- Tytuł:
-
Reakcja Niementowskiego
The Niementowski reaction - Autorzy:
-
Łysakowska, M.
Piotrowska, D. G. - Powiązania:
- https://bibliotekanauki.pl/articles/172007.pdf
- Data publikacji:
- 2015
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
reakcja Niementowskiego
chinolina
chinazolina
chinazolin-4-on
kwas antranilowy
Niementowski reaction
quinoline
quinazoline
quinazolin-4-one
anthranilic acid - Opis:
- The Niementowski reaction depends on the fusion of anthranilic acid with carbonyl compounds or amides and dates back to the end of the nineteenth century. Numerous variations of the reaction components and modifications of the reaction conditions have appeared in the literature through years. Besides anthranilic acid other synthons including: methyl o-aminobenzoate [25], o-nitrobenzoic acid [26], o-acylaminobenzamide [21], o-aminobenzamide [27], o-aminobenzonitrile [28], isatoic anhydride [29], benzoxasinone [30, 31] have been employed as well. Replacement of the amide component with either amine [9, 32], nitrile [33], imidate [34], thioamide [35], amidine [36], aldehyde [37] or carboxylic acid [28] have also been reported. To increase yield and to reduce the reaction time a number of variables in reaction conditions have been investigated. The best results have been achieved by implementation of a microwave irradiation [38]. The Niementowski reaction and its variants have found widespread use in pharmaceutical and agrochemical fields for the synthesis of compounds containing quinoline and quinazoline systems which are present in a number of natural and synthetic alkaloids [12, 13] and many drugs [1–5].
- Źródło:
-
Wiadomości Chemiczne; 2015, 69, 5-6; 369-390
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł