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    Wyświetlanie 1-9 z 9
    Tytuł:
    Patryk Mogilnicki, Książka po okładce. O współczesnym polskim projektowaniu okładek książkowych, Kraków: Karakter 2021, s. 437. ISBN 978-83-65271-80-8
    Autorzy:
    Rybarczyk, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/27311242.pdf
    Data publikacji:
    2022-12-30
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Źródło:
    Biblioteka; 2022, 26 (35); 389-395
    1506-3615
    2391-5838
    Pojawia się w:
    Biblioteka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    „Uksiążkowić świat”, czyli kilka słów o liberaturze
    To “bookize” the world, or a handful of remarks on liberature
    Autorzy:
    Rybarczyk, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/911108.pdf
    Data publikacji:
    2012-01-01
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Tematy:
    Liberature
    Visual poetry
    Typography
    Architecture of the word
    Avant-garde
    Fajfer Zenon
    Bazarnik Katarzyna
    Nowakowski Radosław
    OuLiPo
    Liberatura
    Poezja wizualna
    Typografia
    Architektura słowa
    Awangarda
    Opis:
    Celem artykułu jest przybliżenie kwestii dotyczących nowego zjawiska w literaturze, choć swymi korzeniami sięgającego czasów bardzo odległych, mianowicie liberatury. Przedstawiam nie tylko podstawowe tezy związane z liberaturą, np. postrzeganie utworu jako integralnej całości, w której następuje stopienie słowa i przestrzeni, ale także swoistą ewolucję form literackich, prowadzącą do narodzin nowego nurtu. Sednem tego procesu jest położenie nacisku na współistnienie formy i treści, obecne już w poezji wizualnej wywodzącej się ze starożytności i średniowiecza, a przybierające na sile w twórczości autorów związanych z XX-wiecznymi ruchami awangardowymi. „Totalne” myślenie o literaturze zyskało najciekawszy wyraz w twórczości autorów liberatów: Zenona Fajfera, Katarzyny Bazarnik i Radosława Nowakowskiego (zarówno praktyków, jak i teoretyków liberatury), których sylwetki oraz dzieła przedstawiam pokrótce w niniejszym artykule.
    The article attempts to introduce the reader to some issues concerning a new phenomenon in literature – liberature – though the phenomenon is deeply rooted in the past. My intention is to show and discuss not only the basic tenets of liberature, such as the perception of the work as an integral entity in which the word and the space merge into indivisible wholeness, but also to present a particular evolution of various literary forms that eventually effected in an inception of a new literary current. The core element of this process is to emphasize and highlight the coexistence of the form and the content, i.e., something that was already present in visual poetry stemming from the ancient and medieval times and became increasingly powerful in the output of authors associated with the twentieth-century avantgarde movements. The “total” perception of literature has been most interestingly expressed in the output of authors-liberates: Zenon Fajfer, Katarzyna Bazarnik and Radosław Nowakowski (both authors and theoreticians of liberature), whose profiles are outlined in the present article.
    Źródło:
    Biblioteka; 2012, 16(26); 337-351
    1506-3615
    2391-5838
    Pojawia się w:
    Biblioteka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Computational prediction of non-enzymatic RNA degradation patterns
    Autorzy:
    Rybarczyk, Agnieszka
    Jackowiak, Paulina
    Figlerowicz, Marek
    Blazewicz, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1038733.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    RNA degradation
    non-enzymatic RNA hydrolysis
    branch-and-cut algorithm
    Opis:
    Since the beginning of the 21st century, an increasing interest in the research of ribonucleic acids has been observed in response to a surprising discovery of the role that RNA molecules play in the biological systems. It was demonstrated that they do not only take part in the protein synthesis (mRNA, rRNA, tRNA) but also are involved in the regulation of gene expression. Several classes of small regulatory RNAs have been discovered (e.g. microRNA, small interfering RNA, piwiRNA). Most of them are excised from specific double-stranded RNA precursors by enzymes that belong to the RNaseIII family (Drosha, Dicer or Dicer-like proteins). More recently, it has been shown that small regulatory RNAs are also generated as stable intermediates of RNA degradation (the so called RNA fragments originating from tRNA, snRNA, snoRNA etc.). Unfortunately, the mechanisms underlying biogenesis of the RNA fragments remain unclear. It is thought that several factors may be involved in the formation of the RNA fragments. The most important are the specific RNases, RNA-protein interactions and RNA structure. In this work, we focus on the RNA primary and secondary structures as factors influencing the RNA stability and consequently the pattern of RNA fragmentation. Earlier, we identified the major structural factors affecting non-enzymatic RNA degradation. Now, based on these data, we developed a new branch-and-cut algorithm that is able to predict the products of large RNA molecules' hydrolysis in vitro. We also present the experimental data that verify the results generated using this algorithm.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 4; 745-751
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    AmiRNA Designer - new method of artificial miRNA design
    Autorzy:
    Mickiewicz, Agnieszka
    Rybarczyk, Agnieszka
    Sarzynska, Joanna
    Figlerowicz, Marek
    Blazewicz, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1038843.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    artificial miRNA
    RNAi
    gene regulation
    sequence specific
    thermodynamic profiles
    Opis:
    MicroRNAs (miRNAs) are small non-coding RNAs that have been found in most of the eukaryotic organisms. They are involved in the regulation of gene expression at the post-transcriptional level in a sequence specific manner. MiRNAs are produced from their precursors by Dicer-dependent small RNA biogenesis pathway. Involvement of miRNAs in a wide range of biological processes makes them excellent candidates for studying gene function or for therapeutic applications. For this purpose, different RNA-based gene silencing techniques have been developed. Artificially transformed miRNAs (amiRNAs) targeting one or several genes of interest represent one of such techniques being a potential tool in functional genomics. Here, we present a new approach to amiRNA*design, implemented as AmiRNA Designer software. Our method is based on the thermodynamic analysis of the native miRNA/miRNA* and miRNA/target duplexes. In contrast to the available automated tools, our program allows the user to perform analysis of natural miRNAs for the organism of interest and to create customized constraints for the design stage. It also provides filtering of the amiRNA candidates for the potential off-targets. AmiRNA Designer is freely available at http://www.cs.put.poznan.pl/arybarczyk/AmiRNA/.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 1; 71-77
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Removal of cyclohexane and ethanol from air in biotrickling filters inoculated with Candida albicans and Candida subhashii
    Usuwanie z powietrza cykloheksanu i etanolu w biofiltrach strużkowych zasiedlonych grzybami Candida albicans i Candida subhashii
    Autorzy:
    Rybarczyk, Piotr
    Marycz, Milena
    Szulczyński, Bartosz
    Brillowska-Dąbrowska, Anna
    Rybarczyk, Agnieszka
    Gębicki, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1845437.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    biofilm
    flow cytometry
    removal efficiency
    ethanol
    biofiltration
    cyclohexane
    cytometria przepływowa
    skuteczność usuwania
    etanol
    biofiltracja
    cykloheksan
    Opis:
    This paper presents investigations on the removal of cyclohexane and ethanol from air in polyurethane- -packed biotrickling filters, inoculated with Candida albicans and Candida subhashii fungal species. Results on process performance together with flow cytometry analyses of the biofilm formed over packing elements are presented and discussed. The results indicate that the presence of ethanol enhances the removal efficiency of cyclohexane from air. This synergistic effect may be attributed to both co-metabolism of cyclohexane with ethanol as well as increased sorption efficiency of cyclohexane to mineral salt medium in the presence of ethanol. Maximum elimination capacities of 89 g m-3 h-1 and 36.7 g m-3 h-1 were noted for cyclohexane and ethanol, respectively, when a mixture of these compounds was treated in a biofilter inoculated with C. subhashii. Results of flow cytometry analyses after 100 days of biofiltration revealed that about 91% and 88% of cells in biofilm remained actively dividing, respectively for C. albicans and C. subhashii species, indicating their good condition and ability to utilize cyclohexane and ethanol as a carbon source.
    W pracy przedstawiono badania nad usuwaniem cykloheksanu i etanolu z powietrza w boifiltrach zraszanych, wypełnionych pianką poliuretanową, zasiedloną grzybami z gatunku Candida albicans i Candida subhashii. Przedstawiono i omówiono wyniki dotyczące wydajności procesu (na podstawie pomiarów techniką chromatografii gazowej) wraz z wynikami cytometrii przepływowej dla utworzonego biofilmu. Uzyskano wartości zdolności usuwania, wynoszące około 89 g m-3 h-1 i 36.7 g m-3 h-1, odpowiednio dla cykloheksanu i etanolu, gdy te związki jednocześnie poddawano procesowi biofiltracji w biofiltrze zaszczepionym Candida subhashii. Wyniki wskazują, że obecność etanolu powoduje zwiększenie skuteczności usuwania cykloheksanu z powietrza. Wzrost skuteczności usuwania z powietrza cykloheksanu w obecności etanolu może wynikać z polepszonego metabolizmu cykloheksanu w takich warunkach oraz z ograniczenia bariery dla przenikania masy, wskutek lepszych właściwości sorpcyjnych cieczy zraszającej wobec cykloheksanu w obecności etanolu.
    Źródło:
    Archives of Environmental Protection; 2021, 47, 1; 26-34
    2083-4772
    2083-4810
    Pojawia się w:
    Archives of Environmental Protection
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    RNA-Seq-based analysis of differential gene expression associated with hepatitis C virus infection in a cell culture
    Autorzy:
    Hojka-Osinska, Anna
    Budzko, Lucyna
    Zmienko, Agnieszka
    Rybarczyk, Agnieszka
    Maillard, Patrick
    Budkowska, Agata
    Figlerowicz, Marek
    Jackowiak, Paulina
    Powiązania:
    https://bibliotekanauki.pl/articles/1038741.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    RNA-Seq
    HCV
    transcriptome
    Opis:
    Hepatitis C virus (HCV) infection is one of the major causes of chronic liver diseases. Unfortunately, the mechanisms of HCV infection-induced liver injury and host-virus interactions are still not well recognized. To better understand these processes we determined the changes in the host gene expression that occur during HCV infection of Huh-7.5 cells. As a result, we identified genes that may contribute to the immune and metabolic cellular responses to infection. Pathway enrichment analysis indicated that HCV induced an increased expression of genes involved in mitogen-activated protein kinases signaling, adipocytokine signaling, cell cycle and nitrogen metabolism. In addition, the enrichment analyses of processes and molecular functions revealed that the up-regulated genes were mainly implicated in the negative regulation of phosphorylation. Construction of the pathway-gene-process network enabled exploration of a much more complex landscape of molecular interactions. Consequently, several essential processes altered by HCV infection were identified: negative regulation of cell cycle, response to endoplasmic reticulum stress, response to reactive oxygen species, toll-like receptor signaling and pattern recognition receptor signaling. The analyses of genes whose expression was decreased upon HCV infection showed that the latter were engaged in the metabolism of lipids and amino acids. Moreover, we observed disturbance in the cellular antiviral defense. Altogether, our results demonstrated that HCV infection elicits host response that includes a very wide range of cellular mechanisms. Our findings significantly broaden the understanding of complex processes that accompany HCV infection. Consequently, they may be used for developing new host-oriented therapeutic strategies.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 4; 789-798
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Translational and structural analysis of the shortest legume ENOD40 gene in Lupinus luteus
    Autorzy:
    Podkowinski, Jan
    Zmienko, Agnieszka
    Florek, Blazena
    Wojciechowski, Pawel
    Rybarczyk, Agnieszka
    Wrzesinski, Jan
    Ciesiolka, Jerzy
    Blazewicz, Jacek
    Kondorosi, Adam
    Crespi, Martin
    Legocki, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1040638.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    nitrogen fixation
    transcript structure
    ENOD40
    phylogeny
    Opis:
    Two early nodulin 40 (enod40) genes, ENOD40-1, the shortest legume ENOD40 gene, and ENOD40-2, were isolated from Lupinus luteus, a legume with indeterminate nodules. Both genes were expressed at similar levels during symbiosis with nitrogen-fixing bacteria. ENOD40 phylogeny clustered the L. luteus genes with legumes forming determinate nodules and revealed peptide similarities. The ENOD40-1 small ORF A fused to a reporter gene was efficiently expressed in plant cells, indicating that the start codon is recognized for translation. The ENOD40-1 RNA structure predicted based on Pb(II)-induced cleavage and modeling revealed four structurally conserved domains, an absence of domain 4 characteristic for legumes of indeterminate nodules, and interactions between the conserved region I and a region located upstream of domain 6. Domain 2 contains Mg(II) ion binding sites essential for organizing RNA secondary structure. The differences between L. luteus and Glycine max ENOD40 RNA models suggest the possibility of a switch between two structural states of ENOD40 transcript.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 1; 89-102
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Future healthcare professionals on working conditions in Poland: perspective of medical university students
    Autorzy:
    Rydlewska-Liszkowska, Izabela
    Strzelecka, Agnieszka
    Rybarczyk-Szwajkowska, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/46622680.pdf
    Data publikacji:
    2024-09-17
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    working conditions
    healthcare financing
    workforce
    opinions of medical university students
    healthcare organization
    work factors
    Opis:
    Background Students of medical universities, future employees, will have an impact on the shaping healthcare system. It is important to know and understand their opinions on the factors affecting working conditions and, consequently, changes necessary to improve effectiveness of health care. Students’ expectations can contribute to the changing working conditions for graduates and bring added value to health system redefinition. Material and Methods The study used factor analysis to check whether its use was justified. Reliability analysis was performed and structure indicators were determined for each question. The anonymous survey was conducted from September 2017 until March 2018; 1205 students were randomly selected for the sample. Results Eighty percent of the students declared interest in healthcare changes, >50% reported that the main factors influencing the work were competencies, financing, medical equipment and organization. Over 90% of the respondents indicated too long wait times for an appointment with a specialist and admission to hospital as the reason for the low efficiency of healthcare, whereas >80% of the survey participants considered insufficient funding to be a barrier. The need for changing the financing scheme was underlined by >90% of the students, and of health priorities by about 80%. Approximately 71% of the respondents were in favour of limiting the role of government in decision-making processes and introducing changes into the education system. Conclusions Students’ views on organizational and financial factors of working conditions can contribute to improvement in systemic solutions at both micro and macro levels. Limiting the role of politicians in planning and implementing reforms can motivate employees to be more creative and decisive. Analysis of opinions can bring added value to health policy and systemic changes and should be extended by further research results after the COVID-19 pandemic. Students’ interest in healthcare reform encourages reflection on enriching education with managerial skills.
    Źródło:
    Medycyna Pracy. Workers’ Health and Safety; 2024, 75, 4; 321-332
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy. Workers’ Health and Safety
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cardiac Rehabilitation in Heart Failure. Part II. Does Higher Intensity Means Better Outcome?
    Autorzy:
    Kujawska, Agnieszka
    Perkowski, Radosław
    Skierkowska, Natalia
    Topka, Weronika
    Gajos, Małgorzata
    Androsiuk-Perkowska, Joanna
    Cieślińska, Aleksandra
    Przybysz, Beata
    Kwolik, Dobrawa
    Siekacz, Dominika
    Rybarczyk, Dominika
    Kujawski, Sławomir
    Powiązania:
    https://bibliotekanauki.pl/articles/1030538.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
    Tematy:
    aerobic training
    cardiac rehabilitation
    heart failure
    physical exercise
    resistance training
    Opis:
    Heart failure (HF) due to its universality has become a huge challenge for modern medicine. Second part of the twentieth century brought significant changes in the rehabilitation, diagnostic and pharmacological procedures. There are no definitive guidelines for Cardiac Rehabilitation (CR) in HF. Based on previous studies, the article tried to describe and illustrate the mechanism of effective CR and its intensity in HF patients, which could be helpful in CR protocol development. Cardiac Rehabilitation has confirmed efficacy in increased physical level of participation in inter alia, home/work/recreational activities, improved psychosocial well-being, functional independence, prevention of disability, long-term adherence to maintaining physically active lifestyle, improved cardiopulmonary fitness, strength, muscle endurance, and flexibility, reduced cardiovascular events risk and risk of mortality. Before and after CR conduction, baseline and final aerobic capacity should be examined with an ergospirometry test to evaluate CR protocol intensity and check its effectiveness, respectively. Frequency of training-bouts in CR protocol in HF patients were from 3 to 7 days per week, intensity ranged from 40% to 80% VO2max or 9 to 14 on rating of the perceived exertion (RPE) scale or 6 to 20 on the Borg scale. Duration of single bout-exercise ranged from 20 to 60 minutes.
    Źródło:
    Central European Journal of Sport Sciences and Medicine; 2018, 22, 2; 23-32
    2300-9705
    2353-2807
    Pojawia się w:
    Central European Journal of Sport Sciences and Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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