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Wyświetlanie 1-33 z 33
Tytuł:
Zastosowanie nanocząstek srebra do modyfikacji polimerów
Application of silver nanoparticles in the modification of polymers
Autorzy:
Wenda, M.
Jeziórska, R.
Zielecka, M.
Panasiuk, M.
Powiązania:
https://bibliotekanauki.pl/articles/947245.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Tematy:
nanocząstki
nanocząstki srebra
właściwości antybakteryjne
kompozyty polimerowe
nanoparticles
silver nanoparticles
antibacterial properties
polymer composites
Opis:
Artykuł stanowi przegląd literatury dotyczącej sposobów otrzymywania nanocząstek srebra oraz wpływu warunków prowadzenia syntezy na ich właściwości. Omówiono działanie antybakteryjne nanocząstek srebra oraz możliwość ich wykorzystania w kompozytach polimerowych, które znajdują zastosowanie do wytwarzania m.in. artykułów medycznych, artykułów gospodarstwa domowego, a także w budownictwie i przemyśle motoryzacyjnym. Opisano również właściwości biobójcze koloidalnych roztworów srebra, sposoby ich stabilizacji oraz ograniczenia w aplikacji.
This paper is a review of the literature related to the preparation methods for silver nanoparticles and effects of the synthetic conditions on the properties of nanosilver. Particular attention is paid on the antibacterial properties of silver nanoparticles and their possible use in polymer composites. Such materials can be applied in the production of medical and household articles as well as in the building sector. Also, the biocidal properties of colloidal silver solutions, methods for controlling the stability of colloidal silver particles and limitations of using these materials are described.
Źródło:
Polimery; 2016, 61, 3; 166-171
0032-2725
Pojawia się w:
Polimery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Achieving position accuracy against moving target analyze
Autorzy:
Wąż, M.
Panasiuk, A.
Powiązania:
https://bibliotekanauki.pl/articles/320685.pdf
Data publikacji:
2008
Wydawca:
Polskie Forum Nawigacyjne
Tematy:
manewr taktyczny
śledzenie celu
tactical maneuver
target tracking
Opis:
Each navigator has to be able to achieve position by own ship against all types of targets. Maneuver calculations depend mostly on target position and movement vector measurements accuracy. This article presents how the time and maneuver course changes when changes target movement and position data accuracy changes.
Źródło:
Annual of Navigation; 2008, 13; 131-137
1640-8632
Pojawia się w:
Annual of Navigation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of ionizing radiation on the male reproductive system
Autorzy:
Wdowiak, A.
Skrzypek, M.
Stec, M.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/2083104.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
radiation protection
ionizing radiation
male fertility
human reproductive function
medical exposure
natural exposure
Opis:
Introduction and objective. In the light of current data concerning the growing exposure to ionizing radiation (IR) originating from atrificial sources, especially from medical ones, and also related to occupational exposure, it is justifiable to systematize the state of knowledge concerning the effect of IR on the male reproductive system. Brief description of the state of knowledge. There is no basis for the application of the hypothesis of hormesis in the area of male reproductive health. Regarding the impact of IR on spermatogenesis, spermatogonia are less susceptible to the occurrence of DNA damage after exposition to IR, but are characterized by slower DNA repair compared to somatic cells. Damage to the genes after exposure to IR is possible at each stage of spermatogenesis; however, haploidal spermatids show the highest radiosensitivity in this respect. The genetic risk of the cells differentiating during spermatogenesis is limited to one cycle of spermatogenesis, whereas the genetic instability may persist for the whole period of life, and DNA damage induced by IR may be transmitted to future generations. The minimum dose causing detectable DNA damage was 30 Gy. While exceeding this dose, the number of single-strand DNA breaks increases. Among males exposed to IR, a decrease was observed in sperm motility and in the percentage of morphologically normal spermatozoa as well as in an intensification of vacuolization. The genetic material in the sperm of these males showed higher fragmentation and methylation of genomic DNA. Conclusion. In the context of the epidemiological situation concerning the prevalence of infertility, while assessing the health effects of exposure to IR from artificial, including medical sources, the reproductive risk should be considered.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 2; 210-216
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Charakterystyka wybranych parametrów jakości wody zasilającej ZUW Goczałkowice
Characteristics of selected quality parameters of water supplying Water Treatment Plant Goczałkowice
Autorzy:
Nowacka, A.
Włodarczyk-Makuła, M.
Panasiuk, D.
Powiązania:
https://bibliotekanauki.pl/articles/296845.pdf
Data publikacji:
2011
Wydawca:
Politechnika Częstochowska. Wydawnictwo Politechniki Częstochowskiej
Tematy:
woda powierzchniowa
zakład uzdatniania wody
Goczałkowice
azot amonowy
azot azotynowy
azot azotanowy
fosforany
surface water
ammonium nitrogen
nitrite nitrogen
nitrate nitrogen
phosphates
Opis:
Zbiornik zaporowy w Goczałkowicach pełni znaczącą rolę w zaopatrzeniu w wodę mieszkańców aglomeracji katowickiej i rybnickiej. Woda (czerpana ze zbiornika Goczałkowice na Wiśle oraz Czaniec na rzece Sole) jest przygotowywana do spożycia przez ludzi w Zakładzie Uzdatniania Wody (ZUW) w Goczałkowicach Górnośląskiego Przedsiębiorstwa Wodociągów (GPW S.A.). Udział ZUW Goczałkowice w całkowitej produkcji wody pitnej w GPW S.A. wynosi ok. 45%. Analizą jakościową objęta jest woda ze zbiornika (10 punktów pomiarowych), jego dopływów (punkty pomiarowe Bajerka, Potok Zbytkowski, Rów A) oraz woda w poszczególnych punktach procesu produkcyjnego (w tym woda surowa). Ze względu na źródło zasilania i stosowaną technologię uzdatniania wyróżniono wodę surową: GO-CZA I i GO-CZA II. Wykonywane na bieżąco oznaczenia obejmują takie wskaźniki, jak: temperatura, mętność, barwa, zapach, odczyn, BZT5, utlenialność, ChZTCr, procentowe nasycenie tlenem oraz zawartość azotu amonowego, azotu azotynowego i azotu azotanowego, fosforanów, chlorków, manganu i żelaza. W przypadku niektórych wskaźników zaobserwować można sezonowość zmian. Występowanie pozostałych uwarunkowane jest innymi czynnikami (spływy powierzchniowe, opady atmosferyczne, zakwity glonów). W pracy przedstawiono wyniki analiz takich wskaźników, jak: azot amonowy, azotanowy, azotynowy oraz fosforany, dotyczących wody surowej ujmowanej ze zbiornika Goczałkowice i przesyłanej do zasilania linii technologicznej GO-CZA I. Na podstawie danych archiwalnych pochodzących z lat 80., 90. XX w. oraz wyników z lat 2000-2005 dokonano porównania wybranych wskaźników jakościowych wody przeznaczonej do uzdatniania.
