- Tytuł:
- Photodynamic therapy procedures in the microfluidic system
- Autorzy:
-
Jędrych, E.
Pawlicka, Z.
Chudy, M.
Dybko, A.
Brzózka, Z. - Powiązania:
- https://bibliotekanauki.pl/articles/115635.pdf
- Data publikacji:
- 2010
- Wydawca:
- Fundacja na Rzecz Młodych Naukowców
- Tematy:
-
photodynamic therapy (PDT)
microfl uidic culture system
PDMS
adherent cell culture
concentration gradient generator (CGG)
5-aminolevulinic acid (ALA) - Opis:
- Evaluation of the effi ciency of photodynamic therapy (PDT) in a hybrid microfl uidic culture system was studied. The geometry of the utilized microsystem for PDT procedures consists microchambers for cell culture and microchannels, which create a concentration gradient generator (CGG). 5-aminolevulinic acid (ALA) as a precursor of the photosensitizer was used. The geometry of the microchip allowed to test diff erent concentrations of ALA in a single assay. Evaluation of the effi ciency of photodynamic therapy was determined 24 hours after PDT procedure (irradiation with light which induced accumulated in carcinoma cells). The performed microsystem contained two independent micropatterns, that enables examination simultaneously various cell lines (carcinoma and normal) or various photosensitizers.
- Źródło:
-
Challenges of Modern Technology; 2010, 1, 1; 30-33
2082-2863
2353-4419 - Pojawia się w:
- Challenges of Modern Technology
- Dostawca treści:
- Biblioteka Nauki
Artykuł