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    Wyświetlanie 1-3 z 3
    Tytuł:
    Próba oceny efektywności polityki zagranicznej i bezpieczeństwa Unii Europejskiej
    Effectiveness of EU Foreign and Security Policies: an Attempt at Assessment
    Autorzy:
    Plata, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/16035448.pdf
    Data publikacji:
    2018-06-15
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Tematy:
    Common Foreign and Security Policy
    European Union
    Joint Investigation Teams
    EuroMaidan
    Opis:
    This paper aims to demonstrate the ineptitude of the European Union in implementing action to ensure security of the member states and, in consequence, pursuing effective foreign policy towards states which are indirectly involved in the relationships within the European region. The author argues the proposition through confrontation and interpretation of knowledge conveyed in expert sources.
    Źródło:
    Studia Europaea Gnesnensia; 2018, 17; 195-204
    2082-5951
    Pojawia się w:
    Studia Europaea Gnesnensia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association between uridin diphosphate glucuronosylotransferase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia
    Autorzy:
    Mazur-Kominek, Katarzyna
    Romanowski, Tomasz
    Bielawski, Krzysztof
    Kiełbratowska, Bogumiła
    Preis, Krzysztof
    Domżalska-Popadiuk, Iwona
    Słomińska-Frączek, Magdalena
    Sznurkowska, Katarzyna
    Renke, Joanna
    Plata-Nazar, Katarzyna
    Śledzińska, Karolina
    Sikorska-Wiśniewska, Grażyna
    Góra-Gębka, Magdalena
    Liberek, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038662.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    UGT1A1 gene
    polymorphism
    hyperbilirubinemia
    neonates
    Opis:
    Objective: To assess the prevalence of UGT1A1*28 and UGT1A1*60 polymorphisms of UGT1A1 gene and their association with hyperbilirubinemia. Study design: The study was performed at a single centre - at the Department of Obstetrics of the Medical University of Gdansk in Poland. DNA was isolated from Guthrie cards of 171 infants. Only full term newborns (gestational age 38-42 weeks) were included in the study. Fluorescent molecular probes were used for UGT1A1 promoter variation analysis. The presence of UGT1A1*28 polymorphism was detected with a dual-probe system, and UGT1A1*60 with a SimpleProbe™. Result: Homozygous UGT1A1*28 and UGT1A1*60 genotypes were detected in 14.6% and 20.5% of the newborns, respectively. Homozygous (G/G) genotypes of UGT1A1*60 polymorphism were found in all of the UGT1A1*28 (i.e. (TA)7/(TA)7) homozygotes. More than 80% (55/66) of the children with "wild" type UGT1A1*28 genotype (where no polymorphism was detected) (i.e. (TA)6/(TA)6) carried the "wild" (T/T) genotype of UGT1A1*60 as well. The UGT1A1*28 polymorphism was detected more often among neonates with elevated bilirubin. Hyperbilirubinemia was diagnosed more frequently in boys. Conclusion: Polymorphisms of the UGT1A1 gene frequently co-exist in neonates. The presence of UGT1A1*28 polymorphism and male gender seem to predispose to neonatal hyperbilirubinemia.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 2; 351-356
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical parameters of inflammatory bowel disease in children do not correlate with four common polymorphisms of the transforming growth factor β1 gene
    Autorzy:
    Liberek, Anna
    Jakóbkiewicz-Banecka, Joanna
    Kloska, Anna
    Świderska, Joanna
    Kmieć, Zbigniew
    Łuczak, Grażyna
    Wierzbicki, Piotr
    Liberek, Tomasz
    Marek, Krzysztof
    Plata-Nazar, Katarzyna
    Sikorska-Wiśniewska, Grażyna
    Kamińska, Barbara
    Węgrzyn, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039871.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    pediatric patients
    gene polymorphism
    Transforming growth factor β1
    inflammatory bowel disease
    Opis:
    Transforming growth factor β1 (TGF-β1) is a cytokine affecting cell proliferation and development, which also has an immunomodulatory activity. Correlations between polymorphisms of the TGF-β1 gene and clinical parameters of inflammatory bowel disease (IBD) were reported previously in adults. Here, we tested whether such correlations occur in pediatric patients suffering from IBD. One hundred and four pediatric IBD patients were involved in this study. Among them, 36 were diagnosed with Crohn's Disease (CD) and 68 were diagnosed with ulcerative colitis (UC). The control group consisted of 103 children, in which IBD was excluded. TGF-β1 levels were determined in plasma and intestinal mucosa samples. The presence of the TGF β1 protein and the amount of TGF β1 mRNA were estimated in intestinal mucosa by immunohistochemistry and reverse transcription Real-Time PCR, respectively. Four common polymorphisms of the TGF-β1 gene were investigated: -800G/A, -509C/T, 869T/C and 915G/C. No significant correlation between TGF-β1 genotypes and (i) TGF-β1 levels in plasma and tissue samples, (ii) TGF-β1 gene expression efficiency in intestinal mucosa, (iii) IBD clinical parameters and (iv) inflammatory activity could be detected in children suffering from IBD. We conclude that, contrary to previous suggestions, the four common polymorphisms of the TGF-β1 gene do not influence the susceptibility to or clinical parameters of IBD in the tested population of children.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 4; 641-644
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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