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    Wyświetlanie 1-20 z 20
    Tytuł:
    Studies of gentamycin adsorption on chitosan
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035211.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    Gentamycin
    adsorption
    chitosan
    Opis:
    Chitosan as a dietary supplement has been used in the treatment of obesity due to its capability of binding bioactive compounds. A molecule of a cationic polymer, such as chitosan, may bind gentamycin. The aim of the study was to determine the binding capability of Gentamycin by chitosan’s contained in weight-loss supplements. The Gentamycin absorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions including the required level of nutrients. Mean absorption of gentamycin by chitosan ranged from 2,1% to 34,1% depending on the environmental pH. The highest absorption rate was observed at above pH 6,8. Concluding, the studies confirmed that the investigated gentamycin interact with chitosan, what leads to decrease in their amount and affects the bioavailability of the drugs.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 175-179
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Studies of norfloxacin adsorption on chitosan
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035394.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    adsorption
    chitosan
    norfloxacin
    Opis:
    In clinical practice a lot of natural macromolecular compounds which operation is based on assisting weight loss are used in the obesity treatment. These measures swell in the digestive tract and form the polymer gel system, which has the ability to adsorb up to 5 times more lipids relative to its own weight. When using dietary supplements containing chitosan, sometimes it comes to illness and in the therapy other agents such as chemotherapeutics are used. The aim of our study was to determine the binding capacity of chemotherapeutic norfloxacin present in the digestive tract model by chitosans found in slimming medicines, depending on variable physico-chemical factors. Phenomenon of norrfloxacin adsorption was studied by a dynamic pharmaceutical model simulating in vitro conditions. The amount of adsorbed chemotherapeutic agent by chitosan was calculated by the difference in concentrations of study drug before and after sorption. The results of measurements of quantities bounded norfloxacin were used to calculate the average percentage of adsorbed dose. The results show that norfloxacin is adsorbed by the chitosans in the applicable pH ranges, and the binding capacity depends on the pH, viscosity and concentration of chemotherapeutics, as well as the type of chitosan and additional substances in the gastrointestinal tract. The average amount of chemotherapeutic adsorption in the system chitosan-nutrients, depending on the pH ranged from 80 to 98%. The highest number of adsorption points above pH 7. In conclusion, the addition of dietary supplement such as chitosan reduces the amount of administered uniformly chemotherapeutic and simultaneously has a large impact on the bioavailability. The observed dependence may require changes in therapeutic process.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 103-110
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of preparations pharmaceutical salazosulfapiridin depending used food supplements containing chitosan in model “in vitro”
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035432.pdf
    Data publikacji:
    2011
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2011, 16; 139-146
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Studies on adsorption tiamfenicol on chitosans degraded radiation in pharmaceutical in vitro model
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035368.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan; absorption
    tiamphenicol
    Opis:
    Connections of polymers and biopolymers with biologically active compounds are recently the subject of intensive research. Low molecular weight active ingredient combined with a polymer has, in many cases, the modified action. On the other hand, the use of inappropriate polymers can result in incompatibilities drug-polymer. The phenomenon of adsorption of the antibiotic has been studied by the static method in the concentration range generally taken single dose using a pharmaceutical gastrointestinal tract model. The results of measurements bounded drug quantity were used to determine the average percentage of adsorbed dose. The results show that antibiotic tiamphenicol is adsorbed on chitosan in used pH ranges, and the binding ability depends on the variety of chitosan and directly from the environment reaction. It was observed that the average sorption depending on the type of chitosan was within the limit from 82% to 97%.The fact of the lowest adsorption value at pH 6.4 can be explained by chemical properties of chitosan, which shows the load until the pH > 6.7 and the electrostatic adsorption may be exhibit in relation to weak acid medicinal substance. Thus, the specific polymer surface area and its sorption capacity is increased. Based on the above considerations can be stated that between study drug and the polymer an antagonistic interaction exist by involving the adsorption of drugs from this group on chitosan.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 95-102
