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    Wyświetlanie 1-11 z 11
    Tytuł:
    Influence of selected factors on peak nasal inspiratory flow readings – Epidemiology of Allergic Diseases in Poland study
    Autorzy:
    Krzych-Fałta, Edyta
    Furmańczyk, Konrad
    Piekarska, Barbara
    Sybilski, Adam
    Samoliński, Bolesław
    Powiązania:
    https://bibliotekanauki.pl/articles/1398470.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    peak nasal inspiratory flow
    nasal patency
    parameters affecting peak nasal inspiratory flow
    Opis:
    The aim of this study was to investigate the effect of selected factors/parameters on peak nasal inspiratory flow (PNIF) in the Polish population as part of the Epidemiology of Allergic Diseases in Poland study. Material/methods: The popu¬lation of this study comprised of a group of children aged 6–7 years (n=1123), adolescents aged 13–14 years (n=1136), and adults (n=1876) – all residents of seven large Polish cities. Method – measurement of PNIF. The effect of selected param¬eters on PNIF was measured with translated and validated questionnaires developed for international studies ECRHS II (European Community Respiratory Health Survey II) and ISAAC (International Study of Asthma and Allergies in Child¬hood). Results: Indoor environmental factors including heating with coal, wood or gas significantly increase nasal con¬gestion. In the group of passive smokers, PNIF was lower than in the group of active smokers. PNIF rate decreased with the number of smokers per household. Conclusions: Peak nasal inspiratory flow values were significantly affected by such parameters as selected household environmental factors.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 1; 40-44
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ wybranych czynników środowiskowych na maksymalny przepływ nosowy wdechowy – część projektu ECAP (Epidemiologia Chorób Alergicznych w Polsce)
    Autorzy:
    Krzych-Fałta, Edyta
    Furmańczyk, Konrad
    Piekarska, Barbara
    Sybilski, Adam
    Samoliński, Bolesław
    Powiązania:
    https://bibliotekanauki.pl/articles/1398475.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    maksymalny przepływ nosowy wdechowy
    przepływ nosowy
    parametry modelujące maksymalny przepływ nosowy wdechowy
    Opis:
    Celem niniejszej pracy była próba określenia wpływu wybranych czynników/parametrów na wynik maksymalnego przepływu nosowego wdechowego (PNIF, ang. peak nasal inspiratory flow) w badanej populacji polskiej projektu Epidemiologia Chorób Alergicznych w Polsce (ECAP). Materiał/metody: Badaną populację stanowiła grupa dzieci w wieku 6–7 lat (n=1123), młodzieży w wieku 13–14 lat (n=1136) oraz dorosłych (n=1876) zamieszkałych w siedmiu dużych polskich miastach. W badaniu posłużono się pomiarem maksymalnego przepływu nosowego wdechowego (PNIF). Do oceny wpływu wybranych czynników na wartości PNIF wykorzystano przetłumaczone i walidowane kwestionariusze opracowane na potrzeby światowych badań ECRHS II (European Community Respiratory Health Survey II) i ISAAC (International Study of Asthma and Allergies in Childhood). Wyniki: Określone warunki wewnątrz gospodarstwa domowego, m.in. ogrzewanie węglem, drewnem lub piecem gazowym, istotnie zwiększają przekrwienie błony śluzowej nosa. W grupie biernych palaczy PNIF był niższy niż w grupie czynnych palaczy. Wskaźnik PNIF malał wraz ze wzrostem liczby domowników palących papierosy. Wnioski: Wybrane czynniki środowiska
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 1; 40-44
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Supramolecularity creates nonstandard protein ligands
    Autorzy:
    Piekarska, Barbara
    Rybarska, Janina
    Stopa, Barbara
    Zemanek, Grzegorz
    Król, Marcin
    Roterman, Irena
    Konieczny, Leszek
    Powiązania:
    https://bibliotekanauki.pl/articles/1044440.pdf
    Data publikacji:
    1999
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immunological signal
    supramolecularity
    Congo red
    IgG
    Opis:
    Congo red and a group of structurally related dyes long used to stain amyloid proteins are known to associate in water solutions. The self-association of some dyes belonging to this group appears particularly strong. In water solutions their molecules are arranged in ribbon-like micellar forms with liquid crystalline properties. These compounds have recently been found to form complexeswith some native proteins in a non-standard way. Gaps formed by the local distribution of β-sheets in proteins probably represent the receptor sites for these dye ligands. They may result from higher structural instability in unfolding conditions, but also may appear as long range cooperative fluctuations generated by ligand binding. Immunoglobulins G were chosen as model binding proteins to check the mechanism of binding of these dyes. The sites of structural changes generated by antigen binding in antibodies, believed to act as a signal propagated to distant parts of the molecule, were assumed to be suitable sites for the complexation of liquid-crystalline dyes. This assumption was confirmed by proving that antibodies engaged in immune complexation really do bind these dyes; as expected, this binding affects their function by significantly enhancing antigen binding and simultaneously inhibiting C1q attachment. Binding of these supramolecular dyes by some other native proteins including serpins and their natural complexes was also shown. The strict dependence of the ligation properties on strong self-assembling and the particular arrangement of dye molecules indicate that supramolecularity is the feature that creates non-standard protein ligands, with potential uses in medicine and experimental science.
