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Tytuł:
DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests.
Autorzy:
Palyvoda, Olena
Polańska, Joanna
Wygoda, Andrzej
Rzeszowska-Wolny, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1043662.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ionizing radiation
DNA damage
human lymphocytes
comet assay
head and neck tumors
DNA repair
Opis:
A population study is reported in which the DNA damage induced by γ-radiation (2 Gy) and the kinetics of the subsequent repair were estimated by the comet and micronucleus assays in isolated lymphocytes of 82 healthy donors and patients with head and neck cancer before radiotherapy. The parameters of background and radiation-induced DNA damage, rate of repair, and residual non-repaired damage were measured by comet assay, and the repair kinetics for every donor were computer-fitted to an exponential curve. The level of background DNA damage before irradiation measured by comet assay as well as the level of micronuclei were significantly higher in the head and neck cancer patient group than in the healthy donors, while the parameters of repair were widely scattered in both groups. Cancer patient group contained significantly more individuals, whose irradiated lymphocytes showed high DNA damage, low repair rate and high non-repaired DNA damage level. Lymphocytes of donors belonging to this subgroup showed significantly lower inhibition of cell cycle after irradiation.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 181-190
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
High levels of bulky DNA adducts in human sperm correlate with impaired fertility.
Autorzy:
Horak, Stanisław
Polańska, Joanna
Widłak, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1043666.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
fertility
spermatozoa
human
DNA damage
adducts
32P-postlabelling
Opis:
Progressive decline in fertility and sperm quality has been reported over the last few decades, especially in industrialized nations. It has been proposed that exposure to factors that induce damage in DNA of spermatogenic cells may significantly contribute to impaired fertility. Here, the 32P-postlabelling method was used to analyze the levels of bulky DNA adducts in sperm cells in a group of 179 volunteers, either healthy subjects or patients with an impaired fertility. The levels of DNA adducts were 1.35-fold higher in the infertile group as compared to healthy individuals (P = 0.012). Similarly, a significant negative correlation between the levels of DNA adducts and measures of semen quality (sperm concentration and motility) has been observed (P Ł 0.001). In addition, the levels of bulky DNA adducts in sperm cells positively correlates with amounts of leukocytes in semen, which were significantly higher in semen of infertile subjects.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 197-203
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Calculation of reliable transcript levels of annotated genes on the basis of multiple probe-sets in Affymetrix microarrays
Autorzy:
Jaksik, Roman
Polańska, Joanna
Herok, Robert
Rzeszowska-Wolny, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1040584.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
multiple probe-sets
Affymetrix microarrays
transcript profiles
outlier detection
NucleoDix computer program
Opis:
Microarray methods have become a basic tool in studies of global gene expression and changes in transcript levels. Affymetrix microarrays from the HGU133 series contain multiple probe-sets complementary to the same gene (4742 genes are represented by more than one probe-set in a microarray HGU133A). Individual probe-sets annotated to the same gene often show different hybridization signals and even opposite trends, which may result from some of them matching transcripts of more than one gene and from the existence of different splice-variant transcripts. Existing methods that redefine probe-sets and develop custom probe-set definitions use mathematical tools such as Matlab or the R statistical environment with the Bioconductor package (Gentleman et al., 2004, Genome Biol. 5: 280) and thus are directed to researchers with a good knowledge of bioinformatics. We propose here a new approach based on the principle that a probe-set which hybridizes to more than one transcript can be recognized because it produces a signal significantly different from others assigned to the particular gene, allowing it to be detected as an outlier in the group and eliminated from subsequent analyses. A simple freeware application has been developed (available at www.bioinformatics.aei.polsl.pl) that detects and removes outlying probe-sets and calculates average signal values for individual genes using the latest annotation database provided by Affymetrix. We illustrate this procedure using microarray data from our experiments aiming to study changes of transcription profile induced by ionizing radiation in human cells.
