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    Wyświetlanie 1-5 z 5
    Tytuł:
    Limfocyty Th22, Th17.1, Tc17, Tfh i NKTfh w patogenezie stwardnienia rozsianego
    Th22, Th17.1, Tc17, Tfh and NKTfh lymphocytes in pathogenesis of multiple sclerosis
    Autorzy:
    Zarobkiewicz, Michał K.
    Bojarska-Junak, Agnieszka
    Kowalska, Wioleta
    Roliński, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1035412.pdf
    Data publikacji:
    2019
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    stwardnienie rozsiane
    ms
    sm
    nktfh
    tfh
    tc17
    th17.1
    ahr
    c-maf
    th22
    multiple sclerosis
    Opis:
    Multiple sclerosis (MS) is the most common inflammatory-demyelinating disease, its morbidity varies between 2 per 100 000 inhabitants in sub-Saharan Africa to 100 per 100 000 inhabitants in Europe and North America. Despite the unquestionable progress in medicine, MS is still incurable and all that can be done for a patient is to struggle to slow down the inevitable progress of the disease, which eventually will cause disability. Recognizing the detailed immunopathogenesis of MS is probably the only chance for fully effective treatment. Most of the immunological studies of the previous decades focused on the classic sub-populations of T lymphocytes. This review is focused, however, on novel sub-populations – Th22, Th17.1, Tc17, Tfh and NKTfh lymphocytes in the pathogenesis of MS.
    Stwardnienie rozsiane (multiple sclerosis – MS) jest najczęstszą chorobą zapalno-demielinizacyjną. Chorobowość wynosi od około 2/100 000 w okolicach równika do około 100/100 000 w Europie i Ameryce Północnej. Pomimo znacznego postępu medycyny, jaki dokonał się w ostatnich dziesięcioleciach, schorzenie to cały czas pozostaje nieuleczalne. Jedyną możliwością jest walka o spowolnienie nieuchronnego postępu choroby, który w końcu doprowadzi do niepełnosprawności pacjenta. Z tego względu ważne jest dokładne poznanie immunopatogenezy MS. Prowadzone dotychczas badania skupiały się na klasycznych subpopulacjach komórek T. W niniejszym artykule przyjrzymy się stanowi badań i dostępnej wiedzy na temat udziału „nowych” subpopulacji komórek T, tj. limfocytów Th22, Th17.1, Tc17, Tfh, NKTfh, w patogenezie MS.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2019, 73; 19-24
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression of heat shock protein 70 in the tissue of patients with laryngeal squamous cell carcinoma
    Autorzy:
    Barańska, Aleksandra
    Maziarz, Aleksandra
    Roliński, Jacek
    Klatka, Janusz
    Dudzińska-Ćwiek, Katarzyna
    Tabarkiewicz, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/454793.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    HSP70
    LSCC
    treatment
    Opis:
    Introduction. Laryngeal squamous cell carcinoma (LSCC) is a common type of head and neck malignancy. Because of unsatisfactory results of therapy, development of new strategies for LSCC treatment is needed. It is believed that heat shock protein 70 (HSP70) is involved in pathogenesis of LSCC. Thus, targeting HSP70 seems to be promising strategy for laryngeal cancer treatment. Aim. The aim of the study was to assess the HSP70 concentration in laryngeal squamous cell carcinoma specimens and its correlation with tumor volume and TNM staging. Material and methods. An ELISA method and a Bradford protein assay were used to evaluate the HSP70 concentration in peripheral blood cells, tumor tissue and lymph nodes from the patients suffering from LSCC. Results. We demonstrated that the HSP70 concentration is significantly different between examined compartments. The highest level was observed in peripheral blood, while the lowest was in the lymph nodes. The HSP70 expression was correlated to tumor volume. Conclusion. Our results showed varied expression of HSP70 in tissue from patients with LSCC, but there was no association between HSP70 concentration and TNM staging. Currently, application of HSP70 inhibition as a LSCC treatment could be rather associated with systemic blocking of this molecule than target inhibition in tumor tissue. However, further analysis on a larger group of patients is needed.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 16-21
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of immature monocyte-derived dendritic cells generated from patients with colorectal cancer
    Autorzy:
    Maciejewski, Ryszard
    Radej, Sebastian
    Furmaga, Jacek
    Chrościcki, Andrzej
    Rudzki, Sławomir
    Roliński, Jacek
    Wallner, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/1396521.pdf
    Data publikacji:
    2013-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    dendritic cells
    colon cancer
    immunotherapy
    Opis:
    Dendritic cells are heterogeneous population of the leukocytes and most potent APC in activation of naive T lymphocytes. Therefore the DCs generated in vitro are under research for their application in anti-tumor immunotherapy. The aim of the study was generation of the immature dendritic cells from peripheral blood monocytes collected from colorectal cancer patients and comparison of their ability to endocytosis, cytokine production and immunophenotype to DCs generated from healthy donors. Material and methods. 16 adenocarcinoma stage II patients were included in the study. Dendritic cells were generated in the presence of rhGM-CSF and IL-4. PBMC were isolated from the blood of patients and 16 healthy donors - control group. Immunophenotype, ability of endocytosis of Dextran- FITC as well as intracellular IL-12 expression of the generated dendritic cells was measured using flow cytometry. The cytokines (IL-6, IL-10, IL-12p70, IFN-γ) concentration in the supernatants of DCs culture was measured by ELISA. Results. The percentage of the immature dendritic cells and expression of CD206 and CD209 antigens was significantly higher in patients group (p <0.05 and p <0.001 respectively). Significantly (p <0.001) higher expression of the antigens which initiate the Th2 immune response (CD80-/CD86 + and B7-H2 + / CD209 +) was in the patients group. There were no differences in endocytosis ability and the cytokines (IL-6, IL-10, IL-12p70, IFN-γ) concentration between investigated groups. Conclusions. High immature markers expression on the generated dendritic cells together with identical endocytosis ability in patients group is advantageous in antitumor autologous cells immunotherapy planning. However there is one troubling fact - high expression of markers, which may induce tolerance to particular antigen. It seems to be more reasonable to use the autologous DCs in the antitumor immunotherapy, especially due to the incompatibility in allogenic cells in the context of HLA complex.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 12; 714-720
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunomodelling Characteristics of Mature Dendritic Cells Stimulated by Colon Cancer Cells Lysates
    Autorzy:
    Radej, Sebastian
    Roliński, Jacek
    Rawicz-Pruszyński, Karol
    Bury, Paweł
    Borowski, Grzegorz
    Furmaga, Jacek
    Chrościcki, Andrzej
    Wallner, Grzegorz
    Maciejewski, Ryszard
    Powiązania:
    https://bibliotekanauki.pl/articles/1395534.pdf
    Data publikacji:
    2015-02-01
    Wydawca:
    Index Copernicus International
    Tematy:
    dendritic cells
    colon cancer
    cancer cells lysates
    Th1
    Th2
    Opis:
    Application of cells with high TAA (tumor associated antigen) presentation potential seems to be crucial in neoplasia immunotherapy. Such feature is distributed in dendritic cells, which present peptides from processed TAA - MHC molecules complex to the T cells of a host. The aim of the study was to assess the influence of colon neoplasia tissue lysate on functioning of generated autologous DC’s in the field of autologous CD4+ lymphocytes immunological response towards Th1/Th2 under in vitro environment together with comparison and assessment of DCs’ immunosuppressive properties acquired from patients with colon cancer. Material and methods. The population of this study consisted of 16 healthy- controls, 36colon cancer patients. Blood samples were collected 24h before planned surgery and preventive antibiotic therapy. Neoplastic tissue sample, was digested for cell lysates preparation. DC’s generation from PBMC was carried out in standard conditionsand medium enriched with rhGM-CSF and rhIL-4. Mature DC`s and cocultured autologous CD4 lymphocytes immunophenotype assessment was analyzed with flow cytometer. Intracellular and culture medium cytokines concentration was analyzed with ELISA and FACS method. Results. DC`s generated from colon cancer patients stimulated with lysates presented greater maturity, lower expression of CD206 antigen, significantly higher expression of HLA-DR, CD208 and CD209 and high intracellular expression of IL-12, compared to non-stimulated cells. Conclusions. The neoplastic tissue in vivo produces a number of substances having an unfavorable effect on immune system, our results suggests using lysates as good dendritic cells stimulators that possibly could have application in colon cancer immunotherapy
    Źródło:
    Polish Journal of Surgery; 2015, 87, 2; 71-82
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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