Dam reservoir in Goczałkowice have a vital role in water supply of Upper Silesian agglomeration inhabitants. Water (taken from the Goczałkowice reservoir on the Vistula River and Czaniec reservoir on the Soła River) is prepared for human consumption in the Water Treatment Plant (WTP) in Goczałkowice belonging to the Upper Silesian Waterworks in Katowice. Production of WTP Goczałkowice is around 45% of the total production of drinking water in the whole waterworks. Qualitative analysis includes: water from the reservoir (10 sampling points), its tributaries (measurement points Bajerka, Zbytkowski stream, Ditch A) and water at different points of the production process (including raw water). Depending on supply source and the technology used to water treatment stands out: raw water GO-CZA I (used by production line GO-CZA I) and GO-CZA II (used by production line GO-CZA II). Analysis includes parameters such as: temperature, turbidity, colour, odour, pH, BOD5, oxidation, COD, percentage oxygen saturation and content of ammonium nitrogen, nitrite nitrogen, nitrate nitrogen, phosphates, chlorides, manganese and iron. Some parameters show seasonal changes. The occurrence of the remaining parameters is conditioned by other factors (surface runoff, rainfall, algal blooms). The paper describes results of analysis of selected quality parameters ammonium, nitrate and nitrite nitrogen as well as phosphates of raw water from the Goczałkowice reservoir transmitted to the processing line GO-CZA I. Comparisons of selected quality indicators of water intended for treatment was based on archival data from the 80's, 90's of the 20th century and the results from year 2000-2005. The most accurate measurement data come from the 80's, when the analysis were performed every week. In later periods, their frequency was limited to a month. In the summer seasons of years: 1984-1986, 1994-1998 and 2000-2005 was observed increased concentration of selected raw water quality parameters. Considerable increase in the concentration of ammonium nitrogen was recorded in June and July 1997 and in July and September 2002 and 2003. At the same time during these periods there were lower concentrations of nitrate nitrogen. The lowest concentration of phosphates was noted in the 80's. In the other two periods concentrations were higher.
Źródło:
Inżynieria i Ochrona Środowiska; 2011, 14, 4; 385-396
1505-3695
2391-7253
Pojawia się w:
Inżynieria i Ochrona Środowiska
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Virucidal effect of chosen disinfectants against African swine fever virus (ASFV) – preliminary studies
Autorzy:
Juszkiewicz, M.
Walczak, M.
Mazur-Panasiuk, N.
Woźniakowski, G.
Powiązania:
https://bibliotekanauki.pl/articles/2087427.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
African swine fever (ASF)
African swine fever virus (ASFV)
disinfection
biosecurity
virucidal effects
Źródło:
Polish Journal of Veterinary Sciences; 2019, 4; 777-780
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Scenariusze emisji rtęci do powietrza, wód i gleby w Polsce do roku 2020
Scenarios of mercury emission to air, water and soil in poland to year 2020
Autorzy:
Panasiuk, D.
Głodek, A.
Pacyna, J. M.
Powiązania:
https://bibliotekanauki.pl/articles/126369.pdf
Data publikacji:
2012
Wydawca:
Towarzystwo Chemii i Inżynierii Ekologicznej
Tematy:
scenariusze emisji
rtęć
powietrze
woda
gleba
emission scenarios
mercury
air
water
soil
Opis:
W 2005 r. Polska zajmowała czwarte miejsce wśród państw europejskich w emisji rtęci do powietrza, głównie z powodu spalania węgla kamiennego i brunatnego w energetyce. Zespół NILU Polska oszacował krajową emisję rtęci do powietrza oraz ładunki odprowadzane do wód i gleby dla roku bazowego 2008, a następnie przygotował scenariusze emisji rtęci do 2020 r. Inwentaryzacja emisji do powietrza objęła procesy przemysłowe, użytkowanie produktów zawierających rtęć i praktykę dentystyczną. Ładunki rtęci zrzucane do wód i gleby zostały oszacowane dla dużych i średnich zakładów przemysłowych, oczyszczalni ścieków komunalnych oraz dla potencjalnego uwalniania się rtęci ze składowisk odpadów komunalnych i z wypełnień dentystycznych w grzebanych zwłokach. W porównawczym scenariuszu Status Quo założono, że będą utrzymane bieżące praktyki i metody kontroli emisji rtęci, ale wzrost produkcji i konsumpcji będzie prowadzić do wzrostu emisji rtęci. W scenariuszu EXEC (zwiększonej kontroli emisji) emisja rtęci do powietrza spadnie z 17,7 Mg w roku bazowym do 6,3 Mg w 2020 r., a łączna emisja do powietrza, wód i gleby z 25,7 do 8,9 Mg. W scenariuszu MFTR (maksymalnej możliwej technicznie redukcji) emisja do powietrza osiągnie w 2020 r. poziom 2,8 Mg Hg, a łączna emisja do środowiska - 3,6 Mg Hg rocznie.
Among European countries Poland has fourth place in mercury emission to atmosphere in 2005, mainly due to hard and brown coal combustion in energy sector. NILU Polska estimated Polish national mercury emission to air and loads discharged to water and soil for the base year 2008, then it prepared mercury emission scenarios to 2020. Inventory of emission to the atmosphere covered industrial processes, mercury use in products and dental practice. Loads of mercury discharged to water and soil were estimated for large and medium industrial facilities, municipal waste water treatment plants and also for potential mercury release from municipal landfills and dental amalgam in buried bodies. In comparative Status Quo scenario it was assumed that current practices and methods of mercury emission control will be maintained, but the growth of production and consumption will lead to the increase of mercury emission. In EXEC (EXtended Emission Control) scenario mercury emission to air will fall from 17.7 Mg in base year to 6.3 Mg in 2020 and total emission to air, water and soil from 25.7 to 8.9 Mg. In MFTR (Maximum Feasible Technical Reduction) scenario emission to air will achieve level 2.8 Mg Hg in 2020 and total emission to the environment - 3.6 Mg Hg annually.
Źródło:
Proceedings of ECOpole; 2012, 6, 2; 769-774
1898-617X
2084-4557
Pojawia się w:
Proceedings of ECOpole
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Do Polish doctors suffer from occupational burnout syndrome? An attempt to find an answer - pilot study
Autorzy:
Makara-Studzińska, M.
Załuski, M.
Tylec, A.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/2082055.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
burnout syndrome
physicians
occupational stress
psychological processes
Opis:
Introduction and objective. A nationwide survey, carried out in Poland in 2013, showed that 42% of an examined group of doctors reported occupational burnout syndrome (OBS). The phenomenon of OBS among medical personnel shows a relationship with perceived stress scale (PSS) scores. The aim of the study was to estimate the prevalence of OBS in a group of Polish doctors, and the relationship with selected risk factors and personal resources. Materials and method. A cross-sectional study using quantitative methodology was used with the application of a questionnaire method and correlation design. Questionnaires were administered to 318 doctors (42 different specialties) working in medical facilities in Poland. All participants in the study completed two standardized questionnaires: Link Burnout Questionnaire (LBQ), Perceived Stress Scale (PSS), and responded to the questions on a proprietary questionnaire. ANOVA variance analysis and analysis of regression was performed. Results. The results of the measurement of four aspects of occupational burnout: psychophysical exhaustion (PE), commitment to relationships with patients (CP), effectiveness in performed work (EW), and existential expectations (EE), were in the medium and high levels range. Every second medical doctor who participated in the research declared a high degree of occupational burnout in each of the aspects of OBS. The high level of PSS scores, the large number of duties per month, the short work experience (years of employment) and the low number of holiday leaves, were the predictors of occupational burnout in the group of doctors taking part in the study. Conclusions. The prevalence of the signs of OBS among Polish doctors is consistent with the results of research in other countries. Failures in the interventions taken to reduce stress seem to co-exist with the severity of signs of burnout.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 191-197
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pourazowe przemieszczenie serca połączone z jego amputacją - opis przypadku
Post-traumatic displacement of the heart combined with its amputation - a case report
Autorzy:
Listos, P.
Panasiuk, K.
Slomka, S.
Grela, M.
Gryzinska, M.
Powiązania:
https://bibliotekanauki.pl/articles/861675.pdf
Data publikacji:
2018
Wydawca:
Krajowa Izba Lekarsko-Weterynaryjna
Tematy:
weterynaria sadowa
psy
urazy
wypadki komunikacyjne
pourazowe przemieszczenie serca polaczone z jego amputacja
zmiany sekcyjne
Źródło:
Życie Weterynaryjne; 2018, 93, 01
0137-6810
Pojawia się w:
Życie Weterynaryjne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anthropometric, body composition and behavioural predictors of bioelectrical impedance phase angle in Polish young adults - preliminary results
Autorzy:
Skrzypek, M.
Szponar, B.
Drop, B.
Panasiuk, L.
Malm, M.
Powiązania:
https://bibliotekanauki.pl/articles/2085363.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
young adults
bioelectrical impedance
phase angle
body composition analyzer
phase angle predictors
Opis:
Introduction and objective. Bioimpedance analysis (BIA) phase angle (PhA) is an index of the integrity of cells and cellular membranes. The aim of the study was identification of behavioural and anthropometric predictors of PhA in a group of young adults. Materials and method. A cross-sectional observational study of health behaviours, anthropometric indicators and body composition assessed by the BIA method was conducted in a group of Polish young adults (n=92) aged 18 – 24 (mean – 19.33, STD – 0.915). Behavioural variables included: level of physical activity, eating behaviours and nutritional knowledge. Body composition was analysed by means of BIA phase-sensitive 8-electrode medical SECA mBCA 525 device. Results. The mean PhA value in the examined cohort was 6.38±0.75 (males – 7.22±0.72; females – 6.13±0.57). Males also showed higher statistically significant other body composition indices, excluding fat mass. The multiple regression model, including anthropometric variables and gender, which explained the effect of these variables on PhA, occurred to be significant (p<0.0000) and allowed explanation of the 82.49% of PhA variability. PhA was significantly predicted from body mass index (BMI), absolute fat mass, visceral adipose tissue value, skeletal muscle mass value and gender. The regression model, including behavioural predictors and gender, allowed explanation of the lower percentage of PhA variability (42.75%; p<0.0000) and included general intensity of health behaviours, level of nutritional knowledge, and gender. A regression model which would consider simultaneously anthropometric and behavioural variables could not be constructed. Conclusions. In the examined cohort, anthropometric and body composition variables showed a stronger predictive value with respect to PhA, compared to behavioural variables.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 91-98
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessing levels of knowledge on the principles of pain management during post-graduate education of physicians in Poland
Autorzy:
Brzezinski, K.
Zagorski, J.
Panasiuk, L.
Brzezinska, M.
Powiązania:
https://bibliotekanauki.pl/articles/52065.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comprehensive outpatient rehabilitation increases the ability of people over 60 to live independently
Autorzy:
Czarkowska, M.
Saran, T.
Mazur, A.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/2081979.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
ES-13
I-ADL
Barthel index
independent existence
seniors
rehabilitation
endurance training
Opis:
Introduction. The answer to current social and health needs of people aged over 60 are the multidirectional and carefully planned, comprehensive activation and rehabilitation activities carried out as part of Daycare Centres (DCC). The aim of creating and the functioning of DCCs deployed all over Poland is to improve the health and psychophysical fitness of this group of people. Health factors and psychophysical fitness determine the ability to live independently, both today, and later in life. Objective. The objective of the study was to assess the impact of comprehensive ambulatory rehabilitation, including tailored endurance training preceded by an ergospirometry test, on indicators demonstrating the ability to live independently and the risk ratio of future health problems in the elderly. Materials and method. 60 people participating in a rehabilitation cycle implemented as part of the services provided to patients aged over 60 in the DCC of the Witold Chodźko Institute of Rural Medicine (IMW) in Lublin comprised the sample. The tests were carried out in the test-retest model on the first and last day of the kinesiotherapy cycle. Patients were tested using standardized Barthel, I-ADL and VES-13 questionnaires. The rehabilitation programme applied included systemic kinesiotherapy (endurance training) with a load determined according to individual exercise capacity, determined on the basis of a ergospirometry test, and varied rehabilitation activities resulting from the condition of the locomotor system, as provided for under the project. Results. After completing the rehabilitation cycle, patients obtained higher results in comparison to the tests carried out before the beginning of the cycle in the Barthel index used to measure functional efficiency (Z = 5.41; p = 0.001), as well as lower in the I-ADL scale used to test the degree of dependence on the help of others when performing complex activities of everyday life (Z = 2.63; p = 0.009) and in VES-13 scale used to assess the risk of geriatric health problems (Z = 5.47; p = 0.001). Conclusions. As the result of the use of comprehensive rehabilitation, including obligatory endurance training, desired changes were achieved in terms of fitness and independence in performing advanced daily activities and reducing the risk of geriatric health problems.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 720-724
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of ionizing radiation on the female reproductive system
Autorzy:
Skrzypek, M.
Wdowiak, A.
Panasiuk, L.
Stec, M.
Szczygieł, K.
Zybała, M.
Filip, M.
Powiązania:
https://bibliotekanauki.pl/articles/2085209.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
infertility
ionizing radiation
female reproductive health
gonadotoxic action
Opis:
Introduction and objective. The tendency towards postponement of maternity implies a greater exposure of female germ cells to damaging environmental effects, including ionizing radiation (IR). Progress in paediatric oncology, based on the use of radiotherapy, also implies the occurrence of gonadal dysfunctions and subsequent female fertility disorders. Therefore, it seems justifiable to systematize the state of knowledge concerning the effect of IR on the female reproductive system. Brief description of the state of knowledge. A considerable part of studies concerning the effect of IR on female germ cells have been conducted on animals. Their extrapolation to humans is hindered because in animal studies high acute exposures are applied, which do not reflect human environmental exposures characterized by chronic low dose exposure. Studies on animals provide a heterogenous image, which hinders the formulation of unequivocal conclusions and indicates that radiosensitivity depends, i.a. on IR dose, stage of development of oocytes, the applied marker of the effects of IR, or on the species. LD50 of human oocytes is estimated to be below 2 Gy. The effect of IR depends, i.a. on the dose fractionation and the age (older women are more radiosensitive). In females, the effective sterilizing dose is: at birth 20.3 Gy, at 10 years 18.4 Gy, at 20 years 16.5 Gy, whereas at 30 years 14.3 Gy, which is associated with the available pool of ovarian follicles. Conclusions. Within the range of low doses received as a result of environmental exposure to IR, there is no evidence for the occurrence of either adverse pregnancy outcomes, nor fertility disorders in females. These effects may be related to the cancer radiotherapy, or exposure to high IR doses during nuclear accidents.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 4; 606-616
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vertical transmission of anti-ASFV antibodies as one of potential causes of seropositive results among young wild boar population in Poland
Autorzy:
Walczak, M.
Frant, M.
Juszkiewicz, M.
Mazur-Panasiuk, N.
Szymankiewicz, K.
Bruczyńska, M.
Woźniakowski, G.
Powiązania:
https://bibliotekanauki.pl/articles/2087367.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Polska
African swine fever
ASF
immunoglobulins
antibodies
seropositive
wild boar
surveillance
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 1; 21-25
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Innowacyjny autonomiczny pojazd podwodny do badania stanu środowiska w warunkach trudnych
Innovative autonomous underwater vehicle for research the environment in harsh condition
Autorzy:
Chodnicki, M.
Jażdzewski, M.
Kulwicki, Ł
Ławreszuk, D.
Panasiuk-Chodnicka, A. A.
