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Wyświetlanie 1-4 z 4
Tytuł:
Trudności w leczeniu zakażeń pooperacyjnych – opis przypadku
Autorzy:
Różalska, Małgorzata
Józefowicz-Korczyńska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1398718.pdf
Data publikacji:
2008
Wydawca:
Index Copernicus International
Tematy:
zakażenie rany pooperacyjnej
MRSA
synergizm rifampicyny i ko-trimoksazolu
Opis:
Postoperative wounds infections due to surgical intervention of laryngeal cancer are serious therapeutic problem. This process led to the necrosis of surrounding tissues and in consequence prolongs the wounds healing and cause longer hospitalisation, delay of vocal rehabilitation and cause chronic infl ammation of trachea and bronchi. We investigated a cause of patient after surgical intervention. Postoperative wound as well as upper respiratory tracts of this patient were colonized by methicillinresistant Staphylococcus aureus (MRSA). The following symptoms of in infl ammation were noticed: subfebrile condition, muscles and joints pain, excessive secretion of mucus in respiratory tracts and malaise. Patient was treated many times (repeatedly) with antibiotics and chemotherapeutics ambulatory and during hospitalisation. The susceptibility to antibiotics and chemotherapeutics to isolated MRSA strain was established. The effective therapy occurred using combine of rifampicin and co-trimoxasole. The patient status was radically improved. Patient after therapy was monitored microbiologically for a several month and in clinical material isolated from him did not found MRSA.
Źródło:
Polish Journal of Otolaryngology; 2008, 62, 6; 776-778
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synergistic hemolysins of coagulase-negative staphylococci (CoNS)
Autorzy:
Różalska, Małgorzata
Derczyńska, Anna
Maszewska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1038908.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
coagulase-negative staphylococci
CoNS
synergistic hemolysin
antimicrobial activity
cytotoxicity
Opis:
A total of 104 coagulase negative staphylococci, belonging to S. capitis, S. hominis, S. haemolyticus and S. warneri, originating from the collection of the Department of Pharmaceutical Microbiology (ZMF), Medical University of Lodz, Poland, were tested for their synergistic hemolytic activity. 83% of strains produced δ-hemolysin, however, the percentage of positive strains of S. haemolyticus, S. warneri, S. capitis and S. hominis was different - 98%, 78%, 75% and 68%, respectively. Highly pure hemolysins were obtained from culture supernatants by protein precipitation with ammonium sulphate (0-70% of saturation) and extraction by using a mixture of organic solvents. The purity and molecular mass of hemolysins was determined by TRIS/Tricine PAGE. All CoNS hemolysins were small peptides with a molar mass of about 3.5 kDa; they possessed cytotoxic activity against the line of human foreskin fibroblasts ATCC Hs27 and lysed red cells from different mammalian species, however, the highest activity was observed when guinea pig, dog and human red blood cells were used. The cytotoxic effect on fibroblasts occurred within 30 minutes. The S. cohnii ssp. urealyticus strain was used as a control. The antimicrobial activity was examined using hemolysins of S. capitis, S. hominis, S. cohnii ssp. cohnii and S. cohnii ssp. urealyticus. Hemolysins of the two S. cohnii subspecies did not demonstrate antimicrobial activity. Cytolysins of S. capitis and S. hominis had a very narrow spectrum of action; out of 37 examined strains, the growth of only Micrococcus luteus, Corynebacterium diphtheriae and Pasteurella multocida was inhibited.
Źródło:
Acta Biochimica Polonica; 2015, 62, 4; 757-764
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vaccinium myrtillus leaves and Frangula alnus bark derived extracts as potential antistaphylococcal agents
Autorzy:
Sadowska, Beata
Paszkiewicz, Małgorzata
Podsędek, Anna
Redzynia, Małgorzata
Różalska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1039358.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
phytocompounds
antimicrobial activity
synergism with antibiotics
biocompatibility index
Opis:
Due to constantly increasing antibiotic resistance of pathogens and participation of the biofilms they make in various types of infections, a development of alternative therapeutic strategies becomes an urgent need. Taking advantage of the biological activity of plant-derived compounds can solve this problem. In this study antimicrobial, including those synergistic with classic antibiotics, and cytotoxic properties of newly-obtained extracts from Vaccinium myrtillus leaves (VLE) and Frangula alnus bark (FBE) were evaluated. Both tested extracts exhibited relevant antistaphylococcal activity (MIC range 0.75-1.5 mg/mL) accompanied by a relativly low cytotoxic effect on mammalian cells (BI > 1). Phytochemical analysis of the extracts tested showed a high total content of phenolic compounds with the predominance of hydroxycinnamic acids in VLE and hydroxybenzoic acids and flavanols in FBE. Widely described in the literature antimicrobial properties of phenolics were probably connected with the biological activity of the extracts tested. We also report that the presence of VLE or FBE at sub-MIC concentrations enhances biocidal potential of vancomycin and linezolid. Therefore, we are considering a possibility of an alternative therapy for local infections caused by S. aureus by combining classic antibiotics with plant-derived extracts.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 163-169
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Leonurus cardiaca L. herb - a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis
Autorzy:
Micota, Bartłomiej
Sadowska, Beata
Podsędek, Anna
Redzynia, Małgorzata
Różalska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1039309.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ECM
Leonurus cardiaca
ursolic acid
Staphylococcus aureus
Opis:
The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 385-388
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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