Źródło:
Acta Biochimica Polonica; 2009, 56, 2; 271-277
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polish mother and child cohort study (REPRO_PL) — Methodology of follow-up of the children
Autorzy:
Polańska, Kinga
Hanke, Wojciech
Jurewicz, Joanna
Sobala, Wojciech
Madsen, Christian
Nafstad, Per
Magnus, Per
Powiązania:
https://bibliotekanauki.pl/articles/2185377.pdf
Data publikacji:
2011-12-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
birth cohort
follow-up of children
child’s health
neurodevelopment
Opis:
Background: A prospective cohort study design gives the opportunity for identifi cation, update of different exposures and their verifi cation by biomarker measurements. The aim of The Polish Mother and Child Cohort Study (REPRO_PL) is to evaluate the impact of exposure to different environmental factors during pregnancy and, after birth, on the pregnancy outcome, children’s health and neurodevelopment. Materials and Methods: REPRO_PL cohort was established in 2007. From the cohort of 1300 mother-child pairs, 300 children are followed-up until they are two years old to asses the exposure, health status and neurodevelopment. Children are examined twice: at one and two years of age by a pediatrician and a psychologist/child development specialist. During each visit, detailed questionnaire is conducted with the mothers and supplemented with the information from the medical charts to have appropriate recognition of the child’s health and development. Additionally, the current health status of the child is checked and his/her biometry is performed. A urine sample is collected from each child for the verifi cation of environmental tobacco smoke (ETS) and polycyclic aromatic hydrocarbons (PAH) exposure. Some children have a blood sample collected for the assessment of the lead and cadmium levels. Child’s neurodevelopment is assessed based on Bayley Scales for Infant and Toddler Development (Bayley-III). Results and Conclusions: The results of the study will become available within the next few years and will help to determine the impact of the environmental exposures on children’s health and neurodevelopment. REPRO_PL cohort is a middle-sized cohort, very much focused on specific research questions with the potential for future extension and cooperation.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 4; 391-398
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure to environmental and lifestyle factors and attention-deficit / hyperactivity disorder in children — A review of epidemiological studies
Autorzy:
Polańska, Kinga
Jurewicz, Joanna
Hanke, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2180010.pdf
Data publikacji:
2012-09-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
children
environmental toxicants
attention–defi cit/hyperactivity disorder
inattention
impulsivity
Opis:
Attention-defi cit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children. Although the mechanisms that lead to the development of ADHD remain unclear, genetic and environmental factors have been implicated. These include heavy metals and chemical exposures, nutritional and lifestyle/psychosocial factors. The aim of this review was to investigate the association between ADHD or ADHD-related symptoms and widespread environmental factors such as phthalates, bisphenol A (BPA), tobacco smoke, polycyclic aromatic hydrocarbons (PAHs), polyfl uoroalkyl chemicals (PFCs) and alcohol. Medline, PubMed and Ebsco search was performed to identify the studies which analyze the association of prenatal and postnatal child exposure to environmental toxicants and lifestyle factors and ADHD or ADHD-related symptoms. The review is restricted to human studies published since 2000 in English in peer reviewed journals. Despite much research has been done on the association between environmental risk factors and ADHD or ADHD symptoms, results are not consistent. Most studies in this fi eld, focused on exposure to tobacco smoke, found an association between that exposure and ADHD and ADHD symptoms. On the other hand, the impact of phthalates, BPA, PFCs, PAHs and alcohol is less frequently investigated and does not allow a fi rm conclusion regarding the association with the outcomes of interest.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 330-355
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zagrożenia czynnikami chemicznymi pracowników ochrony zdrowia
Medical institutions personel nad exposition to a chemical risk factors
Autorzy:
Jankowska-Polańska, Beata
Uchmanowicz, Izabella
Rosińczuk-Tonderys, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/470244.pdf
Data publikacji:
2012
Wydawca:
Europejskie Centrum Kształcenia Podyplomowego
Tematy:
czynniki chemiczne
narażenie
personel medyczny
chemical factors
exposure
medical personnel
Opis:
Personel placówek medycznych jest szczególnie narażony na niebezpieczne emisje różnych substancji. Czynniki zagrożeń są określane jako czynniki fizyczne, biologiczne i chemiczne. Czynnik chemiczny spowodowany jest obecnością różnych substancji w związku z anestezją stosowaną w oddziałach szpitalnych, gabinetach zabiegowych, salach operacyjnych i diagnostycznych oraz prowadzoną dekontaminacją wykorzystanego sprzętu medycznego. Celem tej pracy była analiza czynników chemicznych, na które narażony jest personel medyczny.
