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Wyświetlanie 1-6 z 6
Tytuł:
Aleksander Koj in the memories of his alumni and co-workers
Autorzy:
Bereta, Joanna
Rokita, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/702986.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Aleksander Koj
biochemistry in Poland
acute phase proteins
regulation of acute phase response
Jagiellonian University
political transformation in Poland
The Polish Community Association
Conference of Rectors of Academic Schools in Poland
Campus of
Opis:
The article presents personal memories of Professor Aleksander Koj’s alumni. Professor Aleksander Koj was a world-class biochemist of significant scientific achievements, a renowned authority in the field of acute-phase response regulation and acute-phase proteins. He was an excellent academic, a true Master, admired and followed by many Polish biochemists. Thrice he served as the Rector of the Jagiellonian University in Kraków. He navigated the University through a difficult time of political transformation in Poland, modernized the management system of the University and led to the commencement of the construction of the new University campus. He was the co-creator and the first Chairman of the Conference of Rectors of Academic Schools in Poland. He will be remembered as a devoted community worker aiming at strengthening the bond between the Polish community abroad and our homeland, propagating knowledge, promoting the concept of European integration, democracy and tolerance, as well as the collaboration between scientists, artists and men and women of culture. He was wise, righteous, and noble. Many had the honor of calling him their friend, and a great many saw in him a moral authority.
Źródło:
Nauka; 2017, 1
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modulation of GAPDH expression and cellular localization after vaccinia virus infection of human adherent monocytes.
Autorzy:
Nahlik, Krystyna
Mleczko, Anna
Gawlik, Magdalena
Rokita, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/1043440.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
human adherent monocytes
vaccinia virus
subcellular localization
glyceraldehyde-3-phosphate dehydrogenase
apoptosis
Opis:
Vaccinia virus is able to replicate in many cell types and is known to modulate apoptosis in infected cells. In this study, expression of apoptosis-related genes was screened in human adherent monocytes after vaccinia infection using a DNA array. A marked increase of the key glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression was found. Increased expression and nuclear translocation of GAPDH have recently been reported to participate in apoptosis of many cell types. To confirm the array results, levels of GAPDH mRNA were estimated by RT-PCR, showing an increase at 4 h p.i. followed by a slight decrease, which correlated with the viral anti-apoptotic E3L gene transcript levels. Subcellular localization of the enzyme in human monocytes was examined by Western blot and immunostaining of the infected cells. Both experiments revealed accumulation of GAPDH in the nucleus at 14 h p.i., which was completely suppressed at 24 h p.i. This might indicate GAPDH as a novel target for vaccinia anti-apoptotic modulation.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 667-676
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New method for quantitative analysis of GD2 ganglioside in plasma of neuroblastoma patients
Autorzy:
Czaplicki, Dominik
Horwacik, Irena
Kowalczyk, Aleksandra
Wieczorek, Aleksandra
Bolek-Marzec, Katarzyna
Balwierz, Walentyna
Kozik, Andrzej
Rokita, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/1040532.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
gangliosides
HPLC
human blood plasma
quantitative analysis
neuroblastoma
Opis:
Neuroblastoma, the most common extracranial solid tumour of childhood, is a malignancy of unknown origin and non-specific symptoms. One of the markers of the disease is GD2 ganglioside (disialoganglioside), which is abundantly expressed on the surface of neuroblastoma cells. Gangliosides are known to be shed by tumour cells and this phenomenon can be significant in cancer progression as they inhibit a number of immune responses both in vitro and in vivo. In search for novel markers useful in monitoring and prognosis of neuroblastoma, we developed and validated a new quantitative method of GD2 ganglioside analysis in human blood plasma. We evaluated the level of gangliosides in blood serum of 34 neuroblastoma patients using high-performance liquid chromatography. The technique was used to detect fluorescently labelled oligosaccharides derived from serum glycosphingolipids by enzymatic digestion with ceramide glycanase. The developed method allowed determination of GD2 concentrations at the picomole level and required only 40 µl of plasma, which should be particularly useful when the quantity of clinical material is limiting. Moreover, this method can be applied to study concentration of other gangliosides, as shown for GD3 ganglioside. Analysis of plasma samples from the 34 neuroblastoma patients did not reveal any correlations between the concentration of GD2 ganglioside and clinical parameters, including the results of therapy; it showed, however, that the concentration of GD2 ganglioside in the plasma of neuroblastoma patients decreased substantially in the course of treatment.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 423-431
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells
Autorzy:
Horwacik, Irena
Durbas, Małgorzata
Boratyn, Elżbieta
Sawicka, Anna
Węgrzyn, Paulina
Krzanik, Sylwia
Górka, Anna
Drożniak, Joanna
Augustyniak, Ewa
Kowalczyk, Aleksandra
Rokita, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/1038977.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
doxorubicin
GD2 ganglioside
microarray
14G2a
neuroblastoma
mimitin
Opis:
Neuroblastoma is the most common extra-cranial solid tumor of childhood and it is characterized by the presence of a glycosphingolipid, GD2 ganglioside. Monoclonal antibodies targeting the antigen are currently tested in clinical trials. Additionally, several research groups reported results revealing that ganglioside-specific antibodies can affect cellular signaling and cause direct cytotoxicity against tumor cells. To shed more light on gene expression signatures of tumor cells, we used microarrays to analyze changes of transcriptome in IMR-32 human neuroblastoma cell cultures treated with doxorubicin (DOX) or a mouse monoclonal antibody binding to GD2 ganglioside 14G2a (mAb) for 24 h. The obtained results highlight that disparate cellular pathways are regulated by doxorubicin and 14G2a. Next, we used RT-PCR to verify mRNA levels of selected DOX-responsive genes such as RPS27L, PPM1D, SESN1, CDKN1A, TNFSF10B, and 14G2a-responsive genes such as SVIL, JUN, RASSF6, TLX2, ID1. Then, we applied western blot and analyzed levels of RPS27L, PPM1D, sestrin 1 proteins after DOX-treatment. Additionally, we aimed to measure effects of doxorubicin and topotecan (TPT) and 14G2a on expression of a novel human NDUFAF2 gene encoding for mimitin protein (MYC-induced mitochondrial protein) and correlate it with expression of the MYCN gene. We showed that expression of both genes was concomitantly decreased in the 14G2a-treated IMR-32 cells after 24 h and 48 h. Our results extend knowledge on gene expression profiles after application of DOX and 14G2a in our model and reveal promising candidates for further research aimed at finding novel anti-neuroblastoma targets.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 423-433
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Governance effectiveness and green bonds. An empirical evaluation
Efektywność zarządzania i zielone obligacje. Ocena empiryczna
Autorzy:
Kociemska, Hanna
Frydrych, Sylwia
Szczech-Pietkiewicz, Ewelina
Radło, Mariusz
Rokita, Paweł
Pietrzyk, Radosław
Biegun, Krzysztof
Półtorak, Bogusław
Powiązania:
https://bibliotekanauki.pl/articles/24201145.pdf
Data publikacji:
2023
Wydawca:
Fundacja Ekonomistów Środowiska i Zasobów Naturalnych
Tematy:
world governance indicator
green bonds
government effectiveness
green financing
wkaźnik jakości zarządzania publicznego
zielone obligacje
efektywność rządu
zielone finansowanie
Opis:
The study aims to assess the relationship between governance effectiveness, measured by the Worldwide Governance Indicators, and the use of green bonds worldwide. We apply panel data models with random effects and a robust linear regression model that allows us to identify the impact of the family of variables on green bonds. We found a statistically significant correlation between the quality of a government, measured as government effectiveness, and the value of green bond issuances. Thus, it is advised under New Public Governance to increase the effectiveness of their functioning, which may contribute to greater investor interest in environmental projects.
Badanie ma na celu ocenę związku pomiędzy efektywnością zarządzania mierzoną za pomocą Worldwide Governance Indicators, a wykorzystaniem zielonych obligacji na świecie. Stosujemy modele danych panelowych z efektami losowymi oraz solidny model regresji liniowej, który pozwala nam zidentyfikować wpływ rodziny zmiennych na zielone obligacje. Stwierdziliśmy istotną statystycznie korelację pomiędzy jakością rządzenia mierzoną efektywnością rządzenia, a wartością emisji zielonych obligacji. Tym samym w ramach New Public Governance wskazane jest zwiększenie efektywności ich funkcjonowania, co może przyczynić się do zwiększenia zainteresowania inwestorów projektami proekologicznymi.
Źródło:
Ekonomia i Środowisko; 2023, 2; 30--51
0867-8898
Pojawia się w:
Ekonomia i Środowisko
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-6 z 6

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