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigation of fenofibrate solubility in the presence of chitosan
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035391.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    dissolution
    fenofibrate
    solid state
    Opis:
    Fenofibrate is an active substance which is well absorbed from the gastrointestinal tract, but it is characterized by limited solubility. Due to a wide spectrum of its pharmacological activity, it would be beneficial to improve its solubility, and thus increase the drug absorption capability. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions at the drug to polymer ratio of 3:7,5:5,7:3. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 33 to 50 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 79-86
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Technology of preparation and evaluation of ketoprofen-chitosan solid dispersion
    Autorzy:
    Grimling, Bożena
    Szcześniak, Maria
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035182.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    dissolution
    ketoprofen
    molecular weight of the chitosan
    solid state
    Opis:
    The aim of the study was to investigate the effect of chitosan on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in physical mixtures at the drug to polymer ratios of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; the mean amount of dissolved ketoprofen and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multifold increase (33 times) in ketoprofen solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of ketoprofen in the presence of chitosan at the weight ratio 1:9 increased with the decrease of the molecular weight of the chitosan. The results obtained may help to develop new technologies for ketoprofen preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 15-22
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of chitosan in the formulation of methyl cellulose-based hydrogels
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035190.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    methylcellulose
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of this work was to study the properties of methylcellulose hydrogels with supplements containing chitosan and 1% hydrocortisone. Depending on the composition of the substrate, gels are characterised by a variety of pharmaceutical availabilities. Increasing the concentration of chitosan has an influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 139-144
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of the physicochemical factors on dissolution of the substance of class ii bcs from solid dispersions with chitosan
    Autorzy:
    Grimling, Bożena
    Górniak, Agata
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035331.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    different molecular weights of chitosan
    fenofibrate
    solid dispersion prepared solvent evaporation
    solubility
    Opis:
    The BCS class II includes drugs with low solubility and high permeability. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan about average molecular weight in various formulations on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporations at the drug to polymer ratio of 1:9;3:7;5:5. The highest dissolution of fenofibrate, amounting to 72.7%, was observed after 60 minutes from solid dispersions with drug-polymer weight ratio 1:9 in the presence chitosan A and was72 times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. Investigations DSC showed that fenofibrate was remained in crystalline state in solid dispersion.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 157-165
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Studies on adsorption chloramfenicol on chitosans in pharmaceutical “in vitro” model
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Biernat, Paweł
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035338.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    Chloramphenicol
    adsorption
    chitosan
    Opis:
    In clinical practice in the treatment of obesity, uses several natural macromolecular compounds, whose functioning is based on supporting the weight loss. In use of dietary supplements containing chitosan, sometimes reaches the illness and in the treatment, which the other therapeutic agents are chemotherapeutic drugs. The aim of our study was to determine the binding capacity of chloramphenicol chemotherapeutic depending on variable factors physico-chemical properties, present in the intestinal tract model of chitosans present in the drugs. The phenomenon of adsorption of chloramphenicol was examined by a dynamic model simulating the conditions of the pharmaceutical in vitro. the amount of adsorbed chemotherapy. The obtained results show that chloramphenicol is adsorbed by chitosans at pH ranges used, and the binding capacity depends on the pH of the environment and the viscosity and concentration of the chemotherapeutic agent as well as the type of chitosan and the additional substances present in the gastrointestinal tract. The average size of the adsorption system chemotherapeutic chitosan-nutrients depending on the pH of the medium ranged from 22.3 to 100.0%. Maximum number of adsorption points above pH 7 (chitosan precipitated polymer forming the emulsion-gel system).