Personnel of medical institutions is particularly exposed to dangerous emissions of various substances. Risk factors are defined as physical, biological and chemical factors. Chemical factor is caused by presence of various substances in compound with anaesthesia used in hospital department, treatment rooms, operating & diagnostic rooms and conducted decontamination of used medical equipment. The goal of this work was analysis of chemical factors which medical personnel is exposed to.
Źródło:
Współczesne Pielęgniarstwo i Ochrona Zdrowia; 2012, 1; 13-18
2084-4212
Pojawia się w:
Współczesne Pielęgniarstwo i Ochrona Zdrowia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Children’s residential exposure to selected allergens and microbial indicators: endotoxins and (1→3)-β-D-glucans
Autorzy:
Kozajda, Anna
Bródka, Karolina
Sowiak, Małgorzata
Sobala, Wojciech
Polańska, Kinga
Jurewicz, Joanna
Hanke, Wojciech
Szadkowska-Stańczyk, Irena
Powiązania:
https://bibliotekanauki.pl/articles/2179063.pdf
Data publikacji:
2013-12-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
children exposure
residential exposure
allergens
settled dust
endotoxins
glucans
Opis:
Objectives: The study was aimed at assessment of exposure to endotoxins, (1→3)-β-D-glucans and mite, cockroach, cat, dog allergens present in settled dust in premises of children as agents which may be significantly correlated with the occurrence of allergic symptoms and diseases in children. Materials and Methods: The study covered 50 homes of one- or two-year-old children in Poland. Samples of settled dust were taken from the floor and the child's bed. The levels of (1→3)-β-D-glucans (floor), endotoxins (floor) and allergens of mite, cat, dog and cockroach (floor and bed) were analyzed. Results: Average geometric concentrations (geometric standard deviation) of endotoxins, (1→3)-β-D-glucans, Der p1, Fel d1, Can f1 and Bla g1 in children homes were on the floor 42 166.0 EU/g (3.2), 20 478.4 ng/g (2.38), 93.9 ng/g (6.58), 119.8 ng/g (13.0), 288.9 ng/g (3.4), 0.72 U/g (4.4) and in their beds (only allergens) 597.8 ng/g (14.2), 54.1 ng/g (4.4), 158.6 ng/g (3.1) 0.6 U/g (2.9), respectively. When the floor was covered with the carpet, higher concentrations of endotoxins, (1→3)-β-D-glucans and allergens (each type) were found in the settled dust (p < 0.05). The trend was opposite in case of allergens (except dog) analyzed from bed dust and significantly higher concentrations were found in the rooms with smooth floor (p < 0.05). Conclusions: Among the analyzed factors only the type of floor significantly modified both the level of biological indicators and allergens. The results of this study could be the base for verifying a hypothesis that carpeting may have a protective role against high levels of cockroach, dog and cat allergens.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 6; 870-889
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure to widespread environmental toxicants and children’s cognitive development and behavioral problems
Autorzy:
Jurewicz, Joanna
Polańska, Kinga
Hanke, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2179767.pdf
Data publikacji:
2013-04-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
widespread environmental toxicants
children
cognitive development
behavioral problems
Opis:
Nowadays a special attention is focused on prenatal and childhood exposures to a variety of contaminants in the environment, especially toxicants widely present in the environment and their impact on children's health and neurodevelopment. This article aims at evaluating the impact of exposure to several widespread toxicants including: polycyclic aromatic hydrocarbons (PAHs), phthalates, bisphenol A, brominated flame retardants and gas cooking on children's cognitive development and behavioral problems by reviewing most recent published literature. Epidemiological studies focusing on exposure to widespread toxicants and children's development for the last eleven years were identified by a search of the PubMed, Medline, Ebsco and Toxnet literature bases. The combination of following key words was used: 1) referring to the exposure: pregnancy, prenatal exposure, postnatal exposure, gas cooking, exposure to phthalates, bisphenol A, brominated flame retardants, PAHs and 2) referring to outcome: neurodevelopment, neurobehavior, psychomotor development, behavioral problems, cognitive development, mental health, school achievements, learning abilities. The results from the presented studies suggest that there are strong and rather consistent indications that the developing nervous system is particularly vulnerable to insult from low levels of exposure to widespread environmental contaminants such as: phthalates, bisphenol A, brominated flame retardants, polycyclic aromatic hydrocarbons, gas cooking. Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 2; 185-204