    Źródło:
    Acta Biochimica Polonica; 1999, 46, 4; 841-851
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The structure and protein binding of amyloid-specific dye reagents.
    Autorzy:
    Stopa, Barbara
    Piekarska, Barbara
    Konieczny, Leszek
    Rybarska, Janina
    Spólnik, Paweł
    Zemanek, Grzegorz
    Roterman, Irena
    Król, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/1043414.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    dye-protein complexation
    supramolecularity
    immunoglobulin light chain
    amyloid
    Congo red
    Opis:
    The self-assembling tendency and protein complexation capability of dyes related to Congo red and also some dyes of different structure were compared to explain the mechanism of Congo red binding and the reason for its specific affinity for β-structure. Complexation with proteins was measured directly and expressed as the number of dye molecules bound to heat-aggregated IgG and to two light chains with different structural stability. Binding of dyes to rabbit antibodies was measured indirectly as the enhancement effect of the dye on immune complex formation. Self-assembling was tested using dynamic light scattering to measure the size of the supramolecular assemblies. In general the results show that the supramolecular form of a dye is the main factor determining its complexation capability. Dyes that in their compact supramolecular organization are ribbon-shaped may adhere to polypeptides of β-conformation due to the architectural compatibility in this unique structural form. The optimal fit in complexation seems to depend on two contradictory factors involving, on the one hand, the compactness of the non-covalently stabilized supramolecular ligand, and the dynamic character producing its plasticity on the other. As a result, the highest protein binding capability is shown by dyes with a moderate self-assembling tendency, while those arranging into either very rigid or very unstable supramolecular entities are less able to bind.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 4; 1213-1227
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of selected aspects of the hygiene hypothesis and their effect on the incidence of allergy
    Autorzy:
    Krzych-Fałta, Edyta
    Wojas, Oksana
    Furmańczyk, Konrad
    Dziewa-Dawidczyk, Diana
    Piekarska, Barbara
    Samoliński, Bolesław
    Sybilski, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/2188907.pdf
    Data publikacji:
    2023
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    asthma
    allergy
    allergic rhinitis
    hygiene hypothesis
    European Community Respiratory Health Survey II
    International Study of Asthma and Allergies in Childhood
    Opis:
    Objectives The development of allergic conditions is largely dependent on the interactions between genetic (individual genetic predisposition) and environmental factors (exposure to risk factors). The aim of this study was an attempt to assess the influence of selected elements of the hygiene theory in the development of allergic diseases such as allergic rhinitis and asthma. Material and Methods The study group consisted of 5518 women and 3868 men. The method that was used was the European Community Respiratory Health Survey II and International Study of Asthma and Allergies in Childhood questionnaire validated and adapted to Central and Eastern European conditions. The project was conducted in 8 urban areas (Gdańsk, Wrocław, Poznań, Katowice, Kraków, Lublin, Białystok, Warsaw) and 1 rural area (Krasnystaw county). This study had 2 stages; the first stage involved grouping the 22 500 respondents based on their questionnaire responses with the use of a Personal Digital Assistant (PDA); the second stage involved 7000 subjects, who underwent additional assessments: skin prick tests (birch, grasses/cereals, Dermatophagoides pteronyssinus and Dermatophagoides farinae, molds [set I: Botrytis cinerea, Cladosporium herbarum, Alternaria tenuis, Curvularia lunata, Fusarium moniliforme, Helminthosporium], molds [set II: Aspergillus fumigatus, Mucor mucedo, Penicillium notatum, Pullularia pullulans, Rhizopus nigricans, Serpula lacrymans], cat, dog, molds Cladosporium herbarum, Alternaria tenuis) and spirometry tests. Results The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05).The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05). Conclusions The hygiene theory is particularly applicable and can explain the relationship of selected habits in the development of allergic diseases.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2023, 36, 1; 69-83
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of selected aspects of the hygiene hypothesis and their effect on the incidence of allergy
    Autorzy:
    Krzych-Fałta, Edyta
    Wojas, Oksana
    Furmańczyk, Konrad
    Dziewa-Dawidczyk, Diana
    Piekarska, Barbara
    Samoliński, Bolesław
    Sybilski, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/2203019.pdf
    Data publikacji:
    2023-03-02
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    asthma
    allergy
    allergic rhinitis
    hygiene hypothesis
    European Community Respiratory Health Survey II
    International Study of Asthma and Allergies in Childhood
    Opis:
    Objectives The development of allergic conditions is largely dependent on the interactions between genetic (individual genetic predisposition) and environmental factors (exposure to risk factors). The aim of this study was an attempt to assess the influence of selected elements of the hygiene theory in the development of allergic diseases such as allergic rhinitis and asthma. Material and Methods The study group consisted of 5518 women and 3868 men. The method that was used was the European Community Respiratory Health Survey II and International Study of Asthma and Allergies in Childhood questionnaire validated and adapted to Central and Eastern European conditions. The project was conducted in 8 urban areas (Gdańsk, Wrocław, Poznań, Katowice, Kraków, Lublin, Białystok, Warsaw) and 1 rural area (Krasnystaw county). This study had 2 stages; the first stage involved grouping the 22 500 respondents based on their questionnaire responses with the use of a Personal Digital Assistant (PDA); the second stage involved 7000 subjects, who underwent additional assessments: skin prick tests (birch, grasses/cereals, Dermatophagoides pteronyssinus and Dermatophagoides farinae, molds [set I: Botrytis cinerea, Cladosporium herbarum, Alternaria tenuis, Curvularia lunata, Fusarium moniliforme, Helminthosporium], molds [set II: Aspergillus fumigatus, Mucor mucedo, Penicillium notatum, Pullularia pullulans, Rhizopus nigricans, Serpula lacrymans], cat, dog, molds Cladosporium herbarum, Alternaria tenuis) and spirometry tests. Results The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05).The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05). Conclusions The hygiene theory is particularly applicable and can explain the relationship of selected habits in the development of allergic diseases. Int J Occup Med Environ Health. 2023;36(1):69–83
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2023, 36, 1; 69-83
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nasal patency in Poles in the light of research as part of the project on Epidemiology of Allergic Diseases in Poland
    Autorzy:
    Krzych-Fałta, Edyta
    Furmanczyk, Konrad
    Samolinski, Bolesław
    Piekarska, Barbara
    Samel-Kowalik, Piotr
    Lipiec, Agnieszka
    Raciborski, Filip
    Sybilski, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/989279.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    peak nasal inspiratory flow
    nasal patency
    Opis:
    Objective. The aim of this study was to estimate the reference values for nasal inspiratory flow in the study population in Poland as part of the project on Epidemiology of Allergic Diseases in Poland (ECAP). Materials and method. The study subjects were a group of 4,137 people: 1,136 children aged 6–7 years (561 girls and 575 boys), 1,123 adolescents aged 13–14 years (546 girls, 577 boys) and 1,878 adults (1,145 women, 733 men), residing in seven large Polish cities. The method used in the study was the measurement of the peak nasal inspiratory flow (PNIF) using a special mask for rhinomanometry tests, with a measurement scale of 20–350 L/min. Measurements were conducted twice: once before and once after nasal mucosa vasoconstriction with a 0.1% xylometazoline (Xylometazolinum) solution. Results. Nasal patency rates increased with age in healthy subjects (children aged 6–7 years: 75.95 L/min; teenagers aged 13–14 years: 91.44 L/min and adults: 97.13 L/min (P<0.05). Similarly significant correlations were observed in the study group based on the region of residence (P<0.05). A moderate correlation was observed between PNIF and height as well as weight (with correlation coefficients r=0.51, P<0.05; and r=0.49, P<0.05, respectively). Interestingly, the observed difference in nasal vasoconstriction varied considerably between study subgroups with respect to the pre-determined criteria of age, gender, place of residence, and clinical diagnosis (allergic rhinitis vs. healthy controls), with the mean rates of 25–28%. Conclusions. Any attempt to determine reference values for a given study population should include a number of variables, such as age, height, body weight, which can noticeably affect study results.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2016, 23, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Silver ions as em marker of congo red ligation sites in amyloids and amyloid-like aggregates
