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Wyszukujesz frazę "Pencheva, N." wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Curve fitting problem: torque–velocity relationship with polynomials and Boltzmann sigmoid functions
Autorzy:
Milanov, P.
Koroleova, G.
Mavrevski, R.
Pencheva, N.
Powiązania:
https://bibliotekanauki.pl/articles/307013.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
prędkość
staw łokciowy
wielomiany
funkcja Boltzmanna
torque–velocity relationship
elbow flexors
extensors
Boltzmann sigmoid
polynomials
fitting function
model selection criteria
Opis:
The aim of this study was to investigate the curve fitting and model selection problem of the torque–velocity relationship of elbow flexors and extensors in untrained females. The second goal was to determine the optimal models in different function classes and the best, among the optimal ones. Lastly, test the best models to predict the torque were tested. Methods: Using the polynomials (second – fourth degree) and Boltzmann sigmoid functions, and a different presentation of data points (averages, a point cloud, etc.), we determined the optimal models by both error criteria: minimum residual sum of squares and minimum of the maximal absolute residue. To assess the best models, we applied Akaike and Bayesian information criteria, Hausdorff distance and the minimum of the smallest maximal absolute residue and the predictive torque–velocity relationships of the best models with torque values, calculated beyond the experimental velocity interval. Results: The application of different error and model selection criteria showed that the best models in the majority of cases were polynomials of fourth degree, with some exceptions from second and third degree. The criteria values for the optimal Boltzmann sigmoids were very close to those of the best polynomial models. However, the predicted torque–velocity relationships had physiological behavior only in Boltzmann’s sigmoid functions, and their parameters had a clear interpretation. Conclusion: The results obtained suggest that the Boltzmann sigmoid functions are suitable for modeling and predicting of the torque–velocity relationship of elbow flexors and extensors in untrained females, as compared to polynomials, and their curves are physiologically relevant.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 1; 169-184
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ANALYTICAL STUDY AND ANTIMICROBIAL ACTIVITY OF ALPHA-DEFENSIN 2 DISSOLVED IN PHARMACOPOEIA BUFFERS WITH DIFFERENT pH
Autorzy:
Amerikova, Meri N.
Zaharieva, Maya M.
Andonova, Lily A.
Pencheva-El Tibi, Ivanka P.
Maslarska, Vania
Najdenski, Hristo M.
Powiązania:
https://bibliotekanauki.pl/articles/895300.pdf
Data publikacji:
2020-02-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
pH
antimicrobial activity
analytical study
alpha-defensin 2
buffers
Opis:
Human neutrophil peptides (HNPs, alpha-defensins) are a group of six defensins being considered as new antimicrobial drugs because of their multifunctional efficiency against bacteria, viruses and fungi. Regardless of the unique biological properties alpha-defensins are unstable compounds and their activity depends on many physical and chemical factors as well as on the kind of the used cultivation media. This leads to research difficulties and obstructions in their therapeutic application. The purpose of this study was to determine antibacterial activity of alpha-defensin 2 dissolved in pharmacopeia buffers and in parallel to develop selective and accurate analytical tests for identification and assay of alpha-defensin 2 in the course of study. The antibacterial effect of alpha-defensin 2 was determined against the strain Escherichia coli (ATCC 25922). It was found that 10 mg/l of Human neutrophil peptide-2 (HNP-2, alpha-defensin 2) dissolved in pH 9.0 buffer caused 90% inhibition of the bacterial respiratory activity. This buffer was considered as a suitable environment for deploying the antibacterial activity of the alpha-defensin. А selective MS analysis method for identification of alpha-defensin 2 in sample mixtures was developed. Also HPLC method with alternative selectivity was elaborated for identification and assay of mixtures containing alpha-defensin 2 and aminoacids in Mueller Hinton broth. The procedure includes development of system suitability test determination.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 3-10
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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