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Homicide with a single stab wound
Autorzy:
Stojer-Polańska, Joanna
Konopka, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1879421.pdf
Data publikacji:
2013
Wydawca:
Wyższa Szkoła Bezpieczeństwa Publicznego i Indywidualnego Apeiron w Krakowie
Tematy:
stab wound
homicide
penal law
Opis:
Taking life due to dealing single stab wound is very characteristic kind of crime. In most cases the stabbing takes place during an argument, both victim and the killer are drunk, and the thing happens at home of either of them. The purpose of this article was to examine if the classification of a criminal act, which was initially classified as a “murder”, would maintain as such act within the court decision. In most cases of such type, the killer is accused of homicide, however in half of them, it gets changed to dealing damage or hitting with a deadly result later.
Źródło:
Security Dimensions; 2013, 10(10); 136-145
2353-7000
Pojawia się w:
Security Dimensions
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Review of current evidence on the impact of pesticides, polychlorinated biphenyls and selected metals on attention deficit / hyperactivity disorder in children
Autorzy:
Polańska, Kinga
Jurewicz, Joanna
Hanke, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2179788.pdf
Data publikacji:
2013-03-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
children
chemicals
Attention deficit / hyperactivity disorder
inattention
impulsivity
Opis:
The aim of this review was to investigate the association between attention defi cit / hyperactivity disorder (ADHD) or ADHD- related symptoms and industrial chemicals, such as organophosphates and organochlorine pesticides, polychlorinated biphenyls (PCBs), lead, mercury and manganese. Medline, PubMed and EBSCO searches were performed to identify the studies that analyzed the association of prenatal and postnatal child exposure to such toxicants and ADHD or ADHD-related symptoms. The review is restricted to human studies published in English in peer-reviewed journals since 2000. Most of the presented studies focused on pesticides, PCB and lead. The impact of mercury and manganese was investigated less frequently. The fi ndings indicate that children’s exposure to organophosphate pesticides may cause symptoms consistent with pervasive developmental disorder, ADHD or attention problems. Exposures to organochlorine pesticides and PCBs were associated with ADHD-like behaviors such as alertness, quality of alert response, and cost of attention. The studies provided evidence that blood lead level below 10 μg/dl was associated with ADHD or ADHD-related symptoms. Information on the association between exposure to mercury and neurotoxicity is limited, and requires further confi rmation in future research. Two studies indicated that exposure to manganese is related to ADHD; such exposure and its impact on children neurodevelopment need to be further investigated. Future studies should use a prospective design with multiple biological samples collected over time for better assessment of exposure and its critical windows. Additionally, inclusion of potential confounding factors and co-exposures is crucial.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 1; 16-38
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aktywność zawodowa w czasie ciąży na podstawie badania "Polska Kohorta Matka–Dziecko"
Occupational activity during pregnancy based on the Polish Mother and Child Cohort Study
Autorzy:
Polańska, Kinga
Jurewicz, Joanna
Marcinkiewicz, Andrzej
Makowiec-Dąbrowska, Teresa
Hanke, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2166288.pdf
Data publikacji:
2014-10-28
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
ciąża
aktywność zawodowa
grupy zawodowe
poziom stresu zawodowego
dojazd do pracy
