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Wyszukujesz frazę "Przybyłowska, Karolina" wg kryterium: Autor

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    Wyświetlanie 1-10 z 10
    Tytuł:
    Antigen levels of urokinase-type plasminogen activator receptor and its gene polymorphism related to microvessel density in colorectal cancer
    Autorzy:
    Przybylowska, Karolina
    Szemraj, Janusz
    Kulig, Andrzej
    Dziki, Adam
    Ulanska, Joanna
    Blasiak, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1040754.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    plasminogen activation system
    urokinase type plasminogen activator receptor (uPAR)
    gene polymorphism
    colorectal cancer
    cancer progression
    angiogenesis
    microvessel density
    Opis:
    We determined the distribution of genotypes and frequencies of alleles of the (CA)n repeat polymorphism in intron 3 of the urokinase plasminogen activator receptor (uPAR) gene, uPAR antigen levels and microvessel density (MVD) in tumour and distant mucosa samples from 52 patients with colorectal cancer. The uPAR level was higher for patients with high MVD comparing to patients with lower MVD which may suggest that uPAR can be correlated with progression of colorectal cancer. The significant relationship between the high MVD and uPAR antigen level appeared to be independent of the (CA)n repeat polymorphism because no differences in the level of uPAR antigen between carriers of alleles were found. The received results, indicate that uPAR might be considered as a target in colorectal cancer patients' therapy.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 2; 357-363
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Genetic Variations of the CTNNA1 And The CTNNB1 Genes in Sporadic Colorectal Cancer in Polish Population
    Autorzy:
    Sygut, Andrzej
    Przybyłowska, Karolina
    Ferenc, Tomasz
    Dziki, Łukasz
    Spychalski, Michał
    Mik, Michał
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1396892.pdf
    Data publikacji:
    2012-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    sporadic colorectal cancer
    muations
    catenin gene
    adhesion molecules
    Opis:
    Experimental as well as clinical observations have demonstrated that the E-cadherin/catenin complex is a powerful inhibitor of invasion. Abrogation of this pathway is implicated in the carcinogenesis of several malignancies, especially colorectal cancer. The aim of the study was to determine the CTNNA1 and the CTNNB1 mutations and its relationship to clinical and pathological features of sporadic colorectal cancer (CRC) in Polish patients. Material and methods. Paired tumor and normal tissue samples from 110 sporadic CRC patients undergoing resective surgery were prospectively studied for the alpha catenin (CTNNA1) gene and beta catenin (CTNNB1)gene mutations by PCR/single strand conformation polymorphism (SSCP). Results. The CTNNA1 gene alteration in exon 7 were detected in 4 samples and in exon 3 of CTNNB1 gene were found in 3 samples. There was a trend at the limit of statistical significance associating younger age at diagnosis (<50) with CTNNA1 and the CTNNB1 mutations. The mutation of CTNNB1 seemed to occur more frequently in the proximal colon than distal. The CRC patients with CTNNA1 mutation had a significantly increased lymph node metastasis. On the other hand, there was no correlation between mutations and the other clinical variables (e.g. sex, grade and depth of invasion). Conclusion. Although we found a low frequency of mutations in the CTNNA1 and the CTNNB1 genes, but the analysis the relationship with clinical and pathological features of CRC patients may indicated an association of these mutations with the risk and progression of CRC.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 11; 560-564
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association of Polymorphism of Lys589glu Exo1 Gene with the Risk of Colorectal Cancer in the Polish Population
    Autorzy:
    Kabziński, Jacek
    Przybylowska, Karolina
    Mik, Michał
    Sygut, Andrzej
    Dziki, Łukasz
    Dziki, Adam
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1395790.pdf
    Data publikacji:
    2014-08-01
    Wydawca:
    Index Copernicus International
    Tematy:
    colorectal cancer
    polymorphisms
    EXO1
    DNA repair
    Opis:
    The incidence of colorectal cancer (CRC) is increasing from year to year. Despite intensive research CRC etiology remains unknown. Studies suggest that at the basis of the process of carcinogenesis can lie reduced efficiency of DNA repair mechanisms, often caused by polymorphisms in DNA repair genes. The aim of the study was to determine the relationship between gene polymorphism Lys589Glu of EXO1 gene and modulation of the risk of colorectal cancer in the Polish population. Determination of the molecular basis of carcinogenesis process and predicting increased risk will allow qualifying patients to increased risk group and including them in preventive program. Material and methods. The material used in study was blood collected from 130 patients diagnosed with colorectal cancer. The control group consisted of 135 healthy people. Genotyping was performed by TaqMan method. Results. The results obtained indicate that the genotype Lys/Glu is associated with an increased risk of colorectal cancer (OR 1.811, 95% Cl 1.031-3.181, p = 0.038). Conclusion. On the basis of these results, we conclude that Exo1 gene polymorphism Lys589Glu may be associated with an increased risk of colorectal cancer.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 8; 370-373
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The -2518 A/G MCP-1 polymorphism as a risk factor of inflammatory bowel disease
    Autorzy:
    Walczak, Anna
    Przybyłowska, Karolina
    Sygut, Andrzej
    Dziki, Łukasz
    Chojnacki, Cezary
    Chojnacki, Jan
    Dziki, Adam
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1394594.pdf
    Data publikacji:
    2012
    Wydawca:
    Index Copernicus International
    Tematy:
    single nucleotide polymorphism
    MCP-1 gene
    inflammatory bowel disease
    Opis:
    Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances. The aim of the study was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development. Material and methods. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn’s disease) as well as 210 healthy controls. Results. The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn’s disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively). Conclusions. Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 5; 238-241
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of the G/C polymorphism in the 5-untranslated region of the RAD51 gene in breast cancer.
    Autorzy:
    Blasiak, Janusz
    Przybyłowska, Karolina
    Czechowska, Agnieszka
    Zadrożny, Marek
    Pertyński, Tomasz
    Rykała, Jan
    Kołacińska, Agnieszka
    Morawiec, Zbigniew
    Drzewoski, Józef
    Powiązania:
    https://bibliotekanauki.pl/articles/1043672.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    genetic polymorphism
    RAD51 gene
    RFLP-PCR
    breast cancer
    Opis:
    The breast cancer suppressor proteins BRCA1 and BRCA2 interact with RAD51, a protein essential for maintaining genomic stability by playing a central role in homology-dependent recombinational repair of the DNA double-strand breaks. Therefore, genetic variability in the RAD51 gene may contribute to the appearance and/or progression of breast cancer. A single nucleotide polymorphism in the 5'- untranslated region of RAD51 (a G to C substitution at position 135, the G/C polymorphism) is reported to modulate breast cancer risk. We investigated the distribution of genotypes and frequency of alleles of the G/C polymorphism in breast cancer. Tumor tissues were obtained from postmenopausal women with node-negative and node-positive breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The G/C polymorphism was determined by PCR-based MvaI restriction fragment length polymorphism. The distribution of the genotypes of the G/C polymorphism did not differ significantly (P >0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distribution and allele frequencies between node-positive and node-negative patients. There were no significant differences between distributions of the genotypes in subgroups assigned to histological grades according to Scarf-Bloom-Richardson criteria and the distribution predicted by Hardy-Weinberg equilibrium (P >0.05). Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer and so it may not be useful as an independent marker in this disease.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 1; 249-253
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lack of Association Between the 135G/C Rad51 Gene Polymorphism and the Risk of Colorectal Cancer Among Polish Population
    Autorzy:
    Mucha, Bartosz
    Przybyłowska-Sygut, Karolina
    Dziki, Łukasz
    Dziki, Adam
    Sygut, Andrzej
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1396683.pdf
    Data publikacji:
    2012-07-01
    Wydawca:
    Index Copernicus International
    Tematy:
    polymorphism
    135G/C RAD51 gene
    colorectal cancer
    Opis:
    One of the major causes of carcinogenesis is loss of genome stability. RAD51 in process of homologous recombination (HR) played crucial role in maintenance integrity of genome through initiate of DNA double strand breaks repair. Presence of single nucleotide polymorphism (SNP) in RAD51 gene could change the capacity of DNA repair and altered the response to damaging agents. Research on potential impact of genetic variability on development and progression CRC may contribute to setting new genetic markers or/and determined individual susceptibility to CRC.The aim of the study. This study was designed to evaluate the effect of 135 G/C (rs1801320) RAD51 polymorphism located in the 5' untraslated region on the risk and progression of CRC.Material and methods. The subjects consisted of histologically confirmed colorectal cancer (n = 200) and controls (n = 200) with lack of previous history of cancer. The distribution of genotypes was determined by restriction fragment length polymorphism PCR (RFLP - PCR). Statistical analysis was based on multivariate regression model.Results and conclusion. Our study reveal no significance association of 135 G/C RAD51 polymorphism with occurrence and progression of colorectal cancer.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 7; 358-362