    Autorzy:
    Rybarska, Janina
    Konieczny, Leszek
    Jagusiak, Anna
    Chłopaś, Katarzyna
    Zemanek, Grzegorz
    Piekarska, Barbara
    Stopa, Barbara
    Piwowar, Piotr
    Woźnicka, Olga
    Roterman, Irena
    Powiązania:
    https://bibliotekanauki.pl/articles/1038701.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Congo red
    Titan yellow
    amyloids
    supramolecular dyes
    metal markers
    light chain
    amyloid-like aggregates
    edge loop
    Opis:
    Congo red (CR) is a known selective amyloid ligand. The focus of our work is identification (by EM imaging) of dye binding sites and their distribution in amyloids and amyloid-like aggregates formed in vitro. In order to produce the required contrast, CR has been indirectly combined with metal via including Titan yellow (TY) by intercalation which exhibits a relatively strong affinity for silver ions. The resulting combined ligand retains its ability to bind to proteins (which it owes to CR) and can easily be detected in EM studies thanks to TY. We have found, however, that in protein aggregates where unfolding is stabilized by aggregation and therefore is irreversible, TY alone may serve as both, the ligand and the metal carrier. The formation of ordered structures in amyloids was studied using IgG light chains with amyloidogenic properties, converted into amyloids by shaking. The resulting EM images were subjected to interpretation on the basis of the authors' earlier research on the CR/light chain complexation process. Our results indicate that dimeric light chains, which are the subject of our study, produce amyloids or amyloid-like complexes with chain-like properties and strong helicalization tendencies. Cursory analysis suggests that the edge polypeptide loops belonging to unstable light chains form intermolecular bridges which promote creation of loose gel deposits, or are otherwise engaged in the swapping processes leading to higher structural ordering.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 161-169
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Poisoning deaths in Poland: Types and frequencies reported in Łódź, Kraków, Sosnowiec, Gdańsk, Wrocław and Poznań during 2009–2013
    Autorzy:
    Krakowiak, Anna
    Piekarska-Wijatkowska, Anna
    Kobza-Sindlewska, Katarzyna
    Rogaczewska, Anna
    Politański, Piotr
    Hydzik, Piotr
    Szkolnicka, Beata
    Kłopotowski, Tomasz
    Picheta, Sebastian
    Porębska, Barbara
    Antończyk, Andrzej
    Waldman, Wojciech
    Sein Anand, Jacek
    Matuszkiewicz, Eryk
    Łukasik-Głębocka, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/2161844.pdf
    Data publikacji:
    2017-10-06
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    Polska
    epidemiology
    Mortality
    retrospective study
    poisoning death
    fatal poisonings
    Opis:
    Objectives The aim of this study has been to assess the characteristics of acute poisoning deaths in Poland over a period of time 2009–2013. Material and Methods The analysis was based on the data obtained from the patient records stored in toxicology departments in 6 cities – Łódź, Kraków, Sosnowiec, Gdańsk, Wrocław and Poznań. Toxicological analyses were routinely performed in blood and/or urine. Major toxic substances were classified to one of the following categories: pharmaceuticals, alcohol group poisonings (ethanol and other alcohols), gases, solvents, drugs of abuse, pesticides, metals, mushrooms, others. Cases were analyzed according to the following criteria: year, age and gender of analyzed patients, toxic substance category and type of poisoning. The recorded fatal poisonings were classified according to the International Classification of Diseases. Results The record of 261 deaths were retrospectively reviewed. There were 187 males (71.64%) and 74 females (28.36%) and the male to female ratio was 2.52. Alcohol group poisonings were more frequently responsible for deaths in men compared to all poisonings, 91.1% vs. 71.6%, respectively (p < 0.05), and pharmaceutical agents were more frequently responsible for deaths in women, 47.4% vs. 28.4%, (p < 0.05). Methanol was the most common agent in the alcohol group poisonings, accounting for 43.75% (N = 49), followed by ethylene glycol, 39.29% (N = 44), and ethanol, 16.96% (N = 19). Conclusions Epidemiological profile data from investigation of poisoning deaths in Poland may be very useful for the development of preventive programs. Int J Occup Med Environ Health 2017;30(6):897–908
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2017, 30, 6; 897-908
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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