opieka profilaktyczna
pregnancy
working activity
occupational sectors
level of occupational stress
commute for work
preventive care
Opis:
Wstęp: W Polsce powikłania ciąży, porodu i połogu stanowią jedną z najczęstszych przyczyn absencji chorobowej. Celem badania była ocena przebiegu pracy zawodowej kobiet ciężarnych ze szczególnym uwzględnieniem czynników determinujących czasową niezdolność do pracy w czasie ciąży potwierdzoną orzeczeniem lekarskim. Materiał i metody: Podstawę analiz dotyczących aktywności zawodowej w ciąży stanowiło badanie „Polska Kohorta Matka–Dziecko". Analizą objęto dane 954 pracujących kobiet ciężarnych. Z kobietami włączonymi do badania przeprowadzony został wywiad kwestionariuszowy (3-krotnie w czasie trwania ciąży) ze szczególnym uwzględnieniem przebiegu pracy zawodowej oraz oceny poziomu stresu zawodowego na podstawie Kwestionariusza do Subiektywnej Oceny Pracy. Wyniki: Kobiety ciężarne zaprzestawały pracy zawodowej na skutek orzeczenia lekarskiego o czasowej niezdolności do pracy średnio w 16 tygodniu ciąży i nie kontynuowały tej aktywności do końca trwania ciąży. W badanej grupie kobiet zaprzestających zatrudnienia (≤ 12 tygodnia ciąży) na podstawie orzeczenia o czasowej niezdolności do pracy stwierdzono niższy poziom wykształcenia (OR = 2,4; p < 0,001) i gorszy status ekonomiczny (OR = 9,6; p = 0,03). Kobiety te częściej dojeżdżały do pracy komunikacją miejską (OR = 2,7; p < 0,001), dłuższy czas poświęcały na dojazd do pracy (OR = 1,4; p = 0,008) oraz deklarowały wysoki poziom stresu zawodowego (OR = 3,0; p < 0,01). Istotnie częściej orzeczenie lekarskie o czasowej niezdolności do pracy w pierwszym trymestrze ciąży otrzymywały kelnerki (OR = 4,2; p = 0,005), pielęgniarki (OR = 3,3; p = 0,02) oraz osoby pracujące w handlu (OR = 2,3; p < 0,001) w porównaniu z kobietami wykonującymi prace biurowe. Wnioski: Przedstawione dane wskazują na konieczność wypracowania modelu współpracy pomiędzy lekarzem medycyny pracy i ginekologiem oraz większego zaangażowania tego pierwszego w opiekę profilaktyczną nad pracującą kobietą ciężarną. Istotne znaczenie ma również zwiększenie świadomości pracodawców odnośnie do potencjalnych zagrożeń i uciążliwości w miejscu pracy w celu stworzenia warunków pracy bezpiecznych dla przebiegu i wyniku ciąży oraz stanu zdrowia kobiety ciężarnej. Med. Pr. 2014;65(1):65–72
Background: In Poland conditions related to or aggravated by the pregnancy, childbirth or the puerperium are one of the most common causes of sickness absence. The aim of the study was to analyze the occupational activity pattern during pregnancy and to evaluate the determinants of pregnancy-related temporary work disability confirmed by medical certificate. Materials and Methods: The presented analysis is based on data collected under the Polish Mother and Child Cohort Study. The study population consisted of 954 women who reported occupational activity during pregnancy. All women participating in the study were interviewed 3 times during pregnancy. Detail information on occupational activity during pregnancy and occupational stress, based on the Subjective Work Characteristics Questionnaire, was collected from all women. Results: The pregnant women had been issued medical certificate of temporary work disability because of conditions related to or aggravated by the pregnancy, childbirth or by the puerperium at 16 week of gestation on average and did not continue their activities until the end of pregnancy. The statistically significant determinants of receiving such medical certificate in the first trimester of pregnancy (≤ 12 weeks of pregnancy) comprised poor health condition and complications during pregnancy (OR = 1.4; p = 0.01), lower education (OR = 2.4; p < 0.001), socio-economic status (OR = 9.6; p = 0.03), use of public transport to commute to work (OR = 2.7; p < 0.001), a longer work commute (OR = 1.4; p = 0.008) and a higher level of occupational stress (OR = 3.0; p < 0.01). Waitresses, nurses and saleswomen received medical certificate of temporary work disability in the first trimester of pregnancy more frequently than office workers (OR = 4.2; p = 0.005; OR = 3.3; p = 0.02; OR = 2.3; p < 0.001 respectively). Conclusions: It is crucial to develop the model of cooperation between occupational medicine physicians and gynecologists and a greater involvement of the former in the prophylactic care of occupationally active pregnant women. It is also important to increase the employers' awareness of potential risks and arduousness at work to assure working conditions safe for the pregnancy outcome and health of both women and their babies. Med Pr 2014;65(1):65–72
