintillation detector
    Opis:
    A Proton Beam Imaging System (ProBImS) is under development at the Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN). The ProBImS will be used to optimize beam delivery at IFJ PAN proton therapy facilities, delivering two-dimensional distributions of beam profiles. The system consists of a scintillator, optical tract and a sensitive CCD camera which digitally records the light emitted from the proton-irradiated scintillator. The optical system, imaging data transfer and control software have already been developed. Here, we report preliminary results of an evaluation of the DuPont Hi-speed thick back screen EJ 000128 scintillator to determine its applicability in our imaging system. In order to optimize the light conversion with respect to the dose locally deposited by the proton beam in the scintillation detector, we have studied the response of the DuPont scintillator in terms of linearity of dose response, uniformity of light emission and decay rate of background light after deposition of a high dose in the scintillator. We found a linear dependence of scintillator light output vs. beam intensity by showing the intensity of the recorded images to be proportional to the dose deposited in the scintillator volume.
    Źródło:
    Nukleonika; 2015, 60, No. 3, part 2; 683-687
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of 60 MeV Protons and 250 kV X-Rays on Cell Viability
    Autorzy:
    Miszczyk, J.
    Panek, A.
    Rawojć, K.
    Swakoń, J.
    Prasanna, P.
    Rydygier, M.
    Gałaś, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1398817.pdf
    Data publikacji:
    2016-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.-a
    87.53.-j
    87.53.Bn
    Opis:
    Particle radiotherapy such as the one using proton beams, provides a successful treatment approach in many cancer types. However, the cellular and molecular mechanisms by which proton irradiation induces cell death, particularly in a human peripheral blood lymphocyte model has not been examined in detail. Comparative studies of the biological effects, such as cell death, of particle therapy versus conventional X-rays treatment are of utmost importance. Here, we compared the viability of human peripheral blood lymphocyte following in vitro irradiation with protons (therapeutic 60 MeV proton beam) and photon beam (250 kV, X-rays), by applying separate doses within the range of 0.3-4.0 Gy. Cell viability was assessed 1 and 4 h after irradiation with protons and X-rays by the FITC-Annexin V labelling procedure (Apoptotic & Necrotic & Healthy Cells Quantification Kit, Biotium). Results showed that irradiation with both radiation types reduced the number of viable cells in a dose-dependent manner, as assessed as a function of the duration of post-irradiation time. Protons proved more fatal to the cells treated than X-ray photons. This demonstrates a difference in cell viability after irradiation with protons and photons in a human peripheral blood lymphocyte model.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 2; 222-225
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of alanine dosimetry in dose assessment for ocular melanoma patients undergoing proton radiotherapy : preliminary results
    Autorzy:
    Mierzwińska, G.
    Kłodowska, M.
    Michalec, B.
    Pędracka, A.
    Rydygier, M.
    Swakoń, J.
    Waligórski, M. P. R.
    Powiązania:
    https://bibliotekanauki.pl/articles/146382.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    alanine
    EPR dosimetry
    proton beam
    proton radiotherapy
    Quality Assurance (QA)
    Opis:
    Basing on alanine solid state/electron paramagnetic resonance (EPR) dosimetry, a supplementary method of cumulatively recording the therapeutic dose received by ocular cancer patients undergoing fractionated proton radiotherapy is proposed. By applying alanine dosimetry during the delivery of consecutive fractions, the dose received within each fraction can be read out by EPR spectrometry and a fi nal permanent cumulative record of the total dose delivered obtained. The dose response of the alanine detector was found to be practically independent on its position within the extended proton Bragg peak region. Dose measurements based on entrance dose recorded in proton beams individually formed for each patient are presented. The described method will be applied as a complementary Quality Assurance procedure for patients undergoing proton radiotherapy at the Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland (IFJ PAN).
    Źródło:
    Nukleonika; 2015, 60, No. 3, part 2; 609-613
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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