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    Wyświetlanie 1-8 z 8
    Tytuł:
    Combined effect of flavonoid compounds and cytostatics in cancer treatment
    Autorzy:
    Stompor, Monika
    Podgórski, Rafał
    Kubrak, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/454869.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    flavonoids
    anticancer drugs
    co-delivery system
    cytostatics
    Opis:
    Aim. The aim of the study was to review the literature on the combination of cytostatics with flavonoids as a promising way to improve the cancer therapy. Material and methods. A review of Polish and foreign literature was performed. The following databases were searched: PubMed, Scopus, Science Direct, and Polish Medical Bibliography. Literature analysis. Effective strategies to inhibit the progression of cancer are needed. Compounds of natural origin, including plant polyphenols, are a part of our diet. Due to their availability, and antioxidant properties, they may serve as efficacious adjuvants in cancer therapy, enhancing the effectiveness of chemotherapeutics. Epidemiological studies have shown an inverse relationship between diets rich in fruits, vegetables, and supplements, and the risk of all causes of death from cancer. Based on their diverse biological activity, flavonoids may be potential adjuvant therapeutic agents that act synergistically with cytostatics for treatment of many types of cancer. This review of the results is a summary the research on anticancer activity of flavonoids and may also raise consciousness of consumers, who will be able to compose their diet armed with the knowledge of preventive and therapeutic anticancer properties of food ingredients. There is need for further research on polyphenols of plant origin, including interactions among food components that coexist. Another important aspect is to understand how the activity of phytocompounds depends on concentration and the presence of additional factors (e.g. microflore, metal ions), which could possibly make a compound harmful, instead of having positive theraputics effect. Elucidation of the mechanisms involved in biological activity of the described phytocompounds is essential for a better understanding of their influence on an organism.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 157-164
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Natural and Synthetic Coumarins and their Pharmacological Activity
    Autorzy:
    Kubrak, Tomasz
    Podgórski, Rafał
    Sompor, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/454684.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    coumarins
    antimicrobial agents
    neuroprotection
    natural products in medicine
    Opis:
    Coumarins are a structurally diverse group of natural substances derives from plants that display a host of bioactivities. In this paper, we will introduce the reader to coumarins and their applications as medicinal substances. The great diversity in courmarin structure will be discussed along with their extensive use as pharmaceutical agents. Coumarins display a wide range of antimicrobial activity and applications of coumarins as antifungal and antiviral agents will be addressed. Other properties of coumarins such as their role in neuroprotection, anticancer, and as antioxidants will also be reviewed.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 169-175
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neural tube defects: risk factors and prevention
    Autorzy:
    Podgórski, Rafał
    Stompor, Monika
    Kubrak, Tomasz
    Podgórska, Dominika
    Powiązania:
    https://bibliotekanauki.pl/articles/454902.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    neural tube defects
    NTD
    anencephaly
    spina bifida
    Opis:
    Neural tube defects are abnormalities that can occur in the brain (anencephaly, encephalocele), spine (spina bifida, myelomeningocele, myelodysplasia), both brain and spine (craniorachischisis) or spinal column of a developing embryo that are present at birth. They arise when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. Many cases of neural tube defects occur worldwide each year in more than 300,000 newborn babies and are a significant cause of infant death and lifelong disability. Most neural tube defects are preventable. The prevalence of these abnormalities has decreased in the past 20 to 30 years due to periconceptional folate supplementation, food fortification and decreased exposure to environmental factors. Women who are planning to conceive should be informed about the importance of folic acid in fetal development and encouraged to take 400 μg/day of folic acid supplements. Numerous research studies have shown that taking this dosage of folic acid before and during early pregnancy significantly reduces the risk of neural tube defects. For that reason it is important to increase the awareness of women in childbearing age about the necessity of primary prevention and folate intake which is a strong factor that has wide implications in public health in reducing the mortality and morbidity of offspring.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 151-156
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The potential of Fluorine 19F in in Targeted Therapy
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Podgórski, Rafał
    Leksa, Natalia
    Powiązania:
    https://bibliotekanauki.pl/articles/895641.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    cancer
    drug delivery
    Drug Monitoring
    Fluorine-19
    Opis:
    Fluorine-19 (19F) can provides critical information about the mobility of the drug and drug uptake in cancer tissue when used together with 19F Magnetic Resonance Imaging (19F MRI) in vitro or in vivo. This review is aimed at the current limitations of drugs such as quantitative visualization during treatments of tumor cells. The main rationale about the utility of 19F MRI is visualization of fluorinated drug and fluorine conjugates on the cellular in vitro and in vivo levels.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 939-943
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice
    Autorzy:
    Kubrak, Tomasz
    Podgórski, Rafał
    Aebisher, David
    Gala-Błądzińska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/454694.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    NGAL proteins
    KIM-1 proteins
    acute kidney injury (AKI)
    Opis:
    Introduction. Despite advances in medical care AKI (acute kidney injury) is associated with high morbidity and mortality. The lack of adequate early renal injury biomarkers is often a problem for an early AKI diagnosis. In recent years, numerous scientific studies have been carried out which reveal new urine and serum markers to assess the period of the kidney injury before revealing its late clinical effects. In most clinical settings, AKI is due to acute renal tubular necrosis which results in protein accumulation in urine. Determination of the concentrations of proteins such as NGAL (neutrophil gelatinase-associated lipocalin) and KIM-1 (kidney injury molecule-1) are of great significance in the diagnosis of AKI. Aim. The purpose of the study was to review the literature about significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice. Materials and method. Analysis of Polish and foreign literature.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 28-33
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Congenital adrenal hyperplasia: clinical symptoms and diagnostic methods
    Autorzy:
    Podgórski, Rafał
    Aebisher, David
    Stompor, Monika
    Podgórska, Dominika
    Mazur, Artur
    Powiązania:
    https://bibliotekanauki.pl/articles/1038519.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Congenital Adrenal Hyperplasia
    CAH
    steroidogenesis
    21-hydroxylase deficiency
    Opis:
    The aim of this paper is a straightforward presentation of the steroidogenesis process and the most common type of congenital adrenal hyperplasia (CAH) - 21-hydroxylase deficiency - as well as the analytical diagnostic methods that are used to recognize this disease. CAH is a family of common autosomal recessive disorders characterized by impaired adrenal cortisol biosynthesis with associated androgen excess due to a deficiency of one or more enzymes in the steroidogenesis process within the adrenal cortex. The most common and prototypical example of the CAH disorders group (90-95%) is caused by 21-hydroxylase deficiency. Less frequent types of CAH are 11β-hydroxylase deficiency (up to 8% of cases), 17α-hydroxylase deficiency, 3β-hydroxysteroid dehydrogenase deficiency, P450 oxidoreductase deficiency and StAR deficiencies. In the 21-hydroxylase and 11β-hydroxylase deficiency, only adrenal steroidogenesis is affected, whereas a defect in 3β-hydroxysteroid dehydrogenase or 17α-hydroxylase also involves gonadal steroid biosynthesis. Many countries have introduced newborn screening programs based on immunoassays measuring 17-hydroxyprogesterone from blood spots used for other neonatal screening tests which enable faster diagnosis and treatment of CAH. Currently, chromatographic techniques coupled with mass spectrometry are gaining popularity due to an increase in the reliability of the test results.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 25-33
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and biological evaluation of 4-O-acetyl-isoxanthohumol and its analogues as antioxidant and antiproliferative agents
    Autorzy:
    Stompor, Monika
    Świtalska, Marta
    Podgórski, Rafał
    Uram, Łukasz
    Aebisher, David
    Wietrzyk, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038626.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    O-acylated flavanones
    antiproliferative effect
    isoxanthohumol
    hop flavonoids
    Opis:
    Isoxanthohumol (2) and its 4'-O-monoacylated (3) and 7,4'-O-diacetylated (4) derivatives were synthesized and evaluated in vitro for their cytotoxic activity against several cancer cell lines of various origins: MCF-7 (breast), A549 (lung), MESSA (uterine sarcoma), LoVo (colon), drug-resistant human cancer cells (MESSA/DX and LoVo/DX), glioblastoma (U-118 MG), and also towards the non-cancerous cell line MCF-10A (normal breast cells). An antiproliferative assay indicates that 7,4'-di-O-acylisoxanthohumol (4) has similar cytotoxicity to its precursor, isoxanthohumol (2), against selected cell lines (A549, MES-SA, MES-SA/5DX, and U-118 MG). Compound 4 was only slightly more cytotoxic to lung, colon, breast (cancerous and normal) and uterine sarcoma (drug sensitive and drug resistant) cell lines compared to its monoacylated derivative (3). Both acylated isoxanthohumols showed preferential activity against tumor cells (MCF-7) and low cytotoxicity to normal cells (MCF-10A), which suggests selectivity of the acylated isoxanthohumols towards cancer cells. Additionally, the activity of the acylated isoxanthohumols was higher than for 2. To the best of our knowledge this is the first report on bioactivity of monoacylated isoxanthohumol (3) and its ester derivatives as antiproliferative compounds in drug resistant cell cultures. Acylation of 2 decreased the antioxidant activity determined by the DPPH method in the order isoxanthohumol (2) >4'-O-acetylisoxanthohumol (3) >7,4'-di-O-acetylisoxanthohumol (4).
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 3; 577-583
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Applications of cytisine extraction and detection in biological materials for clinical medicine
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Courtney, Ryan
    Sobczak, Andrzej
    Bober, Zuzanna
    Podgórski, Rafał
    Kołodziejczyk, Patrycjusz
    Tutka, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/895314.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    smoking cessation
    chromatography
    Biomedicine
    cytisine extraction
    biopharmacy
    Opis:
    Tobacco use is a leading cause of preventable mortality worldwide. New cost-effective smoking cessation treatments are needed especially in some low-to-middle income countries where smoking rates are rising, and current pharmacotherapy treatments remain cost-prohibitive. Since the 1960’s, cytisine has been used as an effective nicotine substitution agent to aid in smoking cessation albeit limited to a selected few Eastern/Central Europe and Central Asian countries. Cytisine is a biologically active alkaloid of plant origin and is known to be a ligand of nicotinic acetylcholinergic receptors (nAChRs). For several decades, the properties of cytisine have been investigated and reported in the biomedical and pharmaceutical literature. Due to the beneficial impact of cytisine on smoking cessation and its costly multistep synthesis, there is a growing interest in extraction from natural sources as well as in analytical identification and quantification for clinical medicine and forensic toxicology. In this paper, we present several current analytical approaches to cytisine extraction and identification from biological samples of plant and human origin. The development of extraction techniques will allow for the widespread use of the drug in experimental and clinical pharmacology, toxicology and forensic medicine.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 797-804
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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