Źródło:
Medycyna Pracy; 2014, 65, 1; 65-72
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification of serum proteome components associated with progression of non-small cell lung cancer
Autorzy:
Pietrowska, Monika
Jelonek, Karol
Michalak, Malwina
Roś, Małgorzata
Rodziewicz, Paweł
Chmielewska, Klaudia
Polański, Krzysztof
Polańska, Joanna
Gdowicz-Kłosok, Agnieszka
Giglok, Monika
Suwiński, Rafał
Tarnawski, Rafał
Dziadziuszko, Rafał
Rzyman, Witold
Widłak, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1039297.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer staging
early detection
lung cancer
proteomics
serum biomarkers
Opis:
The aim of the present study was to perform comparative analysis of serum from patients with different stages of non-small cell lung cancer (NSCLC) using the three complementary proteomic approaches to identify proteome components associated with the progression of cancer. Serum samples were collected before any treatment from 200 patients with NSCLC, including 103 early stage, 64 locally advanced and 33 metastatic cancer samples, and from 200 donors without malignancy. The low-molecular-weight fraction of serum proteome was MALDI-profiled in all samples. Serum proteins were characterized using 2D-PAGE and LC-MS/MS approaches in a representative group of 30 donors. Several significant differences were detected between serum samples collected from patients with early stage cancer and patients with locally advanced cancer, as well as between patients with metastatic cancer and patients with local disease. Of note, serum components discriminating samples from early stage cancer and healthy persons were also detected. In general, about 70 differentiating serum proteins were identified, including inflammatory and acute phase proteins already reported to be associated with the progression of lung cancer (serum amyloid A or haptoglobin). Several differentiating proteins, including apolipoprotein H or apolipoprotein A1, were not previously associated with NSCLC. No significant differences in patterns of serum proteome components were detected between patients with adenocarcinoma and squamous cell carcinoma. In conclusion, we identified the biomarker candidates with potential importance for molecular proteomic staging of NSCLC. Additionally, several serum proteome components revealed their potential applicability in early detection of the lung cancer.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 325-331
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analiza zaawansowania realizacji idei open government data w wybranych krajach
Advancement of implementing open government data in selected countries – an analysis
Autorzy:
Papińska-Kacperek, Joanna
Polańska, Krystyna
Powiązania:
https://bibliotekanauki.pl/articles/1367419.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
open government data
e-government
open data
otwarte dane
Opis:
Celem artykułu jest przybliżenie idei otwartych danych oraz poddanie analizie portali Open Government Data pod względem ich zaawansowania technicznego. Podstawą analizy jest klasyfikacja opracowana przez Timothy’ego Bernersa-Lee, która pozwala określić stopień zaawansowania portalu udostępniającego otwarte dane. Zwrócono także uwagę na koszty utrzymania tego typu portalu oraz spodziewane korzyści z jego uruchomienia. W podsumowaniu wskazano na społeczne efekty otwartości instytucji publicznych na obywateli, a także przedstawiono polskie lokalne inicjatywy w tym zakresie.
The aim of the article is to introduce the idea of open data and to review Open Government Data in terms of their technical advancement. The analysis is done on the basis of classification developed by Timothy Berners-Lee, which allows for specifying the degree of technical sophistication of portals sharing open data. The article also highlights the costs of maintaining this type of portals and expected benefits of their launch. In the summary social effects of openness of public institutions to citizens were indicated and Polish local initiatives in this respect were presented.