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 187-191
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of physicochemical properties of solid dispersions of bcs class ii substances with chitosan
    Autorzy:
    Grimling, Bożena
    Górniak, Agata
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035366.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    DSC studies
    chitosan
    dissolution
    fenofibrate
    solid state lyophilisation
    Opis:
    The BCS class II includes drugs with low solubility and high permeability. The substances require modification to increase their solubility in the upper part of the digestive system. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation by means of freeze-drying at the drug to polymer ratio of 3:7,5:5,7:3. The study revealed a multi-fold increase (from 33 to 57 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. DSC examination revealed a possible physical interaction between the drug and the polymer. The degree of lowering of temperature and increased heat effects is correlated with increased solubility of the drug in all the formulations. DSC studies confirmed that fenofibrate is present in solid dispersions in a crystalline form.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 87-94
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of substrate composition on the physicochemical properties of hydrogels with chitosan
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1034687.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    Carbopl 934P
    PVP
    chitosane
    hydrogels
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene glycol-1,2 or polyethyleneglycol 400 and glycerol. Addition of polymers had positive influence on the dispersion of hydrogels. The studied gels have thixotropic properties, their viscosity increases with the increase of the concentration of polymers. Increase of the content of polyvinylpyrrolidone K 90 and Carbopol 934 P increases the consistence, gels are more firm and cohesive. Gels with 5 % chitosane, 15% polyvinylpyrrolidone K 90 and Carbopol 934 P in the presence of additives have prolonged half release period of hydrocortisone.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 187-191
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of chitosan on the rheological properties of hydrogels based on sodium carboxymethylcellulose
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Pluta, Janusz
    Meler, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1034876.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    pharmaceutical availability
    rheological parameters
    sodium carboxymethylcellulose
    Opis:
    The aim of the study was to evaluate the effect of changing the concentrations of chitosan on the rheological properties of the obtained formulation. Hydrogels were prepared with 1% hydrocortisone containing 4% sodium carboxymethylcellulose with the addition of chitosan, propylene glycol-1,2 or polyethylene glycol 400 and glycerol or paraffin. The concentration of chitosan and excipients affects the rheological properties of gels and the pharmaceutical availability of hydrocortisone. Increasing the concentration of chitosan have influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 254-259
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adsorption studies of ketoconazole with chitosan
    Autorzy:
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz
    Grimling, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1035196.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    absorption
    chitosan
    ketokonazol
    Opis:
    Combinations of polymers and biopolymers of biologically active compounds in the last period have been the subject of intensive research. The active substance linked to a polymer often has a modified function and sometimes no action. On the other hand, the use of unsuitable polymers may result in a type of mismatch of drug-polymer. The aim of the study was to examine whether the active substance ketoconazole causes incompatibility with dietary supplements containing chitosan. Antifungal drug adsorption phenomenon was investigated by the static method in the concentration range of the single dose using a pharmaceutical model of the gastrointestinal tract. The test results show that the antifungal agent is adsorbed onto the chitosan in the pH ranges used, and the binding ability of the chitosan depends on the variety, or indirectly from the reaction environment. It was observed that the average sorption, depending on the variety of chitosan, was located in the limit from 94% to 100%. The increase of the size of the adsorption of anti-inflammatory drugs on the polymer with increasing pH from 7.6 to 8.0 can be explained by the swelling properties of chitosan, which grow with increasing pH of the environment in the direction of alkaline pH. Thus, the specific surface area and polymer sorption capacity is increased. Based on the above considerations, it can be concluded that, between the test drug and the polymer, there is antagonistic interaction involving the adsorption of the drug of this group on a polymer which is chitosan.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 111-117
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigation of fenofibrate dissolution rate incorporated on solid dispersions into chitosan
    Autorzy:
    Grimling, Bożena
    Szcześniak, Maria
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035351.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    dissolution
    fenofibrate
    molecular weight of the chitosan
    solid state
    Opis:
    The aim of the study was to investigate the effect of chitosan on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in physical mixtures at the drug to polymer ratio of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 13 to 70 times) in fenofibrate solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of fenofibrate in the presence of chitosan at the weight ratio 1:9 increased with the increment of the molecular weight of the chitosan. The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 149-156
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The investigation of physicochemical properties of the solid dispersions in the presence polymeric carrier- chitosan
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1035561.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    DSC
    IR studies
    chitosan
    fenofibrate
    physical mixtures
    saturation solubility
    solid dispersions
    Opis:
    The BCS class II includes drugs with low solubility and high permeability.. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the saturation solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation and physical mixtures at the drug to polymer ratio of 1:9,3:7,5:5.Solid dispersion of fenofibrate containing different ratio of medium and high molecular weight chitosan showed high saturation solubility compared to pure sample of drug. IR spectroscopy reveals that there was no chemical interaction between drug and the polymer. DSC studies showed that there is no change in the crystal structure of drug during the solid dispersion technique. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 167-173
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The adsorption of simvastatin on chitosans in an in vitro pharmaceutical model
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Szcześniak, Maria
    Pluta, Janusz
    Biernat, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1034541.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    adsorption
    chitosan
    simvastatin
    Opis:
    In clinical practice for the treatment of obesity, several natural macromolecular compounds are used, whose operation is based on supporting weight loss. During the use of dietary supplements containing chitosan, disease sometimes occurs and treatment for this often comprises different therapeutic agents and antibiotics. The aim of our study was to determine the binding capacity of simvastatin to chitosan, which is found in dietary supplements promoting weight loss, depending on variable physicochemical factors in the gastrointestinal tract model. The phenomenon of adsorption of simvastatin was investigated by a static and dynamic pharmaceutical model (according to the Modified method of Polish Pharmacopoeia IX) simulating the conditions in vitro. The amount of bound drug is used to calculate the average percentage of the adsorbed dose. The obtained results showed that simvastatin is adsorbed by chitosan in the used pH ranges, and the binding capacity is dependent on the environmental pH, viscosity, the concentration of the drug, the type of chitosan and additional substances present in the gastrointestinal tract. The average adsorption of simvastatin in the system of chitosan-nutrients, depending on the pH of the medium, was in the range of 27 to 95%. The highest amount of adsorption was noted above pH 7 (chitosan precipitated polymer forming the emulsion-gel system), when the bioavailability of dietary supplement using chitosan was almost zero.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 151-158
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The study of physicochemical properties of solid dispersions of ibuprofen in the presence of chitosan
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034797.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    dissolution
    ibuprofen
    solid dispersion
    Opis:
    The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 64-72
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physicochemical characterization and dissolution studies of solid dispersions of clotrimazole with chitosan
    Autorzy:
    Grimling, Bożena
    Jasińska, Justyna
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz M.
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034642.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    FTIR
    XRPD
    chitosan
    clotrimazole
    solid dispersion
    Opis:
    The aim of the present study was to increase the solubility of clotrimazole. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Clotrimazole was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of clotrimazole and chitosan (1:9, 3:7, 5:5, 7:3, 9:1). Formulations were tested dissolution rate of the drug. The highest dissolution of clotrimazole, amounting to 47.95%, was observed after 60 minutes from solid dispersion prepared by grinding method and 42.84% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 37-fold. XRPD analysis indicates the presence of the clotrimazole in crystalline form in the solid dispersion obtained by kneading method.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 63-72
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Uniwersytet przedsiębiorczy – herezja czy nowa orientacja uczelni?
    Entrepreneurial university – heresy or new orientation of university
    Autorzy:
    Olearnik, Janusz
    Pluta-Olearnik, Mirosława
    Powiązania:
    https://bibliotekanauki.pl/articles/1198438.pdf
    Data publikacji:
    2016-12-19
    Wydawca:
    Akademia Ignatianum w Krakowie
    Tematy:
    uniwersytet
    przedsiębiorczość
    uniwersytet przedsiębiorczy
    university
    entrepreneurship
    entrepreneurial university
    Opis:
    CEL NAUKOWY: Celem artykułu jest dokonanie identyfikacji możliwych postaw i działań uczelni, które odzwierciedlałyby ich reorientację w kierunku idei uniwersytetu przedsiębiorczego. PROBLEM I METODY BADAWCZE: W artykule konfrontujemy założenia uniwersytetu przedsiębiorczego z mocno ugruntowanymi koncepcjami konserwatywnymi. Główny problem to poszukiwanie odpowiedzi na pytanie: w jakim stopniu i w jakich obszarach problemowych idea uniwersytetu przedsiębiorczego może wyznaczyć nowe kierunki rozwoju polskich uczelni? Fundamentem teoretycznym są wykonane studia literaturowe, które objęły prace krajowe i zagraniczne, a część empiryczna artykułu bazuje na przeprowadzonych badaniach empirycznych przedsiębiorczości polskich uczelni oraz wieloletniej obserwacji uczestniczącej środowiska akademickiego w Polsce. PROCES WYWODU: Pokazano powstanie i założenia koncepcji uniwersytetu przedsiębiorczego pozostającej w opozycji do idei klasycznej (humboldtowskiej), następnie zaprezentowano własną propozycję atrybutów uniwersytetu, które pozwoliłyby określić go mianem „przedsiębiorczego”, dalej – na podstawie badań empirycznych – sformułowano skrótową ocenę polskich uczelni na tle modelu uniwersytetu przedsiębiorczego, aby w finale dokonać syntetycznego porównania cech uniwersytetu tradycyjnego i uniwersytetu przedsiębiorczego. WYNIKI ANALIZY NAUKOWEJ: Wynikiem badań jest opracowanie atrybutów przedsiębiorczości uniwersytetu, a następnie zestawienie cech przypisywanych koncepcjom uniwersytetu tradycyjnego oraz uniwersytetu przedsiębiorczego. W konkluzji stwierdzono, iż współczesne uniwersytety będą tworzyć modele mieszane, łączące tradycyjne role i wartości z cechami uniwersytetu przedsiębiorczego. WNIOSKI, INNOWACJE, REKOMENDACJE: Wnioski wskazują praktyczne warunki reorientacji polskich uczelni w kierunku modelu uniwersytetu przedsiębiorczego, sugerują obszary, w których idea uniwersytetu przedsiębiorczego może wyznaczyć nowe kierunki rozwoju polskich uczelni.
    The aim The aim of the article is to identify possible attitudes and activities of schools that reflect their reorientation towards the idea of an entrepreneurial university.Problem and research methodsIn this article we confront assumptions entrepreneurial university with well-established conservative concepts. The main problem is the search question: to what extent and in what areas, the idea of the entrepreneurial university may set new directions of development of Polish universities? The article is based on theoretical literature studies, which include domestic and foreign works, and studies based on field research of Polish universities and long-term participant observation academic community in Poland. ConsiderationWe show the main principles of the concept of entrepreneurial university, then we present our own proposal of the entrepreneurial university attributes, further, on the basis of empirical research – we describe several features of polish universities in context of model of entrepreneurial university, finally we compare features of models of traditional universities and entrepreneurial university.The results of the scientific analysisThe result of the research contains characteristics attributed to traditional and entrepreneurial university, and the assumption that modern universities will create mixed models that combine traditional roles and values of the features university entrepreneurial. ConclusionsFinally we indicate to what extent and in what areas, the idea of the entrepreneurial university may set new directions for development of Polish universities.
    Źródło:
    Horyzonty Wychowania; 2016, 15, 35; 55-71
    1643-9171
    2391-9485
    Pojawia się w:
    Horyzonty Wychowania
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Entrepreneurial University – from Ideas to Reality
    Autorzy:
    Olearnik, Janusz
    Pluta-Olearnik, Mirosława
    Powiązania:
    https://bibliotekanauki.pl/articles/429541.pdf
    Data publikacji:
    2015
    Wydawca:
    Uniwersytet w Białymstoku. Wydawnictwo Uniwersytetu w Białymstoku
    Tematy:
    academic entrepreneurship
    entrepreneurial university
    entrepreneurial attributes
    Opis:
    The aim of this study is to formulate and highlight the thesis on reasonability and capability of applying such attitudes and pursuing such activities in the practical operation of institutions of higher education that reflect the idea of the entrepreneurial university which has become prominent nowadays. The idea is described in brief and its present status is indicated here. The authors are seeking conditions for the practical implementation of this idea. They formulate four attributes of the entrepreneurial university, naming them economic, market, innovative and managerial orientations. They point to specific criteria of identifying each of the orientations. They present the general assessment of entrepreneurship of Polish institutions of higher education. Their conclusions highlight the most topical conditions for implementing the idea of entrepreneurial university, such as: building the economic strength and market position of the university, developing relations with the socioeconomic environment, internationalisation and innovativeness. The authors give support to the idea of the entrepreneurial university but – by examining the Polish reality – they notice the need for actions in the sphere of law, which regulates the university’s capabilities to act, and point to the need for entrepreneurship-oriented transformations of lawyers and university management staff’s awareness.
    Źródło:
    Optimum. Economic Studies; 2015, 5(77)
    1506-7637
    Pojawia się w:
    Optimum. Economic Studies
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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