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence
    Autorzy:
    Walczak, Anna
    Przybyłowska-Sygut, Karolina
    Sygut, Andrzej
    Cieślak, Adrianna
    Mik, Michał
    Dziki, Łukasz
    Dziki, Adam
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1393280.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    colorectal cancer
    MCP-1
    CCR-2
    single nucleotide polymorphisms
    Opis:
    The aim of the study: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Material and methods: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. Conclusion: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 5; 1-5
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Związek polimorfizmów genów MCP-1 i CCR2 z występowaniem raka jelita grubego
    Autorzy:
    Walczak, Anna
    Przybyłowska-Sygut, Karolina
    Sygut, Andrzej
    Cieślak, Adrianna
    Mik, Michał
    Dziki, Łukasz
    Dziki, Adam
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1393355.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    rak jelita grubego
    MCP-1
    CCR-2
    polimorfizmy pojedynczych nukleotydów
    Opis:
    Cel badania: Oceniono związek pomiędzy występowaniem wariantów dwóch polimorfizmów pojedynczego nukleotydu -2518 A/G MCP-1 oraz 190 G/A CCR2 z rakiem jelita grubego (RJG). Materiał i metody: Do badania włączono pacjentów z różnym stopniem zaawansowania RJG oraz osoby zdrowe. Genotypy oznaczono metodą reakcji łańcuchowej polimerazy – polimorfizmu długości fragmentów restrykcyjnych (RFLP-PCR). Wyniki: Zaobserwowano związek pomiędzy rakiem jelita grubego i genotypem GG polimorfizmu -2518 G/A MCP-1. Nie zaobserwowano natomiast istotnej statystycznie korelacji pomiędzy RJG a polimorfizmem 190 A/G CCR2. Wnioski: Wyniki tego badania potwierdzają hipotezę, że polimorfizm w promotorze genu MCP-1 może przyczyniać się do rozwoju raka jelita grubego.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 5; 1-5
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression of the PLS3 Gene in Circulating Cells in Patients with Colorectal Cancer
    Autorzy:
    Kujawski, Ryszard
    Przybyłowska-Sygut, Karolina
    Mik, Michał
    Lewandowski, Miłosz
    Trzciński, Radzisław
    Berut, Maciej
    Dziki, Łukasz
    Majsterek, Ireneusz
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1395524.pdf
    Data publikacji:
    2015-02-01
    Wydawca:
    Index Copernicus International
    Tematy:
    Plastin-3
    PL S3
    circulating tumor cells
    CTC
    colorectal cancer
    Opis:
    Circulating tumor cells (CTC) are cells in circulating blood that have the antigen and gene features of tumor cells of a specific type. Since they can be potentially used in diagnostics and monitoring of treatment of many tumors, they have been attracting attention of researchers worldwide. Plastin-3 (PL S3) is one of such markers of CTC. The aim of the study was to assess expression of PL S3 in CTC in patients with colorectal cancer, to conduct a statistical analysis and to demonstrate a link between expression of PL S3 and progress of the disease, level of CEA and Ca19-9 markers, gender and age of the patients. Material and methods. A group of 85 patients of the Department of General and Colorectal Surgery of the Medical University in Łódź were enrolled in this study. Circulating tumor cells were isolated from whole blood of patients with colorectal cancer and an analysis of PL S3 gene expression in CTC was conducted. The next step was to conduct a statistical analysis and to demonstrate a link between expression of PL S3 in patients’ CTC and progress of the disease, level of CEA and Ca19-9 markers, gender and age of the patients. Results. PL S3 is a marker which can be potentially used in prediction and monitoring of colorectal cancer. A link between expression of PL S3 in CTC of patients with colorectal cancer and metastasis to lymph nodes has been demonstrated. It may be of key importance how PL S3 could impact the qualification to supplementary cancer treatment in patients with stage II colorectal cancer. A link between expression of PL S3 gene in CTC and gender requires further in-depth studies. It is beyond doubt that PL S3 must be further investigated to determine its role in diagnostics, prediction, treatment and monitoring of treatment of colorectal cancer
    Źródło:
    Polish Journal of Surgery; 2015, 87, 2; 59-64
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-10 z 10

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