Źródło:
Zeszyty Naukowe. Studia Informatica; 2015, 37; 103-114
0867-1753
Pojawia się w:
Zeszyty Naukowe. Studia Informatica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kryminalistyczne aspekty poszukiwania zwłok
Forensic aspects of the search for corpses
Autorzy:
Stojer-Polańska, Joanna
Lisowicz, Marek
Gołębiowski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1374013.pdf
Data publikacji:
2015
Wydawca:
Centralne Laboratorium Kryminalistyczne Policji
Tematy:
poszukiwanie zwłok
zabójstwo
przewodnik psa służbowego
georadar
corpse search
murder
police dog handler
ground-penetrating radar
Opis:
Artykuł poświęcony jest zagadnieniu poszukiwania zwłok ludzkich. Poszukiwania takie prowadzi się w przypadku podejrzenia popełniania zabójstwa, samobójstwa lub też niewyjaśnionego zaginięcia osoby, kiedy z okoliczności sprawy wynika, że osoba najprawdopodobniej nie żyje. Opisane zostały następujące metody poszukiwań: użycie psa specjalistycznego, metoda georadarowa, metoda fosforanowa, metoda sonarowa, metoda wykopów kontrolnych, metody poszukiwań w wodzie. Omówiono zagadnienie profilowania sprawców zabójstw, bowiem sposób postępowania ze zwłokami oraz miejsce ich ukrycia stanowią istotne wskazówki wykrywcze oraz dowodowe. Przedstawione zostały także aspekty związane ze współpracą interdyscyplinarną w przypadku niewyjaśnionych spraw, w których istnieje podejrzenie popełnienia zabójstwa, chociaż nie udało się ujawnić zwłok, takie jak współpraca z profilerem, a także z biegłymi z różnych dziedzin nauki.
This article focuses on the topie of searching for human corpses. Such searches are conducted when murder, suicide or unexplained disappearance is suspected, with the circumstances of the case indicating that the person is probably dead. The following search methods are described: use of a specially trained dog, ground-penetrating radar method, phosphate method, sonar method, test excavation method, water search methods. The profiling of murder perpetrators is also discussed sińce the way the corpse is treated and the site at which it is concealed are valuable tips for the detection and collection of evidence. Presented are also aspects of interdisciplinary cooperation in unexplained cases in which murder is suspected but the corpse has not been discovered, such as cooperation with profiler and experts in different scientific disciplines.
Źródło:
Problemy Kryminalistyki; 2015, 289; 3-10
0552-2153
Pojawia się w:
Problemy Kryminalistyki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Smoking and alcohol drinking during pregnancy as the risk factors for poor child neurodevelopment – A review of epidemiological studies
Autorzy:
Polańska, Kinga
Jurewicz, Joanna
Hanke, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2177372.pdf
Data publikacji:
2015-05-18
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
children
behavior
prenatal smoking
prenatal alcohol
neurodevelopment
Opis:
Maternal active and passive smoking and low or moderate alcohol drinking during pregnancy, taking into account the level of exposure and developmental or behavioral outcomes, are recognized as a significant issue from both a clinical and a public health perspective. The article aims at evaluating the impact of prenatal exposure to tobacco smoke constituents and low or moderate alcohol drinking during pregnancy on children neurodevelopment by reviewing the most recently published literature. Relevant studies were identified by searching the Pubmed, Medline and Ebsco literature databases. This review is restricted to 29 human studies published in English in peer reviewed journals since 2006. The studies published recently continued to show some relationship between tobacco smoke exposure, from active and passive maternal smoking during pregnancy, and children’s psychomotor development independent of other variables, but this relationship is not straightforward. The association is mostly consistent for measures of academic achievements and behavioral problems which require further attention. The results of the studies on low or moderate exposure to alcohol are not fully conclusive, but some of them suggest that consumption of alcohol during pregnancy may adversely affect children’s intelligence quotient (IQ), mental health, memory and verbal or visual performance. As the reviewed studies indicate, maternal lifestyle during pregnancy like alcohol drinking or smoking may affect children neurodevelopment. All effort should be taken to eliminate such exposure to ensure appropriate children’s development.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2015, 28, 3; 419-443
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
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