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    Wyświetlanie 1-6 z 6
    Tytuł:
    Proximate composition, antioxidant activities and fatty acid profiling of selected Mushrooms collected from Azad Jammu and Kashmir
    Autorzy:
    Shahid, Muhammad
    Fatima, Hina
    Anjum, Fozia
    Riaz, Muhammad
    Powiązania:
    https://bibliotekanauki.pl/articles/895683.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    antioxidants
    fatty acids
    mushroom
    nutraceutical
    Opis:
    Mushrooms can be used in diet as nutraceutical or functional foods for promoting and maintaining health quality and health longevity. Mushrooms just like medicinal plants can be utilized in the form of powder or extract as curative agents of several diseases and in providing a healthy diet. In current study, ten different mushroom species were collected from Azad Jammu and Kashmir. The selected mushrooms were assessed for their nutritional value, biological activities and fatty acid profiling. Before extraction, proximate analysis of all selected mushrooms was performed. Protein, fat, ash and total carbohydrate contents ranged from 10-30%, 0.43-8.08%, 1.1-9.14%, 12.47-92.52%, respectively. Then mushrooms were extracted with three different solvents n-hexane, ethyl acetate and methanol for the assessment of their antioxidant potentials through different antioxidant assays like total phenolics, total flavonoid contents and DPPH inhibition assay. The order of antioxidant potential in different solvent is methanol>Ethyl acetate>n-hexane. Quantification of fatty acids by GC/MS analysis revealed that stearic acid, palmitic acid, oleic acid, linolenic acid were present in significant quantity in different mushrooms and unsaturated fatty acids were found abundant over saturated fatty acids in all the selected mushrooms. So presence of fatty acids in studied samples is one of the main biologically active ingredients from mushrooms. The study concluded that the selected mushrooms from different regions of Azad Jammu and Kashmir are of nutritional importance having significant antioxidant potential and contains several unsaturated fatty acids which contribute to the nutritional value of mushrooms.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 145-153
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Triggering of erythrocyte membrane blebbing by ciprofloxacin
    Autorzy:
    Shabir, Kashif
    Jilani, Kashif
    Zbidah, Mohanad
    Riaz, Muhammad
    Bibi, Ismat
    Asghar, Asma
    Powiązania:
    https://bibliotekanauki.pl/articles/895372.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    oxidative stress
    calcium
    cell size
    Opis:
    An extensively used fluoroquinolone antibiotic ciprofloxacin shows a broad-spectrum antibacterial activity against both gram-positive and gram-negative strains. It works mainly by the inhibition of DNA gyrase and topoisomerase IV which results in impaired DNA replication leading towards microbial cell death. Eryptosis is an alternative term used for suicidal erythrocyte death. In current study, eryptotic effect of ciprofloxacin was investigated by exposing erythrocytes for 48 hours to the different concentrations (45-90µM) of ciprofloxacin. The experimental work related to the investigation of eryptosis was done by cell size measurement and confirmation of calcium role in membrane blebbing. As a possible mechanism of eryptosis, oxidative stress induced by ciprofloxacin was determined by catalase, glutathion peroxidase and superoxide dismutase activities measurement. Similarly, necrotic effect of ciprofloxacin was also illustrated by hemolysis measurement. Results of our study revealed that the therapeutical doses of ciprofloxacin may induce oxidative stress by significant decrease in superoxide dismutase, catalase and glutathione peroxidase activities as well as induce eryptosis, featured by erythrocytes membrane blebbing and hemolysis.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 901-906
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Artificial Intelligence Based Flood Forecasting for River Hunza at Danyor Station in Pakistan
    Autorzy:
    Yaseen, Muhammad Waseem
    Awais, Muhammad
    Riaz, Khuram
    Rasheed, Muhammad Babar
    Waqar, Muhammad
    Rasheed, Sajid
    Powiązania:
    https://bibliotekanauki.pl/articles/31340346.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Instytut Budownictwa Wodnego PAN
    Tematy:
    hydrometeorology
    random forest
    support vector
    multilayer perceptron
    machine learning
    flood forecasting
    Opis:
    Floods can cause significant problems for humans and can damage the economy. Implementing a reliable flood monitoring warning system in risk areas can help to reduce the negative impacts of these natural disasters. Artificial intelligence algorithms and statistical approaches are employed by researchers to enhance flood forecasting. In this study, a dataset was created using unique features measured by sensors along the Hunza River in Pakistan over the past 31 years. The dataset was used for classification and regression problems. Two types of machine learning algorithms were tested for classification: classical algorithms (Random Forest, RF and Support Vector Classifier, SVC) and deep learning algorithms (Multi-Layer Perceptron, MLP). For the regression problem, the result of MLP and Support Vector Regression (SVR) algorithms were compared based on their mean square, root mean square and mean absolute errors. The results obtained show that the accuracy of the RF classifier is 0.99, while the accuracies of the SVC and MLP methods are 0.98; moreover, in the case of flood prediction, the SVR algorithm outperforms the MLP approach.
    Źródło:
    Archives of Hydro-Engineering and Environmental Mechanics; 2022, 69, 1; 59-77
    1231-3726
    Pojawia się w:
    Archives of Hydro-Engineering and Environmental Mechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Observer design estimating the propofol concentration in PKPD model with feedback control of anesthesia administration
    Autorzy:
    Ilyas, Muhammad
    Khan, Awais
    Khan, Muhammad Abbas
    Xie, Wei
    Riaz, Raja Ali
    Khan, Yousaf
    Powiązania:
    https://bibliotekanauki.pl/articles/2106507.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    pharmacokinetic models
    pharmacodynamic model
    bispectral index monitor
    observer design
    sliding mode control
    Opis:
    Propofol infusion in anesthesia administration requires continual adjustment in the manual infusion system to regulate the hypnosis level. Hypnotic level is based on Bispectral Index Monitor (BIS) showing the cortical activity of the brain scaled between 0 to 100. The new challenging aspect of automation in anaesthesia is to estimate the concentration of hypnotic drugs in different compartments of the body including primary, rapid peripheral (muscle), slow peripheral (bones, fat) and effect site (brain) compartment based on Pharmacokinetics (PK) and Pharmacodynamics (PD) model. This paper aimed to regulate the hypnosis level with estimating the Propofol concentrations using a linear observer in feedback control strategy based on Integral Super-Twisting Sliding Mode Controller (ISTSMC). The drug concentration in plasma of the silico patients accurately estimated in nominal transient. The results show that tracking errors between the actual output in form of BIS level and linearized output nearly approaches to zero in the maintenance phase of anesthesia to ensure the controller response on sliding phase with optimum performances by achieving desired hypnotic level 50 on BIS. The robustness of control strategy is further ensured by adding measurement noise of electromagnetic environment of operation theatre distracting signal quality index of the output BIS level.
    Źródło:
    Archives of Control Sciences; 2022, 32, 1; 85--103
    1230-2384
    Pojawia się w:
    Archives of Control Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Flood Frequency Analysis and Hydraulic Design of Bridge at Mashan on River Kunhar
    Autorzy:
    Riaz, Khuram
    Aslam, Hafiz Muhammad Shahzad
    Yaseen, Muhammad Waseem
    Ahmad, Hafiz Haseeb
    Khoshkonesh, Alireza
    Noshin, Sadaf
    Powiązania:
    https://bibliotekanauki.pl/articles/2097753.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Instytut Budownictwa Wodnego PAN
    Tematy:
    flooding
    river hydraulics
    return period
    HEC-RAS
    HEC-GEO-RAS
    ASTER DEM with 90 meters
    DEM
    Opis:
    Kunhar River hydrology and hydraulic design of a bridge on this river are being studied using HEC-Geo-RAS and Hydrologic Engineering Centers River Analysis System (HEC-RAS). The river flows in the northern part of Pakistan and is 170 km long. On both sides of the river, there are residential settlements. The river hydraulics is studied by using 30-metre remotely sensed shuttle radar topographic mission - digital elevation model (SRTM DEM) and Arc Map. 32 cross-sections are imported from Geographic Information System (GIS) to HEC-RAS. On historical peak flow results, the extreme value frequency distribution is applied, and a flood is determined for a 100-year return period, with a discharge estimated as 2223 cubic metres. Three steady flow profiles are adopted for HEC-RAS, the first is for the maximum historical peak data, the second is for the 100-year return period, and the third profile is for the latter 100-year period with a safety factor of 1.28. With remote sensing-based assessments, the proposed location for a bridge is determined and then verified with a field survey which was physically conducted. The maximum water height estimated in the river is about 4.26 m. This bridge will facilitate about 50 thousand population of Masahan and its surroundings. It will create a shortest link between Khyber Pakhtunkhwa and Azad Kashmir and thus will enhance tourism and trade activities.
    Źródło:
    Archives of Hydro-Engineering and Environmental Mechanics; 2022, 69, 1; 1-12
    1231-3726
    Pojawia się w:
    Archives of Hydro-Engineering and Environmental Mechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluating the Total Phenolic, Protein Contents, Antioxidant and Pharmacological Effects of Cynodon dactylon Extracts Against Escherichia coli and Staphylococcus aureus
    Autorzy:
    Ibrahim, Muhammad
    Riaz, Moazama
    Ali, Akbar
    Shaheen, Musarat
    ur Rahman, Shafiq
    Aziz, Riffat
    Alamri, Abdulhakeem S.
    Alhomrani, Majid
    Dablool, Anas S.
    Alghamdi, Saad
    Sameeh, Manal Y.
    Tashkandi, Manal A.
    Powiązania:
    https://bibliotekanauki.pl/articles/27315658.pdf
    Data publikacji:
    2023
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    Cynodon dactylon
    Anti-microbial
    Flavonoids
    Total Soluble Proteins
    Peroxidase
    Antioxidant
    Super oxide Dismutase
    Opis:
    The study was aimed to characterize the antioxidant and anti-microbial activities of Cynodon dactylon with special reference on its precise biochemical analysis. Physiological analysis that total carotenoids content (0.3884 ± 0.0172 mg/g), total chlorophyll content (6.1460 ± 0.2915 mg/g), total phenolic contents (13.4703 ± 0.1494 mg/g), chlorophyll a (3.7708 ± 0.1528 mg/g, catalase (CAT) contents (40.2844 ± 0.1515 units/ mg), total anthocyanin contents (5.0166 ± 0.2966 g–1 FW) total soluble proteins (2.9916 ± 0.1734 mg/g) and total flavonoids content (TFC) (4.7863 ± 0.0442 μg/g) was found higher in the leaves of the Cynodon dactylon whereas, chlorophyll b (2.4881 ± 0.1326 mg/g) was found higher in the stem of Cynodon dactylon, while, peroxidase (POD) contents (81.8763 ± 4.6609 units/mg) and superoxidase dismutase (SOD) activity (80.4346 ± 5.9367 units/mg) was investigated higher in roots of Cynodon dactylon. The anti-microbial activity of Cynodon dactylon extracts was performed using a good diffusion technique against two microbial strains. Among all the plant extracts, the methanolic extracts showed a maximum inhibition zone (26.87 mm) against anti-bacterial strain Escherichia coli whereas n-hexane extract showed a maximum inhibition zone (17.88 mm) against anti-fungal strain Candida albicans. This study reported the antimicrobial activity of Cynodon dactylon against some common pathogens such as Staphylococcus aureus, Escherichia coli, and Candida albicans, which are highly associated with nosocomial infection. From the given results it is concluded that Cynodon dactylon could be exploited in pharmacology due to its antioxidant and anti-microbial properties.
    Źródło:
    Polish Journal of Chemical Technology; 2023, 25, 3; 110--119
    1509-8117
    1899-4741
    Pojawia się w:
    Polish Journal of Chemical Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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