Powiązania:
https://bibliotekanauki.pl/articles/137196.pdf
Data publikacji:
2014
Wydawca:
Uczelnia Jana Wyżykowskiego
Tematy:
autonomiczny pojazd podwodny
nawigacja
sterowanie
Zatoka Admiralicji
Antarktyka
autonomous underwater vehicle
navigation
control system
Admiralty Bay
Antarctica
Opis:
Na podstawie rzeczywistej, aktualnej wiedzy w temacie rozwoju robotów podwodnych został zaprojektowany nowy pojazd wyposażony w innowacyjne rozwiązania. Autonomiczny robot podwodny dedykowany jest do pracy w trudnych warunkach środowiskowych, wymagających odporności na wysokie ciśnienie, niskie temperatury i silne prądy, które są typowe dla regionów polarnych. W pracy opisano charakterystykę docelowego rejonu, w którym ma być używany robot podwodny, tj. Zatokę Admiralicji w rejonie Archipelagu Szetlandów Południowych. Istotnym aspektem pracy był także dobór odpowiedniego systemu sterowania, który będzie zdolny przeprowadzić pojazd przez trudne i wymagające warunki stawiane przez środowisko zewnętrzne. Kolejnym elementem projektu jest ocena istniejących systemów nawigacji. Ostatnią częścią jest opracowanie kształtu robota, odpowiedniego do warunków otoczenia z uwzględnieniem możliwości zamontowania dodatkowych urządzeń mechanicznych, elektrycznych i pomiarowych, odpowiedzialnych za wykonywanie powierzonych zadań podczas misji robota.
The use of Autonomic Underwater Vehicles (AUV) continuously recording the basic environmental parameters in marine polar regions are extremely difficult. This study provides a summary and a description of the existing solutions for the AUV, their use, construction, actuators and transmitters. Based on the actual knowledge a new vehicle equipped with innovative solutions and components was designed. The underwater robot is dedicated to be working in harsh environmental conditions requiring resistance to high pressure, low temperatures and strong currents, which are typical for the polar regions. The first stage of the design process consist of selection miniature sensors, vision systems to collect information about the environment. The next step was to develop a method for processing and storing data from the measurements. There has been elaborated a special communication and data transfer for this system. An important aspect of this design is a proprietary control system, which includes selecting an appropriate drive with the control program Marek Chodnicki, Marek Jażdzewski, Łukasz Kulwicki, Dawid Ławreszuk, Anna A. Panasiuk-Chodnicka 8 according to the external conditions. Another part of the research was the review of the existing navigation systems and subsequently implementation to the designed vehicle. Then, the power system with automatic charging was elaborated, which is possible to use natural energy sources. The last part was to design the shape of the mobile robot, taking into account the environmental conditions and the possibility of mechanical and electronic devices to be installed.
Źródło:
Zeszyty Naukowe Dolnośląskiej Wyższej Szkoły Przedsiębiorczości i Techniki. Studia z Nauk Technicznych; 2014, 3; 7-16
2299-3355
Pojawia się w:
Zeszyty Naukowe Dolnośląskiej Wyższej Szkoły Przedsiębiorczości i Techniki. Studia z Nauk Technicznych
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of health care systems in Poland and Great Britain by Poles staying temporarily in Great Britain prior to the COVID pandemic
Autorzy:
Myśliński, W.
Szwed, M.
Szwed, J.
Panasiuk, L.
Mosiewicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/28685989.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2022, 29, 4; 588-591
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modyfikowane mykotoksyny - ukryte zagrożenia poza urzędową kontrolą
Modified mycotoxins - a hidden threats beyond official control
Autorzy:
Panasiuk, L.
Piatkowska, M.
Pietruszka, K.
Jedziniak, P.
Posyniak, A.
Powiązania:
https://bibliotekanauki.pl/articles/859761.pdf
Data publikacji:
2018
Wydawca:
Krajowa Izba Lekarsko-Weterynaryjna
Tematy:
toksykologia weterynaryjna
mikotoksyny
mikotoksyny maskowane
mikotoksyny modyfikowane
wystepowanie
pasze
wykrywanie
zagrozenia zdrowia
regulacja prawna
Źródło:
Życie Weterynaryjne; 2018, 93, 08
0137-6810
Pojawia się w:
Życie Weterynaryjne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A 56-year-old man with RT-PCR negative nasopharyngeal swabs with Coronavirus Disease 2019 (COVID-19) Pneumonia
Autorzy:
Dworzańska, A.
Tudrujek-Zdunek, M.
Mosiewicz, J.
Panasiuk, L.
Tomasiewicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/2085530.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
RT-PCR
pneumonia
Covid-19
Coronavirus Disease 2019
chest computed tomography
real-time-reverse transcription-polymerase chain-reaction
Opis:
Introduction. Diagnostic procedure in Coronavirus Disease 2019 (COVID-19) is based mainly on performing real-time-reverse transcription-polymerase chain-reaction (RT-PCR), which has been accepted as the gold standard method. In some cases, such as mutations of the SARS-CoV-2 genome, variable viral load kinetics or laboratory errors, it can be false-negative. Case report. The case is presented of a 56-year-old man with respiratory tract symptoms, with twice negative results of real-time-reverse transcription-polymerase chain-reaction of nasopharyngeal swabs and positive chest computed tomography, with typical findings for COVID-19 pneumonia. Conclusions. Patients with negative RT-PCR results, but with positive computed tomography findings characteristic for COVID-19, should be treated as well as those infected.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 317-318
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Medical and socio-demographic determinants of depressive disorders in diabetic patients
Autorzy:
Florek-Łuszczki, M.
Choina, P.
Kostrzewa-Zabłocka, E.
Panasiuk, L.
Dziemidok, P.
Powiązania:
https://bibliotekanauki.pl/articles/2085636.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
diabetes
medical and socio-demographic factors
depressive disorders
Opis:
Introduction. Diabetes is a civilisation disease creating a serious challenge for public health. In Poland, approximately 2 million people suffer from diabetes, of which about 25% are unaware of their illness. A considerable part of persons with diabetes experience complications related with the disease. Objective. The aim of the study was to determine the relationship between elements of the state of health and socio-demographic characteristics of diabetic patients treated in the Diabetes Clinic at the Institute of Rural Health (IMW) in Lublin, eastern Poland, and the occurrence of depressive symptoms in these patients. Materials and method. The study was conducted in 2017–2018 among patients treated in the Diabetes Clinic at the Institute of Rural Health in Lublin, by the method of a diagnostic survey using the Beck’s Depression Inventory and an author-constructed questionnaire, as well as data from the patients’ medical records. The study included 314 patients from the Diabetes Clinic who expressed their informed consent to participate in the research. Results. The study showed that diabetes is a disease which predisposes for the occurrence of depression. The occurrence of depressive symptoms of various degrees of intensity was confirmed in more than a half of the examined patients. Among the factors which exerted a significant effect on the occurrence of depressive symptoms were: diabetic neuropathy, type 2 diabetes, high BMI value, lack of occupational activity, poor material standard, and the need to obtain assistance in daily functioning due to the fact of being ill with diabetes. Conclusions. It is necessary to implement routinely performed examinations into the diagnostic-therapeutic process to assess the state of psychological health of diabetic patients, which would allow sufficiently early application of appropriate psychological or psychiatric intervention.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 255-259
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevalence of target organ damage in hypertensive patients with coexisting obstructive sleep apnea
Autorzy:
Myśliński, W.
Szwed, M.
Szwed, J.
Panasiuk, L.
Brożyna-Tkaczyk, K.
Borysowicz, M.
Mosiewicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/28761829.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2022, 29, 2; 294-299
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevalence of cigarette smoking among adult population in Eastern Poland
Autorzy:
Panasiuk, L
Mierzecki, A.
Wdowiak, L.
Paprzycki, P.
Lukas, W.
Godycki-Cwirko, M.
Powiązania:
https://bibliotekanauki.pl/articles/51791.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
Polska
Eastern Poland
adult population
cigarette smoking
prevalence
risk
cancer
respiratory disease
cardiovascular disease
Źródło:
Annals of Agricultural and Environmental Medicine; 2010, 17, 1; 133-138
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Air pollution: how many cigarettes does each Pole ‘smoke’ every year and how does it influence health, with special respect to lung cancer?
Autorzy:
Chudzik, R.
Rybojad, P.
Jarosz-Chudzik, K.
Sawicki, M.
Rybojad, B.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/2085106.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
lung cancer
PM2.5
air pollution
nitrogen dioxide
PM10
Opis:
Introduction. Air pollution is one of the most important issues of our times. Air quality assessment is based on the measurement of the concentration of substances formed during the combustion process and micro-particles suspended in the air in the form of an aerosol. Microscopic atmospheric particulate matters (PM) 2.5 and 10 are mixtures of organic and inorganic pollutants smaller than 2.5 and 10 μm, respectively. They are the main cause of negative phenomena in the earth’s atmosphere of Earth and human health, especially on the respiratory and cardiovascular systems. Particulates have the ability to cause permanent mutations of tissue, leading to neoplasms and even premature deaths. Nitrogen dioxide (NO2) is one of the main pollutants which arises mainly during the burning of fossil fuels. Based on numerous scientific researches, it has been proved that long-term exposure to NO2 could increase morbidity of cancer due to inflammatory processes increasing abnormal mutations. Materials and method. Data available in the Polish National Cancer Registry, Chief Inspectorate for Environmental Protection and Map of Health Needs in the Field of Oncology for Poland, WHO Air Quality Guidelines 2005 were analyzed. Air pollution was also evaluated: PM2.5, PM10, NO2, and compared with lung cancer morbidity. Results and conclusions. Based on the available data and literature, it can be concluded that in 2009–2017, on average, each Pole smoked ten cigarettes a day +/- 2. Therefore, it can be estimated that after 60 years everyone had 30 package-years of smoking, leading to a high risk of lung cancer and other smoking related diseases. Additionally air quality in Poland is not satisfactory, exceeding the standards presented in the WHO Guidelines 2005. It can be assumed that this may translate into an additional, independent continuous increase in morbidity and mortality dependent on smoking.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 4; 566-571
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Associations between overweight and obesity and health enhancing behaviours among female nurses in Poland
Autorzy:
Woynarowska-Sołdan, M.
Panczyk, M.
Iwanow, L.
Gałązkowski, R.
Wójcik-Fatla, A.
Panasiuk, L.
Gotlib, J.
Powiązania:
https://bibliotekanauki.pl/articles/2081941.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
health behaviours
lifestyle
obesity
overweigh
nurses
Opis:
Introduction and objective. The nursing profession entails many negative factors and high risk of chronic diseases, including overweight and obesity. The aim of the study is to investigate the prevalence of overweight and obesity and health enhancing behaviours in Polish female nurses, and associations between overweight and 4 groups of such behaviours, age and shift work. Materials and method. The analysis covered data obtained through cross-sectional survey carried out in a group of 994 nurses with an average age of 43. The analysis covered answers about 29 health-enhancing behaviours divided into 4 categories (subscales): 1) nutrition, 2) physical activity, 3) sleep, rest and behaviours related to mental health, 4) preventive behaviours. They were analysed through the validated Positive Health Behaviours Scale for adults. The analysis also covered answers about avoiding drinking large amounts of alcohol in one go, not smoking, avoiding passive smoking, not abusing unprescribed drugs. Results. The prevalence of overweight and obesity was 44%. Of 29 health behaviours concerned with nutrition, physical activity, sleep, rest, and mental health, preventive behaviours, 3 were exhibited always or almost always by over a half of the nurses. Health behaviours were more common in nurses whose BMI was normal than in nurses with BMI ≥ 25.0. Age and low physical activity levels were related to overweight and obesity in nurses. Conclusions. The study revealed a high prevalence of overweight and obesity and many deficits in health behaviours. Obesity and health behaviour deficits pose risks to the health of nurses, limit their involvement in prevention and treatment of patient obesity and impact as health educators. It is essential to engage in actions for health promotion among nurses.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 714-719
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-vaccine movements – health care, ignorance or a diversion aimed at destabilizing the health situation? Part 2. Contemporary conditions for the functioning and development of anti-vaccination movements
Autorzy:
Kołłątaj, B.M.
Kołłątaj, W.P.
Karwat, I.D.
Sobieszczański, J.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/28762967.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 4; 553-561
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Background ionizing radiation and semen parameters of men with reproductive problems
Autorzy:
Wdowiak, A.
Stec, M.
Raczkiewicz, D.
Bień, A.
Iwanowicz-Palus, G.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/2085376.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
ionizing radiation
men
semen analysis
sperm quality
reproduction
male infertility
Opis:
Introduction and objective. The male reproductive system constitutes a set of tissues which are particularly sensitive to external factors. The aim of the study was to analyze the relationship between background radioactivity and the quality of the semen of the men who have reported to the infertility treatment facility in 2000–2016 in the Lublin region of eastern Poland. Materials and method. The radioactivity of the ground-level air layer obtained from the Institute of Meteorology and Water Management in Włodawa in the Lublin region was analysed. 4,250 spermiograms of patients who reported to the treatment facility for the first time due to infertility were analysed and correlated to background radioactivity in the Lublin region in 2000–2016. Results. A long-term decrease in the percentage of morphologically normal spermatozoa of the patients was observed (r=-0.970; p<0.001 in 2000–2009 and r=-0.925; p=0.003 in 2010–2016). Men’s age correlated negatively with sperm motility (r=-0.164; p=0.009) and morphology (r=-0.186; p=0.009). The percentage of spermatozoa with normal morphology was lowered by beta-isotopes of artificial origin in the air in 2000–2009 (r=-0.655; p=0.040) and by the exposure to gamma radiation of the ground-level atmosphere in 2010–2016 (r=-0.676; p=0.048). The percentage of sperm vitality was lowered by gamma radiation in the atmosphere (r=-0.636; p=0.006), but improved by beta isotopes in precipitation (r=0.686; p=0.002) in the whole of the analyzed period. Conclusions. The percentage of morphologically normal spermatozoa in patients who reported to the infertility treatment depends not only on the age of patient, but also on beta-isotopes of artificial origin and gamma radiation in the atmosphere. Beta isotopes in precipitation affect the improvement of sperm vitality.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 43-48
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An evaluation of the genetic conditioning of evoking pain
Autorzy:
Pacian, A.B.
Kocki, J.
Pacian, J.
Kaczoruk, M.
Bylina, M.
Kaczor-Szkodny, P.
Galińska, E.M.
Kulik, T.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/2085535.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
genetics
chronic pain
genes expression
DRD1 gene
molecular research
Opis:
Introduction and objective. Pain is an integral element of the pathogenic process and sometimes determines its course. Disorders in pain sensation, as well as its lack, the pain threshold, and variability in sensation of the same pain stimuli as more or less intensive by different persons, may be genetically conditioned. The aim of the study is to examine genes in pathogenesis of chronic pain. Materials and method. The study was conducted in a specially selected group of 31 persons: study group – 20 patients with chronic pain, and control group – 11 healthy individuals who did not experience pain. The control group of 11 healthy persons, compared with the study group, was the catalyst for determining the relative quantification (RQ) of gene expression. Biological material in the form of venous blood was collected from the study participants into the tubes containing anticoagulant EDTA KE/2.7 ml (ethylenediaminetetraacetic acid), preventing extracorporeal blood clotting. Results. Analysis of expression of the examined genes showed over-expression of the DRD1 gene in patients experiencing chronic pain, which means that in these patients an increased number of dopamine D1 receptors encoded by this gene should be expected. The dopamine D1 receptor is a G-protein-coupled receptor which regulates (stimulates or inhibits) adenyl cyclase – the enzyme responsible for synthesis of cyclic AMP (cAMP). An increase in the concentration of cAMP in neurons enhances the sensation of pain. Conclusions. The genes (DRD1, COMT, OPRK1, HCN2) have a significant role in the pathogenesis of chronic pain in various diseases; they can also influence the perception of pain. Knowledge of these genes can contribute to the development of effective methods of combating pain.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 274-278
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prediction value of soluble urokinase plasminogen activator receptor (suPAR) in COVID-19 patients - a systematic review and meta-analysis
Autorzy:
Matuszewski, M.
Ładny, J.
Rafique, Z.
Peacock, F.
Pruc, M.
Gasecka, A.
Szwed, P.
Jankowski, L.
Chmielewski, J.
Panasiuk, L.
Szarpak, L.
Powiązania:
https://bibliotekanauki.pl/articles/28761646.pdf
Data publikacji:
2023
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2023, 30, 1; 142-147
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quality of life of patients undergoing specific allergen immunotherapy in allergic rhinitis
Autorzy:
Brodowicz-Król, M.
Guz, E.
Hawryluk, D.
Kulbaka, E.
Panasiuk, L.
Lutomski, P.
Kaczor-Szkodny, P.
Choina, P.
Powiązania:
https://bibliotekanauki.pl/articles/28762884.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 4; 657-663
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevalence and selected determinants of the risk of problem gambling among Polish secondary school students
Autorzy:
Niewiadomska, I.
Panasiuk, L.
Chwaszcz, J.
