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    Tytuł:
    Gruźlica - zapomniana choroba, o której warto pamiętać
    Tuberculosis - the forgotten disease worth to remember
    Autorzy:
    Włodarczyk, Marcin
    Rudnicka, Wiesława
    Druszczyńska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/1034186.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Tematy:
    BCG
    diagnosis
    interferon-γ release assays
    TB
    tuberculosis
    diagnozowanie
    gruźlica
    testy interferonowe
    Opis:
    Gruźlica wciąż stanowi poważny problem epidemiologiczny na całym świecie. Ponad 130 lat wytężonej pracy naukowców na całym świecie nie przyniosło zapewniającej protekcję szczepionki przeciwgruźliczej, szybkich i pewnych metod diagnozowania tej choroby oraz skutecznych sposobów leczenia gruźlicy wywoływanej przez izolowane ze wzrastającą częstością wielolekooporne prątki gruźlicy. Wywołujące gruźlicę prątki Mycobacterium tuberculosis są Gram-dodatnimi pałeczkami tlenowymi o unikatowej w świecie bakterii ścianie komórkowej, która zbudowana jest, poza peptydoglikanem i polisacharydami, z nietypowych glikolipidów i lipidów, w tym długołańcuchowych kwasów mykolowych, będących silnymi modulatorami układu odpornościowego człowieka. Diagnozowanie gruźlicy oparte jest na hodowli prątków na podłożach bakteriologicznych, obok której wykonywane jest badanie bakterioskopowe plwociny, radiologiczna ocena zmian w klatce piersiowej, tuberkulinowy test skórny, czy też testy molekularne (AMPLICOR Mycobacterium tuberculosisis Xpert MTB/RIF) lub metody wykorzystujące mykobakteriofagi (FastPlaque oraz ReporterPhage). Istotnym problem epidemiologicznym są uśpione (latente) zakażenia prątkami gruźlicy, które wykrywa się testami interferonowymi (QuantiFERON®-TB Gold Plus oraz T-SPOT.TB). Mimo znacznego postępu wciąż brakuje szybkich, wiarygodnych i tanich testów diagnostycznych gruźlicy.
    Tuberculosis (TB) remains a serious epidemiological problem throughout the world. More than 130 years of hard work of scientists around the world has not delivered fully protective vaccine for TB, fast and reliable methods for diagnosing and effective treatment of tuberculosis caused by multi-drug resistant Mycobacterium tuberculosis (MDR-TB), isolated recently with an increasing incidence. MDR- TB are Gram-positive, aerobic bacilli with the unique bacterial cell wall, which is built not only of peptidoglycan and polysaccharides, but also of unusual glycolipids and lipids, including long-chain mycolic acids, which are potential modulators of the human immune system. Diagnosis of tuberculosis is based on the culture of mycobacteria on bacteriological media, alongside which are carried out: bacterioscopy of sputum, radiographic assessment of changes in the chest, tuberculin skin test, or molecular test (AMPLICOR Mycobacterium tuberculosisis Xpert MTB/RIF), and tests with mycobacteriohages (FastPlaque and ReporterPhage). The important epidemiological issue are dormant (latent) mycobacterial infections, which can be detected by interferon-γ release assays (QuantiFERON®-TB Gold Plus and T-SPOT.TB). Despite considerable progress we are still lacking high-speed, reliable and low-cost diagnostic tests for tuberculosis.
    Źródło:
    Kosmos; 2017, 66, 2; 313-325
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Interleukin 18 (IL-18) as a target for immune intervention
    Autorzy:
    Wawrocki, Sebastian
    Druszczynska, Magdalena
    Kowalewicz-Kulbat, Magdalena
    Rudnicka, Wieslawa
    Powiązania:
    https://bibliotekanauki.pl/articles/1038841.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    interleukin-18 (IL-18)
    IL-18 receptor
    IL-18 binding protein
    Opis:
    Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune response. In the milieu of IL-12 or IL-15, IL-18 is a potent inducer of IFN-gamma in natural killer (NK) cells and CD4 T helper (Th) 1 lymphocytes. However, IL-18 also modulates Th2 and Th17 cell responses, as well as the activity of CD8 cytotoxic cells and neutrophils, in a host microenvironment-dependent manner. It is produced by various hematopoietic and nonhematopoietic cells, including dendritic cells and macrophages. In an organism, bioactivity of the cytokine depends on the intensity of IL-18 production, the level of its natural inhibitory protein - IL-18BP (IL-18 binding protein) and the surface expression of IL-18 receptors (IL-18R) on the responding cells. This review summarizes the biology of the IL-18/IL-18BP/IL-18R system and its role in the host defense against infections. The prospects for IL-18 application in immunotherapeutic or prophylactic interventions in infectious and non-infectious diseases are discussed.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 1; 59-63
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection
    Autorzy:
    Miszczyk, Eliza
    Walencka, Maria
    Rudnicka, Karolina
    Matusiak, Agnieszka
    Rudnicka, Wiesława
    Chmiela, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/1039292.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Helicobacter pylori
    T cells
    proliferation
    guinea pigs
    Opis:
    Helicobacter pylori (H. pylori) bacteria are human pathogens causing symptomatic gastritis, peptic ulcer or gastric cancer. Little is known about the kinetics of immune responses in H. pylori infected patients because the initial moment of infection has not been identified. Various animal models are used to investigate the immune processes related to H. pylori infection. In this study we checked whether H. pylori infection in guinea pigs, mimicking natural H. pylori infection in humans, resulted in the development of specific immune responses to H. pylori antigens by measuring the proliferation of lymphocytes localized in mesenteric lymph nodes, spleen and peripheral blood. The maturity of macrophages and cytokines, delivered by monocyte-macrophage lineage or lymphocytes, were considered as mediators, which might influence the lymphocyte blastogenic response. The obtained results showed the activation of T cells localized in mesenteric lymph nodes by H. pylori antigens in H. pylori infected guinea pigs four weeks postinfection. The blastogenic activity of lymphocytes was shaped by their interaction with antigen presenting cells, which were present in the cell cultures during the whole culture period. Moreover, the balance between cytokines derived from adherent leukocytes including interleukin 8 - IL-8 as well as interferon gamma - IFN-γ, and transforming growth factor beta - TGF-β delivered by lymphocytes, was probably important for the successful proliferation of lymphocytes. The H. pylori specific lymphocytes were not propagated in peripheral blood and spleen of H. pylori infected animals. The modulation of immunocompetent cells by H. pylori antigens or their different distribution cannot be excluded.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 2; 295-303
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immune response gene polymorphisms in tuberculosis
    Autorzy:
    Fol, Marek
    Druszczynska, Magdalena
    Wlodarczyk, Marcin
    Ograczyk, Elzbieta
    Rudnicka, Wieslawa
    Powiązania:
    https://bibliotekanauki.pl/articles/1038871.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    tuberculosis
    susceptibility/resistance genes
    Opis:
    Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (M.tb), remains a leading public health problem in most parts of the world. Despite the discovery of the bacilli over 100 years ago, there are still many unanswered questions about the host resistance to TB. Although one third of the world's population is infected with virulent M.tb, no more than 5-10% develop active disease within their lifetime. A lot of studies suggest that host genetic factors determine the outcome of M.tb-host interactions, however, specific genes and polymorphisms that govern the development of TB are not completely understood. Strong evidence exists for genes encoding pattern recognition receptors (TLR, CD14), C-type lectins, cytokines/chemokines and their receptors (IFN-γ, TNF-α, IL-12, IL-10, MCP-1, MMP-1), major histocompatibility complex (MHC) molecules, vitamin D receptor (VDR), and proton-coupled divalent metal ion transporters (SLC11A1). Polymorphisms in these genes have a diverse influence on the susceptibility to or protection against TB among particular families, ethnicities and races. In this paper, we review recent discoveries in genetic studies and correlate these findings with their influence on TB susceptibility.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 4; 633-640
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The balance between pro- and anti-inflammatory cytokines in the immune responses to BCG and DTwP vaccines
    Autorzy:
    Druszczynska, Magdalena
    Kowalewicz-Kulbat, Magdalena
    Maszewska, Agnieszka
    Rudnicka, Karolina
    Szpakowski, Piotr
    Wawrocki, Sebastian
    Wlodarczyk, Marcin
    Rudnicka, Wiesława
    Powiązania:
    https://bibliotekanauki.pl/articles/1038943.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    BCG
    pertussis
    IFN-gamma
    IL-10
    tuberculin skin test
    dendritic cells
    Opis:
    Bacillus Calmette-Guérin (BCG) and pertussis vaccines have been found to be insufficient and their further improvement is required. In order to develop improved vaccines, a better understanding of the main pathways involved in the host's protective immunity to the pathogens is crucial. We address the question as to whether the balance between pro- and anti-inflammatory cytokine production might affect the host responses to BCG and diphtheria-tetanus toxoids-whole cell pertussis (DTwP) vaccines. The study population consisted of 118 healthy people, age range 18-30 years, who had been subjected to BCG and DTwP vaccination according to the state policy. Tuberculin skin testing (TST) revealed a delayed type hypersensitivity (DTH) to PPD (purified protein derivative) in 53% volunteers. The variability in development of the BCG-driven DTH to tuberculin prompted us to address a question as to whether Th1/Th2 polarization is involved in the lack of skin responsiveness to PPD. PPD-stimulated blood lymphocytes from TST+ participants produced significantly more IFN-γ and less IL-10 than lymphocytes from TST- volunteers. However, TST- volunteers' sera contained more anti-pertussis IgG but not anti-diphtheria toxin IgG. Mycobacterial antigens and particularly PPD induced a higher expression of HLA-DR and co-stimulatory CD80 receptors on DCs from TST+ than TST- participants. BCG but not PPD pulsed DCs from TST- volunteers produced significantly more IL-10. Mycobacterial antigen stimulated DCs from TST+ volunteers induced a more intense IFN-γ production in co-cultures with autologous lymphocytes than the cells from TST- participants. Differences among the types of dendritic cell activities contribute to development of tuberculin reactivity in BCG vaccinated volunteers.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 4; 913-921
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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