- Tytuł:
- Genotoxic effects of 60Co gamma-rays on Chinese hamster ovary (CHO) cells
- Autorzy:
-
Dicu, T.
Brie, I.
Virag, P.
Fischer, E.
Perde, M.
Foriş, V.
Cernea, V.
Cosma, C. - Powiązania:
- https://bibliotekanauki.pl/articles/147740.pdf
- Data publikacji:
- 2008
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
cellular radiosensitivity
genotoxic effects
ionizing radiation
comet assay - Opis:
- The aim of the present study was to evaluate the cellular radiosensitivity and radiation-induced DNA damage and repair in Chinese hamster ovary (CHO) cells. Cell survival after irradiation was assessed using the clonogenic assay. The initial, radio-induced and residual DNA damage in Chinese hamster ovary (CHO) cells exposed to 60Co gamma-rays were determined using the alkaline comet assay. A linear-quadratic (LQ) survival curve was observed in CHO line. Data obtained by comet assay demonstrated a linear dose-response correlation in the range of tested doses (0.3-4 Gy). The process of DNA repair was modeled by exponential equation. In addition, we found a good correlation (R2 = 0.995) between clonogenic cell survival and radio-induced DNA damage.
- Źródło:
-
Nukleonika; 2008, 53, 4; 161-165
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł