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Wyświetlanie 1-6 z 6
Tytuł:
Azapirones for the treatment of anxiety – an overview
Autorzy:
Knap, Bartosz
Kwiatkowski, Stanisław
Kolasińska, Karolina
Knap-Czop, Karolina
Przystupski, Dawid
Roguzińska, Sylwia
Kędzierska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1163274.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
anxiety disorder
azapirones
buspirone
gepirone
ipsapirone
tandospirone
Opis:
Anxiety disorders belong to the most common psychiatric diagnosis. Over the years, benzodiazepines were considered the gold standard for pharmacological treatment of anxiety. They are effective anxiolytics, but unfortunately the long-term use of benzodiazepines is accompanied by many adverse events. An alternative to classical anxiolytics is a relatively new class of psychotherapeutic drugs – azapirones. They are 5-HT1A partial agonists commonly used in the treatment of generalized anxiety disorder and as augmentation for SSRI in social anxiety disorder and depression. Due to the high ratio of benefits to risk, azapirones are extensively studied for their use in other disease entities. The aim of this article was to overviewed current information on azapirones. Their history of development, mechanism of action, pharmacokinetics, interactions, clinical use and their role in the modern pharmacotherapy of anxiety.
Źródło:
World Scientific News; 2018, 109; 14-25
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contemporary management and novel therapies in ovarian cancer – literature review
Autorzy:
Kotowski, Krzysztof
Przystupski, Dawid
Kwiatkowski, Stanisław
Kolasińska, Karolina
Bartosik, Weronika
Górska, Agata
Saczko, Jolanta
Baczyńska, Dagmara
Kulbacka, Julita
Powiązania:
https://bibliotekanauki.pl/articles/1162168.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Anti-VEGF monoclonal IgG1 antibody
Interval Cytoreductive Surgery
Interval Debuking Surgery
bevacizumab
electrochemotherapy
hormone therapy
immunotherapy
ovarian cancer
photodynamic therapy
Opis:
Ovarian cancer is characterized by an extremely poor prognosis in women with an advanced stage of this carcinoma. In United States every year 20,000 women are diagnosed with ovarian cancer. It is the fifth most frequent cause of death from cancer in females and the most common cause of death for 15 years after diagnosis in women with stage III-IV tumors. Among ovarian neoplasms the most frequent are surface epithelial-stromal tumors. Moreover, non-epithelial ovarian tumors are distinguished. This group matters 10% of patients with diagnosed ovarian tumors. Due to a huge variety of ovarian tumors, the following work focuses mainly on the current clinical treatment of the epithelial ovarian cancer. The following paper summarizes current clinical treatment of epithelial ovarian cancer, including surgical procedure, chemo- and immunotherapy including modern therapeutic approaches.
Źródło:
World Scientific News; 2018, 111; 51-63
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An overview of paraneoplastic neurological syndromes – pathophysiology and clinical insight
Autorzy:
Kwiatkowski, Stanisław
Kolasińska, Karolina
Knap, Bartosz
Przystupski, Dawid
Kotowski, Krzysztof
Bartosik, Weronika
Kulbacka, Julita
Powiązania:
https://bibliotekanauki.pl/articles/1163959.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dermatomyositis
encephalitis
opsoclonus-myoclonus
paraneoplastic neurological syndromes
Opis:
Paraneoplastic syndrome (PS) is a dysfunction of organs or systems, associated with neoplastic disease, but not related to the local growth of tumor, metastasis or adverse anti-cancer drugs reactions. Neurological paraneoplastic syndromes (NPSs) may affect every region of a human nervous system - both central, peripheral, and/or autonomic nervous system. The symptoms are caused by a neoplastic process in other organ or system. PNSs usually precede the development of cancer for months or even years, and can be therefore useful diagnostic markers of cancer. They present an autoimmune background associated with the response of the immune system against cancer cells. In the blood serum and cerebrospinal fluid of patients with PNS appear onconeural antibodies, reacting with tumor antigens and the brain, the spinal cord and peripheral ganglia antigens. Many authors emphasize the significance of paraneoplastic syndromes in the modern oncology. Due to this reason, the knowledge of paraneoplastic syndromes and their mechanisms is very important in the contemporary medicine. The purpose of this research review is to summarize the information about the clinical features of the most common PNSs and the pathological mechanisms of their development.
Źródło:
World Scientific News; 2018, 108; 87-98
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current clinical management of malignant melanoma – diagnosis process and innovative therapies
Autorzy:
Kwiatkowski, Stanisław
Przystupski, Dawid
Kotowski, Krzysztof
Kolasińska, Karolina
Saczko, Jolanta
Kulbacka, Julita
Powiązania:
https://bibliotekanauki.pl/articles/1177464.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
AJCC
Melanoma malignum
dabrafenib
electrochemotherapy
ipilimumab
melanoma
melanoma staging
pembrolizumab
photodynamic therapy
vemurafenib
Opis:
Malignant melanoma is a highly invasive cancer which derives from neuroectodermic melanocytic cells. It is characterized by the highest frequency of cases in both sexes and all age groups. High metastatic potential of melanoma and its multidrug resistance might be a significant problem in the treatment. Permanent and complete remissions are rare, while the 5-year survival rate remains relatively low. In the last years there has been a breakthrough in the systemic therapy of malignant melanoma. Modern drugs have revolutionized previous therapeutic management of melanoma. As part of therapeutic programs, new medicines are available: dabrafenib, ipilimumab, pembrolizumab, trametinib and vemurafenib. The following paper presents current clinical management standards for melanoma diagnoses, based on the widely accepted scientific data and expert experience - with emphasis on modern methods of treatment of this cancer.
Źródło:
World Scientific News; 2018, 102; 30-46
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The favourable effect of catechin in electrochemotherapy in human pancreatic cancer cells
Autorzy:
Michel, Olga
Przystupski, Dawid
Saczko, Jolanta
Szewczyk, Anna
Niedzielska, Natalia
Rossowska, Joanna
Kulbacka, Julita
Powiązania:
https://bibliotekanauki.pl/articles/1038385.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
electroporation
cisplatin
catechin
pancreatic cancer
in vitro
Opis:
Until recently, green tea polyphenols were considered strong antioxidants. However, the latest reports have revealed that bioflavonoids can play a multiple role in anticancer therapy, including the inhibition of cell proliferation and generation of the oxidative stress in a dose-dependent manner. The presented research was designed to examine the potential of the green tea (±)-catechin as a reinforcement of the electrochemotherapy (ECT) with cisplatin in pancreatic cancer in vitro. The study was performed on two cell lines of the pancreatic ductal adenocarcinoma (PDA) - parental EPP85-181P and multidrug-resistant EPP85-181RNOV. Prior to the ECT protocol the cells were preincubated with high or low concentration of catechin for 2 or 24 hours, respectively. We assessed the influence of preincubation on the cisplatin toxicity with and without electroporation (EP), the electrosensitivity of PDA cell lines and the uptake of the daunorubicin and propidium iodide. Additionally, we evaluated the antioxidative properties of catechin by the measurement of the ROS-related fluorescence and the immunoreactivity of the oxidative stress-related enzymes superoxide dismutase (SOD2) and glutathione S-transferase (GST). We found that co-treatment with catechin can firmly enhance the efficacy of electroporation with cisplatin in vitro. More favorable effect was obtained for 2-hour incubation, which indicates the involvement of the transcriptional-independent mechanisms of catechin action. The effect may be partially explained by the increased oxidative stress level, which was higher in multidrug-resistant cells. However, further studies on cisplatin-catechin interplay and the thorough examination of the catechin-cell membrane interaction need to be performed.
Źródło:
Acta Biochimica Polonica; 2018, 65, 2; 173-184
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A review of current literature on the diagnosis, prophylaxis and treatment of HIV/AIDS
Autorzy:
Sobieski, Mateusz
Przystupski, Dawid
Korzeniewska, Aleksandra
Kwiatkowski, Stanisław
Górska, Agata
Kotowski, Krzysztof
Baczyńska, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/1162996.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
AIDS
AIDS-related cancers
HIV
cART
Opis:
Acquired immunodeficiency syndrome (AIDS) is a spectrum of various diseases associated with the human immunodeficiency virus (HIV) infection. AIDS is one of the most common infectious illness with 1.8 million of new cases and approximately 36.7 million living with HIV. AIDS becomes a worldwide problem and due to rising number of HIV-positive patients, the appropriate medical care is needed. This article takes into consideration the current information about pathogenesis of HIV infection, clinical and biochemical symptoms, diagnosis, prophylaxis and treatment the disease. Furthermore, the article describes the side effects of the treatment, the methods of their diagnosis and prevalence, and focuses on the psychological problems of HIV-positive people.
Źródło:
World Scientific News; 2018, 110; 129-146
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-6 z 6

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