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    Wyświetlanie 1-4 z 4
    Tytuł:
    Androgen receptor modulation and bladder cancer prevention – a short review
    Autorzy:
    Wieczorek, Edyta
    Farooqi, Ammad A.
    Reszka, Edyta
    Powiązania:
    https://bibliotekanauki.pl/articles/2081138.pdf
    Data publikacji:
    2022-04-22
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    AR
    detoxification
    DIM
    epigenetic regulation
    occupational exposure
    UGT
    Opis:
    The prevalence of bladder cancer (BCa) is 4 times higher in men as compared to women, and gender differences have been the focus of attention for few years. Androgen receptor (AR) may be a putative explanation for gender differences. It may also be related to unfavourable BCa progression and development because of the increased androgen sensitivity of urothelium to carcinogens. Moreover, cigarette smoking and occupational exposure to carcinogens have been reported to play contributory roles with the highest attributable risk of BCa. In this review, the authors attempt to summarize the seminal research works that synthesized current understanding of the central role of AR in the negative regulation of carcinogen detoxification activity in BCa. In particular, the authors discuss the regulatory effects of 3,3’-diindolylmethane on AR gene transcription through microRNA as its suggested effect on the prevention of BCa. Moreover, to show the still existing problem of occupational exposure and BCa incidence, the authors review recent studies in this area. Based on the rapidly accumulating scientific evidence, it seems pragmatic that androgen/AR-mediated interference in the detoxification mechanism may be inhibited by phytochemicals. Therefore, collectively, nutrition has a key role as gene–nutrient interactions are important contributors to BCa prevention, also through epigenetic modifications. Here, the authors have derived suggestions for future research. Med Pr. 2022;73(2):151–62
    Źródło:
    Medycyna Pracy; 2022, 73, 2; 151-162
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Transformacja i detoksykacja herbicydów fenoksylowych w środowisku oraz organizmach żywych
    Transformation and detoxication phenoxyherbicides in environm ent and living organism
    Autorzy:
    Bukowska, Bożena
    Reszka, Edyta
    Michałowicz, Jaromir
    Duda, Wirgiliusz
    Powiązania:
    https://bibliotekanauki.pl/articles/944950.pdf
    Data publikacji:
    1998
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Opis:
    The phenoxyherbiddes are commonly used in Poland. In great numbers the herbicides can reach the environment and be accumulated in living organisms. The reactions of the degradations of those herbicides may lead to create many of their derivatives. Some of them may demonstrate greater degree of their toxical action in compare with original substrate. Among many of the toxical effects we should pay special attention to the tumor and mutagen changes which have been observed among organisms (mammals including human being) exposed to the influence of these herbicides. Main participation in the detoxication of discussing compounds possess microorganisms which use them as a source of carbon and energy.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1998, 13
    0208-614X
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Gene-occupation interactions: a review of the literature on bladder and prostate cancer
    Autorzy:
    Wieczorek, Edyta
    Wolniakowska, Anna
    Roszak, Joanna
    Rodrigues, Robim M.
    Vanhaecke, Tamara
    Reszka, Edyta
    Powiązania:
    https://bibliotekanauki.pl/articles/2203023.pdf
    Data publikacji:
    2023-05-19
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    bladder cancer
    gene
    genetic susceptibility
    occupational exposure
    prostate cancer
    workplace
    Opis:
    Bladder cancer (BCa) and prostate cancer (PCa) are genitourinary cancers which constitute significant health problems in men and in which environmental factors play an important role. Understanding the genetic susceptibility to BCa or PCa and occupational exposure is paramount to improving cancer prevention and early detection. The aim of this review article was to address the scientific evidence on the genetic risk factors and occupational exposure associated with the occurrence of BCa and PCa. The authors identified relevant original articles that have been published between 1994 and 2023. Variations of the following search terms: “gene” and “occupational” combined with one of the following terms: “bladder cancer” or “prostate cancer” were applied for the search purpose. The authors found 342 publications of which 50 population studies met their requirements for gene-occupation interactions. In total, 34 full-text manuscripts were about BCa and 16 about PCa. These research examines the genes involved in detoxification processes of xenobiotics (glutathione S-transferase, N-acetyltransferase, cytochrome P450, UDP-glucuronosyltransferase), oxidative stress (glutathione peroxidase 1, manganese superoxide dismutase, catalase), altering DNA repair capacity (X-ray repair cross-complementing 1, base excision repair, nucleotide excision repair), tumour suppression (TP53 gene), and vitamin D pathway (vitamin D receptor gene). The role of genetic factors in the occupational exposure has not been conclusively established, but it appears the possibility of genetic involvement. Determination of environmentally responsive genes provides important mechanistic implications for the etiology of occupational cancers, and valuable input in occupational exposure limits set by taking genetic susceptibility into account. More genetic research is needed to corroborate these findings and assess their significance in the workplace. Med Pr. 2023;74(2):127–44
    Źródło:
    Medycyna Pracy; 2023, 74, 2; 127-144
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues
    Autorzy:
    Król, Magdalena
    Galicki, Michał
    Grešner, Peter
    Wieczorek, Edyta
    Jabłońska, Ewa
    Reszka, Edyta
    Morawiec, Zbigniew
    Wąsowicz, Wojciech
    Gromadzińska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1038523.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    estrogen receptor
    antioxidant enzymes
    gene expression
    breast cancer tissue
    Opis:
    Background: The aim of this study was to establish whether the gene expression of estrogen receptor alpha (encoded by ESR1) correlates with the expression of glutathione peroxidase 1 (encoded by GPX1) in the tumor and adjacent tumor-free breast tissue, and whether this correlation is affected by breast cancer. Such relationships may give further insights into breast cancer pathology with respect to the status of estrogen receptor. Methods: We used the quantitative real-time PCR technique to analyze differences in the expression levels of the ESR1 and GPX1 genes in paired malignant and non-malignant tissues from breast cancer patients. Results: ESR1 and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one. Down-regulation of these genes was independent of the tumor histopathology classification and clinicopathological factors, while the ESR1 mRNA level was reduced with increasing tumor grade (G1: 103% vs. G2: 85.8% vs. G3: 84.5%; p<0.05). In the non-malignant and malignant breast tissues, the expression levels of ESR1 and GPX1 were significantly correlated with each other (Rs=0.450 and Rs=0.360; respectively). Conclusion: Our data suggest that down-regulation of ESR1 and GPX1 was independent of clinicopathological factors. Down-regulation of ESR1 gene expression was enhanced by the development of the disease. Moreover, GPX1 and ESR1 gene expression was interdependent in the malignant breast tissue and further work is needed to determine the mechanism underlying this relationship.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 51-57
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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