Furtak-Niczyporuk, M.
Dreher, P.
Zygo, K.
Jaroszyński, J.
Mela, A.
Powiązania:
https://bibliotekanauki.pl/articles/28762887.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 4; 650-656
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of novel serum markers of fibrosis and angiogenesis in patients with alcoholic liver cirrhosis
Autorzy:
Prystupa, A.
Kiciński, P.
Luchowska-Kocot, D.
Nowicki, G.
Dzida, G.
Myśliński, W.
Zakrzewski, M.
Mosiewicz, J.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/28762972.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 4; 568-573
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of zinc supplementation on the course of COVID-19 - A systematic review and meta-analysis
Autorzy:
Olczak-Pruc, M.
Szarpak, L.
Navolokina, A.
Chmielewski, J.
Panasiuk, L.
Juárez-Vela, R.
Pruc, M.
Swieczkowski, D.
Majer, R.
Rafique, Z.
Peacock, R.W.
Powiązania:
https://bibliotekanauki.pl/articles/28761725.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2022, 29, 4; 568-574
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Uncovering the effects of COVID-19 on in-hospital cardiac arrest – a living systematic review and meta-analysis
Autorzy:
Bielski, K.
Pruc, M.
Rafique, Z.
Peacock, F.W.
Chmielewski, J.
Panasiuk, L.
Szarpak, L.
Bragazzi, N.L.
Chojnowska-Ćwiąkała, I.
Powiązania:
https://bibliotekanauki.pl/articles/28763041.pdf
Data publikacji:
2023
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2023, 30, 3; 498-504
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model
Antagonistyczna interakcja lakozamidu z karbamazepiną i walproainianem w modelu drgawek toniczno-klonicznych u myszy
Autorzy:
Kondrat-Wróbel, M.W.
Załuska, K.
Walczak, A.
Panasiuk-Poterek, A.N.
Gut-Lepiech, A.
Wróblewska-Łuczka, P.
Łuszczki, J.J.
Powiązania:
https://bibliotekanauki.pl/articles/2053463.pdf
Data publikacji:
2019
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
antiepileptic drugs
isobolography
maximal electroshock
three-drug combination
antagonism
leki przeciwpadaczkowe
izobolografia
elektrowstrząsy
kombinacja trzech leków
antagonizm
Opis:
Background. It is estimated that approximately 1% of people worldwide suffer from epilepsy. Currently available antiepileptic drugs (AEDs) are able to control epileptic seizures in about 70% of cases. In the remaining patients (30%), the application of two or three AEDs in combination is necessary for effective seizure management. The goal of this work was to characterize the interaction of three AEDs: lacosamide (LCM), carbamazepine (CBZ) and valproate (VPA) at the fixed-ratio of 1:1:1 in the mouse tonic-clonic seizure model. Material and methods. Male albino Swiss mice, after receiving a combination of LCM, CBZ and VPA, were challenged with electric current to evoke tonic hind limb extension (seizure activity). Protection of the mice from tonic-clonic seizures was assessed by isobolographic analysis to determine the type of interaction occurring between these drugs. Results. Type I isobolographic analysis revealed that the combination of LCM, CBZ and VPA produced infra-additive (antagonistic) interaction in the mouse tonic-clonic seizure model. Conclusions. Since the three-drug mixture of LCM, CBZ a nd VPA exerted an antagonistic interaction in the tonic-clonic seizure test in mice, we would caution physicians against treating epilepsy patients with this unfavorable combination.
Wprowadzenie. Szacuje się, że około 1% osób na całym świecie cierpi na padaczkę. Obecnie dostępne leki przeciwpadaczkowe pozwalają na opanowanie napadów padaczkowych w około 70% przypadków. U pozostałych pacjentów z padaczką (30%) konieczne jest zastosowanie dwóch lub trzech leków przeciwpadaczkowych w kombinacji. Celem pracy było scharakteryzowanie interakcji między trzema lekami przeciwpadaczkowymi: lakozamidem (LCM), karbamazepiną (CBZ) i walproinianem (VPA) w stałym stosunku dawek 1:1:1 w modelu drgawek toniczno-klonicznych u myszy. Materiał i metody. Samce myszy albino Swiss, po otrzymaniu kombinacji LCM, CBZ i VPA, poddano działaniu prądu elektrycznego, aby wywołać toniczny wyprost kończyn tylnych (aktywność drgawkową). Ochronę myszy przed napadami toniczno-klonicznymi oszacowano za pomocą analizy izobolograficznej, aby określić typ interakcji zachodzącej między tymi lekami. Wyniki. Analiza izobolograficzna typu I ujawniła, że kombinacja LCM, CBZ i VPA powodowała oddziaływanie infra-addytywne (antagonistyczne) w modelu drgawek toniczno-klonicznych u myszy. Wnioski. Ponieważ trójlekowa mieszanina LCM, CBZ i VPA wywierała antagonistyczną interakcję w teście napadów toniczno-klonicznych u myszy, specjalne ostrzeżenie jest konieczne dla lekarzy, aby nie leczyć pacjentów z padaczką tą niekorzystną kombinacją.
Źródło:
Health Problems of Civilization; 2019, 13, 1; 92-98
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synergy among oxcarbazepine, pregabalin and topiramate in the mouse maximal electroshockinduced seizure test – an isobolographic analysis
Autorzy:
Zaluska, K.
Panasiuk-Poterek, A.N.
Kondrad-Wrobel, M.W.
Marzeda, P.
Walczak, A.
Gut-Lepiech, A.
Wroblewska-Luczka, P.
Luszczki, J.J.
Powiązania:
https://bibliotekanauki.pl/articles/3409.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Źródło:
Journal of Pre-Clinical and Clinical Research; 2018, 12, 4
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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