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    Wyświetlanie 1-3 z 3
    Tytuł:
    Emulsion electrospinning - method to introduce proteins for biomedical applications
    Autorzy:
    Kurpanik, Roksana
    Rapacz-Kmita, Alicja
    Stodolak-Zych, Ewa
    Ścisłowska-Czarnecka, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1844868.pdf
    Data publikacji:
    2021
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Źródło:
    Engineering of Biomaterials; 2021, 24, 163; 48
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Emulsion electrospinning – method to introduce proteins for biomedical applications
    Autorzy:
    Kurpanik, Roksana
    Rapacz-Kmita, Alicja
    Ścisłowska-Czarnecka, Anna
    Stodolak-Zych, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/2058398.pdf
    Data publikacji:
    2021
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    emulsion electrospinning
    alanine
    polycaprolactone
    Tween 80
    Triton X-100
    micelle
    proteiny
    zastosowanie
    biomedycyna
    Opis:
    The aim of this work was to obtain polymer fibers by the emulsion electrospinning. For this purpose, polycaprolactone (PCL) was used, which was modified before the electrospinning stage with micelles obtained by the oil-in-water (O/W) emulsion method. Micelles were obtained by combining the non-ionic surfactant Tween 80 or Triton X-100 used at different concentrations with the amino acid alanine. The obtained fibrous substrates had a typical unimodal fiber size distribution and their average size was in the range of 590-800 nm. The effectiveness of the emulsion electrospinning process was confirmed by Fourier Transform Infrared Spectroscopy - Attenuated Total Reflectance (FTIR-ATR) showing the presence of surfactants. The addition of micelles to the polymer solution significantly reduces the contact angle of nonwoven fabrics: from 120° (for PCL) to ~20-30° for surfactant-loaded nonwovens, and the micellar form allows tracking the release of alanine into the solution (UV-Vis). The combination of the core-shell- -morphology of the emulsion electrospun fibers allows comparable amino acid release times. There were no significant differences in both the amount of alanine released and the rate of its release between PCL/ Tween80/alanine and PCL/Triton X-100/alanine fibers, which were characterized by a similar fiber size.
    Źródło:
    Engineering of Biomaterials; 2021, 24, 162; 20--25
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Multifunctional biodegradable polymer/clay nanocomposites with antibacterial properties in drug delivery systems
    Autorzy:
    Rapacz-Kmita, Alicja
    Szaraniec, Barbara
    Mikołajczyk, Maciej
    Stodolak-Zych, Ewa
    Dzierzkowska, Ewa
    Gajek, Marcin
    Dudek, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/27324154.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    nanocomposite
    clay mineral
    drug carrier
    mechanical properties
    antimicrobial activities
    nanokompozyt
    minerał ilasty
    nośnik leku
    właściwości mechaniczne
    działanie przeciwdrobnoustrojowe
    Opis:
    Purpose: The aim of this study was to investigate the possibility of intercalation of gentamicin and neomycin in montmorillonite (MMT) nanofillers, as well as to study the in vitro antimicrobial properties of nanocomposite films containing a small amount of thus obtained nanofillers. Methods: The polylactide matrix (PLA) nanocomposite films with drug-intercalated montmorillonite fillers were obtained by casting after intercalation of drugs in aqueous solutions. The efficiency of intercalation has been confirmed by X-ray diffraction (XRD) and Zeta potential measurements. The materials were studied for surface wettability, roughness and mechanical properties during 6 weeks of incubation in phosphate buffer saline, and their bactericidal activity was tested against Escherichia coli bacteria before and after 6 weeks of incubation in distilled water at 37 C. The presence of antibiotics during the incubation was monitored by conductivity and pH measurements. Results: The results indicate that nanocomposite polylactide films with montmorillonite filler intercalated with gentamicin and neomycin tend to degrade faster that their counterparts with non-intercalated fillers, which affects their mechanical properties. However, drug intercalation provided an antibacterial activity, which was confirmed by the presence of zones inhibiting the growth of Gram-negative bacteria for both antibiotics. It was also confirmed that the interaction of antibiotics with clay and polymer matrix did not adversely affect this bactericidal effect. Conclusions: Montmorillonite can be successfully intercalated with both gentamicin and neomycin, and then used as active filler for polylactide films having very good antibacterial properties, therefore their use in biomedical applications can be significantly expanded.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2020, 22, 2; 83--92
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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